CN105142628A - 氘取代的富马酸盐衍生物 - Google Patents

氘取代的富马酸盐衍生物 Download PDF

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Publication number
CN105142628A
CN105142628A CN201380073599.5A CN201380073599A CN105142628A CN 105142628 A CN105142628 A CN 105142628A CN 201380073599 A CN201380073599 A CN 201380073599A CN 105142628 A CN105142628 A CN 105142628A
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disease
compound
syndrome
acute
fibrosis
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Chinese (zh)
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建华·赵
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Biogen Inc
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Biogen Idec Inc
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    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
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  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Psychology (AREA)
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  • Ophthalmology & Optometry (AREA)
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CN201380073599.5A 2012-12-21 2013-12-20 氘取代的富马酸盐衍生物 Pending CN105142628A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745115P 2012-12-21 2012-12-21
US61/745,115 2012-12-21
PCT/US2013/077248 WO2014100728A1 (en) 2012-12-21 2013-12-20 Deuterium substituted fumarate derivatives

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CN105142628A true CN105142628A (zh) 2015-12-09

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CN201380073599.5A Pending CN105142628A (zh) 2012-12-21 2013-12-20 氘取代的富马酸盐衍生物

Country Status (8)

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US (2) US20140179779A1 (https=)
EP (2) EP2934503B1 (https=)
JP (2) JP6506174B2 (https=)
CN (1) CN105142628A (https=)
AR (1) AR094277A1 (https=)
ES (1) ES2733961T3 (https=)
TW (1) TW201436790A (https=)
WO (1) WO2014100728A1 (https=)

Cited By (5)

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WO2018177114A1 (zh) * 2017-03-28 2018-10-04 重庆纽源生物科技有限公司 一种水杨酸基富马酸盐衍生物及在治疗帕金森症和其他神经退行性疾病应用
CN108699011A (zh) * 2016-02-03 2018-10-23 参宿七制药股份有限公司 Nrf2活化性化合物及其用途
CN112675159A (zh) * 2021-01-12 2021-04-20 杭州师范大学 L-苹果酸在制备防治肝脏缺血再灌注损伤药物中的应用
CN114286811A (zh) * 2019-04-17 2022-04-05 伊克斯切尔制药有限责任公司 富马酸单甲酯的前药
CN116440113A (zh) * 2023-03-27 2023-07-18 天津农学院 富马酸二甲酯作为t-2毒素神经保护剂方面的应用

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HRP20140640T1 (hr) 2008-08-19 2014-11-21 Xenoport, Inc. Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe
SMT201800098T1 (it) 2011-06-08 2018-03-08 Biogen Ma Inc Processo per la preparazione di dimetilfumarato cristallino e con purezza elevata
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
AR094277A1 (es) * 2012-12-21 2015-07-22 Biogen Idec Inc Derivados de fumarato sustituidos con deuterio
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
BR112015022854A2 (pt) 2013-03-14 2017-07-18 Alkermes Pharma Ireland Ltd pró-farmacos de fumaratos e uso do mesmo no tratamento de várias doenças
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
CN104415026A (zh) * 2013-08-31 2015-03-18 成都渊源生物科技有限公司 氘代富马酸衍生物在治疗多发性硬化症中的应用
EP3041467A1 (en) 2013-09-06 2016-07-13 XenoPort, Inc. Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use
JP6337135B2 (ja) 2014-02-24 2018-06-06 アルカーメス ファーマ アイルランド リミテッド フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
AU2015222880B2 (en) 2014-02-28 2016-11-24 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
MA40985A (fr) 2014-11-17 2017-09-26 Biogen Ma Inc Méthodes de traitement de la sclérose en plaques
MA40990A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle
WO2016147108A1 (en) * 2015-03-17 2016-09-22 Hetero Research Foundation Pharmaceutical compositions of dimethyl fumarate
MA41785A (fr) 2015-03-20 2018-01-23 Biogen Ma Inc Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
KR102486434B1 (ko) * 2016-11-08 2023-01-09 리아타 파마슈티컬즈 홀딩스, 엘엘씨 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법
WO2020094767A1 (en) 2018-11-08 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of nrf2 activators for the treatment of staphylococcus aureus infections
CN109364058A (zh) * 2018-12-05 2019-02-22 中南大学湘雅医院 富马酸酯及其可药用盐在制备治疗铁死亡相关疾病的药物中的应用
US11903918B2 (en) 2020-01-10 2024-02-20 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
EP4146190A2 (en) 2020-05-06 2023-03-15 Imcyse SA Combination treatment for fumarate-related diseases
EP4580612A1 (en) 2022-09-02 2025-07-09 Institut National de la Santé et de la Recherche Médicale Use of nrf2 activators for the treatment of cerebral small vessel disease

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