CN105130855B - 二酰基化的羟基胺衍生物及其用途 - Google Patents

二酰基化的羟基胺衍生物及其用途 Download PDF

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CN105130855B
CN105130855B CN201510390382.8A CN201510390382A CN105130855B CN 105130855 B CN105130855 B CN 105130855B CN 201510390382 A CN201510390382 A CN 201510390382A CN 105130855 B CN105130855 B CN 105130855B
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tert
alkyl
carbonyl
butoxy
compound
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CN105130855A (zh
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J·P·托斯卡诺
A·苏顿
V·J·卡利什
F·A·布鲁克菲尔德
S·M·考特尼
L·M·弗罗斯特
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Johns Hopkins University
Cardioxyl Pharmaceuticals Inc
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Cardioxyl Pharmaceuticals Inc
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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  • Animal Behavior & Ethology (AREA)
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  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN201510390382.8A 2009-12-07 2010-12-07 二酰基化的羟基胺衍生物及其用途 Expired - Fee Related CN105130855B (zh)

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US26739909P 2009-12-07 2009-12-07
US61/267,399 2009-12-07
US29122409P 2009-12-30 2009-12-30
US61/291,224 2009-12-30
CN201080063220.9A CN102753519B (zh) 2009-12-07 2010-12-07 二酰基化的羟基胺衍生物

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US (2) US9018411B2 (https=)
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AU (1) AU2010328230B2 (https=)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) * 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
AU2013201929B2 (en) * 2011-10-17 2015-07-23 The Johns Hopkins University N-substituted hydroxylamine derivatives with carbon-based leaving groups
WO2014070919A1 (en) 2012-11-01 2014-05-08 The Johns Hopkins University Controlled hno release through intramolecular cyclization-elimination
HRP20180121T1 (hr) 2013-01-18 2018-02-23 Cardioxyl Pharmaceuticals Inc. Donori nitroksila s poboljšanim terapijskim indeksom
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3148983A1 (en) 2014-05-27 2017-04-05 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
CN107922371B (zh) 2015-06-26 2022-04-19 约翰斯霍普金斯大学 作为有效的hno供体的具有碳基离去基团的n-取代的异羟肟酸及其用途
KR20180063326A (ko) 2015-10-19 2018-06-11 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 피라졸론 유도체
US10730828B2 (en) 2015-10-19 2020-08-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
US10913728B2 (en) 2016-07-28 2021-02-09 The Johns Hopkins University O-substituted hydroxamic acids
US11083704B2 (en) 2017-01-03 2021-08-10 Bristol-Myers Squibb Company Method of administering nitroxyl donating compounds
CN114072205A (zh) * 2019-04-18 2022-02-18 视点制药公司 用tie-2激活剂治疗高血压的方法
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds
CN116924946B (zh) * 2023-09-15 2023-11-21 成都泰和伟业生物科技有限公司 一种化合物及其制备方法和作为氨基保护试剂的用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409367A (en) * 1981-01-20 1983-10-11 Akzona Incorporated Process for cross-linking polymers
CN1143950A (zh) * 1994-01-19 1997-02-26 比克荷兰有限公司 含硝酰基的苄胺衍生物及其在治疗心血管疾病和治疗升高眼压中的应用
US20040038947A1 (en) * 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
CN101472576A (zh) * 2006-03-17 2009-07-01 约翰斯·霍普金斯大学医学院 作为新的有生理学价值的硝酰氧基供体的n-羟基磺酰胺衍生物

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1283890A (fr) 1959-12-28 1962-02-09 Ajinomoto Kk Procédé de préparation d'inosinate de sodium
US3219428A (en) 1961-04-17 1965-11-23 Hooker Chemical Corp O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides
US3382243A (en) 1965-05-17 1968-05-07 American Home Prod Acetamides and their preparation
CH476084A (de) * 1965-11-16 1969-07-31 Ciba Geigy Verfahren zur Herstellung neuer Azofarbstoffe
US3458570A (en) 1966-07-28 1969-07-29 Stauffer Chemical Co N-substituted phenylsulfonyl-hydroxylamines
JPS4425772Y1 (https=) 1967-09-28 1969-10-29
US3948967A (en) * 1968-01-03 1976-04-06 Velsicol Chemical Corporation Aryl urea carbonates
DE1768511A1 (de) * 1968-05-21 1971-10-28 Basf Ag Substituierte N-Hydroxysaeureanilide
US3661944A (en) 1970-07-01 1972-05-09 Smith Kline French Lab 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds
US3746727A (en) 1971-06-07 1973-07-17 Shell Oil Co Benzenesulfhydroxamic acids and their derivatives
GB1330609A (en) 1972-05-09 1973-09-19 Smith Kline French Lab 4-n-lower alkanoyl hydroxylamino 4- aminodiphenylsulphone compounds
FR2344050A1 (fr) 1976-03-09 1977-10-07 Agfa Gevaert Ag Technique d'introduction d'additifs photographiques dans des emulsions d'un sel d'argent
JPS567710A (en) 1979-06-28 1981-01-27 Sansho Seiyaku Kk Whitening cosmetic
US4405357A (en) * 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
US4539321A (en) 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
DE3583799D1 (de) 1985-01-11 1991-09-19 Abbott Lab Ltd Feste zubereitung mit langsamer freisetzung.
US4663351A (en) 1985-08-23 1987-05-05 Berlex Laboratories, Inc. Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4954526A (en) 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5124480A (en) * 1989-10-10 1992-06-23 Monsanto Company Peroxygen bleach activators and bleaching compositions
US5212204A (en) 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
JPH04235171A (ja) 1990-07-26 1992-08-24 Sumitomo Chem Co Ltd スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤
JP3259022B2 (ja) 1990-05-22 2002-02-18 株式会社リコー 荷電粉体粒子の帯電量測定方法及び装置
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
US5278192A (en) 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
ATE192922T1 (de) 1993-11-02 2000-06-15 Us Health Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden
US5532256A (en) 1994-05-18 1996-07-02 American Home Products Corporation New azolidinediones and thiadiazolidinediones as antihyperglycemic agents
DE19533023B4 (de) 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
US6043232A (en) 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5674894A (en) 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
DE19545878A1 (de) * 1995-12-08 1997-06-12 Basf Ag Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5962521A (en) 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
WO1998029408A1 (en) 1996-12-26 1998-07-09 Nikken Chemicals Co., Ltd. N-hydroxyurea derivatives and medicinal compositions containing the same
US6030975A (en) 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
WO1998043621A1 (en) 1997-03-31 1998-10-08 The Children's Medical Center Corporation Nitrosylation to inactivate apoptotic enzymes
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB9726989D0 (en) 1997-12-22 1998-02-18 Ciba Geigy Ag Organic compounds
AU1770299A (en) 1997-12-23 1999-07-19 Nycomed Imaging As Nitric oxide releasing chelating agents and their therapeutic use
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE69924735T2 (de) 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
AU772188B2 (en) 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
PL353199A1 (en) 1999-08-30 2003-11-03 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US20010053795A1 (en) 2000-06-20 2001-12-20 Bond Richard A. Paradoxical pharmacology
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
GB2371262B (en) 2001-01-17 2005-02-16 Megaprint Group Ltd Folding card
US20030068386A1 (en) * 2001-09-05 2003-04-10 Stoyanovsky Detcho A. Method of treating cancerous disease
FR2832634A1 (fr) 2001-11-29 2003-05-30 Univ Pasteur Utilisation des isomeres l de derives aminoacides de l'hydroxyguanidine pour la production de no, compositions pharmaceutiques les contenant et utilisations pharmaceutiques
US20040077691A1 (en) 2002-06-21 2004-04-22 Medinox, Inc. Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
DE10239905A1 (de) * 2002-08-30 2004-03-04 Bayer Cropscience Gmbh Substituierte Pyridine oder Pyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
EP1909779A1 (en) 2005-06-23 2008-04-16 Johns Hopkins University Thiol-sensitive positive inotropes
TWI282084B (en) 2005-07-08 2007-06-01 Jeng-Tzung Chen Guitar
US20070088043A1 (en) 2005-10-18 2007-04-19 Orchid Research Laboratories Limited. Novel HDAC inhibitors
EP1962596A4 (en) 2005-12-08 2010-09-22 Univ Johns Hopkins TRIOXAN-DIMERE WITH HIGH ANTIMALARIA AND PERMANENT ANTIMALARIA ACTIVITY
JP4783657B2 (ja) 2006-03-27 2011-09-28 富士フイルム株式会社 ポジ型レジスト組成物及び該組成物を用いたパターン形成方法
EP2010476A4 (en) 2006-04-13 2011-01-26 Univ Wake Forest Health Sciences NITROXYL DISPENSERS FROM C-NITROSO COMPOUNDS
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
LT2278975T (lt) * 2008-05-07 2016-11-25 Cardioxyl Pharmaceuticals Inc. Nauji nitrozo junginiai kaip nitroksilo donorai, ir jų panaudojimo būdas
WO2011063339A1 (en) 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409367A (en) * 1981-01-20 1983-10-11 Akzona Incorporated Process for cross-linking polymers
CN1143950A (zh) * 1994-01-19 1997-02-26 比克荷兰有限公司 含硝酰基的苄胺衍生物及其在治疗心血管疾病和治疗升高眼压中的应用
US20040038947A1 (en) * 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
CN101472576A (zh) * 2006-03-17 2009-07-01 约翰斯·霍普金斯大学医学院 作为新的有生理学价值的硝酰氧基供体的n-羟基磺酰胺衍生物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Hydroxylamine Derivatives;Klaus Rehse和Tawfig Shahrouri;《Arch. Pharm. Pharm. Med. Chem.》;19980424;第331卷;365–367页 *
Melinda J. C. Lee等.Prodrugs of Nitroxyl as Inhibitors of Aldehyde Dehydrogenase.《J. Med. Chem.》.1992,第35卷3648-3652页. *
N-Hydroxybenzenecarboximidic Acid Derivatives: A New Class of Nitroxyl-Generating Prodrugs;Melinda J. C. Lee等;《Biology and Chemistry》;20010630;第5卷(第3期);278-287页 *
Prodrugs of Nitroxyl as Inhibitors of Aldehyde Dehydrogenase;Melinda J. C. Lee 等;《J. Med. Chem.》;19920101;第35卷(第20期);3648-3652页 *
The oxidation of hydroxamic acids;Boyland E.和Nery R.;《Journal of the Chemical Society [Section] C: Organic》;19661231(第3期);346-350页 *
The synthesis and some reactions of N-hydroxycarbamates;Boyland E.和Nery R.;《Journal of the Chemical Society [Section] C: Organic》;19661231(第3期);354-358页 *

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