CN105125803A - Traditional Chinese medicine used in radiology department and for preventing ographic contrast nephropathy, and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine used in the radiology department and for preventing radiographic contrast nephropathy, and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw herbal materials: emilia sonchifolia, hibiscus tiliaceus, welted thistle, herb of diversifolious pimpinella, american eleutherine rhizome, radermachera sinica, fructus viticis, herb of rush-like bulrush, sowthistle-leaf ixeris seedling, blumea, trollflower, textile screw pine flower, herba drymariae, herb of maidenhair, alkali halide, flexuose climbing fern, radix tinosporae and zornia diphylla pers. The traditional Chinese medicine provided by the invention has the following beneficial effects: the traditional Chinese medicine has an exact effect on preventing radiographic contrast nephropathy, and has little toxic or side effect.

Description

A kind of radiology department Chinese medicine and the preparation method of preventing radiographic contrast nephropathy

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to Chinese medicine and the preparation method of a kind of radiology department prevention radiographic contrast nephropathy.

Background technology

Along with extensively carrying out of modern shadowgraph technique, radiographic contrast nephropathy (contrastassociatednephropathy, CAN) receives the concern of nephropathy worker day by day.CAN refers to the hurried decline of renal function caused by contrast agent.Conventional contrast agent is generally hypertonicity, and amount of iodine, up to 37%, is not absorbed by renal tubules by glomerular filtration with original shape in vivo, and during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.Acute renal failure report caused by contrast agent increases increasingly, and even its incidence rate has exceeded caused by aminoglycoside antibiotics.Large quantity research report, CAN accompanies renal insufficiency to be 6% ~ 92%, does not accompany renal insufficiency to be 0 ~ 22%.A large amount of prospective control study is pointed out, after general injection contrast agent, namely serum creatinine value has diagnostic significance higher than 25% ~ 50% of basic value.

Person's serum creatinine raises usually in 24h to accept contrast agent, 96h peaking, within general 7 ~ 10 days, replys afterwards and reaches basic value.But also have report, renal function declined in Progressive symmetric erythrokeratodermia in 1 ~ 3 week, then reply and reach basic value.Can there is oliguria in early days in more than 60% CAN patient, have resistance, also have non-oliguria person to button loop diuretic.Most patients renal function can clear-cutting forestland, and 10% need dialysis treatment, and irreversible renal failure person is rare, needs long term maintenance to dialyse.

There is renal cells, cast and various fragment in uroscopy, non-specific in urinating as seen, uncorrelated with change in renal function.Urate crystal is common, and even visible Citric acid calcium crystallization, High-grade Proteinuria is uncommon.Have the Most patients of acute tubular necrosis, renal sodium excretion is often greater than 40mmol/L, and fractional excretion of sodium (FENa) is greater than 1%; But have 1/3 acute renal failure person renal sodium excretion lower than 20mmol/L, oliguria person's fractional excretion of sodium is less than 1%.

After contrast agent application, x-ray is taken the photograph the two kidney development of sheet and is continued to reach the characteristic performance that 24 ~ 48h is CAN.Older under observation finds, x-ray is taken the photograph sheet sensitivity and reached 83%, and specificity up to 93%, but also has false positive and false negative result.Therefore CAN still needs in addition clear and definite in conjunction with serum creatinine measured value in 24 ~ 48h.

The renal failure that CAN must cause with cholesterol micro-embolization (cholesterolmicroemboli) is differentiated mutually.Cholesterol emboli ties up to conduit in angiographic procedure and assigns caused by injured blood vessel.Can be there is the sings and symptoms (as lower limb or chronic foot pain, stomachache, back pain, numb limbs and tense tendons are even benumbed, skin of lower extremity is pale) of blood vessel embolism in acute person, diagnose more difficult after accepting contrast agent.Patient can occur that hypotension, oliguria are even cause death due to multi viscera infarction.Chronic type person is usually expressed as Progressive symmetric erythrokeratodermia renal insufficiency and reaches more than several weeks and develop into irreversibility renal failure.In skin, microembolism syndrome diagnosis basis occurs that livedo reticularis, amylase raise and peripheral blood eosinophilia, uropsammus examination is negative, and Renal biospy shows distinctive cholesterol emboli.

Conventional contrast agent is hypertonicity, and do not absorbed by renal tubules by glomerular filtration with original shape in vivo, during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.It is below easily cause the risk factor of renal damage and possible risk factor: 1, risk factor; (1) original renal insufficiency.(2) with the diabetes of renal insufficiency: have diabetes medical history more than 10 years, more than 50 years old, there are cardiovascular complication and renal insufficiency person danger at the age greatly.(3) congestive heart failure: the congestive heart failure person that cardiac function is IV grade is obvious risk factor.Because contrast agent can make Renal vascular shrink, renal blood flow reduces, and adds the danger of patients with congestive heart failure generation ischemic renal failure.(4) nephrotic syndrome.(5) liver cirrhosis companion renal function injury.(6) hypovolemia or dehydration: find in the experimentation of Canis familiaris L., under dewatering state, contrast agent can cause blood vessel in kidney significantly to shrink.(7) multiple myeloma: intravenous contrast agent can cause acute renal failure, was once once thinking that the agent of multiple myeloma person's intravenous contrast was anti-indication.But find that CAN incidence rate is only 0.6% ~ 1.25% in the observation after one group of retrospective multiple myeloma accepts contrast agent.Therefore if desired clinical, carefully monitor, still can carry out after supplementing capacity.(8) apply other nephrotoxic drugs simultaneously.(9) multiple radiocontrast medium person is accepted in a short time.(10) dosage of contrast agent: dosage is larger, renal damage increases, and as dosage > 30ml, during radiography, mean blood pressure is less than 13.3kPa (100mmHg) then dangerous increase.(11) hypercalcemia.2, possible risk factor; (1) age: because People nephron reduces and the reduction of renal blood flow, GFR declined with the age, and CAN incidence rate is high.(2) diabetics of absent renal function infringement.(3) anemia.(4) albuminuria (without nephrotic syndrome).(5) abnormal liver function.(6) hyperuricemia.(7) male patient.(8) hypertension.(9) renal transplantation person is accepted.

Summary of the invention

Technical problem to be solved by this invention is, provide Chinese medicine and the preparation method of a kind of radiology department prevention radiographic contrast nephropathy, Chinese medicine of the present invention has definite curative effect to prevention radiographic contrast nephropathy, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides the Chinese medicine of a kind of radiology department with prevention radiographic contrast nephropathy, each raw medicinal material of described Chinese medicine comprises: Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae, Herba Blumeae Lacerae, Flos Trollii, Flos pandani tectorii, Herba drymariae cordatae, Herba Adianti, salt alkali, Herba Lygodii Flexuosi, Radix Tinosporae and Herba Zornia Diphyllae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Duchesneae Indicae 10 ~ 20 parts, Cortex seu flos hibisci tiliacei 15 ~ 25 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba pimpinellae diversifoliae 20 ~ 30 parts, Bulbus Eleutherines Plicatae 15 ~ 25 parts, Radix radermacherae sinicae 12 ~ 22 parts, Fructus Viticis 15 ~ 25 parts, Herba scirpi juncoidis 20 ~ 30 parts, Herba Ixeritis Sonchifoliae 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Flos Trollii 20 ~ 30 parts, Flos pandani tectorii 10 ~ 20 parts, Herba drymariae cordatae 20 ~ 30 parts, Herba Adianti 22 ~ 32 parts, salt alkali 10 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 30 parts, Radix Tinosporae 10 ~ 20 parts and Herba Zornia Diphyllae 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be as follows: Herba Duchesneae Indicae 15 ~ 20 parts, Cortex seu flos hibisci tiliacei 17 ~ 22 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba pimpinellae diversifoliae 22 ~ 27 parts, Bulbus Eleutherines Plicatae 18 ~ 23 parts, Radix radermacherae sinicae 14 ~ 19 parts, Fructus Viticis 17 ~ 22 parts, Herba scirpi juncoidis 20 ~ 25 parts, Herba Ixeritis Sonchifoliae 13 ~ 18 parts, Herba Blumeae Lacerae 8 ~ 13 parts, Flos Trollii 22 ~ 27 parts, Flos pandani tectorii 13 ~ 18 parts, Herba drymariae cordatae 25 ~ 30 parts, Herba Adianti 24 ~ 29 parts, salt alkali 15 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 25 parts, Radix Tinosporae 13 ~ 18 parts and Herba Zornia Diphyllae 10 ~ 15 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 18 parts, Cortex seu flos hibisci tiliacei 18 parts, Herba Cardui Crispi 14 parts, Herba pimpinellae diversifoliae 23 parts, Bulbus Eleutherines Plicatae 22 parts, Radix radermacherae sinicae 15 parts, Fructus Viticis 21 parts, Herba scirpi juncoidis 22 parts, Herba Ixeritis Sonchifoliae 16 parts, Herba Blumeae Lacerae 9 parts, Flos Trollii 26 parts, Flos pandani tectorii 14 parts, Herba drymariae cordatae 28 parts, Herba Adianti 25 parts, salt alkali 18 parts, Herba Lygodii Flexuosi 22 parts, Radix Tinosporae 16 parts and Herba Zornia Diphyllae 12 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 16 parts, Cortex seu flos hibisci tiliacei 20 parts, Herba Cardui Crispi 12 parts, Herba pimpinellae diversifoliae 25 parts, Bulbus Eleutherines Plicatae 20 parts, Radix radermacherae sinicae 18 parts, Fructus Viticis 19 parts, Herba scirpi juncoidis 25 parts, Herba Ixeritis Sonchifoliae 15 parts, Herba Blumeae Lacerae 12 parts, Flos Trollii 23 parts, Flos pandani tectorii 17 parts, Herba drymariae cordatae 26 parts, Herba Adianti 28 parts, salt alkali 15 parts, Herba Lygodii Flexuosi 25 parts, Radix Tinosporae 13 parts and Herba Zornia Diphyllae 15 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae and Herba Blumeae Lacerae, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Beneficial effect of the present invention: Chinese medicine of the present invention, has determined curative effect, the advantage that toxic and side effects is little to prevention radiographic contrast nephropathy.

Detailed description of the invention

The invention provides the Chinese medicine of a kind of radiology department with prevention radiographic contrast nephropathy, its raw medicinal material comprises: Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae, Herba Blumeae Lacerae, Flos Trollii, Flos pandani tectorii, Herba drymariae cordatae, Herba Adianti, salt alkali, Herba Lygodii Flexuosi, Radix Tinosporae and Herba Zornia Diphyllae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Duchesneae Indicae: [another name] Radix seu Folium Alchorneae trewioidis, YEXIAHONG, Herba Emiliae.[source] is Compositae Herba Duchesneae Indicae platymiscium Herba Duchesneae Indicae Emiliasonchifolia (L.) DC., with all herbal medicine.Summer, autumn gather.[nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Upper respiratory tract infection, laryngopharynx swelling and pain, oral ulcer, pneumonia, acute enteritis, bacillary dysentery, urinary system infection, orchitis, mastitis, furuncle and phyma skin infection, skin eczema, osteopatia sprain.[extracts] " national Chinese herbal medicine compilation "

Cortex seu flos hibisci tiliacei: [another name] Gang flower, salt water surface folder fruit, Piao son, sea fiber crops, Hai Luoshu, back of a bow tree.[source] medical material Ji Yuan: be the leaf of Malvaceae plant Cortex seu flos hibisci tiliacei, bark or flower.[nature and flavor] are sweet; Light; Cold nature.[return through] lung meridian.[function cures mainly] clearing away lung-heat to relieve cough; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Furuncle swells and ache; Manihot poisoning.[extracts] " China's book on Chinese herbal medicine "

Herba Cardui Crispi: [another name] flies gently, sky shepherd's purse, lie prostrate pig, lie prostrate rabbit, fly Phasiana, wooden standing grain, Herba Cardui Crispi Artemisia, old cattle mistake, Semen astragali sinici, thorn are beaten the grass, Thunder God dish, Radix seu Caulis Embeliae Parviflorae, maple head, fly curtain, red spur, thorn lid, Ci Luobu, Radix Cirsii Japonici, old cattle file.[source] medical material Ji Yuan: be feverfew silk hair Herba Cardui Crispi and the herb or the root that save hair Herba Cardui Crispi.[nature and flavor] mildly bitter flavor; Cool in nature.[function cures mainly] dispels the wind; Heat clearing away; Dampness removing; Cooling blood for hemostasis; Promoting blood circulation and detumescence.Main cold cough; Have a headache dizzy; Urinary system infection; Chyluria; Leucorrhea; Jaundice; Rheumatic arthralgia; Spit blood; Epistaxis; Hematuria; Menorrhagia; Dysfunctional uterine hemorrhage; Traumatic injury; Furuncle furuncle and phyma; Swelling and pain of hemorrhoid; Burn.[extracts] " China's book on Chinese herbal medicine "

Herba pimpinellae diversifoliae: [another name] Radix Pimpinellae Candolleanae, scabies infections stock, bitter father's dish, Herba Lespedezae Cuneatae, spades head, tripod Oviductus Ranae, sheep have a strong smell seven, little Herba Caryopteridis Terniflorae, wild Radix Angelicae Sinensis, Hu Yangding, mountain Radix Angelicae Sinensis, Pemisetum flaccidum Griseb, old Magnoliacoco, Rhizoma typhonii divaricati, sheep have a strong smell grass, Serpentis stings grass, Herba Caryopteridis Terniflorae, hair rises Herba Amaranthi tricoloris, BAILUTONG 36 is good, August white, JINSUOSHI, Radix Talini Paniculati, Pimpinella anisum Linn., bitter father's dish, wild rhizome of chuanxiong, TUXIXIN, spend perfume (or spice), liver-cold medicine in vain.[source] medical material Ji Yuan: be the herb of the different leaf Pimpinella anisum Linn. of samphire.[nature and flavor] acrid in the mouth; Bitter; Micro-sweet; Slightly warm in nature.[return through] returns lung; Stomach; Liver Channel.[function cures mainly] falls apart wind lung qi dispersing; Regulating QI to relieve pain; Removing food stagnancy spleen invigorating; Promoting blood circulation to restore menstrual flow; Removing dampness and detoxicating.Main flu; Cough; Pertussis; Pulmonary tuberculosis; Lung abscess; Headache; Headache; Bud pain; Crisp hypochondriac pain; Peratodynia; Abdominal distention and pain; Koro cold type of pain; Rheumatic arthritis; Impairment caused by overstrain; Bone labor; Dyspepsia; Food stagnation; Infantile malnutrition; Acute filthy disease; Dysentery; Jaundice; Malaria; Menoxenia; Dysmenorrhea; Amenorrhea; Swelling of the breast; Corneal nebula; Pharyngeal swelling; Mumps; Traumatic injury; Eczema; Skin pruritus; Snakeworm hinders.[extracts] " China's book on Chinese herbal medicine "

Bulbus Eleutherines Plicatae: [another name] Allium ascalonicum L., little Bulbus Eleutherines Plicatae, fearness ripple bright [Dai Nationality's language].[source] medical material Ji Yuan: be Iridaceae Bulbus Eleutherines Plicatae, be used as medicine with herb, bulb.[nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, hemostasis.[extracts] " national Chinese herbal medicine compilation "

Radix radermacherae sinicae: [another name] oxtail bean, the young bean of Serpentis, Cicer arietinum Linn. wood, fresh kidney beans are wooden, synthetism sunshade, great Lang umbrella, large Chaoyang, gloomy wooden youth's umbrella, fresh kidney beans tree, white crane ginseng, oxtail tree, sunflower, oxtail wood, She Shu, Fructus Capsici tree, blunt forces tree, mountain Kidney bean, bitter Siberian cocklebur uncle (mother's brother), Semen vignae sinensis are set, fall dead cat sets.[source] medical material Ji Yuan: be the root of Bignoniaceae plant Radix radermacherae sinicae, leaf or fruit.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] summer heat clearing toxin resolving; Dissipating blood stasis for subsidence of swelling.Main Sunstroke heating; Carbuncle; Injury and bone fracture; Venom.[extracts] " China's book on Chinese herbal medicine "

Fructus Viticis: [another name] wild pepper reality, Fructus Vitics Simplicifoliae, FRUCTUS VITICIS, turnip.[source] medical material Ji Yuan: be the fruit of Verbenaceae Vitex rotundifolia and wild pepper.[nature and flavor] acrid in the mouth; Bitter; Cold nature.[return through] liver; Stomach; Urinary bladder channel.[function cures mainly] dispelling wind and heat pathogens; The clear sharp head.Main affection due to external wind and heat; Dizzy headache; Migraine; Gingival swelling and pain; The many tear of conjunctival congestion and swelling pain; Pain in order eyeball; Dim not clear; Arthralgia chiefly caused by damp pathogen contracture.[extracts] " China's book on Chinese herbal medicine "

Herba scirpi juncoidis: [source] medical material Ji Yuan: be the herb of sedge firefly Lin.[nature and flavor] sweet in the mouth; Light; Cool in nature.[return through] lung; Bladder; Liver Channel.[function cures mainly] clearing away heat and cooling blood; Detoxification and promoting urination; Removing food stagnancy whets the appetite.Djumah rash pyretic toxicity; Pulmonary tuberculosis hemoptysis; Toothache; Conjunctival congestion; Pyretic stranguria; Nebulousurine; Food stagnation is stagnated.[extracts] " China's book on Chinese herbal medicine "

Herba Ixeritis Sonchifoliae: [another name] Caulis et folium pavettae hongkongensis, Herba Ixeritis Denticulatae.[source] medical material Ji Yuan: be the herb of feverfew Herba Ixeritis Sonchifoliae.[nature and flavor] bitter in the mouth; Pungent; Property.[function cures mainly] alleviating pain and detumescence; Heat-clearing and toxic substances removing.Main headache; Toothache; Stomachache; Postoperative pain; Traumatic pain; Appendicitis; Intestinal is scorching; Pulmonary abscess; Laryngopharynx swelling and pain; Carbuncle furuncle.[extracts] " China's book on Chinese herbal medicine "

Herba Blumeae Lacerae: [another name] white hair Herba Carpesii Cernui, Arisaema balansae Engl., native Artemisia branch, Arisaema balansae Engl. grass, the battle of first winter.[source] medical material Ji Yuan: for Compositae plants the yellow herb of special frost.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Toothache due to stomach-fire; Zha rib; Carbuncle sore tumefacting virus.[extracts] " China's book on Chinese herbal medicine "

Flos Trollii: [another name] nonirrigated farmland lotus, golden Hibisci Mutabilis, nasturtium, golden pimple.[source] medical material Ji Yuan: be the flower of ranunculaceae plant Flos Trollii and party's lobe Flos Trollii, Trollius farreri Stapf, Trollius ledebouri.[nature and flavor] bitter in the mouth; Cold nature.[return through] returns lung; Stomach warp.[function cures mainly] heat-clearing and toxic substances removing; Detumescence; Improving eyesight.Cure mainly cold, fever; Laryngopharynx swelling and pain; Aphtha; Gingival swelling and pain; Gingival hemorrhage; Conjunctival congestion and swelling pain; Furuncle swelling toxin; Acute myringitis; Acute lymphangitis.[extracts] " China's book on Chinese herbal medicine "

Flos pandani tectorii: [another name] road is dead.[source] medical material Ji Yuan: be the flower of Pandanaceae plant Pandanus tectorius.[nature and flavor] sweet in the mouth; Cold in nature.[return through] bladder; Liver Channel.[function cures mainly] heat clearing away; Dampness removing.Main cold cough; Stranguria with turbid discharge; Dysuria; Diarrhea of heat type; Hernia; Boil on the nape opposite the mouth.[extracts] " China's book on Chinese herbal medicine "

Herba drymariae cordatae: [another name] group leaf goose intestinal, blue green grass or young crops of water, water-ice sheet, threading Serpentis, string lotus is careless, water is Dutch, vetch is sharp, Purple Loosestrife, blue or green fragrant grass, Flos Camelliae Japonicae variant grass, Twotooth Achyranthes Root, moonlight grass, magnificent rattan, 12 time grass, Tian Xing, the spoon of falling rattan, Radix Polygalae Crotalarioidis, ruffian's medicine, the moon toyo, vetch dish.[source] medical material Ji Yuan: be the herb of pinkwort lotus lotus bean list.[nature and flavor] are bitter; Cool in nature.[return through] liver; Stomach; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation and detoxication.Main jaundice; Edema; Malaria; Infantile convulsion; Wind beriberi caused by pathogenic damp; Carbuncle sore furuncle poison; Infantile malnutrition; Corneal nebula; Bulbar conjunctiva polyp.[extracts] " China's book on Chinese herbal medicine "

Herba Adianti: [another name] Shi Zhongzhu, Pilus Sus domestica paint, iron wire grass, bristles paint, Herba Hemiboeae, piglets MAOQI, rock Herba Spirodelae, Pilus Sus domestica false aloe, Herba cynodontis, fish scale grass, black foot awns, Pilus Sus domestica seven, rock palm fibre, the comprehensive grass of pig, Herba cynodontis, iron wire button, Shi Zhongzhu, Pilus Sus domestica paint, Adiantum monochlamys, black hair are returned to life from the nether world, touched grass, ferrum bachelor, iron wire parting, water Pilus Sus domestica seven, pig palm fibre seven, bristles seven, blackwort symphytum, flabellum venushair fern, Herba Parnassiae Delavayi, Yan Jia, besom beanstalk, gagger wolf beanstalk.[source] medical material Ji Yuan: be the herb of adiantaceae plant iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb., white back iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb..[nature and flavor] are bitter; Cool; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main cold, fever; Cough due to lung-heat; Diarrhea due to damp-heat; Dysentery; Stranguria with turbid discharge; Leukorrhagia; Acute mastitis; Scrofula; Furunculosis; Scald; Venom.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Salt alkali: [another name] halogen, cold stone, halogen are salty, alkalium, salt, salt brine.[source] medical material Ji Yuan: for enriched bittern cake (solid salt) decocts through processing the white crystals body made.[nature and flavor] are bitter salty; Cold; Nontoxic.[return through] heart; Lung; Kidney channel.[function cures mainly] clearing away heat-fire; Reduce phlegm; Softening the hard mass; Improving eyesight.Main large hot excessive thirst; The puckery pain of wind heat conjunctival congestion; Keshan disease; Kaschin-Beck disease; Goiter; Hypertension; Rheumatic heart disease; Chronic bronchitis; Rheumatic arthritis.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Herba Lygodii Flexuosi: [another name] lygodium flexuosum Sweet, refute muscle rattan, be situated between refer to rattan, twine rattan, Folium Salicis Babylonicae Spora Lygodii, Spora Lygodii, Zuo Zhuanteng, seat turn rattan, add and hang rattan, ring rattan.[source] medical material Ji Yuan: be the herb of Lygodiaceae plant bent axle Spora Lygodii.[nature and flavor] are sweet; Micro-hardship; Cold.[return through] kidney; Liver; Large intestine channel.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Clearing away heat-damp and promoting diuresis; Hemostasis.Main rheumatic numbness; Traumatic injury; Urinary tract infection; Urinary system calculus; Edema; Dysentery; Sore and toxic; Oral aphthae in children; Acute catarrhal conjunctivitis; Tinea disease; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Tinosporae: [another name] JinBroken-utensil Lan, golden bitter olive, Herba Sonerilae cantonensis, Saxidomus purpuratus, nine Fel Bovis seu Bubali, copper sliding weight of steelyard, gold silver bag, Jin Lan, Pseudobulbus Cremastrae Seu Pleiones, Kowloon gallbladder, golden Fel Canitis, gold Gu, Taurus gallbladder, gold thread hoist, Herba Elephantopi scaberis, nine Fructus Arctii, limacia sagittata, Herba Elephantopi scaberis, golden lion gallbladder, nine Semen Nelumbinis, Stachys geobombycis C. Y. Wu, tetrastigma hemsleyanum, broken rock pearl, nine Fel Bovis seu Bubali, Radix Clematidis Henryi, Fel Mylopharyngodon piceus.[source] medical material Ji Yuan: be the tuber of menispermaceae plant Radix Tinosporae.[nature and flavor] are bitter; Cold.[return through] spleen; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main laryngopharynx swelling and pain; Aphthous stomatitis; Diphtheria; Mumps; Heat syndrome cough aphonia; Epigastric pain; Dysentery; Carbuncle furunculosis; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Zornia Diphyllae: [another name] Kummerowia striata (Thunb.) Schindl, bitter to rest the head on, Hydrocotyle sibthorpioides, black fly wing grass, Ding Guicao, Herba euphorbiae prostratae, gold thread hang Rana limnocharis, two leaf Kummerowia striata (Thunb.) Schindl, the fly wing, Sha Ganli, Glycine tomentella, oolong grass, red bone fourth ground are blue or green.[source] medical material Ji Yuan: be the herb of leguminous plant Herba Zornia Diphyllae.[nature and flavor] sweet in the mouth; Cool in nature.[return through] spleen, Liver Channel.[function cures mainly] clearing away heat and expelling pathogen in the exterior; Removing pathogenic heat from blood and toxic substance from the body; Dehumidifying diuresis.Main anemopyretic cold; Pharyngalgia; Conjunctival congestion; Acute mastitis; Sore swollen toxin; Venom; Jaundice; Have loose bowels; Dysentery; Infantile malnutrition.[extracts] " China's book on Chinese herbal medicine "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 10 ~ 20 parts, Cortex seu flos hibisci tiliacei 15 ~ 25 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba pimpinellae diversifoliae 20 ~ 30 parts, Bulbus Eleutherines Plicatae 15 ~ 25 parts, Radix radermacherae sinicae 12 ~ 22 parts, Fructus Viticis 15 ~ 25 parts, Herba scirpi juncoidis 20 ~ 30 parts, Herba Ixeritis Sonchifoliae 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Flos Trollii 20 ~ 30 parts, Flos pandani tectorii 10 ~ 20 parts, Herba drymariae cordatae 20 ~ 30 parts, Herba Adianti 22 ~ 32 parts, salt alkali 10 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 30 parts, Radix Tinosporae 10 ~ 20 parts and Herba Zornia Diphyllae 10 ~ 20 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 15 ~ 20 parts, Cortex seu flos hibisci tiliacei 17 ~ 22 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba pimpinellae diversifoliae 22 ~ 27 parts, Bulbus Eleutherines Plicatae 18 ~ 23 parts, Radix radermacherae sinicae 14 ~ 19 parts, Fructus Viticis 17 ~ 22 parts, Herba scirpi juncoidis 20 ~ 25 parts, Herba Ixeritis Sonchifoliae 13 ~ 18 parts, Herba Blumeae Lacerae 8 ~ 13 parts, Flos Trollii 22 ~ 27 parts, Flos pandani tectorii 13 ~ 18 parts, Herba drymariae cordatae 25 ~ 30 parts, Herba Adianti 24 ~ 29 parts, salt alkali 15 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 25 parts, Radix Tinosporae 13 ~ 18 parts and Herba Zornia Diphyllae 10 ~ 15 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 18 parts, Cortex seu flos hibisci tiliacei 18 parts, Herba Cardui Crispi 14 parts, Herba pimpinellae diversifoliae 23 parts, Bulbus Eleutherines Plicatae 22 parts, Radix radermacherae sinicae 15 parts, Fructus Viticis 21 parts, Herba scirpi juncoidis 22 parts, Herba Ixeritis Sonchifoliae 16 parts, Herba Blumeae Lacerae 9 parts, Flos Trollii 26 parts, Flos pandani tectorii 14 parts, Herba drymariae cordatae 28 parts, Herba Adianti 25 parts, salt alkali 18 parts, Herba Lygodii Flexuosi 22 parts, Radix Tinosporae 16 parts and Herba Zornia Diphyllae 12 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Duchesneae Indicae 16 parts, Cortex seu flos hibisci tiliacei 20 parts, Herba Cardui Crispi 12 parts, Herba pimpinellae diversifoliae 25 parts, Bulbus Eleutherines Plicatae 20 parts, Radix radermacherae sinicae 18 parts, Fructus Viticis 19 parts, Herba scirpi juncoidis 25 parts, Herba Ixeritis Sonchifoliae 15 parts, Herba Blumeae Lacerae 12 parts, Flos Trollii 23 parts, Flos pandani tectorii 17 parts, Herba drymariae cordatae 26 parts, Herba Adianti 28 parts, salt alkali 15 parts, Herba Lygodii Flexuosi 25 parts, Radix Tinosporae 13 parts and Herba Zornia Diphyllae 15 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae and Herba Blumeae Lacerae, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: granule

Get Herba Duchesneae Indicae 160g, Cortex seu flos hibisci tiliacei 200g, Herba Cardui Crispi 120g, Herba pimpinellae diversifoliae 250g, Bulbus Eleutherines Plicatae 200g, Radix radermacherae sinicae 180g, Fructus Viticis 190g, Herba scirpi juncoidis 250g, Herba Ixeritis Sonchifoliae 150g, Herba Blumeae Lacerae 120g, Flos Trollii 230g, Flos pandani tectorii 170g, Herba drymariae cordatae 260g, Herba Adianti 280g, salt alkali 150g, Herba Lygodii Flexuosi 250g, Radix Tinosporae 130g and Herba Zornia Diphyllae 150g;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C of dryings, obtains granule.

Embodiment 2: oral solutions

Get Herba Duchesneae Indicae 180g, Cortex seu flos hibisci tiliacei 180g, Herba Cardui Crispi 140g, Herba pimpinellae diversifoliae 230g, Bulbus Eleutherines Plicatae 220g, Radix radermacherae sinicae 150g, Fructus Viticis 210g, Herba scirpi juncoidis 220g, Herba Ixeritis Sonchifoliae 160g, Herba Blumeae Lacerae 90g, Flos Trollii 260g, Flos pandani tectorii 140g, Herba drymariae cordatae 280g, Herba Adianti 250g, salt alkali 180g, Herba Lygodii Flexuosi 220g, Radix Tinosporae 160g and Herba Zornia Diphyllae 120g;

Its preparation method comprises the following steps:

The first step, by Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae and Herba Blumeae Lacerae, add relative to mixture 3.5 times amount determining alcohol be 65% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 2 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours, and refrigerated storage temperature is 4 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 30 minutes, and temperature is 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 7.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 37.9 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>37.9 crude drug/kg, every day, maximum dosage-feeding was 75.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 541 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 15) by 16.38,24.62 and 36.48g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Prophylactic tria is carried out to the routine radiography patient in the court 100, treatment group 50 example, male 23 example, women 27 example, 22 ~ 65 years old age, wherein with original renal insufficiency person 8 example, the glycosuria patient 5 with renal insufficiency is routine, congestive heart failure person 2 is routine, nephrotic syndrome person 3 example, liver cirrhosis accompany renal function injury 2 example, anemia person 8 is routine, abnormal liver function 3 is routine and hyperpietic 9 example.Matched group 50 example, male 22 example, women 28 example, at 24 ~ 63 years old age, wherein accompany renal function injury 1 example, anemia person 7 example, abnormal liver function 4 example and hyperpietic 10 example with original renal insufficiency person 7 example, glycosuria patient 6 example with renal insufficiency, congestive heart failure person 3 example, nephrotic syndrome person 4 example, liver cirrhosis.

Therapeutic Method:

Treatment group: the granule giving the embodiment of the present invention 1 after the radiography same day and radiography is for three days on end oral, each 15g, every day 3 times, and advise patient to drink more water;

Matched group: after 6h and radiography, 6h gives 0.9% sodium chloride solution 1ml/kgh intravenous injection hydration treatment respectively before radiography, and advises patient to drink more water.

Curative effect judging standard: measure respectively and the serum creatinine numerical value of 1 day, 2 days, 3 days, 5 days and 7 days before recording radiography, after radiography, serum creatinine situation of change is as standard before and after radiography.Effective: serum creatinine rises lower than 10%, does not occur oliguria, the clinical symptoms such as anuria; Effective: serum creatinine rises 10% ~ 25%, oliguria, and the clinical symptoms such as anuria do not have substantially; Invalid: serum creatinine rises and is more than or equal to 25%, with oliguria, the clinical symptoms such as anuria.

Therapeutic outcome: observe 7 days after radiography, statistical result is see table 1.

Before and after table 1 radiography, two groups of prevention situations compare (example):

Group	n	Effective	Effectively	Invalid	Effectively total
						Treatment group	50	39	9	2	48(96％)
Matched group	50	26	17	7	43(86％)

As can be seen from Table 1, adopt Chinese herb on the prevention radiographic contrast nephropathy of the present invention, relative to matched group, on therapeutic effect, tool increases significantly, namely Chinese medicine of the present invention effectively can avoid the generation of radiographic contrast nephropathy, even radiography patient have the risk factors such as original renal insufficiency exist time, still there is excellent preventive effect.

The effective patient of two groups is followed the tracks of respectively simultaneously and follow up a case by regular visits to one month, measure serum creatinine numerical value once weekly.The routine effective patient for the treatment of group 39, compared with serum creatinine numerical value before radiography, the change of the serum creatinine of all patients is less than 3% and all within normal range; The routine effective patient of matched group 26, compared with serum creatinine numerical value before radiography, serum creatinine raises phenomenon to have 4 routine patients to occur in 2 weeks, lifting range is at 5%-8% and do not exceed range of normal value, can recover voluntarily in 5 days, the change of the serum creatinine of all the other patients is less than 3% and all within normal range.

Concrete case: remaining certain, male, 55 years old, the diabetics of renal insufficiency, because cardiovascular needs radiography, the continuous granule giving the embodiment of the present invention 1 for two days after the radiography same day and radiography, each 15g, every day 3 times, after radiography in 7 days, after radiography when the 3rd day, serum creatinine rises to the highest, raises 5% than before radiography, after radiography the 5th day, serum creatinine returns to normal level before radiography, does not occur anuria, the clinical symptoms such as oliguria in 7 days.

Claims (9)

1. radiology department's Chinese medicine for prevention radiographic contrast nephropathy, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae, Herba Blumeae Lacerae, Flos Trollii, Flos pandani tectorii, Herba drymariae cordatae, Herba Adianti, salt alkali, Herba Lygodii Flexuosi, Radix Tinosporae and Herba Zornia Diphyllae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Duchesneae Indicae 10 ~ 20 parts, Cortex seu flos hibisci tiliacei 15 ~ 25 parts, Herba Cardui Crispi 10 ~ 20 parts, Herba pimpinellae diversifoliae 20 ~ 30 parts, Bulbus Eleutherines Plicatae 15 ~ 25 parts, Radix radermacherae sinicae 12 ~ 22 parts, Fructus Viticis 15 ~ 25 parts, Herba scirpi juncoidis 20 ~ 30 parts, Herba Ixeritis Sonchifoliae 10 ~ 20 parts, Herba Blumeae Lacerae 5 ~ 15 parts, Flos Trollii 20 ~ 30 parts, Flos pandani tectorii 10 ~ 20 parts, Herba drymariae cordatae 20 ~ 30 parts, Herba Adianti 22 ~ 32 parts, salt alkali 10 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 30 parts, Radix Tinosporae 10 ~ 20 parts and Herba Zornia Diphyllae 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Duchesneae Indicae 15 ~ 20 parts, Cortex seu flos hibisci tiliacei 17 ~ 22 parts, Herba Cardui Crispi 10 ~ 15 parts, Herba pimpinellae diversifoliae 22 ~ 27 parts, Bulbus Eleutherines Plicatae 18 ~ 23 parts, Radix radermacherae sinicae 14 ~ 19 parts, Fructus Viticis 17 ~ 22 parts, Herba scirpi juncoidis 20 ~ 25 parts, Herba Ixeritis Sonchifoliae 13 ~ 18 parts, Herba Blumeae Lacerae 8 ~ 13 parts, Flos Trollii 22 ~ 27 parts, Flos pandani tectorii 13 ~ 18 parts, Herba drymariae cordatae 25 ~ 30 parts, Herba Adianti 24 ~ 29 parts, salt alkali 15 ~ 20 parts, Herba Lygodii Flexuosi 20 ~ 25 parts, Radix Tinosporae 13 ~ 18 parts and Herba Zornia Diphyllae 10 ~ 15 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Duchesneae Indicae 18 parts, Cortex seu flos hibisci tiliacei 18 parts, Herba Cardui Crispi 14 parts, Herba pimpinellae diversifoliae 23 parts, Bulbus Eleutherines Plicatae 22 parts, Radix radermacherae sinicae 15 parts, Fructus Viticis 21 parts, Herba scirpi juncoidis 22 parts, Herba Ixeritis Sonchifoliae 16 parts, Herba Blumeae Lacerae 9 parts, Flos Trollii 26 parts, Flos pandani tectorii 14 parts, Herba drymariae cordatae 28 parts, Herba Adianti 25 parts, salt alkali 18 parts, Herba Lygodii Flexuosi 22 parts, Radix Tinosporae 16 parts and Herba Zornia Diphyllae 12 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Duchesneae Indicae 16 parts, Cortex seu flos hibisci tiliacei 20 parts, Herba Cardui Crispi 12 parts, Herba pimpinellae diversifoliae 25 parts, Bulbus Eleutherines Plicatae 20 parts, Radix radermacherae sinicae 18 parts, Fructus Viticis 19 parts, Herba scirpi juncoidis 25 parts, Herba Ixeritis Sonchifoliae 15 parts, Herba Blumeae Lacerae 12 parts, Flos Trollii 23 parts, Flos pandani tectorii 17 parts, Herba drymariae cordatae 26 parts, Herba Adianti 28 parts, salt alkali 15 parts, Herba Lygodii Flexuosi 25 parts, Radix Tinosporae 13 parts and Herba Zornia Diphyllae 15 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:

The first step, by Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae and Herba Blumeae Lacerae, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:

The first step, by Herba Duchesneae Indicae, Cortex seu flos hibisci tiliacei, Herba Cardui Crispi, Herba pimpinellae diversifoliae, Bulbus Eleutherines Plicatae, Radix radermacherae sinicae, Fructus Viticis, Herba scirpi juncoidis, Herba Ixeritis Sonchifoliae and Herba Blumeae Lacerae, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.