CN106074991A - A kind of combination of Chinese and Western medicine mode treats Chinese medicine and the preparation method of radiographic contrast nephropathy - Google Patents

Abstract

The invention provides a kind of combination of Chinese and Western medicine mode and treat Chinese medicine and the preparation method of radiographic contrast nephropathy, each raw medicinal material of Chinese medicine includes: Streptopus simplex D. Don, Herba Elsholtziae Blandae, Herba Galii Teneri, Lindernia ruellioides (Colsm.) Pennell, Folium Rudbeckiae Laciniatae, Herba Selaginellae Doederleinii, Herba Cynanchi Thesioidis, Forsyihia viridissima Lindl, Diplazium lanceum (Thunb), Herba galinsogae parviflorae, tongue spray, Herba Commelinae Bengalensis, Fructus Lagenariae gourdae, Herba indigoferae Pseudotinctoriae, Herba Oenanthes Javanicae and scarlet woollen blanket.Beneficial effects of the present invention: Chinese medicine of the present invention can combine conventional western medicine treatment radiographic contrast nephropathy, treats better efficacy, has no side effect and untoward reaction.

Description

A kind of combination of Chinese and Western medicine mode treats Chinese medicine and the preparation method of radiographic contrast nephropathy

Technical field

The present invention relates to containing the medicinal preparation deriving from plant, animal or mineral component, particularly relate to a kind of Chinese and Western The Chinese medicine of doctor's combination treatment radiographic contrast nephropathy and preparation method.

Background technology

Along with radiodiagnostic techniques and the development of interventional therapy, radiographic contrast nephropathy (contrast induced Nephrapathy, CIN) see clinic more and more, contrast agent has become the third-largest disease of hospital acquired acute renal failure Cause.CIN sickness rate in general population is 0.6%～6%, but at specific crowd, as old people, diabetes, chronic nephropathy, In the patient such as chronic cardiac insufficiency, acute myocardial infarction, sickness rate may be up to more than 20%, has in multiple high risk factor crowd Sickness rate is up to 40%～90%.

By milliosmolarity difference contrast agent can be divided into 3 classes: hypertonicity [> 1400mOsm/ (kg H2O), hypo-osmoticity [600～ 700mOsm/ (kg H2O)] and isotonicity [290～320mOsm/ (kg H2O).Contrast agent is further divided into ion-type and non- Ion-type.Compared with hypo-osmoticity contrast agent, hypertonicity contrast agent causes the risk of renal function injury high, and hypo-osmoticity contrast agent wind Danger is again higher than isotonic contrast media.In addition contrast agent dosage is also the important risk factor of radiographic contrast nephropathy, dosage the biggest (> 100ml), the risk of nephropathy is the highest.High-risk group should select isotonic or hypo-osmoticity non-ionic contrast agent as far as possible, and tries one's best Reduce contrast agent consumption.Conventional contrast agent is typically hypertonicity, and amount of iodine is up to 37%, in vivo with original shape by glomerule Filtering and do not absorbed by renal tubules, during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occurs.Contrast agent Caused acute renal failure report increases increasingly, and even its incidence rate has exceeded caused by aminoglycoside antibiotics.In a large number Research report, CAN companion's renal insufficiency is 6%～92%, and not accompanying renal insufficiency is 0～22%.A large amount of perspective comparisons are ground Studying carefully and point out, after general injection contrast agent, serum creatinine value i.e. has diagnostic significance higher than 25%～the 50% of basic value.

Person's serum creatinine generally raises in 24h to accept contrast agent, 96h peaking, replys and reach basis after general 7～10 days Value.But also having been reported that, renal function declined in Progressive symmetric erythrokeratodermia in 1～3 week, then reply and reach basic value.More than 60% CAN patient is early Phase i.e. may occur in which oliguria, button loop diuretic is had resistance, also has non-oliguria person.Most patients renal function can clear-cutting forestland, 10% Person needs dialysis treatment, and irreversible renal failure person is rare, needs long term maintenance to dialyse.

There is renal cells, cast and various fragment in the visible urine of uroscopy, non-specific, change with renal function Become uncorrelated.Urate crystal is common, and even visible Citric acid calcium crystallization, High-grade Proteinuria is the most common.There is acute tubular necrosis Most patients, renal sodium excretion is more than 1% commonly greater than 40mmol/L, fractional excretion of sodium (FENa)；But there is 1/3 acute renal failure person Renal sodium excretion is less than 20mmol/L, and oliguria person's fractional excretion of sodium is less than 1%.

After contrast agent application, x-ray is taken the photograph sheet double kidney development and lasted up to 24～48h is the characteristic performance of CAN.Older is observing Middle discovery, x-ray takes the photograph sheet sensitivity and reaches 83%, and specificity is up to 93%, but also has false positive and false negative result.Therefore CAN is still Need to be the clearest and the most definite in conjunction with serum creatinine measured value in 24～48h.

The renal failure that CAN must cause with cholesterol micro-embolization (cholesterol microemboli) differentiates mutually.Gallbladder Sterin embolus ties up to conduit in angiographic procedure and assigns caused by injured blood vessel.Acute person may occur in which blood vessel bolt after accepting contrast agent The sings and symptoms (as lower limb or chronic foot pain, stomachache, back pain, numb limbs and tense tendons are even benumbed, skin of lower extremity is pale) of plug, diagnosis More difficult.Patient may occur in which that hypotension, oliguria even cause death due to multi viscera infarction.Chronic type person be usually expressed as into Row renal insufficiency reaches more than several weeks and develops into irreversibility renal failure.Microembolism syndrome diagnosis basis is in skin Occurring that livedo reticularis, amylase raise and peripheral blood eosinophilia, uropsammus examination is negative, and Renal biospy shows spy The cholesterol emboli of levying property.

Conventional contrast agent is hypertonicity, is not absorbed by renal tubules by glomerular filtration with original shape in vivo, dehydration Time this medicine concentration in kidney increase, renal damage can be caused and acute renal failure occurs.The following is easily cause renal damage risk factor and Possible risk factor: 1, risk factor；(1) original renal insufficiency.(2) with the diabetes of renal insufficiency: there is glycosuria Sick medical history more than 10 years, the age, more than 50 years old, has cardiovascular complication and renal insufficiency person dangerous big.(3) the congested heart Force failure: the congestive heart failure person that cardiac function is IV grade is obvious risk factor.Owing to contrast agent can make Renal vascular shrink, kidney Blood flow reduces, and adds the danger of patients with congestive heart failure generation ischemic renal failure.(4) nephrotic syndrome.(5) Liver cirrhosis companion's renal function injury.(6) hypovolemia or dehydration: find in the experimentation of Canis familiaris L., under dewatering state, contrast agent In can causing kidney, blood vessel significantly shrinks.(7) multiple myeloma: intravenous contrast agent can cause acute renal failure, the most once Think that multiple myeloma person's intravenous contrast agent is anti-indication.But accept radiography one group of retrospective multiple myeloma Observation after agent finding, CAN incidence rate is only 0.6%～1.25%.Therefore clinic is if desired, carefully monitors, after supplementing capacity Still can carry out.(8) apply other nephrotoxic drugs simultaneously.(9) multiple radiocontrast medium person is accepted in a short time.(10) radiography The dosage of agent: dosage is the biggest, renal damage increases, and as dosage ＞ 30ml, during radiography, mean blood pressure is less than 13.3kPa (100mmHg) then dangerous increase.(11) hypercalcemia.2, possible risk factor；(1) age: owing to People nephron subtracts Less and the reduction of renal blood flow, GFR declined with the age, and CAN incidence rate is high.(2) diabetics of absent renal function infringement. (3) anemia.(4) albuminuria (without nephrotic syndrome).(5) abnormal liver function.(6) hyperuricemia.(7) male patient. (8) hypertension.(9) renal transplantation person is accepted.

Summary of the invention

The technical problem to be solved is, it is provided that a kind of combination of Chinese and Western medicine mode is treated in radiographic contrast nephropathy Medicine and preparation method, Chinese medicine of the present invention has definite curative effect to treatment radiographic contrast nephropathy, and toxic and side effects is little.

In order to solve above-mentioned technical problem, the invention provides a kind of combination of Chinese and Western medicine mode and treat in radiographic contrast nephropathy Medicine, each raw medicinal material of described Chinese medicine includes: Streptopus simplex D. Don, Herba Elsholtziae Blandae, Herba Galii Teneri, Lindernia ruellioides (Colsm.) Pennell, Folium Rudbeckiae Laciniatae, Herba Selaginellae Doederleinii, Herba Cynanchi Thesioidis, gold Campanilla, Diplazium lanceum (Thunb), Herba galinsogae parviflorae, tongue spray, Herba Commelinae Bengalensis, Fructus Lagenariae gourdae, Herba indigoferae Pseudotinctoriae, Herba Oenanthes Javanicae and scarlet woollen blanket.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Streptopus simplex D. Don 10～20 parts, Herba Elsholtziae Blandae 20～30 Part, Herba Galii Teneri 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～20 parts, Folium Rudbeckiae Laciniatae 20～30 parts, Herba Selaginellae Doederleinii 15～25 parts, Herba Cynanchi Thesioidis 10～20 Part, Forsyihia viridissima Lindl 15～25 parts, Diplazium lanceum (Thunb) 20～30 parts, Herba galinsogae parviflorae 5～15 parts, tongue spray 15～25 parts, Herba Commelinae Bengalensis 10～20 parts, Fructus Lagenariae gourdae 10～20 parts, Herba indigoferae Pseudotinctoriae 12～22 parts, Herba Oenanthes Javanicae 20～30 parts and scarlet woollen blanket 15～25 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Streptopus simplex D. Don 15～20 parts, Herba Elsholtziae Blandae 20～25 Part, Herba Galii Teneri 17～22 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Folium Rudbeckiae Laciniatae 25～30 parts, Herba Selaginellae Doederleinii 18～23 parts, Herba Cynanchi Thesioidis 13～18 Part, Forsyihia viridissima Lindl 17～22 parts, Diplazium lanceum (Thunb) 20～25 parts, Herba galinsogae parviflorae 8～13 parts, tongue spray 18～23 parts, Herba Commelinae Bengalensis 10～15 parts, Fructus Lagenariae gourdae 15～20 parts, Herba indigoferae Pseudotinctoriae 13～18 parts, Herba Oenanthes Javanicae 22～27 parts and scarlet woollen blanket 17～22 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Streptopus simplex D. Don 18 parts, Herba Elsholtziae Blandae 22 Part, Herba Galii Teneri 21 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Folium Rudbeckiae Laciniatae 28 parts, Herba Selaginellae Doederleinii 20 parts, Herba Cynanchi Thesioidis 17 parts, Forsyihia viridissima Lindl 18 parts, Diplazium lanceum (Thunb) 24 Part, Herba galinsogae parviflorae 10 parts, tongue spray 22 parts, Herba Commelinae Bengalensis 11 parts, Fructus Lagenariae gourdae 19 parts, Herba indigoferae Pseudotinctoriae 14 parts, Herba Oenanthes Javanicae 26 parts and scarlet woollen blanket 18 Part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Streptopus simplex D. Don 16 parts, Herba Elsholtziae Blandae 24 Part, Herba Galii Teneri 18 parts, Lindernia ruellioides (Colsm.) Pennell 14 parts, Folium Rudbeckiae Laciniatae 26 parts, Herba Selaginellae Doederleinii 22 parts, Herba Cynanchi Thesioidis 14 parts, Forsyihia viridissima Lindl 21 parts, Diplazium lanceum (Thunb) 20 Part, Herba galinsogae parviflorae 12 parts, tongue spray 20 parts, Herba Commelinae Bengalensis 14 parts, Fructus Lagenariae gourdae 16 parts, Herba indigoferae Pseudotinctoriae 18 parts, Herba Oenanthes Javanicae 24 parts and scarlet woollen blanket 20 Part.

When the dosage form of any one described Chinese medicine above-mentioned is granule, its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds and relative to the determining alcohol of mixture 4～8 times is The ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, and with backflow as solvent, with filtering residue as solute, uses Percolation, with the speed slowly percolation of per minute 1～2ml, is collected percolate, is reduced pressure subsequently under vacuum 0.06～0.09Mpa When being concentrated into 50～60 DEG C, relative density is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～ 175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add in the dried cream powder obtained relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～ The dextrin of 0.2 times, makes granule, is dried in 40～50 DEG C, it is thus achieved that granule.

When the dosage form of any one described Chinese medicine above-mentioned is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 2～the alcohol of 4 times Concentration is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained Add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, Filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, obtains Get dry extract；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, obtain Obtain 300 mesh～the micropowders of 400 mesh；

3rd step, adds in the micropowders obtained by second step relative to its quality 2～the starch of 4 times, mixing, obtains Obtain powder.

Beneficial effects of the present invention: Chinese medicine of the present invention can combine conventional western medicine treatment radiographic contrast nephropathy, and treatment curative effect is more Good, have no side effect and untoward reaction.

Detailed description of the invention

The invention provides a kind of combination of Chinese and Western medicine mode and treat the Chinese medicine of radiographic contrast nephropathy, its raw medicinal material includes: calculate Dish seven, Herba Elsholtziae Blandae, Herba Galii Teneri, Lindernia ruellioides (Colsm.) Pennell, Folium Rudbeckiae Laciniatae, Herba Selaginellae Doederleinii, Herba Cynanchi Thesioidis, Forsyihia viridissima Lindl, Diplazium lanceum (Thunb), Herba galinsogae parviflorae, tongue spray, bamboo Leaf vegetables, Fructus Lagenariae gourdae, Herba indigoferae Pseudotinctoriae, Herba Oenanthes Javanicae and scarlet woollen blanket.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Streptopus simplex D. Don: [another name] Radix Streptopi Simplicis, female's short, bristly hair or beard.[source] medical material Ji Yuan: for the root of liliaceous plant Streptopus simplex. [nature and flavor] are sweet；It is slightly cold.[function cures mainly] clearing away lung-heat to relieve cough；Invigorating the spleen and regulating the stomach.Main cough due to lung-heat；Deficiency of YIN chronic cough；Few food of incoordination between the spleen and stomach； Nausea.[extracts] " China's book on Chinese herbal medicine "

Herba Elsholtziae Blandae: [another name] white Herba Moslae, sandworm medicine, Herba Elsholtziae penduliforare, four rib Artemisias, Yunnan Herba Moslae, thin wild greenbrier, Kochia scoparia, wild revive, Climing dam, wild mint.[source] medical material Ji Yuan: for the herb of labiate Elsholtzia blanda.[nature and flavor] bitter in the mouth；Pungent；Property flat.[function Cure mainly] heat clearing away；Dampness removing；Removing toxic substances.Main cold, fever；Sensible heat dysentery；Jaundice；Dysuria；Foot a word used for translation is rotten itches；Burn.[extracts] " in China's book on Chinese herbal medicine "

Herba Galii Teneri: [another name] draw rattan, Galium spurium L., spire Radix Rubiae, saw saw careless, little grass, HUOXUECAO, little standing grain sickle grass, Saw Auricled Hedyotis Herb.[source] Rubiaceae clivers Herba Galii Teneri is with all herbal medicine.Summer gathers, using fresh herb or dry.[nature and flavor] pungent, Hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.Flu, gingival hemorrhage, acute and chronic appendicitis, urinary system infection, water Swollen, dysmenorrhea, metrorrhagia, leucorrhea, cancer, leukemia；External controls mastitis from the beginning of, carbuncle furuncle and phyma poison, traumatic injury.[extracts] " whole nation Chinese herbal medicine collects "

Lindernia ruellioides (Colsm.) Pennell: [another name] Herba Linderniae ruellioidis, Radix Euonymi japonici, small size tiger tongue Huang, tiger tongue Herba pteridis vittatae, field jasmine, underground tea, Testudinis medicine, Saw sickle grass, Tian Suxiang, Herba Linderniae anagallis, snake melon is fragrant, spend son in vain, double end town, 80 lack, alpine yarrow, Herba sagittariae pygmaeae Huang, earrings careless.[source] Medical material Ji Yuan: for the herb of goatweed Lindernia ruellioides (Colsm.) Pennell.[nature and flavor] sweet in the mouth；Light；Property flat.[function cures mainly] vital energy regualting and blood circulation-promoting；Removing toxic substances Detumescence.Main menoxenia；Dysmenorrhea；Amenorrhea；Stomachache；Acute mastitis；Scrofula；Traumatic injury；Serpentis lyssodexis.[extracts] " China's book on Chinese herbal medicine "

Folium Rudbeckiae Laciniatae: [source] medical material Ji Yuan: for the leaf of the golden yellow smooth chrysanthemum of feverfew.[nature and flavor] bitter in the mouth；Cold in nature.[function master Control] clearing away damp-heat；Removing toxicity for eliminating carbuncles.Main damp and hot vomiting and diarrhoea；Stomachache；Skin sore.[extracts] " China's book on Chinese herbal medicine "

Herba Selaginellae Doederleinii: [another name] Herba Selaginellae Doederleinii, Roegneria thoroldiana, Marchantia polymorpha L., Jin Longcao, Herba Titanotrichi oldhamii, Cacumen Platycladi, shrimp Folium Cannabis, rice crust grass, Rock green grass or young crops, rock Cupressus funebris, the Scolopendra that passes by one's way, big Herba Pteridis Multifidae, Sabina procumbens grass.[source] medical material Ji Yuan: complete for Spikemoss plant selaginella doederleinii Grass.[nature and flavor] are sweet；Micro-hardship；Puckery；Cool；Light；Temperature.[function cures mainly] heat-clearing and toxic substances removing；Expelling wind and removing dampness.Main laryngopharynx swelling and pain；Conjunctival congestion and swelling pain； Cough due to lung-heat；Mastitis；Jaundice due to damp-heat；Rheumatic arthralgia；Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba Cynanchi Thesioidis: [another name] female green grass or young crops, angle, mountain, Radix Pachyrhizi Erosi, sheep not milk fruit, little Fructus Luffae, floating wooden dipper, old melon gourd dipper, husky grandmother, horse Grandmother, husky Herba Euphorbiae Humifusae, spire cynanchum auriculatum Royle ex Wight, passeris montani saturati melon, arhat grass, Semen Pachyrhizi Erosi, Pueraria lobota, Radix Pachyrhizi Erosi wooden dipper, interwined dragon grass, cattle tip melon, sheep milk is careless, sheep Bar milk.[source] medical material Ji Yuan: for the herb of dicotyledon Yao Luo section plant spire Rhizoma Cynanchi Stauntonii.[nature and flavor] sweet in the mouth；Cool in nature. [return through] lung meridian.[function cures mainly] tonifying the lung gas；Resolving heat and reducing pathogenic fire；Promoting the production of body fluid to quench thirst；Anti-inflammatory analgetic.Main hyperactivity of deficient fire；Have sore throat；Gas Deficiency of YIN；Mental fatigue is forgetful；Fidgets due to deficiency is thirsty；Dizzy insomnia；Puerperal asthenia；Hypogalactia.[extracts] " China's book on Chinese herbal medicine "

Forsyihia viridissima Lindl: [another name] Fructus Hyperici belli.[source] medical material Ji Yuan: for shell, root or the leaf of Oleaceae plants Forsyihia viridissima Lindl. [nature and flavor] are bitter；Cool in nature.[function cures mainly] heat clearing away；Removing toxic substances；Eliminating stagnation.Main cold, fever；Conjunctival congestion swells.[extracts] " China's book on Chinese herbal medicine "

Diplazium lanceum (Thunb): [another name] lance leaf female dragon, mountain duck Herba pteridii latiusculi, fingernail, tongue wind, gravelstone sword, sword-like leave volume lotus, parting grass, Green grass or young crops, little Jin cutter, sky Scolopendra, QINGGEN, stone indocalamus, little Lian ironweed, mountain duck Herba pteridii latiusculi, hands first grass, Andrographis paniculata(Burm.f.）Nees under leaf.[source] medical material Ji Yuan: Herb or rhizome for Athyriaceae plant vacation Diplazium donianum (Mett.) Tard. Blet..[nature and flavor] are bitter；Puckery；It is slightly cold；Nontoxic.[return through] lung；Kidney channel.[function Cure mainly] stop blooding treating stranguria；Heat-clearing and toxic substances removing.Main hemoptysis；Stranguria；Hematuria；Infantile malnutrition；" Chinese medicine is big for tinea pedis [extracts] " China's book on Chinese herbal medicine " Dictionary "

Herba galinsogae parviflorae: [another name] rabbit grass, Herba oxalidis corymbosae, Herba Phyllanthi Urinariae.[source] medical material Ji Yuan: complete for feverfew Herba galinsogae parviflorae Grass.[nature and flavor] are lightly seasoned；Property flat.[function cures mainly] heat-clearing and toxic substances removing；Relieving cough and asthma；Hemostasis.Main tonsillitis；Pharyngolaryngitis；Icteric Hepatitis；Cough with asthma；Pulmonary tuberculosis；Nova skin ulcer；Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Tongue spray: [another name] Japan Rhizoma Belamcandae.[source] medical material Ji Yuan: for the herb of contrayerva mountain Rhizoma Belamcandae.[property Taste] sweet；Cool in nature.[function cures mainly] heat-clearing and toxic substances removing；Relieving stranguria by diuresis；Hemostasis.Main urine leaching pain；Hematuria；Laryngalgia；Tonsillitis；Children's's tire Poison；Erysipelas；Leucorrhea with red and white discharge；Pudendal pruritus.[extracts] " China's book on Chinese herbal medicine "

Herba Commelinae Bengalensis: [another name] Radix Cyaonsis cristate, goose hat grass.[source] medical material Ji Yuan: for the herb of Commelianaceae plant four hole grass. [function cures mainly] heat clearing away；Removing toxic substances；Hemostasis.Main sore and toxic；Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Fructus Lagenariae gourdae: [another name] bitter gourd, Pulu, bitter an a kind of edible gourd, about kettle, about abdomen kettle, bitter a kind of edible gourd Lou, sub-waist Pericarpium Lagenariae sicerariae, long handle teapot Lu, medicine Pericarpium Lagenariae sicerariae, thin neck calabash, long handle calabash, gold calabash, capital calabash, small gourd.[source] medical material Ji Yuan: for cucurbitaceous plant small gourd Fruit.[nature and flavor] bitter in the mouth；Cold in nature.[return through] returns kidney；Lung；Spleen channel.[function cures mainly] diuretic；Detumescence；Heat clearing away eliminating stagnation.Main water Swollen；Jaundice；Quench one's thirst；The difficulty in urination；Carbuncle malignant boil；Scabies.[extracts] " China's book on Chinese herbal medicine "

Herba indigoferae Pseudotinctoriae: [another name] wild Sophora japonica L. mountain Fructus Gleditsia, iron soap angle, mountain Semen phaseoli radiati, Herba indigoferae Pseudotinctoriae, the pale reddish brown material tip, wild Semen phaseoli radiati, horse material The tip, night close grass, Semen phaseoli radiati bavin, suffering happiness, Semen Sojae Preparatum wood.[source] medical material Ji Yuan: for root or the aerial parts of leguminous plant horse spine. [nature and flavor] bitter in the mouth；Puckery；Property flat.[return through] spleen, stomach warp.[function cures mainly] clearing away heat and expelling pathogen in the exterior；Dissipating blood stasis removing food stagnancy.Main anemopyretic cold；Lung-heat Cough；Burn and scald；Furuncle；Venom；Scrofula；Traumatic injury；Dyspeptic abdominal distention.[extracts] " China's book on Chinese herbal medicine "

Herba Oenanthes Javanicae: [another name] Chu Kui, water, water English, Herba Apii graveolentis, Herba Apii, smallage, Ma Qin, river celery, lobule celery.[nature and flavor] Acrid in the mouth；Sweet；Cool in nature.[return through] returns lung；Liver；Bladder warp.[function cures mainly] heat-clearing and toxic substances removing；Diuresis；Hemostasis.Main flu；Sudden high fever is tired of Yearningly；Vomit and diarrhoea；Edema；Dysuria；Drench pain；Hematuria；Have blood in stool；Spit blood；Epistaxis；Metrorrhagia；Through many；Conjunctival congestion；Pharyngalgia；Larynx swells；Aphtha； Ulcerative gingivitis；Acute mastitis；Carbuncle subcutaneous ulcer；Scrofula；Mumps；Herpes zoster；Hemorrhoid；Traumatic injury wound is swollen.[extracts] " China's book on Chinese herbal medicine "

Scarlet woollen blanket: [another name] Herba Ardisiae Pusillae, Ardisia mamillata, hair sunshade, red gallbladder, red eight pawls, red hair pin, mountain pig ear, caterpillar medicine, red Hair Rhizoma Ardisiae Gigantifoliae, red hair Radix Sophorae Tonkinensis, floor file felt, red carpet, breast hair Herba Ardisiae Japonicae.[source] is the Myrsinacea red hair of Ardisa plant Herba Ardisiae Japonicae, is used as medicine with Herb and root.The whole year can adopt, and clean section is dried.[nature and flavor] are bitter, micro-pungent, cool.[function cures mainly] dissipating blood stasis is only Blood, clearing away heat-damp and promoting diuresis.For rheumatic arthritis, traumatic injury, hemoptysis of pulmonary tuberculosis, menorrhagia, stimulate the menstrual flow, hepatitis, dysentery, children's's infantile malnutrition Long-pending.[extracts] " whole nation Chinese herbal medicine compilation "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Streptopus simplex D. Don 10～20 parts, Herba Elsholtziae Blandae 20～30 parts, Herba Galii Teneri 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～20 parts, Folium Rudbeckiae Laciniatae 20～30 parts, Herba Selaginellae Doederleinii 15～25 parts, Herba Cynanchi Thesioidis 10 ～20 parts, Forsyihia viridissima Lindl 15～25 parts, Diplazium lanceum (Thunb) 20～30 parts, Herba galinsogae parviflorae 5～15 parts, tongue spray 15～25 parts, Herba Commelinae Bengalensis 10～ 20 parts, Fructus Lagenariae gourdae 10～20 parts, Herba indigoferae Pseudotinctoriae 12～22 parts, Herba Oenanthes Javanicae 20～30 parts and scarlet woollen blanket 15～25 parts, Neolepisorus ovatus (Bedd.) Ching. 15～25 Part and Fructus Seu Herba Pubescentis 35～45 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Streptopus simplex D. Don 15～20 parts, Herba Elsholtziae Blandae 20～25 parts, Herba Galii Teneri 17～22 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Folium Rudbeckiae Laciniatae 25～30 parts, Herba Selaginellae Doederleinii 18～23 parts, Herba Cynanchi Thesioidis 13 ～18 parts, Forsyihia viridissima Lindl 17～22 parts, Diplazium lanceum (Thunb) 20～25 parts, Herba galinsogae parviflorae 8～13 parts, tongue spray 18～23 parts, Herba Commelinae Bengalensis 10～ 15 parts, Fructus Lagenariae gourdae 15～20 parts, Herba indigoferae Pseudotinctoriae 13～18 parts, Herba Oenanthes Javanicae 22～27 parts and scarlet woollen blanket 17～22 parts, Neolepisorus ovatus (Bedd.) Ching. 18～25 Part and Fructus Seu Herba Pubescentis 38～45 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Streptopus simplex D. Don 18 parts, Herba Elsholtziae Blandae 22 Part, Herba Galii Teneri 21 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Folium Rudbeckiae Laciniatae 28 parts, Herba Selaginellae Doederleinii 20 parts, Herba Cynanchi Thesioidis 17 parts, Forsyihia viridissima Lindl 18 parts, Diplazium lanceum (Thunb) 24 Part, Herba galinsogae parviflorae 10 parts, tongue spray 22 parts, Herba Commelinae Bengalensis 11 parts, Fructus Lagenariae gourdae 19 parts, Herba indigoferae Pseudotinctoriae 14 parts, Herba Oenanthes Javanicae 26 parts and scarlet woollen blanket 18 Part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Streptopus simplex D. Don 16 parts, Herba Elsholtziae Blandae 24 Part, Herba Galii Teneri 18 parts, Lindernia ruellioides (Colsm.) Pennell 14 parts, Folium Rudbeckiae Laciniatae 26 parts, Herba Selaginellae Doederleinii 22 parts, Herba Cynanchi Thesioidis 14 parts, Forsyihia viridissima Lindl 21 parts, Diplazium lanceum (Thunb) 20 Part, Herba galinsogae parviflorae 12 parts, tongue spray 20 parts, Herba Commelinae Bengalensis 14 parts, Fructus Lagenariae gourdae 16 parts, Herba indigoferae Pseudotinctoriae 18 parts, Herba Oenanthes Javanicae 24 parts and scarlet woollen blanket 20 Part.

When the dosage form of any one described Chinese medicine above-mentioned is granule, its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds and relative to the determining alcohol of mixture 4～8 times is The ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, and with backflow as solvent, with filtering residue as solute, uses Percolation, with the speed slowly percolation of per minute 1～2ml, is collected percolate, is reduced pressure subsequently under vacuum 0.06～0.09Mpa When being concentrated into 50～60 DEG C, relative density is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～ 175 DEG C, leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add in the dried cream powder obtained relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～ The dextrin of 0.2 times, makes granule, is dried in 40～50 DEG C, it is thus achieved that granule.

When the dosage form of any one described Chinese medicine above-mentioned is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 2～the alcohol of 4 times Concentration is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained Add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, Filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, obtains Get dry extract；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, obtain Obtain 300 mesh～the micropowders of 400 mesh；

3rd step, adds in the micropowders obtained by second step relative to its quality 2～the starch of 4 times, mixing, obtains Obtain powder.

Embodiment 1: granule

Take Streptopus simplex D. Don 160g, Herba Elsholtziae Blandae 240g, Herba Galii Teneri 180g, Lindernia ruellioides (Colsm.) Pennell 140g, Folium Rudbeckiae Laciniatae 260g, Herba Selaginellae Doederleinii 220g, Herba Cynanchi Thesioidis 140g, Forsyihia viridissima Lindl 210g, Diplazium lanceum (Thunb) 200g, Herba galinsogae parviflorae 120g, tongue spray 200g, Herba Commelinae Bengalensis 140g, Fructus Lagenariae gourdae 160g, Herba indigoferae Pseudotinctoriae 180g, Herba Oenanthes Javanicae 240g and scarlet woollen blanket 200g.

Its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adding relative to the determining alcohol of 6 times of mixture is 95% Ethanol, is heated to boiling reflux 4 hours, filters, and with backflow as solvent, with filtering residue as solute, uses percolation with per minute The speed of 2ml slowly percolation, collects percolate, and when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is The mastic of 1.08, is spray-dried, the inlet temperature of spray dryer 170 DEG C, leaving air temp 80 DEG C, is ground into powder subsequently, system Become dried cream powder；

Step 2: add the cane sugar powder relative to dried cream powder quality 0.2 times and the paste of 0.1 times in the dried cream powder obtained Essence, makes granule, is dried in 45 DEG C, it is thus achieved that granule.

Embodiment 2: powder

Take Streptopus simplex D. Don 180g, Herba Elsholtziae Blandae 220g, Herba Galii Teneri 210g, Lindernia ruellioides (Colsm.) Pennell 120g, Folium Rudbeckiae Laciniatae 280g, Herba Selaginellae Doederleinii 200g, Herba Cynanchi Thesioidis 170g, Forsyihia viridissima Lindl 180g, Diplazium lanceum (Thunb) 240g, Herba galinsogae parviflorae 100g, tongue spray 220g, Herba Commelinae Bengalensis 110g, Fructus Lagenariae gourdae 190g, Herba indigoferae Pseudotinctoriae 140g, Herba Oenanthes Javanicae 260g and scarlet woollen blanket 180g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the determining alcohol relative to mixture quality 4 times It is the ethanol of 90%, is heated to reflux 2 hours, extract, filter and obtain the first extracting solution；Filter obtain medicinal residues add relative to The ethanol that determining alcohol is 95% of described medicinal residues quality 1 times, is heated to reflux 3 hours, extracts, and filters and obtains the second extracting solution；Will First extracting solution and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；

Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that The micropowders of 400 mesh；

3rd step, adds the starch relative to its quality 4 times in the micropowders obtained by second step, mixing, it is thus achieved that Powder.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20～36g, carries out acute toxicity test.Mice It is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours, the Chinese medicine prepared by embodiments of the invention 1 before experiment Granule is dissolved in water, and (concentration is 7.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (i.e. single-dose Dosage is 37.9 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, is administered Rear Continuous Observation 14 days, and record toxic reaction and the death toll of mice.Test result indicate that: compare with matched group, after administration Mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.Mice The medicine granule LD50 > 37.9 crude drugs/kg of the oral administration gavage present invention, every day, maximum dosage-feeding was 75.8 crude drugs/kg/ day.This Bright Chinese medicine clinical application amount is 8.4g crude drug/day/people, adult body weight in terms of 60KG, average dosage be 0.14g crude drug/ Kg/ day.By weighing machine: the dosis tolerata of the Chinese medicine of mice (average weight is in terms of 28g) the oral administration gavage present invention is as quantity 541 times.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: three groups of mices (often group 20) are pressed 16.38,24.62 by Chinese medicine embodiment 1 granule of the present invention After 36.48g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks, result shows: this Bright Chinese medicine is equal to indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat Having no significant effect, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference Reaction, application safety.

Clinical data:

Case selection: whole 90 example cases are my Out-patient Department or radiographic contrast nephropathy patient in hospital, wherein, male 42 example, Women 48 example, age 30～64 years old, the course of disease 1～23 months.It is randomly divided into treatment group and matched group, wherein, treatment group 45 people, its In, male 21 example, women 24 example, age 31～64 years old, the course of disease 2～23 months.Matched group 45 people, wherein, male 21 example, women 24 examples, age 30～62 years old, the course of disease 1～22 months.The aspect comparing differences such as two groups of sexes, age, the course of disease and clinical manifestation are equal Not statistically significant, has comparability.

Diagnostic criteria: on the premise of eliminating other kidney damage factors, serum creatinine (Cr) water of 2～3d after radiography Flat ratio raises 25%～50% or raise 50～100mg/L before radiography；It is also possible to oliguria in after radiography 24～48h, Anuria, erythra, cardiopalmus, it is in a cold sweat, blood pressure drops, there is anaphylactic shock in severe patient, and urine examination is abnormal, and the hurried change of renal function is outstanding Its tubule function is substantially abnormal.

Therapeutic Method:

Matched group: oral BAZHENG HEJI, one time 20 milliliters, 3 times on the one；Take FUSAIMI PIAN simultaneously, the most a piece of, one day 3 times；5% sodium bicarbonate injection 250ml intravenous drip, every day 1 time；Within 7 days, it is 1 course for the treatment of, is used in conjunction 2 courses for the treatment of.

Treatment group: on the basis of matched group western medicine routine treatment, gives the embodiment of the present invention 1 granule three times a day, every time 15 grams, 7 days be 1 course for the treatment of, is used in conjunction 2 courses for the treatment of；

Curative effect judging standard: cure: renal function and serum creatinine recover the clinical symptoms such as normal, oliguria, anuria on inspection All disappear；Effective: renal function is clearly better on inspection, serum creatinine declines 10%～20%, oliguria, the clinical symptoms such as anuria Substantially alleviate.Effective: renal function has taken a turn for the better on inspection, serum creatinine declines 5%～10%, oliguria, the clinical symptoms such as anuria Alleviate.Invalid: renal function is without taking a turn for the better or increasing the weight of on inspection, and serum creatinine descends below 5% or raises, oliguria, anuria etc. Clinical symptoms is without alleviating or increasing the weight of.

Therapeutic outcome: after two groups are treated 2 courses for the treatment of respectively, statistical result sees table 1.

1 liang of table is organized and is treated two groups of comparitive study (example) after 2 courses for the treatment of respectively:

Group	n	Cure	Effective	Effectively	Invalid	Total effective
							Treatment group	45	32	7	6	0	45 (100%)
Matched group	45	16	13	8	8	37 (82.2%)

As it can be seen from table 1 treatment group uses the Chinese medicine associating conventional western medicine treatment radiographic contrast nephropathy of the present invention, relative to Matched group, has on therapeutic effect and is markedly improved.

Untoward reaction: during treatment, matched group and treatment group patient hepatic and renal function injure all do not occur or other are bad instead Should.

Concrete case: in certain, male, 51 years old, patient had smoking history, hyperlipemia, type 2 diabetes mellitus,

Going to a doctor because burst chest pain enters the court's emergency treatment, row coronary angiography finds, left anterior descending branch near-end has that ＞'s 75 is narrow, gives Coating stent of medicine is treated, and successively accepts radiography twice, and after radiography, the second afternoon serum creatinine peak level ratio is made for the second time Raise 70mg/L before shadow, simultaneously with anuria, cardiopalmus, blood pressure drops, be diagnosed as radiographic contrast nephropathy, go to the treatment of these section office.Root According to the state of an illness, give BAZHENG HEJI and FUSAIMI PIAN is oral, 5% sodium bicarbonate injection intravenous drip, give in the present invention simultaneously Medicine embodiment 1 granule is administered orally, after treating 6 days, and all clinical symptom disappearance, serum creatinine recovers to normal level, cures, with Visit and do not recur for 3 months.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims (9)

1. a combination of Chinese and Western medicine mode treats the Chinese medicine of radiographic contrast nephropathy, it is characterised in that described Chinese medicine each raw medicinal material bag Include: Streptopus simplex D. Don, Herba Elsholtziae Blandae, Herba Galii Teneri, Lindernia ruellioides (Colsm.) Pennell, Folium Rudbeckiae Laciniatae, Herba Selaginellae Doederleinii, Herba Cynanchi Thesioidis, Forsyihia viridissima Lindl, Diplazium lanceum (Thunb), Herba galinsogae parviflorae, tongue water Flower, Herba Commelinae Bengalensis, Fructus Lagenariae gourdae, Herba indigoferae Pseudotinctoriae, Herba Oenanthes Javanicae and scarlet woollen blanket.

2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: calculate Dish 7 10～20 parts, Herba Elsholtziae Blandae 20～30 parts, Herba Galii Teneri 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～20 parts, Folium Rudbeckiae Laciniatae 20～30 parts, Shi Shang Cypress 15～25 parts, Herba Cynanchi Thesioidis 10～20 parts, Forsyihia viridissima Lindl 15～25 parts, Diplazium lanceum (Thunb) 20～30 parts, Herba galinsogae parviflorae 5～15 parts, tongue spray 15～25 parts, Herba Commelinae Bengalensis 10～20 parts, Fructus Lagenariae gourdae 10～20 parts, Herba indigoferae Pseudotinctoriae 12～22 parts, Herba Oenanthes Javanicae 20～30 parts and scarlet woollen blanket 15 ～25 parts, Neolepisorus ovatus (Bedd.) Ching. 15～25 parts and Fructus Seu Herba Pubescentis 35～45 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Streptopus simplex D. Don 15～20 parts, Herba Elsholtziae Blandae 20～25 parts, Herba Galii Teneri 17～22 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Folium Rudbeckiae Laciniatae 25～30 parts, stone Upper cypress 18～23 parts, Herba Cynanchi Thesioidis 13～18 parts, Forsyihia viridissima Lindl 17～22 parts, Diplazium lanceum (Thunb) 20～25 parts, Herba galinsogae parviflorae 8～13 parts, tongue water Spend 18～23 parts, Herba Commelinae Bengalensis 10～15 parts, Fructus Lagenariae gourdae 15～20 parts, Herba indigoferae Pseudotinctoriae 13～18 parts, Herba Oenanthes Javanicae 22～27 parts and scarlet woollen blanket 17～22 parts, Neolepisorus ovatus (Bedd.) Ching. 18～25 parts and Fructus Seu Herba Pubescentis 38～45 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the weight of each raw medicinal material of described Chinese medicine takes number such as Under: Streptopus simplex D. Don 18 parts, Herba Elsholtziae Blandae 22 parts, Herba Galii Teneri 21 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Folium Rudbeckiae Laciniatae 28 parts, Herba Selaginellae Doederleinii 20 parts, Herba Cynanchi Thesioidis 17 Part, Forsyihia viridissima Lindl 18 parts, Diplazium lanceum (Thunb) 24 parts, Herba galinsogae parviflorae 10 parts, tongue spray 22 parts, Herba Commelinae Bengalensis 11 parts, Fructus Lagenariae gourdae 19 parts, Herba indigoferae Pseudotinctoriae 14 Part, Herba Oenanthes Javanicae 26 parts and scarlet woollen blanket 18 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Streptopus simplex D. Don 16 parts, Herba Elsholtziae Blandae 24 parts, Herba Galii Teneri 18 parts, Lindernia ruellioides (Colsm.) Pennell 14 parts, Folium Rudbeckiae Laciniatae 26 parts, Herba Selaginellae Doederleinii 22 parts, Herba Cynanchi Thesioidis 14 parts, Forsyihia viridissima Lindl 21 parts, Diplazium lanceum (Thunb) 20 parts, Herba galinsogae parviflorae 12 parts, tongue spray 20 parts, Herba Commelinae Bengalensis 14 parts, Fructus Lagenariae gourdae 16 parts, Herba indigoferae Pseudotinctoriae 18 parts, Herba Oenanthes Javanicae 24 parts and scarlet woollen blanket 20 parts.

6. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is granule, its preparation method bag Include following steps:

Step one: described raw medicinal material is mixed in described ratio, add relative to the determining alcohol of mixture 4～8 times be 85%～ The ethanol of 95%, is heated to boiling reflux 3～5 hours, filters, and with backflow as solvent, with filtering residue as solute, uses percolation With the speed slowly percolation of per minute 1～2ml, collect percolate, be evaporated under vacuum 0.06～0.09Mpa subsequently When 50～60 DEG C, relative density is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, Leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add in the dried cream powder obtained relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.

7. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method includes Following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 2～the determining alcohol of 4 times It is the ethanol of 85～95%, is heated to reflux 1～3 hour, extract, filter and obtain the first extracting solution；Filter the medicinal residues obtained to add again Enter the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter Obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry Cream；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300 Mesh～the micropowders of 400 mesh；

3rd step, adds relative to its quality 2～the starch of 4 times, mixing, it is thus achieved that dissipate in the micropowders obtained by second step Agent.

8. the preparation method of Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is granule, its Preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add relative to the determining alcohol of mixture 4～8 times be 85%～ The ethanol of 95%, is heated to boiling reflux 3～5 hours, filters, and with backflow as solvent, with filtering residue as solute, uses percolation With the speed slowly percolation of per minute 1～2ml, collect percolate, be evaporated under vacuum 0.06～0.09Mpa subsequently When 50～60 DEG C, relative density is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, Leaving air temp 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add in the dried cream powder obtained relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.

9. the preparation method of Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, its system Preparation Method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 2～the determining alcohol of 4 times It is the ethanol of 85～95%, is heated to reflux 1～3 hour, extract, filter and obtain the first extracting solution；Filter the medicinal residues obtained to add again Enter the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter Obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry Cream；

Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300 Mesh～the micropowders of 400 mesh；

3rd step, adds relative to its quality 2～the starch of 4 times, mixing, it is thus achieved that dissipate in the micropowders obtained by second step Agent.