CN105125730B - Concocting method for radix scrophulariae - Google Patents

Abstract

This patent discloses the concocting method for radix scrophulariae, operating procedure is A, cutting: by under vacuum condition by radix scrophulariae cutting be sheet, obtain radix scrophulariae piece；B, it impregnates: radix scrophulariae piece being placed under vacuum conditions in the pure water of 0.8 times of quality of radix scrophulariae tablet quality and impregnate 21.5h, be transferred in solvent naphtha and impregnate after then pulling out, radix scrophulariae piece must be infiltrated；C, steam: infiltration radix scrophulariae piece is steamed with peppermint, dried orange peel, must steam radix scrophulariae piece；D, drying: being 48 DEG C of dry 43min with temperature under vacuum conditions；E, detection, pack, obtain finished product.The technical problem to be solved in the present invention is to provide one kind to avoid section viscosity, while the concocting method for radix scrophulariae for making active constituent content increment big.

Description

Concocting method for radix scrophulariae

Technical field

The present invention relates to the manufacture fields of vegetable drug, and in particular to a kind of concocting method for radix scrophulariae.

Background technique

This product is the dry root of scrophulariaceae radix scrophulariae, and winter cauline leaf is excavated when withered.Radix scrophulariae contains alkaloid, carbohydrate, steroid Alcohol, amino acid (left-handed asparagine L-Asparagine etc.), fatty acid (mainly oleic acid, linolenic acid, stearic acid), volatilization Oil, carrotene and vitamin A substance.Radix scrophulariae nature and flavor are sweet, bitter, salty, slightly cold, return lung, stomach, kidney channel；With clearing heat and cooling blood, Nourishing yin and lessening fire, the effect of detoxicating and resolving a mass enter ying blood commonly used in heat, febrile virulent maculae, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, Hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.

It processes, refers to the process that drug is made of herbal raw material, there is the processing methods such as fire system, water system or preparing with water and fire together, mesh Mainly reinforce medicinal effectiveness, toxicity or side effect are reduced, convenient for storing and convenient for taking.Chinese medicine is being applied or is being made Before dosage form, the process of necessary working process is carried out.Also known as big gun processs, repairs thing, repairs and renovate.Wherein big gun toast is also referred exclusively to at fiery processing The method for managing medicinal material.Since Chinese medicine is mostly crude drug, mostly with soil and other foreign matters, or there is peculiar smell or toxic, or tide It is wet to be unsuitable for saving etc., handled by certain processing, can achieve make pure medicinal material, flavoring, reduce toxicity and it is dry without Rotten purpose.In addition, processing also enhancing curative effect of medication, the effects of changing pharmaceutical properties, be convenient for adjustment preparation.Chinese medicine preparation Method is generally divided into the system of repairing, water system, fiery system, preparing with water and fire together, other 5 major class of preparation method.

The processing of radix scrophulariae is usually to impregnate, is dry, and separately not having person is to impregnate, steam, drying, it was found that can but make after processing Obtain the effective component harpagide (C of radix scrophulariae₁₅H₂₄O₁₀) and harpagoside (C₂₄H₃₀O₁₁) measure and increase, still, after radix scrophulariae processes, Section would generally be in black, and have viscosity, and viscosity makes radix scrophulariae easy adhesion in storage, it is difficult to separate.

Summary of the invention

The technical problem to be solved in the present invention is to provide one kind to avoid section viscosity, while making active constituent content increment The big concocting method for radix scrophulariae.

In order to solve the above technical problem, the present invention provides following technical solutions:

For the concocting method of radix scrophulariae, operating procedure is as follows,

A, cutting: by under vacuum condition by radix scrophulariae cutting be sheet, obtain radix scrophulariae piece；

B, it impregnates: radix scrophulariae piece being placed under vacuum conditions in the pure water of 0.8 times of quality of radix scrophulariae tablet quality and impregnated 21.5h is transferred in solvent naphtha after then pulling out and impregnates, and must infiltrate radix scrophulariae piece；

C, steam: infiltration radix scrophulariae piece is steamed with peppermint, dried orange peel, must steam radix scrophulariae piece；

D, drying: being 85 DEG C of dry 43min with temperature under vacuum conditions；

E, detection, pack, obtain finished product.

Using the concocting method for radix scrophulariae of technical solution of the present invention, step A, cutting under vacuum, avoid air with The contact of radix scrophulariae section, is factually issued after examination and approval now, and it is shallow and viscous that the radix scrophulariae segment face color of cutting under air conditions is compared under vacuum condition Property is low.Step B, radix scrophulariae piece impregnate in water, can increase effective component, and impregnate under vacuum conditions, factually issue after examination and approval now, break Face color is relatively shallower and sticky low；And it is impregnated in solvent naphtha, in order to, solvent naphtha can coat the section of radix scrophulariae piece, Its section is avoided to contact with air the experiment has found that after solvent naphtha impregnates, not only active constituent content to be increased, Er Qietong When reduce section viscosity.Step C, steams radix scrophulariae piece using the steam for steaming peppermint, dried orange peel when steaming, and factually issues after examination and approval now,.Step Rapid D, when drying temperature is 48 DEG C, the increment of active constituent content is most.

The invention has the benefit that being found through experiments that after aforesaid operations step；Radix scrophulariae piece after processing breaks Face color is of light color compared to existing concocting method, viscosity is small, in addition the experiment has found that through the invention made from concocting method Its active constituent content increment of radix scrophulariae is big.

Further, in the step B, solvent naphtha is castor oil.Castor oil is the extract oil of Chinese medicine castor bean, on the one hand The section of radix scrophulariae piece is wrapped up, on the other hand, castor oil returns large intestine, lung channel, can protect stomach, avoids its injury.

Further, in the step B, the dosage of castor oil is 0.5 times of radix scrophulariae tablet quality.Radix scrophulariae piece section viscosity is most It is low.

Further, in the step B, the time that radix scrophulariae piece impregnates in castor oil is 2h.Active constituent content increment It is maximum.

Further, in the step C, during steaming, peppermint, dried orange peel, water mass fraction are as follows: 21 parts of peppermint, 16 parts of dried orange peel, 100 parts of water.Active constituent content increment is maximum.

Specific embodiment

Embodiment one:

The present invention is used for the concocting method of radix scrophulariae, and operating procedure is as follows:

A, cutting: taking radix scrophulariae 500g, under vacuum conditions by radix scrophulariae cutting be sheet, radix scrophulariae piece with a thickness of 1cm, obtain profound Join piece；

B, it impregnates: radix scrophulariae piece being placed in 400g pure water impregnate 21.5h under vacuum conditions, shifted after then pulling out To 250g solvent naphtha, i.e., 2h is impregnated in castor oil, radix scrophulariae piece must be infiltrated, the amount of castor oil is to flood radix scrophulariae piece；

C, it steams: taking peppermint 42g, dried orange peel 32g, be placed in 200g water, decoct, infiltration radix scrophulariae piece is placed in food steamer In, 30min is steamed, radix scrophulariae piece must be steamed；

D, drying: being 48 DEG C of dry 43min with temperature under vacuum conditions；

E, detection, pack, obtain finished product.

Embodiment two:

Difference with embodiment one is: solvent naphtha uses rapeseed oil, remaining is consistent with embodiment one.

Comparative example:

A, cutting: taking radix scrophulariae 500g, under field conditions (factors) by radix scrophulariae cutting be sheet, radix scrophulariae piece with a thickness of 1cm, obtain profound Join piece；

B, it impregnates: radix scrophulariae piece being placed in 400g pure water impregnate 21.5h under field conditions (factors)；

C, it steams: taking pure water and be placed in radix scrophulariae piece is infiltrated in food steamer, steam 30min, radix scrophulariae piece must be steamed；

D, drying: being 48 DEG C of dry 43min with temperature under field conditions (factors)；

E, detection, pack, obtain finished product.

The following are experiment, the total amount detection of the effective component harpagide, harpagoside of radix scrophulariae piece passes through Agilent 1200S series of high efficiency hplc determination；The color and viscosity of radix scrophulariae piece section are obtained by feel and observation.

Experiment one:

Embodiment one, embodiment two and the effective component increment and its color of comparative example, viscosity are measured, as a result such as 1 institute of table Show:

Table 1

Medicinal material active constituent content refers to the active constituent content of the radix scrophulariae piece before not processing；Medicine materical crude slice active constituent content is Refer to the active constituent content of the radix scrophulariae piece after processing.

It can be seen that through the invention its active constituent content increment of radix scrophulariae medicine materical crude slice made from concocting method it is big, it is of light color, Viscosity is small.

Experiment two:

Difference with embodiment one is: in step B, radix scrophulariae piece being respectively placed in 300g, 450g, 500g pure water 21.5h is impregnated, 0.6 times, 0.9 times, 1 times of radix scrophulariae tablet quality are equivalent to, remaining operation is consistent with embodiment one, measures radix scrophulariae The increment of the effective component harpagide of piece, harpagoside, the results are shown in Table 2:

Table 2

It can be seen that the content increment of effective component is most when the amount for impregnating pure water is 0.8 times of radix scrophulariae tablet quality Greatly.

Experiment three:

Difference with embodiment one is: in step B, by radix scrophulariae piece be placed in pure water impregnate respectively 20h, 21h, 22h, 23h, remaining operation is consistent with embodiment one, measures the effective component harpagide of radix scrophulariae piece, the increment of harpagoside, knot Fruit is as shown in table 3:

Table 3

It can be seen that the content increment of effective component is maximum when soaking time is 21.5.

Experiment four:

Difference with embodiment one is: in step B, operating after impregnating in pure water, respectively, is directly steamed System impregnates 2h with rapeseed oil, continues immersion 2h with pure water, 1.5h is impregnated with castor oil, 2.5h is impregnated with castor oil, uses castor-oil plant 3h is steeped in oil immersion, remaining operation is consistent with embodiment one, detects its active constituent content increment and observation radix scrophulariae piece section respectively Color and viscosity, with comparative example compare, the results are shown in Table 4:

Table 4

It can be seen that castor oil impregnates its effective component increment maximum of 2h and color is most shallow, sticky minimum.

Experiment five:

Difference with embodiment one is: the processing of step C is respectively as follows: to be steamed with pure water；With peppermint, dried orange peel, pure Water steams, and mass fraction ratio is respectively 20:16:100,21:17:100,21:16:101, detects active constituent content respectively Increment, as shown in table 5:

Table 5

It can be seen that with peppermint, the mass fraction ratio of dried orange peel, water are as follows: 21:16:100 steams radix scrophulariae piece, effectively at Divide content increment maximum.

For those skilled in the art, without departing from the structure of the invention, several changes can also be made Shape and improvement, these also should be considered as protection scope of the present invention, these all will not influence the effect and patent that the present invention is implemented Practicability.

Claims (2)

1. being used for the concocting method of radix scrophulariae, it is characterised in that: its operating procedure is as follows,

A, cutting: by under vacuum condition by radix scrophulariae cutting be sheet, obtain radix scrophulariae piece；

B, it impregnates: radix scrophulariae piece being placed under vacuum conditions in the pure water of 0.8 times of quality of radix scrophulariae tablet quality and impregnated 21.5h is transferred in castor oil after then pulling out and impregnates 2h, must infiltrate radix scrophulariae piece；

C, steam: infiltration radix scrophulariae piece is steamed with peppermint, dried orange peel, must steam radix scrophulariae piece；During steaming, peppermint, dried orange peel, water matter Measure number ratio are as follows: 21:16:100；

D, drying: being 48 DEG C of dry 43min with temperature under vacuum conditions；

E, detection, pack, obtain finished product.

2. the concocting method according to claim 1 for radix scrophulariae, it is characterised in that: in the step B, castor oil Dosage is 0.5 times of radix scrophulariae tablet quality.