CN105124315B - It is a kind of promote sow embryo muscle cell proliferation differentiation compound additive and application - Google Patents
It is a kind of promote sow embryo muscle cell proliferation differentiation compound additive and application Download PDFInfo
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- CN105124315B CN105124315B CN201510623803.7A CN201510623803A CN105124315B CN 105124315 B CN105124315 B CN 105124315B CN 201510623803 A CN201510623803 A CN 201510623803A CN 105124315 B CN105124315 B CN 105124315B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a kind of compound additive of promotion sow embryo muscle cell proliferation differentiation and applications.It is by creatine, arginine, 25-hydroxyvitamin D3(HY.D), carnitine, glutamine, a-ketoglutaric acid, beta-hydroxy-Beta-methyl butyric acid composition.The present invention enhances the additive amount of functional amino, vitamin from the growth requirement of sow embryo's muscle cell, and increases the development that part functionalities feed addictive promotes sow embryo's muscle cell.Product safety is high, use cost is low, palatability is preferable, it is made an addition in pregnant sow diet according to ‰ weight ratio of 1.5-2.0, it can significantly promote the proliferation of sow embryo's muscle cell, increase newborn piglet birth weight and survival rate, is a kind of ideal compound functional feedstuff additive for improving sow reproductive performance.
Description
Technical field
The present invention relates to animal feed additive technical field more particularly to a kind of promotion sow embryo's muscle cell proliferations
The compound additive of differentiation and application.
Background technique
Animal carcasses are made of muscle, fat, bone and the tissue that is connected, and wherein skeletal muscle is most important composition portion
Point.Muscle growth speed is the main determining factor of growth of animal performance, muscle growth speed and animal daily gain, feed-weight ratio,
Carcass weight is closely related.And the growth and development of pig muscle is mainly in foetal period and juvenile phase, it is fine in 90 days pig fetus flesh of gestation
The total quantity of dimension determines substantially.The quantity of muscle fibre directly affects growth potential and carcass quality after pig life.Parent battalion
Supporting has important influence to the development of offspring's muscle fibre and type conversion, shows muscle fibre number to the development impact of offspring's skeletal muscle
It is had differences on amount, diameter or cross-sectional area, the Growth of Muscle Fiber speed of early stage and growth period after final influence is raw, and influences pig
The meat of listing.
Pregnant sow is had been a concern in production at present is sow reproductive performance, including litter size (total farrowing
Number, litter size living) and birth weight etc..For a long time, the development of sow embryo muscle cell does not cause enough attention, especially
It is the increase with number born of sow, the incidence of IUGR piglet increases, and directly affects growth performance and the offering day of offspring
Age, especially offspring list the yield decline of lean meat.
Summary of the invention
The invention reside in a kind of composite feed additive that sow embryo's muscle cell proliferation can be improved is provided, can significantly promote
Into the development of sow fetus myofibroblasts, newborn piglet birth weight is promoted to increase, while reducing sow embryonic period, embryonic phase IUGR piglet
Incidence.
The technical solution adopted by the present invention is that:
The compound additive of promotion sow embryo's muscle cell proliferation differentiation of the invention is by creatine, arginine, 25- hydroxyl
Base vitamin D3(HY.D), carnitine, glutamine, a-ketoglutaric acid, beta-hydroxy-Beta-methyl butyric acid and carrier composition, carrier are
Zeolite powder and defatted rice bran.
The weight of compound additive of the invention is as follows: 50-100 parts of creatine, 100-200 parts of arginine, 25- hydroxyl
Vitamin D3(HY.D) 10-20 parts, 50-100 parts of carnitine, 100-200 parts of glutamine, 50-100 parts of a-ketoglutaric acid, β-hydroxyl
Base -50-100 parts of Beta-methyl butyric acid, carrier and totally 1000 parts of raw material, remaining as carrier, carrier is zeolite powder and defatted rice bran (weight
Amount is than being 3:1).
It is preferred that: the weight of compound additive of the invention is as follows: 50 parts of creatine, 80 parts of arginine, the dimension life of 25- hydroxyl
Plain D3(HY.D) 10 parts, it is 50 parts of carnitine, 80 parts of glutamine, 80 parts of a-ketoglutaric acid, beta-hydroxy -50 parts of Beta-methyl butyric acid, de-
150 parts of rouge rice bran, 450 parts of zeolite powder.150 parts of defatted rice bran are used for carnitine and 25-hydroxyvitamin D3Premix carrier.
Compound additive of the invention can be used for the differentiation of sow embryo's muscle cell proliferation, increase newborn piglet survival rate
And birth weight.It is made an addition in pregnant sow diet when use according to ‰ weight ratio of 1.5-2.
Arginine can promote the nitric oxide production generation of sow placenta, and then promote the increase of placenta angiogenesis, improve
Parent nutrient is transported into tire pig body, promotes the development of fetus skeletal muscle fiber.
25-hydroxyvitamin D3 is the metabolin of vitamin D, can improve the vitamin D content of sow and fetus, and is promoted
Into the proliferation of embryo's muscle cell.
Creatine, glutamine, a ketoglutaric acid can promote the proliferation of muscle cell, provide energy for piglet muscle cell.
Beta-hydroxy-Beta-methyl butyric acid can promote the proliferation of piglet muscle cell, while increase the immunity of piglet.
The positive effect of the present invention is as follows:
The composite feed additive of promotion sow embryo muscle cell proliferation of the invention, has the advantage that
1) product additive amount is small, easy to use and at low cost.
2) birth weight that can dramatically increase piglet, improves the survival rate of newborn piglet.
3) the lean meat yield that can significantly improve the listing of offspring pig improves every sow year indirectly and provides lean meat yield.
4) pork carcass quality that offspring pig butchers the listing phase can be significantly improved.
The present invention enhances functional amino, vitamin adds from the growth requirement of sow embryo's muscle cell
Dosage, and increase the development that part functionalities feed addictive promotes sow embryo's muscle.Product safety is high, using at
This is low, and palatability is preferable, makes an addition in pregnant sow diet, can significantly promote the proliferation of sow embryo's muscle cell, increases just
Newborn pig birth weight and survival rate are a kind of ideal compound functional feedstuff additives for improving sow reproductive performance.
Specific embodiment
The following examples are a further detailed description of the invention.
Embodiment 1
The weight of compound additive of the invention is as follows: 50 parts of creatine, 00 part of arginase 12,25-hydroxyvitamin D3
(HY.D) 10 parts, 100 parts of carnitine, 100 parts of glutamine, 100 parts of a-ketoglutaric acid, beta-hydroxy -50 parts of Beta-methyl butyric acid, carrier
With totally 1000 parts of raw material, remaining as carrier, carrier is zeolite powder and defatted rice bran (weight ratio 3:1).
Embodiment 2
The weight of compound additive of the invention is as follows: 100 parts of creatine, 100 parts of arginine, 25- hydroxyvitamin
D3(HY.D) 20 parts, 50 parts of carnitine, 200 parts of glutamine, 50 parts of a-ketoglutaric acid, beta-hydroxy -100 parts of Beta-methyl butyric acid carry
Body and totally 1000 parts of raw material, remaining as carrier, carrier is zeolite powder and defatted rice bran (weight ratio 3:1).
Embodiment 3
The weight of compound additive of the invention is as follows: 80 parts of creatine, 150 parts of arginine, 25-hydroxyvitamin D3
(HY.D) 15 parts, 65 parts of carnitine, 150 parts of glutamine, 80 parts of a-ketoglutaric acid, beta-hydroxy -70 parts of Beta-methyl butyric acid, carrier and
Totally 1000 parts of raw material, remaining as carrier, carrier is zeolite powder and defatted rice bran (weight ratio 3:1).
Embodiment 4
The weight of compound additive of the invention is as follows: 50 parts of creatine, 80 parts of arginine, 25-hydroxyvitamin D3
(HY.D) 10 parts, 50 parts of carnitine, 80 parts of glutamine, 80 parts of a-ketoglutaric acid, beta-hydroxy -50 parts of Beta-methyl butyric acid, degreasing rice
150 parts of chaff, 450 parts of zeolite powder.150 parts of defatted rice bran are used for carnitine and 25-hydroxyvitamin D3Premix carrier.
Additive prepared by the embodiment of the present invention 4 is added in sow feed and is tested, as a result such as embodiment 5-7 institute
Show:
Embodiment 5
Test uses and is produced long sow 30 (parity is 3-5 tire), is divided into 2 groups, and every group is 15 sows, Mei Gechong
It is again 1 sow, every sow separated raising.Processing 1 is control group, and processing 2 is test group, the wherein addition of compound additive
Dosage is respectively (0,2.0g/kg), and 0-85 days daily scales of feeding of all test sows are 2.2kg, 85-110 days feeding 2.8kg,
Gradually material reducing is to 2.0kg within 3-4 days before childbirth, 2 times (8:00,16:00) of feeding daily.Nursing period is freely eaten.In breeding process
It keeps giving up interior room temperature being 18-25 DEG C, sow free water.It is found through overtesting, the survival rate of additive test group sow and son
The birth weight of pig improves 7% and 5% compared with the control group respectively, and IUGR piglet incidence reduces 6%, and weaned piglet
Weight also improves 6% compared with the control group.
Embodiment 6
Test uses and is produced long sow 30 (parity is 3-5 tire), is divided into 2 groups, and every group is 15 sows, Mei Gechong
It is again 1 sow, every sow separated raising.Processing 1 is control group, and processing 2 is test group, the wherein addition of compound additive
Dosage is respectively (0,2.0g/kg), and 0-85 days daily scales of feeding of all test sows are 2.2kg, 85-110 days feeding 2.8kg,
Gradually material reducing is to 2.0kg within 3-4 days before childbirth, 2 times (8:00,16:00) of feeding daily.Nursing period is freely eaten.In breeding process
It keeps giving up interior room temperature being 18-25 DEG C, sow free water.Piglet is weaned in 28 ages in days, and every group of 8 nest of selection is carried out into one after wean
Step fattening, sow identical milking sow diet of 2 groups of feedings after childbirth, fed after weaned piglet respectively child care material, small pig feed, in
It 180 days after pig feed and big pig feed to life, is found through overtesting, the offspring pig of additive test group sow mentions to lean meat percentage when listing
High by 3%, dripping for muscle reduces 20% and 25% with cooking loss respectively compared with the control group.
Embodiment 7
Test uses and is produced long sow 150 (parity is 3-5 tire), is divided into 5 groups, and every group is 30 sows, each
It repeats to be 1 sow, every sow separated raising.Processing 1 is control group, and processing 2-5 is test group, wherein compound additive
Additive capacity is respectively (0,1.0,2.0,3.0,4.0g/kg), and 0-85 days daily scales of feeding of all test sows are 2.2kg, 85-
110 days feeding 2.8kg, gradually material reducing is to 2.0kg within 3-4 days before childbirth, 2 times (8:00,16:00) of feeding daily.Nursing period is free
Feeding.It keeps giving up interior room temperature in breeding process being 18-25 DEG C, sow free water.It is found through overtesting, when additive test group
When dosage 1.0-3.0g/kg, the survival rate of sow and the birth weight of piglet improve 4-8% and 3- compared with the control group respectively
7%, IUGR piglet incidence reduce 5-10%.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of compound additive for promoting the differentiation of sow embryo muscle cell proliferation, it is characterised in that: the compound addition
Agent is by creatine, arginine, 25-hydroxyvitamin D3, carnitine, glutamine, α-ketoglutaric acid, beta-hydroxy-Beta-methyl butyric acid and
Carrier composition, carrier are zeolite powder and defatted rice bran；
The weight of the compound additive is as follows: 50-100 parts of creatine, 100-200 parts of arginine, 25- hydroxyvitamin
D310-20 parts, 50-100 parts of carnitine, 100-200 parts of glutamine, 50-100 parts of α-ketoglutaric acid, beta-hydroxy-Beta-methyl fourth
50-100 parts sour, carrier and totally 1000 parts of raw material, remaining as carrier, carrier is the zeolite powder and defatted rice bran of weight ratio 3:1.
2. compound additive as described in claim 1 is nascent for the differentiation of sow embryo muscle cell proliferation, increase in preparation
It is applied in piglet survival ratio and the pregnant sow diet of birth weight.
3. application as claimed in claim 2, it is characterised in that: make an addition to pregnant sow diet according to ‰ weight ratio of 1.5-2
In.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105475230B (en) * | 2015-12-17 | 2018-04-20 | 中国农业大学 | A kind of method for improving above the average age for marriage animal reproduction power |
| CN105941912A (en) * | 2016-05-16 | 2016-09-21 | 华南农业大学 | Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition |
| CN109007362A (en) * | 2018-08-16 | 2018-12-18 | 新乡市佰牧饲料有限公司 | A kind of feed addictive for sow health care |
| CN109694848A (en) * | 2018-12-06 | 2019-04-30 | 中国农业大学 | A method of promoting Muscular appendicularis ectogenesis and improves embryo transfer efficiency |
| CN110537631A (en) * | 2019-08-19 | 2019-12-06 | 华南农业大学 | Method for promoting growth of mammalian offspring by adding plant sterol ester from mother source |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090030660A (en) * | 2007-09-20 | 2009-03-25 | 양승창 | A feed additive for livestock and poultry, a feed composition, and a breeding method thereof |
| CN101744109A (en) * | 2008-12-15 | 2010-06-23 | 天津中敖生物科技有限公司 | Anti-stress reproduction-promoting feed additive special for breeding pigs |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090030660A (en) * | 2007-09-20 | 2009-03-25 | 양승창 | A feed additive for livestock and poultry, a feed composition, and a breeding method thereof |
| CN101744109A (en) * | 2008-12-15 | 2010-06-23 | 天津中敖生物科技有限公司 | Anti-stress reproduction-promoting feed additive special for breeding pigs |
Non-Patent Citations (1)
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| 母猪饲粮添加β-羟基-β-甲基丁酸对母猪繁殖性能及仔猪生长性能和免疫功能的影响;李永明等;《动物营养学报》;20121231;第24卷(第9期);第1745-1753页 |
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