CN105124315A - Composite additive for promoting sow embryonic muscle cell proliferation and differentiation and application - Google Patents
Composite additive for promoting sow embryonic muscle cell proliferation and differentiation and application Download PDFInfo
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- CN105124315A CN105124315A CN201510623803.7A CN201510623803A CN105124315A CN 105124315 A CN105124315 A CN 105124315A CN 201510623803 A CN201510623803 A CN 201510623803A CN 105124315 A CN105124315 A CN 105124315A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a composite additive for promoting sow embryonic muscle cell proliferation and differentiation and application. The composite additive is prepared from creatine, arginine, 25-hydroxyvitamin D3 (HY.D), carnitine, glutamine, a-oxoglutarate and beta-hydroxy-beta-methylbutyric acid. Based on the development demand of sow embryonic muscle cells, the addition amounts of functional amino acids and vitamins are increased, and some functional feed additives are added to promote the development of the sow embryonic muscle cells; the composite additive is high in product safety, low in use cost and better in palatability, can remarkably promote the multiplication of the sow embryonic muscle cells and increase newborn piglet birth weight and survival rate after being added in a pregnant sow diet according to the weight ratio of 1.5 to 2.0 thousandths, and is an ideal composite type functional feed additive for improving sow reproductive performance.
Description
Technical field
The present invention relates to animal feed additive technical field, particularly relate to and a kind ofly promote the compound additive that sow embryo muscle cell proliferation breaks up and application.
Background technology
Animal carcasses is made up of muscle, fat, bone and the tissue that is connected, and wherein skeletal muscle is most important part.Muscle growth speed is the main determining factor of growth of animal performance, and muscle growth speed and animal daily gain, feed-weight ratio, carcass weight are closely related.And growing of pig muscle is main in foetal period and juvenile phase, substantially determine in gestation 90 days myofibrillar total quantitys of pig fetus.Myofibrillar quantity directly affects the growth potential after pig life and carcass quality.Maternal nutrition is grown offspring's muscle fibre and conversion in type has important impact, the development impact of offspring's skeletal muscle is shown muscle fibre quantity, diameter or cross-sectional area there are differences, the Growth of Muscle Fiber speed in early stage and growth period after final impact is raw, and the meat affecting that pig goes on the market.
What receive much concern for in-pig in current production is sow reproductive performance always, comprises litter size (total yield coefficient, litter size of living) and birth weight etc.For a long time, the growth of sow embryo muscle cell does not cause enough attention, and especially along with the increase of number born of sow, the incidence of IUGR piglet increases, directly affects growth performance and the listing age in days of offspring, especially offspring is gone on the market the production declining of lean meat.
Summary of the invention
The invention reside in and a kind of composite feed additive improving sow embryo muscle cell proliferation is provided, significantly can promote the growth of sow fetus myofibroblasts, promote that newborn piglet birth weight increases, reduce the incidence of sow IUGR embryonic period, embryonic phase piglet simultaneously.
The technical scheme that the present invention takes is:
The compound additive of promotion sow embryo muscle cell proliferation of the present invention differentiation is by creatine, arginine, 25-hydroxy-vitamin D
3(HY.D), carnitine, glutamine, a-ketoglutaric acid, beta-hydroxy-Beta-methyl butyric acid and carrier composition, carrier is zeolite powder and defatted rice bran.
The weight of compound additive of the present invention is as follows: creatine 50-100 part, arginine 100-200 part, 25-hydroxyvitamin D
3(HY.D) 10-20 part, carnitine 50-100 part, glutamine 100-200 part, a-ketoglutaric acid 50-100 part, beta-hydroxy-Beta-methyl butyric acid 50-100 part, carrier and raw material totally 1000 parts, remaining as carrier, carrier is zeolite powder and defatted rice bran (weight ratio is 3:1).
Preferred: the weight of compound additive of the present invention is as follows: creatine 50 parts, arginine 80 parts, 25-hydroxyvitamin D
3(HY.D) 10 parts, carnitine 50 parts, glutamine 80 parts, a-ketoglutaric acid 80 parts, beta-hydroxy-Beta-methyl butyric acid 50 parts, defatted rice bran 150 parts, zeolite powder 450 parts.Defatted rice bran 150 parts is for carnitine and 25-hydroxyvitamin D
3premix carrier.
Compound additive of the present invention may be used for the differentiation of sow embryo muscle cell proliferation, increases newborn piglet survival rate and birth weight.Make an addition in in-pig diet according to 1.5-2 ‰ part by weight during use.
Arginine can promote the nitric oxide production generation of sow placenta, and then promotes the increase of placenta Angiogenesis, improves parent nutrient and transports in tire pig body, promotes the growth of fetus skeletal muscle fiber.
25-hydroxyvitamin D3 is the metabolin of vitamin D, can improve the vitamin D content of sow and fetus, and promotes the propagation of embryo's muscle cell.
Creatine, glutamine, a ketoglutaric acid can promote the propagation of muscle cell, for piglet muscle cell provides energy.
Beta-hydroxy-Beta-methyl butyric acid can promote the propagation of piglet muscle cell, increases the immunity of piglet simultaneously.
Good effect of the present invention is as follows:
The composite feed additive of promotion sow embryo muscle cell proliferation of the present invention, has the following advantages:
1) product addition is little, easy to use and cost is low.
2) significantly can increase the birth weight of piglet, improve the survival rate of newborn piglet.
3) significantly can improve the lean meat output of offspring pig listing, indirectly improving every sow year provides lean meat output.
4) pork carcass quality that offspring pig butchers the listing phase can be significantly improved.
The present invention, from the growth requirement of sow embryo muscle cell, enhances the addition of functional amino, vitamin, and adds the growth that part functionalities feed addictive facilitates sow embryo muscle.Product safety is high, and use cost is low, and palatability is better, make an addition in in-pig diet, significantly can promote the propagation of sow embryo muscle cell, increasing newborn piglet birth weight and survival rate, is a kind of compound functional feedstuff additive of desirable raising sow reproductive performance.
Detailed description of the invention
The following examples describe in further detail of the present invention.
Embodiment 1
The weight of compound additive of the present invention is as follows: creatine 50 parts, arginase 12 00 part, 25-hydroxyvitamin D
3(HY.D) 10 parts, carnitine 100 parts, glutamine 100 parts, a-ketoglutaric acid 100 parts, beta-hydroxy-Beta-methyl butyric acid 50 parts, carrier and raw material totally 1000 parts, remaining as carrier, carrier is zeolite powder and defatted rice bran (part by weight is 3:1).
Embodiment 2
The weight of compound additive of the present invention is as follows: creatine 100 parts, arginine 100 parts, 25-hydroxyvitamin D
3(HY.D) 20 parts, carnitine 50 parts, glutamine 200 parts, a-ketoglutaric acid 50 parts, beta-hydroxy-Beta-methyl butyric acid 100 parts, carrier and raw material totally 1000 parts, remaining as carrier, carrier is zeolite powder and defatted rice bran (part by weight is 3:1).
Embodiment 3
The weight of compound additive of the present invention is as follows: creatine 80 parts, arginine 150 parts, 25-hydroxyvitamin D
3(HY.D) 15 parts, carnitine 65 parts, glutamine 150 parts, a-ketoglutaric acid 80 parts, beta-hydroxy-Beta-methyl butyric acid 70 parts, carrier and raw material totally 1000 parts, remaining as carrier, carrier is zeolite powder and defatted rice bran (part by weight is 3:1).
Embodiment 4
The weight of compound additive of the present invention is as follows: creatine 50 parts, arginine 80 parts, 25-hydroxyvitamin D
3(HY.D) 10 parts, carnitine 50 parts, glutamine 80 parts, a-ketoglutaric acid 80 parts, beta-hydroxy-Beta-methyl butyric acid 50 parts, defatted rice bran 150 parts, zeolite powder 450 parts.Defatted rice bran 150 parts is for carnitine and 25-hydroxyvitamin D
3premix carrier.
Added in sow feed additive prepared by the embodiment of the present invention 4 and test, result is as shown in embodiment 5-7:
Embodiment 5
Test adopts multiparity to grow up sow 30 (parity is 3-5 tire), and be divided into 2 groups, often group is 15 sows, and each repetition is 1 sow, every sow separated raising.Process 1 is control group, process 2 is test group, wherein the additive capacity of compound additive is respectively (0,2.0g/kg), all test sow scales of feeding 0-85 days every days are 2.2kg, the 85-110 days 2.8kg that feed, childbirth before 3-4 days progressively material reducing to 2.0kg, feed every day 2 times (8:00,16:00).Lactation free choice feeding.Keep room temperature in house to be 18-25 DEG C in feeding process, sow freely drinks water.Find through overtesting, the survival rate of additive test group sow and the birth weight of piglet improve compared with control group respectively 7% and 5%, IUGR piglet incidence decrease 6%, and weaned piglet is heavy also improves 6% compared with control group.
Embodiment 6
Test adopts multiparity to grow up sow 30 (parity is 3-5 tire), and be divided into 2 groups, often group is 15 sows, and each repetition is 1 sow, every sow separated raising.Process 1 is control group, process 2 is test group, wherein the additive capacity of compound additive is respectively (0,2.0g/kg), all test sow scales of feeding 0-85 days every days are 2.2kg, the 85-110 days 2.8kg that feed, childbirth before 3-4 days progressively material reducing to 2.0kg, feed every day 2 times (8:00,16:00).Lactation free choice feeding.Keep room temperature in house to be 18-25 DEG C in feeding process, sow freely drinks water.Piglet is weaned in 28 ages in days, after wean, often group is chosen 8 nests and is fattened further, sow to be fed identical milking sow diet in point puerperium 2 groups, child care material, little pig feed, middle pig feed and large pig feed fed respectively to raw latter 180 days after weaned piglet, find through overtesting, the offspring pig of additive test group sow improves 3% to lean meat percentage during listing, and dripping of muscle reduces 20% and 25% with cooking loss respectively compared with control group.
Embodiment 7
Test adopts multiparity to grow up sow 150 (parity is 3-5 tire), and be divided into 5 groups, often group is 30 sows, and each repetition is 1 sow, every sow separated raising.Process 1 is control group, process 2-5 is test group, and wherein the additive capacity of compound additive is respectively (0,1.0,2.0,3.0,4.0g/kg), all test sow scales of feeding 0-85 days every days are 2.2kg, the 85-110 days 2.8kg that feed, before childbirth, within 3-4 days, progressively material reducing is to 2.0kg, and feed every day 2 times (8:00,16:00).Lactation free choice feeding.Keep room temperature in house to be 18-25 DEG C in feeding process, sow freely drinks water.Find through overtesting, as additive test group dosage 1.0-3.0g/kg, the survival rate of sow and the birth weight of piglet improve 4-8% and 3-7% respectively compared with control group, and IUGR piglet incidence decreases 5-10%.
Although illustrate and describe embodiments of the invention, for the ordinary skill in the art, be appreciated that and can carry out multiple change, amendment, replacement and modification to these embodiments without departing from the principles and spirit of the present invention, scope of the present invention is by claims and equivalents thereof.
Claims (6)
1. promote to it is characterized in that the compound additive that sow embryo muscle cell proliferation breaks up: described compound additive is by creatine, arginine, 25-hydroxyvitamin D
3(HY.D), carnitine, glutamine, a-ketoglutaric acid, beta-hydroxy-Beta-methyl butyric acid and carrier composition, carrier is zeolite powder and defatted rice bran.
2. the compound additive promoting the differentiation of sow embryo muscle cell proliferation as claimed in claim 1, is characterized in that: the weight of described compound additive is as follows: creatine 50-100 part, arginine 100-200 part, 25-hydroxyvitamin D
3(HY.D) 10-20 part, carnitine 50-100 part, glutamine 100-200 part, a-ketoglutaric acid 50-100 part, beta-hydroxy-Beta-methyl butyric acid 50-100 part, carrier and raw material totally 1000 parts, remaining as carrier, carrier is zeolite powder and the defatted rice bran of weight ratio 3:1.
3. the compound additive promoting the differentiation of sow embryo muscle cell proliferation as claimed in claim 1, is characterized in that: the weight of described compound additive is as follows: creatine 50 parts, arginine 100 parts, 25-hydroxyvitamin D
3(HY.D) 10 parts, carnitine 50 parts, glutamine 100 parts, a-ketoglutaric acid 100 parts, beta-hydroxy-Beta-methyl butyric acid 50 parts, defatted rice bran 100 parts, zeolite powder 440 parts.
4. the compound additive promoting the differentiation of sow embryo muscle cell proliferation as claimed in claim 3, is characterized in that: defatted rice bran 100 parts is for carnitine and 25-hydroxyvitamin D
3premix carrier.
5. the compound additive as described in any one of claim 1-4 is used for the differentiation of sow embryo muscle cell proliferation, increases the application of newborn piglet survival rate and birth weight.
6. apply as claimed in claim 5, it is characterized in that: make an addition in in-pig diet according to 1.5-2 ‰ part by weight during use.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105475230A (en) * | 2015-12-17 | 2016-04-13 | 中国农业大学 | Method for improving fertility of older animals |
| CN105941912A (en) * | 2016-05-16 | 2016-09-21 | 华南农业大学 | Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition |
| CN109007362A (en) * | 2018-08-16 | 2018-12-18 | 新乡市佰牧饲料有限公司 | A kind of feed addictive for sow health care |
| CN110537631A (en) * | 2019-08-19 | 2019-12-06 | 华南农业大学 | Method for promoting growth of mammalian offspring by adding plant sterol ester from mother source |
| CN114507636A (en) * | 2018-12-06 | 2022-05-17 | 中国农业大学 | Method for improving animal embryo development efficiency |
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| KR20090030660A (en) * | 2007-09-20 | 2009-03-25 | 양승창 | A feed additive for livestock and poultry, a feed composition, and a breeding method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105475230A (en) * | 2015-12-17 | 2016-04-13 | 中国农业大学 | Method for improving fertility of older animals |
| CN105475230B (en) * | 2015-12-17 | 2018-04-20 | 中国农业大学 | A kind of method for improving above the average age for marriage animal reproduction power |
| CN105941912A (en) * | 2016-05-16 | 2016-09-21 | 华南农业大学 | Application of alpha-ketoglutaric acid and alpha-ketoglutarate in preparation of feed additive capable of improving pig carcass composition |
| CN109007362A (en) * | 2018-08-16 | 2018-12-18 | 新乡市佰牧饲料有限公司 | A kind of feed addictive for sow health care |
| CN114507636A (en) * | 2018-12-06 | 2022-05-17 | 中国农业大学 | Method for improving animal embryo development efficiency |
| CN110537631A (en) * | 2019-08-19 | 2019-12-06 | 华南农业大学 | Method for promoting growth of mammalian offspring by adding plant sterol ester from mother source |
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