CN105475230B - A kind of method for improving above the average age for marriage animal reproduction power - Google Patents
A kind of method for improving above the average age for marriage animal reproduction power Download PDFInfo
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- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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- 102000004067 Osteocalcin Human genes 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fodder In General (AREA)
Abstract
The present invention relates to herding and animal reproduction field, specifically discloses a kind of above the average age for marriage animal reproduction power of raising, including the method for litter size and feelings phase breeding rate.Present invention firstly discovers that the alpha Ketoglutarate that above the average age for marriage Long term Animal takes orally suitable dose (0.05~1.58g/kg of daily dose) is set to significantly increase the feelings phase breeding rate and litter size of multiparous animal.Multiparous animal is absorbed alpha Ketoglutarate by way of adding alpha Ketoglutarate in the drinking water or feed in animal, can not only accomplish easily to add on demand, change dosage in time, and a wide range of use can be realized in the case where mechanical feed feeds water system.The method of the invention is applied to livestock-raising, can ensure that the edible safety of meat, while also promotes the development of aquaculture.
Description
Technical field
The present invention relates to herding and animal reproduction field, specifically, is related to a kind of side for improving above the average age for marriage animal reproduction power
Method.
Background technology
The reproductive capacity for improving animal to greatest extent is one of target that husbandry sector is pursued, and improves animal husbandry economy
The important channel of benefit.China is populous nation, very big to the demand of meat product.Wherein, pork is China's consumption of resident
Main meat.But due to that be subject to environment, nutrition, heredity, factor stress be waited to be influenced, the nest litter size of market pig is relatively low.At present,
China year live pig amount of delivering for sale is about 600,000,000, and sow breeding stock is minimum at 41,000,000, an average sow total amount of livestock for sale 15
Head.One of thinking solved the problems, such as is to improve animal reproduction efficiency, such as nest litter size.Therefore, a kind of raising multiparous animal is sought
The method of breeding potential becomes particularly important.
A-ketoglutaric acid (α-Ketoglutaric acid, α-KG) is very important cellular energy metabolism intermediate product,
It and amino acid, sodium, potassium, calcium, magnesium etc. can form series of products into salt, can be organic as the component of sport nutrition beverage
Intermediate, the matched reagent of biochemical reagents.Some researches show that α-ketoglutaric acid can alleviate grice diarrhoea, promote weight to increase
Adduction skeleton development, improves insulin in blood plasma, the growth of Insulin-like growth factor II -1, promotes pancreas beta-secretase insulin, improving should
Swash the level of osteocalcin under state, improve negative nitrogen balance and muscle alienation of postoperative patient etc..In the recent period, there is scholar's discovery, necessarily
The α-ketoglutaric acid of concentration can extend the service life of nematode.
The content of the invention
In order to solve the problems in the existing technology, the object of the present invention is to provide one kind to improve above the average age for marriage animal reproduction power
Method.
In order to realize the object of the invention, technical scheme is as follows：
A kind of method for improving above the average age for marriage animal reproduction power, makes animal absorb α-ketoglutaric acid by oral way.The present invention
Inventor has found, multiparous animal is taken orally litter size and feelings that suitable dose α-ketoglutaric acid significantly improves above the average age for marriage animal
Phase breeding rate.
Preferably, the daily dose of animal consumption α-ketoglutaric acid and the weight of animals ratio are 0.05~1.58g/kg.At this
Under the intake daily dose of α-ketoglutaric acid, above the average age for marriage animal can significantly improve litter size.
More preferably, the daily dose of animal consumption α-ketoglutaric acid and the weight of animals ratio are 0.30g/kg.In the α -one penta
Under the intake daily dose of diacid, the best results of above the average age for marriage animal litter size are improved.
For the present invention by the way that many animals are carried out with the research of intake α-ketoglutaric acid, preferably go out that litter size significantly improves is dynamic
Thing is：Mouse, rat, pig, fox, rabbit and mink.Above-mentioned multiparous animal is after α-ketoglutaric acid is absorbed, with respect to other animals more
Add and significantly enhance litter size.
The preferred daily dose and weight ratio of the multiparous animals such as mouse, rat, pig, fox, rabbit and mink are 0.30g/kg.
Further, the present invention is directed to above-mentioned animal, the method for providing more preferred raising litter size respectively.
When the animal is mouse or rat, at 2~12 monthly ages, α-ketoglutaric acid is absorbed by oral way daily
0.28~0.32g/kg；
Preferably, at the 2-3 monthly ages, per daily ingestion 0.285g/kg, at the 3-4 monthly ages, per daily ingestion 0.290g/kg,
At the 4-5 monthly ages, per daily ingestion 0.295g/kg, at the 5-6 monthly ages, per daily ingestion 0.300g/kg, at the 6-7 monthly ages, daily
0.305g/kg is absorbed, at the 7-8 monthly ages, per daily ingestion 0.310g/kg, at the 8-9 monthly ages, per daily ingestion 0.315g/kg,
During the 9-10 monthly ages, per daily ingestion 0.310g/kg, at the 10-11 monthly ages, per daily ingestion 0.305g/kg, at the 11-12 monthly ages, often
Daily ingestion 0.300g/kg.
When the animal is pig, at 14~84 monthly ages, daily by oral way absorb α-ketoglutaric acid 0.28~
0.32g/kg；
Preferably, at the 14-21 monthly ages, per daily ingestion 0.285g/kg, at the 21-28 monthly ages, per daily ingestion
0.290g/kg, at the 28-35 monthly ages, per daily ingestion 0.295g/kg, at the 35-42 monthly ages, per daily ingestion 0.300g/kg,
During the 42-49 monthly ages, per daily ingestion 0.305g/kg, at, 49-56 monthly ages, per daily ingestion 0.310g/kg, at the 56-63 monthly ages,
Per daily ingestion 0.315g/kg, at the 63-70 monthly ages, per daily ingestion 0.310g/kg, at the 70-77 monthly ages, per daily ingestion
0.305g/kg, at the 77-84 monthly ages, per daily ingestion 0.300g/kg.
When the animal is fox, rabbit or mink, at 10~60 monthly ages, passes through oral way daily and absorb α -one penta 2
0.28~0.32g/kg of acid；
Preferably, at the 10-15 monthly ages, per daily ingestion 0.285g/kg；At the 15-20 monthly ages, per daily ingestion
0.290g/kg；At the 20-25 monthly ages, per daily ingestion 0.295g/kg；At the 25-30 monthly ages, per daily ingestion 0.300g/kg；
During the 30-35 monthly ages, per daily ingestion 0.305g/kg；At the 35-40 monthly ages, per daily ingestion 0.310g/kg；At the 40-45 monthly ages,
Per daily ingestion 0.315g/kg；At the 45-50 monthly ages, per daily ingestion 0.310g/kg；At the 50-55 monthly ages, per daily ingestion
0.305g/kg；At the 55-60 monthly ages, per daily ingestion 0.300g/kg.
Further, the mode that the α-ketoglutaric acid is ingested is passive by being added in drinking water or animal feed
Thing absorbs.The feed or drinking water are replaced daily.
The beneficial effects of the present invention are：
Present invention firstly discovers that multiparous animal is taken orally suitable dose α-ketoglutaric acid significantly improves above the average age for marriage animal
Litter size, safely and effectively improve the reproductive efficiency of above the average age for marriage animal.By adding α -one penta in the feed or drinking water of animal
The mode of diacid makes animal consumption α-ketoglutaric acid, can not only accomplish easily to add on demand, change dosage, Er Qie in time
Mechanical feed is fed can realize a wide range of use under water system.
A-ketoglutaric acid used in the present invention can conveniently bought on the market, be applied to and improved above the average age for marriage animal farrowing
Number aspect, can bring considerable economic benefit and good social benefit：Pig, fox, mink, rabbit can be allowed using this method
Directly be benefited Deng farm and cultivation self-employed worker, improve nest litter size, improve farm and cultivate the income of self-employed worker；For pig
The direct individual consumer of meat, rabbit meat, present aspect the method also ensure that the edible safety of meat, ensure that people's body and mind is good for
Health, while also promote the development of aquaculture.
By the numerous sow breeding stock 496,000,000 of whole nation energy in 2014, every sow annual 1.5 nests of farrowing, per nest about 10
Head.By average nest litter size 0.08~2.35 is improved, final live pig total amount of livestock for sale will increase production 5952~1,165,600,000, directly pass through
Ji benefit 297.6~582,800,000,000 yuan, overall economic benefit is considerable.
Brief description of the drawings
Fig. 1 is to take shadow of the different daily dose α-ketoglutaric acids to 6 monthly age mouse feelings phase breeding rates in experimental example 1 of the present invention
Ring；
Fig. 2 is to take different daily dose α-ketoglutaric acids to 12 monthly age mouse feelings phase breeding rates in experimental example 1 of the present invention
Influence；
Fig. 3 is to take influence of the different daily dose α-ketoglutaric acids to 6 monthly age mouse litter sizes in experimental example 1 of the present invention；
Fig. 4 is to take influence of the different daily dose α-ketoglutaric acids to 12 monthly age mouse litter sizes in experimental example 1 of the present invention.
Embodiment
The preferred embodiment of the present invention is described in detail below in conjunction with embodiment.It is it will be appreciated that following real
Providing merely to play the purpose of explanation for example is applied, is not used to limit the scope of the present invention.The skill of this area
Art personnel can carry out various modifications and replacement in the case of without departing substantially from spirit of the invention and spirit to the present invention.
Experimental method used in following embodiments is conventional method unless otherwise specified.
The reagent and material used in following embodiments is commercial goods.Use α-ketoglutaric acid (α-
Ketoglutaric acid, α-KG) it is purchased from Sigma companies (St.Louis, MO, USA).
Embodiment 1
The present embodiment be related to it is a kind of the method for mouse litter size is improved by oral α-ketoglutaric acid, specially by α -one
Glutaric acid is added in the feed or drinking-water of mouse, and the daily dose that mouse takes α-ketoglutaric acid is 0.05g/kg.Respectively small
During 6 monthly age of mouse, spontaneous estrus female rat is selected, mates and mates with public mouse, the next morning inspection bolt, chooses and see bolt female rat, calculate feelings
Phase breeding rate, and count litter size.
Embodiment 2~5
Compared with Example 1, distinctive points are only that：In embodiment 2~5, the daily dose for taking α-ketoglutaric acid is respectively
0.00g/kg、0.30g/kg、0.78g/kg、1.58g/kg。
Record display, the daily dose for taking α-ketoglutaric acid can improve 6 monthly ages and December when being 0.05g/kg, 0.30g/kg
The feelings phase breeding rate and litter size of age mouse.Daily dose 0.78g/kg, does not have effect to the mouse at 6 monthly ages, but can improve 12
The feelings phase breeding rate and litter size of monthly age mouse.Daily dose 1.58g/kg, can significantly improve the litter size of 6 monthly age mouse, but
There is no effect to 12 monthly age mouse.
Experimental example 1
1. experimental animal
Above-described embodiment 1~5 is carried out using the Kunming white female rat of 277 8 week old or so, Kunming white female rat is purchased from Chinese army
Thing Academy of Medical Sciences Experimental Animal Center, is randomly divided into 5 groups, every group 50, female rat can free choice feeding (military affairs by Kunming white female rat
Academy of Medical Sciences Experimental Animal Center production full nutrition pellet) and drinking-water.
2. experiment condition is：Illumination 12h/d, indoor temperature are 20~22 DEG C.
3. experimentation
Female rat will be tested after the adaptability raising of one week, α-ketoglutaric acid is added in feed or drinking-water, make female rat
The daily dose for taking α-ketoglutaric acid is 0.05g/kg to 1.58g/kg, replaces feed or drinking-water daily.At 6 monthly age of mouse and 12
During the monthly age, every group of female rat and public mouse are mated, morning inspection bolt.Continuous 4 days.Picking out introitus has faint yellow solid
The female rat of (vaginal plug).It will a few days ago see that bolt female rat divides cage in the expected date of childbirth, individually raising, and observe childbirth situation sooner or later daily.Note
Record counts every group of nest litter size.
4. experimental result
Data processing is carried out to the data result of above-mentioned record：Data are carried out respectively using spass18.0 statistical softwares
One-way analysis of variance (ANOVA), P<0.05 thinks that data have significant difference, p<0.01 thinks that data difference heteropole is shown
Write.The Multiple range test of average is carried out using DuncanShi, is as a result represented with Means ± SEM.
Influence of the 4.1 different groups to mouse feelings phase breeding rate
Fig. 1 shows that the feelings phase breeding rate of remaining each group does not have in addition to the feelings phase breeding rate of 0.78g/kg groups is extremely relatively low
Too big difference.
Fig. 2 shows that the feelings phase breeding rate of 0.30g/kg groups is all higher than remaining each group, and the feelings phase breeding rate of remaining each group does not have
Too big difference.
Influence of the 4.2 different groups to mouse litter size
Table 1 takes influence of the different daily dose α-ketoglutaric acids to 6 monthly age mouse litter sizes
| Group | α-ketoglutaric acid daily dose | Gravid mouse number (only) | Average nest litter size (only) |
| 8 week old young controls | 0.00g/kg | 43 | 13.93±2.098b |
| 6 monthly age control groups | 0.00g/kg | 50 | 12.52±2.288a |
| 6 monthly age low dose groups | 0.05g/kg | 42 | 12.6±2.307ab |
| Low dose group in 6 monthly ages | 0.30g/kg | 49 | 14.2±2.227bc |
| 6 monthly age middle dose groups | 0.78g/kg | 43 | 12.51±2.453a |
| 6 monthly age high dose groups | 1.58g/kg | 50 | 13.45±2.189ab |
Note：Shoulder mark difference letter represents the significant P of difference<0.05, shoulder mark contains same letter and represents the not significant P of difference>
0.05。
From upper table 1, in 6 monthly age mouse, α-ketoglutaric acid daily dose 0.05g/Kg groups, 0.30g/Kg groups,
The average nest litter size of 1.58g/Kg groups is all remarkably higher than control group, wherein in 6 monthly ages low dosage 0.30g/Kg groups litter size
It is more taller than 8 week old control groups, and 0.78g/Kg groups have no significant effect nest litter size.
Table 2 takes influence of the different daily dose α-ketoglutaric acids to 12 monthly age mouse litter sizes
Note：Shoulder mark difference letter represents the significant P of difference<0.05, shoulder mark contains same letter and represents the not significant P of difference>
0.05.
From upper table 2, in 12 monthly age mouse, α-ketoglutaric acid daily dose 0.05g/Kg groups, 0.30g/Kg groups,
The average nest litter size of 0.78g/Kg groups is all remarkably higher than control group, and 1.58g/Kg groups have no significant effect nest litter size, but
Because the reason for aging, substantially lower than 8 week old control groups.
In summary, feeding the α-ketoglutaric acid that daily dose is 0.05g/Kg to 1.58g/Kg can above carry in certain level
The average nest litter size of high mouse, especially when daily dose is 0.30g/Kg, nest litter size is improved the standard significantly, average every
Nest improves about 2 or so.In addition, the feelings phase breeding rate of daily dose 0.30g/Kg group mouse is also high compared with other experimental groups.Therefore, originally
The method of invention provides a kind of beneficial reference to improve the production practices of multiparous animal litter size.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (5)
- A kind of 1. method for improving above the average age for marriage animal reproduction power, it is characterised in that make animal absorb α -one penta 2 by oral way Acid；When the animal is mouse or rat, at 2~12 monthly ages, daily by oral way absorb α-ketoglutaric acid 0.28~ 0.32g/kg weight；When the animal is pig, at 14~84 monthly ages, 0.28~0.32g/ of α-ketoglutaric acid is absorbed by oral way daily Kg weight；When the animal is fox, rabbit or mink, at 10~60 monthly ages, α-ketoglutaric acid is absorbed by oral way daily 0.28~0.32g/kg weight.
- 2. according to the method described in claim 1, it is characterized in that, when the animal is mouse or rat, at the 2-3 monthly ages When, per daily ingestion 0.285g/kg, at the 3-4 monthly ages, per daily ingestion 0.290g/kg, at the 4-5 monthly ages, per daily ingestion 0.295g/kg, at the 5-6 monthly ages, per daily ingestion 0.300g/kg, at the 6-7 monthly ages, per daily ingestion 0.305g/kg, in the 7-8 months During age, per daily ingestion 0.310g/kg, at the 8-9 monthly ages, per daily ingestion 0.315g/kg, at the 9-10 monthly ages, per daily ingestion 0.310g/kg, at the 10-11 monthly ages, per daily ingestion 0.305g/kg, at the 11-12 monthly ages, per daily ingestion 0.300g/kg.
- 3. according to the method described in claim 1, it is characterized in that, when the animal is pig, at the 14-21 monthly ages, daily 0.285g/kg is absorbed, at the 21-28 monthly ages, per daily ingestion 0.290g/kg, at the 28-35 monthly ages, per daily ingestion 0.295g/ Kg, at the 35-42 monthly ages, per daily ingestion 0.300g/kg, at the 42-49 monthly ages, per daily ingestion 0.305g/kg, in the 49-56 months During age, per daily ingestion 0.310g/kg, at the 56-63 monthly ages, per daily ingestion 0.315g/kg, at the 63-70 monthly ages, per daily ingestion 0.310g/kg, at the 70-77 monthly ages, per daily ingestion 0.305g/kg, at the 77-84 monthly ages, per daily ingestion 0.300g/kg.
- 4. according to the method described in claim 1, it is characterized in that, when the animal is fox, rabbit or during mink, in 10-15 During the monthly age, per daily ingestion 0.285g/kg；At the 15-20 monthly ages, per daily ingestion 0.290g/kg；At the 20-25 monthly ages, take the photograph daily Take 0.295g/kg；At the 25-30 monthly ages, per daily ingestion 0.300g/kg；At the 30-35 monthly ages, per daily ingestion 0.305g/kg； At the 35-40 monthly ages, per daily ingestion 0.310g/kg；At the 40-45 monthly ages, per daily ingestion 0.315g/kg；At the 45-50 monthly ages When, per daily ingestion 0.310g/kg；At the 50-55 monthly ages, per daily ingestion 0.305g/kg；At the 55-60 monthly ages, per daily ingestion 0.300g/kg。
- 5. according to Claims 1 to 4 any one of them method, it is characterised in that the α-ketoglutaric acid is dynamic by being added to Absorbed in thing feed or drinking water by multiparous animal.
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| CN111387349A (en) * | 2016-07-07 | 2020-07-10 | 中国农业大学 | Animal feeding additive and animal feeding method |
| CN107412216B (en) * | 2017-07-26 | 2020-08-07 | 华南农业大学 | α application of ketoglutaric acid in improving animal reproductive function injury caused by high fat diet |
| CN109694848A (en) * | 2018-12-06 | 2019-04-30 | 中国农业大学 | A method of promoting Muscular appendicularis ectogenesis and improves embryo transfer efficiency |
| CN111249265B (en) * | 2020-03-26 | 2023-03-31 | 华南农业大学 | Application of alpha-ketone short-chain dicarboxylic acid substances in improving reproductive capacity of animals |
| CN112715475B (en) * | 2020-12-28 | 2023-11-24 | 无锡珊瑚礁生物科技有限公司 | Method for improving farrowing rate of ferrets |
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