CN105102631A - 用于癌症的分子诊断测试 - Google Patents

用于癌症的分子诊断测试 Download PDF

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Publication number
CN105102631A
CN105102631A CN201380071098.3A CN201380071098A CN105102631A CN 105102631 A CN105102631 A CN 105102631A CN 201380071098 A CN201380071098 A CN 201380071098A CN 105102631 A CN105102631 A CN 105102631A
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biomarker
justice
sample
property
sub
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Chinese (zh)
Inventor
D·P·哈金
F·帕特森
C·特林德
E·J·奥布赖恩
C·米奇
C·古尔利
L·A·希尔
K·E·基廷
J·奥唐纳
M·拜尔斯乔
S·德哈罗
V·普劳特斯基
R·肯尼迪
T·戴维森
A·温特
A·麦克卡维甘
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Almac Diagnostics Ltd
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Almac Diagnostics Ltd
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Publication of CN105102631A publication Critical patent/CN105102631A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
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  • Immunology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380071098.3A 2012-12-03 2013-12-03 用于癌症的分子诊断测试 Pending CN105102631A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261732761P 2012-12-03 2012-12-03
US61/732,761 2012-12-03
PCT/GB2013/053202 WO2014087156A1 (en) 2012-12-03 2013-12-03 Molecular diagnostic test for cancer

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CN105102631A true CN105102631A (zh) 2015-11-25

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US (1) US11091809B2 (https=)
EP (1) EP2925885B1 (https=)
JP (1) JP2015536667A (https=)
KR (1) KR20150090246A (https=)
CN (1) CN105102631A (https=)
AU (1) AU2013353839A1 (https=)
CA (1) CA2893033A1 (https=)
HK (1) HK1214633A1 (https=)
IL (1) IL239196A0 (https=)
MX (1) MX2015006955A (https=)
SG (1) SG11201504023SA (https=)
WO (1) WO2014087156A1 (https=)

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CN107621545A (zh) * 2017-07-26 2018-01-23 东南大学 Bicc1蛋白对精神疾病诊断的新用途
CN108496084A (zh) * 2016-01-25 2018-09-04 赛诺菲 通过测量血浆生物标记的水平预测疑似患有癌症的患者使用阿柏西普的治疗的结果的方法
CN108524937A (zh) * 2018-05-11 2018-09-14 中南大学湘雅三医院 Mrvi1-as1作为靶位点在制备治疗鼻咽癌紫杉醇化疗增敏药物中的应用
CN109585011A (zh) * 2018-10-26 2019-04-05 朱海燕 胸痛患者的病症诊断方法及机器可读存储介质
CN110358827A (zh) * 2019-07-09 2019-10-22 中国人民解放军第四军医大学 Vmp1基因在病理诊断胶质母细胞瘤中的应用及其试剂盒的制备
CN111164700A (zh) * 2017-07-14 2020-05-15 余因子基因组学公司 使用下一代测序的免疫-肿瘤学应用
CN111735949A (zh) * 2020-07-17 2020-10-02 北京信诺卫康科技有限公司 Wnt7a和CA125联合用作早期卵巢癌生物标志物以及试剂盒
CN112266961A (zh) * 2020-10-29 2021-01-26 中山大学附属第六医院 Tsg-6基因在预测结直肠癌转移及预后方面的应用
CN112592397A (zh) * 2020-12-31 2021-04-02 上海市胸科医院 Ccdc80来源的多肽及其用途
CN112996444A (zh) * 2018-08-31 2021-06-18 西诺医疗器械股份有限公司 基于超声和/或光声(oa/us)特征确定癌症分子亚型的方法和系统
CN113035298A (zh) * 2021-04-02 2021-06-25 南京信息工程大学 递归生成大阶数行限制覆盖阵列的药物临床试验设计方法
CN114127312A (zh) * 2019-04-30 2022-03-01 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
CN116243003A (zh) * 2023-02-20 2023-06-09 东莞市滨海湾中心医院(东莞市太平人民医院、东莞市第五人民医院) Smox在制备结直肠癌诊断或预后预测产品中的应用
CN116482367A (zh) * 2023-05-04 2023-07-25 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法
CN117089621A (zh) * 2023-09-28 2023-11-21 上海爱谱蒂康生物科技有限公司 生物标志物组合及其在预测结直肠癌疗效中的应用

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CN110546277B (zh) 2017-03-01 2024-06-11 豪夫迈·罗氏有限公司 用于癌症的诊断和治疗方法
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WO2021034091A1 (ko) * 2019-08-19 2021-02-25 재단법인 아산사회복지재단 교모세포종의 진단 방법
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CN111105843B (zh) * 2019-12-31 2023-07-21 杭州纽安津生物科技有限公司 一种hlai型分子与多肽的亲和力预测方法
KR102897399B1 (ko) * 2021-04-12 2025-12-08 연세대학교 산학협력단 유방암 진단을 위한 신규 바이오마커
US20250266162A1 (en) * 2021-05-13 2025-08-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Method of targeted multi-panel approach and tiered a.i. use for differential diagnosis and prognosis
CN116519954B (zh) * 2023-06-28 2023-10-27 杭州广科安德生物科技有限公司 一种结直肠癌检测模型构建方法、系统及生物标志物

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