CN105072909A - 应用控制食欲不振的化合物的组合物和方法 - Google Patents

应用控制食欲不振的化合物的组合物和方法 Download PDF

Info

Publication number
CN105072909A
CN105072909A CN201380061931.6A CN201380061931A CN105072909A CN 105072909 A CN105072909 A CN 105072909A CN 201380061931 A CN201380061931 A CN 201380061931A CN 105072909 A CN105072909 A CN 105072909A
Authority
CN
China
Prior art keywords
composition
camorelin
carmorelin
animal
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380061931.6A
Other languages
English (en)
Chinese (zh)
Inventor
B·佐勒斯
L·罗兹
E·海宁
G·德瓦拉杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aratana Therapeutics Inc
Original Assignee
Aratana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aratana Therapeutics Inc filed Critical Aratana Therapeutics Inc
Priority to CN202010001164.1A priority Critical patent/CN111419845A/zh
Publication of CN105072909A publication Critical patent/CN105072909A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Feed For Specific Animals (AREA)
  • Dermatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380061931.6A 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法 Pending CN105072909A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010001164.1A CN111419845A (zh) 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706164P 2012-09-27 2012-09-27
US61/706,164 2012-09-27
PCT/US2013/062227 WO2014052780A2 (en) 2012-09-27 2013-09-27 Compositions and methods of use of an inappetance-controlling compound

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010001164.1A Division CN111419845A (zh) 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法

Publications (1)

Publication Number Publication Date
CN105072909A true CN105072909A (zh) 2015-11-18

Family

ID=50339468

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010001164.1A Pending CN111419845A (zh) 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法
CN201380061931.6A Pending CN105072909A (zh) 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202010001164.1A Pending CN111419845A (zh) 2012-09-27 2013-09-27 应用控制食欲不振的化合物的组合物和方法

Country Status (18)

Country Link
US (1) US11090292B2 (enExample)
EP (3) EP2906041A4 (enExample)
JP (2) JP6779618B2 (enExample)
KR (6) KR20210009438A (enExample)
CN (2) CN111419845A (enExample)
AR (2) AR092713A1 (enExample)
AU (2) AU2013323349B2 (enExample)
BR (1) BR112015006282B1 (enExample)
CA (1) CA2886091C (enExample)
DK (1) DK3524260T3 (enExample)
ES (1) ES2959427T3 (enExample)
MX (2) MX2015003564A (enExample)
NZ (2) NZ746394A (enExample)
PL (1) PL3524260T3 (enExample)
PT (1) PT3524260T (enExample)
RU (1) RU2648958C2 (enExample)
TW (3) TWI667024B (enExample)
WO (1) WO2014052780A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110022688A (zh) * 2016-11-11 2019-07-16 希尔氏宠物营养品公司 宠物食物的组合物和方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10975070B2 (en) 2010-02-26 2021-04-13 Raqualia Pharma Inc. Ghrelin receptor agonist for treatment of cachexia
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
KR20210009438A (ko) 2012-09-27 2021-01-26 아라타나 세라퓨틱스, 인크. 식욕부진을 조절 화합물 조성물 및 이의 이용 방법
WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
ES2902795T3 (es) * 2015-01-28 2022-03-29 Elanco Animal Health Incorporated Composición para uso crónico como compuesto para aumentar de peso
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170757A1 (en) * 2003-06-18 2009-07-02 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US193273A (en) * 1877-07-17 Improvement in material for pulley-covers
JP2893901B2 (ja) * 1990-09-07 1999-05-24 株式会社岐阜免疫研究所 動物用抗体含有油性ペースト製剤
CA2095786A1 (en) * 1992-05-08 1993-11-09 Franco J. Vaccarino Method of stimulating appetite
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
EP1181933A3 (en) * 2000-06-29 2002-04-10 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating or increasing appetite
US8309603B2 (en) * 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CA2603295A1 (en) * 2004-04-07 2006-10-20 Gastrotech Pharma A/S Use of ghrelin for the treatment of hyperthyroidism
EP1812045A2 (en) * 2004-10-27 2007-08-01 Gastrotech Pharma A/S Uses of secretagogues for treatment of organ transplant patients
WO2007051629A1 (en) * 2005-11-02 2007-05-10 Nestec S.A. Isoflavone compositions for reducing accumulation of body fat in male mammals, and methods for their use
JP5325092B2 (ja) * 2006-03-13 2013-10-23 リアット・ミンツ 悪液質および／または食欲不振症および／または食欲不振症−悪液質および／または栄養失調および／または脂肪異栄養症および／または筋肉消耗および／または食欲−刺激を治療するためのグレリンスプライス変異体の使用
KR101197541B1 (ko) * 2006-09-27 2013-01-02 입센 파마 에스.에이.에스 Ｎ-말단이 치환된 그렐린 유사체
JP2008127377A (ja) * 2006-11-24 2008-06-05 Jichi Medical Univ Ｇｈｓ−ｒ作動薬を含有してなるメタボリックシンドローム又は高血圧症の予防・治療剤。
US20080226802A1 (en) * 2007-03-14 2008-09-18 Concentrate Manufacturing Company Of Ireland Beverage having natural sweeteners with one or more stevia components and source of berry
TWI429436B (zh) * 2007-04-10 2014-03-11 Helsinn Therapeutics Us Inc 使用生長激素促泌素治療或預防嘔吐之方法
RU2007129408A (ru) * 2007-07-31 2009-02-10 Игорь Николаевич Жирков (RU) Способ выращивания поросят в период откорма
FR2920295B1 (fr) 2007-09-05 2009-12-11 Desvac Dispositif d'injection de produits veterinaires a des volailles, comprenant un element de contention presentant une forme anatomique incluant des moyens de calage d'un os reperable
JP5258783B2 (ja) * 2007-11-12 2013-08-07 三栄源エフ・エフ・アイ株式会社 ステビア抽出物の甘味質改善
CN102448953B (zh) * 2009-03-26 2014-05-07 武田药品工业株式会社 吡唑化合物
US10975070B2 (en) * 2010-02-26 2021-04-13 Raqualia Pharma Inc. Ghrelin receptor agonist for treatment of cachexia
KR20210009438A (ko) 2012-09-27 2021-01-26 아라타나 세라퓨틱스, 인크. 식욕부진을 조절 화합물 조성물 및 이의 이용 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170757A1 (en) * 2003-06-18 2009-07-02 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PHILIP A. CARPINO等: "Pyrazolinone-piperidine Dipeptide Growth Hormone Secretagogues (GHSs): Discovery of Capromorelin", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
张秀文等: "生长激素释放肽的研究进展", 《安徽农业科学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110022688A (zh) * 2016-11-11 2019-07-16 希尔氏宠物营养品公司 宠物食物的组合物和方法

Also Published As

Publication number Publication date
WO2014052780A3 (en) 2014-06-26
EP2906041A2 (en) 2015-08-19
BR112015006282A2 (pt) 2017-07-04
TW201417812A (zh) 2014-05-16
AR123902A2 (es) 2023-01-25
PL3524260T3 (pl) 2023-11-27
AU2016216741B2 (en) 2018-02-15
NZ746394A (en) 2019-01-25
CA2886091A1 (en) 2014-04-03
JP2018117625A (ja) 2018-08-02
US20140088139A1 (en) 2014-03-27
JP6779618B2 (ja) 2020-11-04
BR112015006282B1 (pt) 2021-11-23
KR20230097201A (ko) 2023-06-30
PT3524260T (pt) 2023-10-13
EP4302825A3 (en) 2024-07-03
TWI667024B (zh) 2019-08-01
RU2648958C2 (ru) 2018-03-28
DK3524260T3 (da) 2023-10-09
MX2022015141A (es) 2023-02-01
KR20150058345A (ko) 2015-05-28
CN111419845A (zh) 2020-07-17
TW201924680A (zh) 2019-07-01
AU2013323349B2 (en) 2016-09-15
NZ707174A (en) 2018-10-26
KR20250048114A (ko) 2025-04-07
MX2015003564A (es) 2015-11-16
JP6796097B2 (ja) 2020-12-02
AU2016216741A1 (en) 2016-09-15
KR20190143484A (ko) 2019-12-30
WO2014052780A2 (en) 2014-04-03
AR092713A1 (es) 2015-04-29
EP3524260B1 (en) 2023-09-13
JP2016500660A (ja) 2016-01-14
CA2886091C (en) 2021-11-30
EP2906041A4 (en) 2016-10-26
ES2959427T3 (es) 2024-02-26
EP4302825A2 (en) 2024-01-10
RU2015114996A (ru) 2016-11-20
TWI732158B (zh) 2021-07-01
US11090292B2 (en) 2021-08-17
KR20220003640A (ko) 2022-01-10
EP3524260A1 (en) 2019-08-14
KR20210009438A (ko) 2021-01-26
TW202106298A (zh) 2021-02-16
AU2013323349A1 (en) 2015-05-07

Similar Documents

Publication Publication Date Title
JP6796097B2 (ja) 食欲不振制御化合物の組成物および使用方法
JP7120718B2 (ja) 体重増加用化合物の長期使用のための組成物と方法
HK40104431A (en) Pharmaceutical compositions for treatment of inappetence

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20151118