CN105056033A - Traditional Chinese medicine for treating incision effusion and relieving pains after endoscopic thyroid operation - Google Patents

Abstract

The invention belongs to the technical field of medicine and particularly relates to traditional Chinese medicine for treating incision effusion and relieving pains after an endoscopic thyroid operation. The traditional Chinese medicine is composed of, by weight, 8-16 parts of smilax perfoliate, 8-16 parts of indigofera stachyoides, 8-16 parts of frankincense, 8-16 parts of myrrh, 8-16 parts of frogs, 6-14 parts of tongoloa dunnii roots, 6-14 parts of fructus aurantii, 6-14 parts of dalbergia hancei, 8-16 parts of exocarpium benincasae, 8-16 parts of dutchmanspipe vine and 4-8 parts of licorice roots. By means of the traditional Chinese medicine, the postoperative pains can be effectively relieved, the postoperative inflammatory reaction is alleviated, and a certain haemostasis function is achieved, so that the amount of the effusion which generated in the operation incision and is guided is reduced. A patient has no adverse reaction, and the medicine is high in safety.

Description

A kind of Chinese medicine for the treatment of device for endoscopic thyroid postoperative wound hydrops and pain

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of device for endoscopic thyroid postoperative wound hydrops and pain.

Background technology

Thyroid nodule refers to the agglomerate occurring one or more organizational structure exception in the thyroid that a variety of causes causes, and be commonly encountered diseases clinically, frequently-occurring disease, prevalence is higher.Thyroid nodule expectant treatment does not prove effective more, and operative treatment often has the effect of getting instant result.The modus operandi of thyroid nodule can be divided into traditional open operation and device for endoscopic thyroid surgery now.So far oneself has the history of over one hundred year to open operation, and technical operation is ripe, and safety is high, but for the maximum women of number of the infected, the postoperative tired trace left over of cervical region but becomes the injury larger than operation itself, and is more and more difficult to accept.In recent years, there is the chamber mirror technology of the innate advantage such as Wicresoft, beauty treatment in development constantly and renewal, and be applied in the treatment of thyroid nodule by surgical specialist both domestic and external rapidly, also developed multiple device for endoscopic thyroid art formula thus.Due to device for endoscopic thyroid surgery art mouth microminiaturization and be transferred to more hidden position, obtain the favor of modern young woman.

Although device for endoscopic thyroid surgery has the young and hidden feature of art, but as a kind of modus operandi, it is also inevitable brings wound on patient body, and the art mouth in order to the effect device for endoscopic thyroid surgery reaching beauty treatment is often designed in the position of bilateral mammary areola, axillary fossa or breastbone.Although cervical region does not leave surgical scars, directly cause being separated of operative incision and actual operation position, often need to do large-area subcutaneous separation and just can reach operative site.Add chamber mirror technology not long in the practical development time of China, operation level is also uneven because of the physical condition of each hospital.Existence for above-mentioned reasons, the incidence rate of complication such as making device for endoscopic thyroid postoperative art mouth hydrops, swim speckle, be hemorrhage increases, and too increases post-surgical infection's probability simultaneously.So more allowing patient unacceptable is that most clinicist does not draw attention to complication such as postoperative art mouth hydrops, trip speckles.The way that the treatment of above-mentioned complication does not also get instant result.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine for the treatment of device for endoscopic thyroid postoperative wound hydrops and pain.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 8-16 part, Indigofera stachyoides Lindl. 8-16 part, Olibanum 8-16 part, Myrrha 8-16 part, trip frog 8-16 part, Radix Tongoloae Dunnii 6-14 part, Fructus Aurantii 6-14 part, rattan wingceltis 6-14 part, Exocarpium Benincasae 8-16 part, Herba Aristolochiae 8-16 part, Radix Glycyrrhizae 4-8 part.

Preferably, above-mentioned treatment device for endoscopic thyroid postoperative wound hydrops and the Chinese medicine of pain, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 10-14 part, Indigofera stachyoides Lindl. 10-14 part, Olibanum 10-14 part, Myrrha 10-14 part, trip frog 10-14 part, Radix Tongoloae Dunnii 8-12 part, Fructus Aurantii 8-12 part, rattan wingceltis 8-12 part, Exocarpium Benincasae 10-14 part, Herba Aristolochiae 10-14 part, Radix Glycyrrhizae 5-7 part.

Preferred, above-mentioned treatment device for endoscopic thyroid postoperative wound hydrops and the Chinese medicine of pain, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 12 parts, Indigofera stachyoides Lindl. 12 parts, Olibanum 12 parts, Myrrha 12 parts, the trip frog 12 parts, Radix Tongoloae Dunnii 10 parts, Fructus Aurantii 10 parts, 10 parts, rattan wingceltis, Exocarpium Benincasae 12 parts, Herba Aristolochiae 12 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of device for endoscopic thyroid postoperative wound hydrops and pain.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine of the present invention,

Rhizoma et radix smilacis santis source is tuber and the root of liliaceous plant sheath handle Rhizoma Smilacis Chinensis.Bitter in the mouth, property is put down.Function expelling wind and removing dampness, activating blood cirulation to regulate QI flow, pain relieving.Dispelling the wind and dampness pathogens pain, traumatic injury, traumatic hemorrhage, fishbone bone stuck in the throat.

Indigofera stachyoides Lindl. another name mountain Flos Carthami, Radix Lespedezae Buergeri, red hardship thorn, derive from pulse family Indigofera stachyoides Lindl. IndigoferastachyoidesLindl., be used as medicine with root.Mildly bitter flavor, puckery, warm in nature.Function promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral, enriching yin and nourishing kidney, hemostasis by invigorating QI.Cure mainly metrorrhagia, traumatic injury and rheumatism, liver cirrhosis, infantile malnutrition, dysentery; Ulcer is QI and blood deficiency with the passing of time.

Trip frog another name penetrates urine (worm is another), QINGZHU (worm is another), the trip frog, oil (worm is another), is the entirety of Shu Wa section animal Rhacophorus leuconystax Rhacophorusleucomystax (Gravenhorst).Salty in the mouth; Cold nature.Return liver; Kidney channel.Function blood stasis dispelling stopping bleeding and knitting the fractured bone continues muscle.Main traumatic hemorrhage; Traumatic injury; Fracture.

Radix Tongoloae Dunnii another name sweet seven is the root of east Russia celery Tongoloadunnii (Boiss.) Wolff, samphire entrance of the city [PimpinellasilaifoliadeBoiss.].Sweet in the mouth; Bitter; Property is put down.Function removing stasis to stop bleeding; Dispel the wind aobvious; Bone and muscle strengthening.Main traumatic injury; Swelling and pain due to blood stasis; Traumatic hemorrhage; Metrorrhagia; The new arthralgia pain of rheumatism; Boat bone is aching and limp; Impairment caused by overstrain lumbago.

Rattan wingceltis another name Lignum Dalbergiae Odoriferae, large Fissistigma bracteolatum Chatt., pain must spirit, Ash fruit rattan, Flos Caryophylli bavin, derive from pulse family Dalbergia rattan of plant yellow wingceltis DalbergiahanceiBenth., be used as medicine with stem and root.Acrid in the mouth, warm in nature.Function regulating QI to relieve pain.Stem: for stomachache, stomachache, chest and hypochondrium.Root: for lumbago arthralgia.

Herba Aristolochiae is the dry aerial parts of aristolochiaceae plant Fructus Aristolochiae AristolochiadebilisSieb.etZucc. or Aristolochia contorta AristolochiacontortaBunge..Bitter in the mouth, warm in nature.Return liver,spleen,kidney warp.Function promoting flow of QI and blood, inducing diuresis to remove edema.For gastral cavity ventral spine pain, arthralgia, edema during pregnancy.

Other Chinese medicine related in prescriptions of Chinese medicine of the present invention all records in Chinese Pharmacopoeia 2010 editions.

In traditional medicine, various golden sword wound or injury from falling down all belong to the category of " damaged lung ", and device for endoscopic thyroid, as one of modus operandi, also can sum up the category of the traditional Chinese medical science " damaged lung ", and etiology and pathogenesis is syndrome of blood stasis.In view of traditional medicine is to the understanding-syndrome of blood stasis of device for endoscopic thyroid postoperative pain pathogenesis.The Therapeutic Principle of blood circulation promoting and blood stasis dispelling is just meeting to the treatment that device for endoscopic thyroid is postoperative that traditional medicine is dialectical to be treated, careful disease look into because of requirement.Therefore need blood circulation promoting and blood stasis dispelling be adopted, device for endoscopic thyroid postoperative wound hydrops and pain are treated in removing obstruction in the collateral to relieve pain ruling by law.

The Chinese prescription mechanism for the treatment of device for endoscopic thyroid postoperative wound hydrops of the present invention and pain is as follows:

Monarch drug: Rhizoma et radix smilacis santis, Indigofera stachyoides Lindl., Olibanum, Myrrha merit are with promoting blood circulation and stopping pain.

Ministerial drug: penetrate urine, Radix Tongoloae Dunnii merit with removing stasis to stop bleeding

Adjuvant drug: Fructus Aurantii, rattan wingceltis merit are with regulating QI to relieve pain, and blood relies the operation in gas, the capable then blood of gas, blood stasis is from going.Exocarpium Benincasae, Herba Aristolochiae merit are with inducing diuresis to remove edema.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, all medicines share plays blood circulation promoting and blood stasis dispelling altogether, the effect of removing obstruction in the collateral to relieve pain, inducing diuresis to remove edema, the basic pathogenesis of device for endoscopic thyroid postoperative wound hydrops and the pain of linking closely, for device for endoscopic thyroid aftertreatment, effectively can alleviate postoperative pain, alleviate Postoperative inflammatory reaction, there is certain anastalsis, thus reduce art mouth drainage flow.Patient has no adverse reaction, and safety is high, can in clinical extensive popularization.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, each crude drug weight proportion is as follows:

Rhizoma et radix smilacis santis 12g, Indigofera stachyoides Lindl. 12g, Olibanum 12g, Myrrha 12g, trip frog 12g, Radix Tongoloae Dunnii 10g, Fructus Aurantii 10g, rattan wingceltis 10g, Exocarpium Benincasae 12g, Herba Aristolochiae 12g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, each crude drug weight proportion is as follows:

Rhizoma et radix smilacis santis 10g, Indigofera stachyoides Lindl. 10g, Olibanum 10g, Myrrha 10g, trip frog 10g, Radix Tongoloae Dunnii 8g, Fructus Aurantii 8g, rattan wingceltis 8g, Exocarpium Benincasae 10g, Herba Aristolochiae 10g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, each crude drug weight proportion is as follows:

Rhizoma et radix smilacis santis 14g, Indigofera stachyoides Lindl. 14g, Olibanum 14g, Myrrha 14g, trip frog 14g, Radix Tongoloae Dunnii 12g, Fructus Aurantii 12g, rattan wingceltis 12g, Exocarpium Benincasae 14g, Herba Aristolochiae 14g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, each crude drug weight proportion is as follows:

Rhizoma et radix smilacis santis 8g, Indigofera stachyoides Lindl. 8g, Olibanum 8g, Myrrha 8g, trip frog 8g, Radix Tongoloae Dunnii 6g, Fructus Aurantii 6g, rattan wingceltis 6g, Exocarpium Benincasae 8g, Herba Aristolochiae 8g, Radix Glycyrrhizae 4g.

Embodiment 5

Treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, each crude drug weight proportion is as follows:

Rhizoma et radix smilacis santis 16g, Indigofera stachyoides Lindl. 16g, Olibanum 16g, Myrrha 16g, trip frog 16g, Radix Tongoloae Dunnii 14g, Fructus Aurantii 14g, rattan wingceltis 14g, Exocarpium Benincasae 16g, Herba Aristolochiae 16g, Radix Glycyrrhizae 8g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose and carry out device for endoscopic thyroid surgery and treat patient 100 example of one-sided Solitary Thyroid benign protuberance for object of study.

1.2 inclusive criteria

1. diameter of tumor be less than and frozen section pathology prompt for optimum thyroid tumor nodular goiter or companion cystic hyperplasia, thyroid adenoma etc. or degree the following thyroid function side of enlargement enter;

2. the patient of an actor's rendering of an operatic tune videoendoscopic surgery is ready.

1.3 exclusion standard

1. paraffin pathology shows and belongs to malignant tumor patient;

2. preoperative planning hepatic and renal function and the abnormal patient of coagulation function or be associated with the patient of cardiovascular and cerebrovascular disease, lung pattern disease, diabetes, uremia, hyperlipemia etc.;

3. postoperatively there is massive hemorrhage, first permits the severe complication persons such as crisis;

4. there is the infected in postoperative patient art mouth;

5. thyroid operation history person was had;

6. to the patient of medicine allergy, spiritedness disease patient.

1.4 reject standard

1. include rear discovery in and do not meet the case that hoof selects condition;

Though 2. meet inclusive criteria and the medicine person that do not take medicine on request after including in;

3. the patient of the medicine that may affect the treatment is taken without authorization;

1.5 come off standard

1. in tested process, patient compliance is poor, affects effectiveness and reliability estimator;

2. sb.'s illness took a turn for the worse, can not improver in the short time;

3. determining because treating other the complication persons caused, comprising the severe allergic reaction of appearance or serious adverse events;

4. patient is unwilling to proceed clinical investigators.

1.6 Therapeutic Method

Therapeutic Method: the mammary areola pathway partial thyroidectomy all adopting standard.Postoperative conventional treatment is outer and connect negative pressure drainage vessel, but refuse anti-inflammation and analgesic drugs, start to give extract oral in postoperative 7h, prescription is as follows: Rhizoma et radix smilacis santis 12g, Indigofera stachyoides Lindl. 12g, Olibanum 12g, Myrrha 12g, penetrate urine 12g, Radix Tongoloae Dunnii 10g, Fructus Aurantii 10g, rattan wingceltis 10g, Exocarpium Benincasae 12g, Herba Aristolochiae 12g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sub-service is sooner or later a course for the treatment of with 3d.

1.7 observation index

(1) MAIN OUTCOME MEASURES: 1. postoperative 24h, 36h, 72h drainage flow of record patient.2. VAS evaluation form is adopted to assess the pain degree of postoperative 24h, 48h patient.

(2) lab index: 1. detect two groups of preoperative skies of patient and Post operation take Chinese medicine the 1st, 2, the leukocyte of 3d and, the change of c reactive protein; 2. PT, APTT time of first 1 day of operation in patients and postoperative 48h is checked.

(3) security inspection: routine blood test, hepatic and renal function, heart enzyme and cardiac inspection before and after treatment.

1.8 statistical method

Application SPSS14.0 version statistical package carries out the statistical procedures of data.Group data adopts X2 inspection, and ranked data adopt rank test, and own control adopts t inspection, baseline homogeneity of variance analysis between group, P<0.05.

2. result

2.1 postoperative different time cervical region drainage flows

Postoperative cervical region drainage flow reduces, gradually in table 1

Table 1 postoperative different time cervical region drainage flow (ml)

Number of cases	Postoperative 1d	Postoperative 2d	Postoperative 3d
				100	45.32±13.76	34.87±9.32	18.54±4.37

2.2 postoperative pain situations

Postoperative 24h pain VAS marks (0.78 ± 0.22) point, and postoperative 48h is reduced to (0.46 ± 0.12) point, and difference has statistical significance (t=2.172, P<0.05).

2.3 perioperatively inflammatory parameters changes

Postoperative 1d serum leukocyte and the more preoperative obvious rising of c reactive protein, postoperative 2nd, 3d declines gradually, and difference has statistical significance (P<0.05), in table 2.

Table 2 post operative inflammatory index changes

Index	Preoperative	Postoperative 1d	Postoperative 2d	Postoperative 3d
					Leukocyte	5.12±0.72	19.34±2.14	8.34±1.12	6.35±0.53
C reactive protein	4.23±1.25	83.26±14.27	32.26±10.22	10.25±3.25

2.4 perioperatively coagulation indexes changes

The all preoperative obvious reduction of postoperative 2d blood-serum P T, APTT, difference has statistical significance (P<0.05), in table 3.

Table 3 perioperatively coagulation indexes changes

Index	Preoperative	Postoperative 2d
			PT	15.12±1.54	39.67±2.57
APTT	8.12±1.45	20.23±2.43

2.5 safety observations

Before and after treatment, routine blood test, hepatic and renal function, heart enzyme and cardiac inspection are all without obviously changing, and point out Chinese medicine of the present invention not affect, to human-body safety these indexs.

Claims (3)

1. treat a Chinese medicine for device for endoscopic thyroid postoperative wound hydrops and pain, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 8-16 part, Indigofera stachyoides Lindl. 8-16 part, Olibanum 8-16 part, Myrrha 8-16 part, trip frog 8-16 part, Radix Tongoloae Dunnii 6-14 part, Fructus Aurantii 6-14 part, rattan wingceltis 6-14 part, Exocarpium Benincasae 8-16 part, Herba Aristolochiae 8-16 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of device for endoscopic thyroid postoperative wound hydrops according to claim 1 and pain, is characterized in that, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 10-14 part, Indigofera stachyoides Lindl. 10-14 part, Olibanum 10-14 part, Myrrha 10-14 part, trip frog 10-14 part, Radix Tongoloae Dunnii 8-12 part, Fructus Aurantii 8-12 part, rattan wingceltis 8-12 part, Exocarpium Benincasae 10-14 part, Herba Aristolochiae 10-14 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of device for endoscopic thyroid postoperative wound hydrops according to claim 3 and pain, is characterized in that, be made up of the Chinese medicine of following weight portion:

Rhizoma et radix smilacis santis 12 parts, Indigofera stachyoides Lindl. 12 parts, Olibanum 12 parts, Myrrha 12 parts, the trip frog 12 parts, Radix Tongoloae Dunnii 10 parts, Fructus Aurantii 10 parts, 10 parts, rattan wingceltis, Exocarpium Benincasae 12 parts, Herba Aristolochiae 12 parts, 6 parts, Radix Glycyrrhizae.