CN104258083A - Traditional Chinese medicine composition for treating chronic aplastic anemia - Google Patents
Traditional Chinese medicine composition for treating chronic aplastic anemia Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating chronic aplastic anemia. The traditional Chinese medicine composition comprises the following raw materials by weight: 3-8 g of unpleasant swallowwort herb, 5-10 g of trichosanthes palmata, 5-10 g of polygonum multiflorum, 3-10 g of smallflower microtis, 3-5 parts of herba lycopi, 5-8 g of sambucus chinensis, 10-15 g of madder, 6-9 g of evergreen mucuna root and leaf, 5-10 g of lacca, 5-12 g of cyrtomium fortunei, 3-5 g of radix cynanchi, 3-7 g of emilia sonchifolia and 2-5 g of mallow root. According to the traditional Chinese medicine composition, the unpleasant swallowwort herb, the polygonum multiflorum and the smallflower microtis have the effects of nourishing yin and the kidney; the herba lycopi, the sambucus chinensis, the madder and the evergreen mucuna root and leaf have the effects of activating blood to remove stasis; the lacca, the trichosanthes palmate and the cyrtomium fortunei have the effects of cooling blood and removing toxic materials; the radix cynanchi, the emilia sonchifolia and the mallow root have the effects of benefiting vital energy and nourishing blood; a kidney-tonifying drug can promote the hematopoietic stem cell differentiation; a blood-activating drug can improve the hematopoietic microenvironment, promote the hematopoietic stem cell growth and improve the body immunity, so that the purpose of treating the chronic aplastic anemia is achieved. The traditional Chinese medicine composition is definite in treatment effect, high in effective rate and free of toxic and side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of chronic aplastic anemia.
Background technology
Aplastic anemia is called for short aplastic anemia, it is one group of syndrome of marrow hematopoiesis function failure, it is the hematopoietic disorders because the many factors such as biology, chemistry, physics causes, cause red bone marrow total capacity to reduce, generation with fatty marrow, Haematopoietic failure, cause hemopoietic tissue hypofunction or exhaustion and cause pancytopenia, take pancytopenia as main manifestations, clinical manifestation is one group of syndrome of the symptoms such as anemia, hemorrhage, infection, is the more common disease of hemopoietic system.
Aplastic anemia is the marrow hematopoiesis function failure caused by many reasons, external blood pancytopenia, clinical with anemia, hemorrhage, infect disease for main manifestations.According to its cause of disease, aplastic anemia can be divided into congenital (reason has still shown) and Secondary cases two kinds, congenital aplastic anemia is many fell ill before 10 years old, the generation of Secondary cases aplastic anemia and physical factor (as ionizing radiation), (medicine and chemicals are as chlorine for chemical factor, suntomycinum, Phenylbutazone, sulphonamides, indomethacin, aspirin, cimetidine, chlorpromazine, anticarcinogen, organophosphor man medicine and hair dye etc.), biological factor is (as antibacterial, virus, parasite, infect as hematogenous disseminated pulmonary tuberculosis, typhoid fever) etc. cause marrow hemopoietic stem cells defect, hematopoieticmicroenviron-ment change and immunosuppressant abnormal relevant.
Aplastic anemia is divided into acute and chronic type clinically, and external point light-duty, heavy, and amphitypy is widely different in prognosis, and acute aplastic anemia morbidity is anxious, and the course of disease is short, infection, bleeding weight, bone marrow injury degree weight, prognosis mala; Chronic aplastic anemia morbidity is hidden attacks, and the course of disease is long, and gently, based on anemia, bone marrow injury mild degree, may long-term surviving through treating for infection, bleeding.Although each age group all can be fallen ill, primary disease occurs common with person between twenty and fifty, and male is more than women, and the north is more than south.Chronic type aplastic anemia adult is more than child, and man is more than female, and how slow onset is, often falls ill with anemia.Extent of hemorrhage is comparatively light, and there are subcutaneous, nasal mucosa and gums in common bleeding part, and women can have menorrhagia, seldom has visceral hemorrhage, infects rare and lighter.
The traditional Chinese medical science thinks that aplastic anemia belongs to " asthenia " category.Asthenia is divided into the heart, liver, spleen, lung, kidney deficient five internal organs, and aplastic anemia and spleen wherein, kidney two are dirty relevant.Generation and the spleen kidney of QI and blood are in close relations.The spleen being located in middle-JIAO, " in Jiao be bullied and get meter, change and red, be meaning blood "; The kidney being the origin of congenital constitution, kidney storing essence, the raw marrow of main bone, essence and blood sharing the same origin.The damage if spleen is suffered from a deficiency of the kidney, resembling of a series of insufficiency of vital energy and blood is then seen in the biochemical weary source of QI and blood.In " Medical Treasures of the Golden Chamber arthralgia due to stagnation of blood asthenia disease arteries and veins is demonstrate,proved and controls " ' labor of hissing pain in the abdomen, throb with fear, be defeated in battle "; " consumptive disease with abdominal contraction, various symptoms and signs of deficiency "; ' pine torch deficient,deep and stringy pulse, without cold and heat, short breath with abdominal contraction ... pale complexion, often closing the eyes, double be defeated in battle ' wait be the deficient performance of asthenia taste, similar to aplastic anemia bleeding.
Chinese medicine hematopathy has wide resources advantage, be free from side effects and also curative effect fine.Hemopathic paathogenic factor mostly is caused by " evil poison ", and as lonizing radiation, chemical drugs, pesticide, virus, antibacterial etc. are the traditional Chinese medical science " evil poison " category.The pure Chinese medicinal formulae of expert takes dialectical differential diagnosis of diseases to combine to various disease, takes different therapeutic schemes for the cause of disease, for Chinese traditional treatment hematopathy provides theoretical foundation and the therapeutic rules of system, clinically achieves remarkable result.
According to the theory of Chinese medical science of " in healthy energy deposits; heresy can not be done " in hemopathic Chinese traditional treatment, " strengthening vital QI to eliminate pathogenic factors, cooling blood and removing stasis, detoxicating change marrow; blood circulation promoting and blood stasis dispelling; hard masses softening and resolving " is adopted to be principle for the treatment of, can obviously improve the expendable symptoms such as the hemorrhage pain of patient, achieve breakthrough, make heat move back blood and only get instant result.This not only substantially reduced the hemopathic treatment phase, and centering patients with terminal adopts heavy dose of Chinese herbal treatment, and extending life is with healthy.
Summary of the invention
The object of the present invention is to provide the Chinese medicine composition for the treatment of chronic aplastic anemia that a kind of determined curative effect, effective percentage are high, have no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 3-8g, Radix Stephaniae Cepharanthae 5-10g, Radix Polygoni Multiflori 5-10g, Herba Microtis taiwanianae 3-10g, Herba Lycopi 3-5g, Herba Sambuci Chiensis 5-8g, Radix Rubiae 10-15g, Radix Seu Caulis Mucunae Sempervirentis 6-9g, Lacca 5-10g, Rhizoma Osmundae 5-12g, Radix cynanchi wilfordii 3-5g, Herba Duchesneae Indicae 3-7g, Radix Malvae 2-5g.
Preferably, the Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 5g, Radix Stephaniae Cepharanthae 7g, Radix Polygoni Multiflori 5g, Herba Microtis taiwanianae 8g, Herba Lycopi 3g, Herba Sambuci Chiensis 7g, Radix Rubiae 10g, Radix Seu Caulis Mucunae Sempervirentis 7g, Lacca 7g, Rhizoma Osmundae 10g, Radix cynanchi wilfordii 3g, Herba Duchesneae Indicae 5g, Radix Malvae 3g.
The pharmacologically active of the former treatment of each Chinese medicine of the present invention is as follows:
Radix Tylophorae arenicolae is the root and rhizome of peento in trailing plants Mi section plant snow, bitter in the mouth, and micro-pungent, property is put down, and returns lung meridian, clearing away heat and cooling blood; Function of gallbladder promoting; Removing toxic substances.Main fever due to yin deficiency; Asthenia chronic cough; Spitting of blood; Distending pain over the hypochondrium; Vomiting and nausea; Dysentery; Puerperal fidgets due to deficiency; Scrofula; Innominate toxic swelling; Serpentis worm; Mad dog is bitten." Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea.″
Radix Stephaniae Cepharanthae is the tuber of menispermaceous plants Radix Stephaniae Cepharanthae, bitter, cold.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.For acute hepatitis, bacillary dysentery, acute appendicitis, stomachache, internal hemorrhage, traumatic injury, venom; Mumps is controlled in external, lymphadenitis, neurodermatitis.
Radix Polygoni Multiflori is the tuber of polygonum multiflorum thunb, bitter, sweet, puckery, and temperature, returns liver, the heart, kidney channel, tonifying liver, kidney tonifying, nourish blood, dispel the wind.Control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids." medicineization justice ": " the liver benefiting, holds back blood, YIN nourishing.Control waist knee joint weak, muscles and bones is ached, and cuts intermittent fever of deficiency type, and only kidney rushes down, and except metrorrhagia, separates leukorrhagia.″
Herba Microtis taiwanianae is the herb of orchid Folium Allii fistulosi orchid, sweet, light, flat, returns kidney channel, nourishing YIN for benefiting the kidney.The kidney invigorating; Leukorrhagia stopping; Invigorate blood circulation.Main lumbago due to renal deficiency; Bend-band is too much; Traumatic injury.
Herba Lycopi is the stem and leaf of labiate lycopus lucidus, and bitter, pungent, tepor, returns liver, spleen channel, blood circulation promoting and blood stasis dispelling; Line water detumescence; Removing toxicity for eliminating carbuncles.Housewife female's amenorrhea; Dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen edema; Traumatic injury; Carbuncle sore tumefacting virus." Japan hanako materia medica ": " nourish blood gas for logical nine orifices, sharp GUAN-pulse, broken stagnated blood, eliminating mass abdominal mass, antenatal puerperal all kinds of diseases and ailments, logical small intestinal, granulation promoting of putting on flesh, disappears and flutters damage blood stasis, and control serious epistaxis and spit blood, wind syndrome of head ophthalmalgia, married woman's labor is thin, husband's yellowish complexion.″
Herba Sambuci Chiensis is the flower of caprifoliaceae plant Herba sambuci chinensis, sweet in the mouth, micro-hardship, and property is put down, soothing liver and strengthening spleen, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.For acute viral hepatitis, oedema due to nephritis, rheumatalgia, dislocation, oedema due to nephritis, beriberi edema, urticaria, injury from falling down, fracture.
Radix Rubiae, bitter, cold, returning Liver Channel, is the root of Maguireothamnus speciosus Radix Rubiae, cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling.Main heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid swell.
Radix Seu Caulis Mucunae Sempervirentis is root and the stem and leaf of the evergreen mucuna of leguminous plant, bitter, and micro-hardship is warm in nature, returns liver, stomach warp, promoting blood flow to regulate menstruation; Promoting the circulation of blood is enriched blood.Main menoxenia; Dysmenorrhea; Amenorrhea; Puerperal blood deficiency; Anemia; Rheumatic arthralgia; Numb limbs and tense tendons; Traumatic injury.
Lacca is the colloid that Lacciferidae insecticide lac insect is secreted on branch, sweet, salty, flat, heat clearing away, removing heat from blood, removing toxic substances, hemostasis, blood circulation promoting and blood stasis dispelling.For blood consumptive disease heat, toxic swelling malignant boil, blood stasis is not changed, and controls measles, macule is not easily sent out thoroughly, puerperal blood faints, leukorrhagia, skin ulcer scabies toxic swelling.
Rhizoma Osmundae is rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma, bitter, cool, returns liver, stomach warp, parasite killing; Heat clearing away; Removing toxic substances; Cooling blood for hemostasis.Main anemopyretic cold; Warm skin eruption; Spit blood; Hemoptysis; Epistaxis; Have blood in stool; Metrorrhagia; Dysentery; The intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.
Radix cynanchi wilfordii is the tuber of asclepiadaceae plant cynanchum auriculatum Royle, sweet in the mouth, micro-hardship, and slightly warm in nature, returns spleen, stomach, kidney channel, invigorating the liver and kidney; Bone and muscle strengthening; Strengthening the spleen and stomach; Removing toxic substances.Main Liver and kidney two is empty; Feel dizzy; Insomnia forgetfulness; Early whitening of beard and hair; Sexual impotence; Seminal emission; The acid of waist knee joint is climbed; Spleen insufficiency; Distension and fullness in the abdomen; Ren is for depressed; Have loose bowels; Puerperal, breast was few; Lymphogranuloma inguinale sore." Shaanxi Chinese herbal medicine ": " nourishing YIN and benefiting blood, spleen invigorating is pleasant, sedation-analgesia, lactogenic.To treat for stomachache abdominal distention, asthenia, lumbago due to renal deficiency, sexual impotence, the abdominal lump of chilren, leucorrhea, hypogalactia.″
Herba Duchesneae Indicae is the rhizome of Begoniaceae plant Rhizoma Begoniae Willsonii Flos Begoniae Evansianae, sweet, bitter, and flat, air making-up and spleen enlivening, nourishes blood and enrich blood, eliminating stasis to stop pain.Main weak after being ill; Impairment caused by overstrain; Blood deficiency amenorrhea; Metrorrhagia; Leucorrhea; Spit blood; Spitting of blood; Epistaxis; Traumatic hemorrhage; Treating swelling and pain by traumatic injury.
Radix Malvae is the root of Malvaceae plant Semen Abutili, sweet, temperature, heat clearing away, removing toxic substances, sharp key, and invigorating the spleen and replenishing QI is weak for the deficiency of vital energy, soreness of the waist and knees, the empty spontaneous perspiration of body, proctoptosis, uterine prolapse, chronic nephritis, diabetes.
The traditional Chinese medical science is thought, the clinical manifestation of chronic aplastic anemia usually has fatigue and weak, dizzy, breathe hard, cardiopalmus, epistaxis, bleeding from the gum, hematohidrosis, feverish sensation in the palms and soles, or be afraid of cold, loose stool, the soreness of waist, lower limb is soft, loss of appetite, thready and rapid pulse or sliding number, pale tongue, tongue is white, or have lingual surface ecchymosis, show as insufficiency of vital energy and blood, spleen kidney two loses, deficiency of both YIN and YANG.The morbidity of chronic aplastic anemia and the heart, liver,spleen,kidney are relevant, especially the closest with the relation of kidney and hemopoietic, and controlling the kidney invigorating to be this, benefiting QI for activating blood circulation of holding concurrently.Radix Tylophorae arenicolae of the present invention, Radix Polygoni Multiflori, Herba Microtis taiwanianae enriching yin and nourishing kidney, Herba Lycopi, Herba Sambuci Chiensis, Radix Rubiae, Radix Seu Caulis Mucunae Sempervirentis blood circulation promoting and blood stasis dispelling, Lacca, Radix Stephaniae Cepharanthae, Rhizoma Osmundae removing pathogenic heat from blood and toxic substance from the body, Radix cynanchi wilfordii, Herba Duchesneae Indicae, Radix Malvae benefiting QI and nourishing blood, kidney-reinforcing drug can promote that hematopoietic stem cell breaks up, blood circulation promoting medicine can improve hematopoieticmicroenviron-ment, is conducive to the growth of hematopoietic stem cell, improves the ability of immunity of organisms, thus reach the object for the treatment of chronic aplastic anemia, determined curative effect, effective percentage is high, has no side effect.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
The Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 8g, Radix Stephaniae Cepharanthae 5g, Radix Polygoni Multiflori 10g, Herba Microtis taiwanianae 5g, Herba Lycopi 4g, Herba Sambuci Chiensis 5g, Radix Rubiae 15g, Radix Seu Caulis Mucunae Sempervirentis 9g, Lacca 8g, Rhizoma Osmundae 12g, Radix cynanchi wilfordii 5g, Herba Duchesneae Indicae 4g, Radix Malvae 2g.
Embodiment 2
The Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 5g, Radix Stephaniae Cepharanthae 7g, Radix Polygoni Multiflori 5g, Herba Microtis taiwanianae 8g, Herba Lycopi 3g, Herba Sambuci Chiensis 7g, Radix Rubiae 10g, Radix Seu Caulis Mucunae Sempervirentis 7g, Lacca 7g, Rhizoma Osmundae 10g, Radix cynanchi wilfordii 3g, Herba Duchesneae Indicae 5g, Radix Malvae 3g.
Embodiment 3
The Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 6g, Radix Stephaniae Cepharanthae 8g, Radix Polygoni Multiflori 8g, Herba Microtis taiwanianae 3g, Herba Lycopi 5g, Herba Sambuci Chiensis 6g, Radix Rubiae 12g, Radix Seu Caulis Mucunae Sempervirentis 6g, Lacca 10g, Rhizoma Osmundae 5g, Radix cynanchi wilfordii 4g, Herba Duchesneae Indicae 7g, Radix Malvae 5g.
Embodiment 4
The Chinese medicine composition for the treatment of chronic aplastic anemia, is made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 3g, Radix Stephaniae Cepharanthae 10g, Radix Polygoni Multiflori 6g, Herba Microtis taiwanianae 10g, Herba Lycopi 4g, Herba Sambuci Chiensis 8g, Radix Rubiae 13g, Radix Seu Caulis Mucunae Sempervirentis 8g, Lacca 5g, Rhizoma Osmundae 8g, Radix cynanchi wilfordii 3g, Herba Duchesneae Indicae 6g, Radix Malvae 4g.
Clinical data
Physical data: accept for medical treatment altogether Chronic Aplastic Anemia Patients 91 example, wherein male 57 example, women 34 example, age 17-64 year, 38 years old mean age.
Therapeutic Method: Chinese medicine composition of the present invention is decocted in water for oral dose, every day potion, one day twice, sooner or later sub-service two months was a course for the treatment of.
Curative effect judging standard:
Cure: anemia, the clinical symptom disappearance such as hemorrhage, hemoglobin, leukocyte, platelet inspection are normal, follow up a case by regular visits to and do not recur half a year;
Effective: clinical symptom remission or improvement;
Invalid: clinical symptoms has no improvement and even increases the weight of.
Therapeutic outcome: through the treatment of 2-3 the course for the treatment of, cures 47 examples in 91 routine patients, effective 40 examples, invalid 4 examples, clinical cure rate 51.6%, total effective rate 95.6%, and determined curative effect, significantly, effective percentage is high, and in therapeutic process, untoward reaction does not appear in patient.
Model case
Pan so-and-so, man, 40 years old, started dizziness, weak without inducement before 2 years, and interruption skin of lower extremity petechia, brushes teeth hemorrhage, took 20 multi-agent Chinese medicines and do not feel any better, and within 1 week, increased the weight of.After being ill without epistaxis and melena, two is just normal, take food, without particular about food and monophagia, urinates without color of soy sauce, sleep can, body weight is unchanged.Previously body is good for, and no radiation and toxicant exposure history, without susceptibility history.Have a medical check-up: T36 DEG C, P100 beat/min, R20 beat/min, BP120/70mmHg, anemia looks, two lower limb are dispersed in petechia, and superficial lymph knot does not touch, and sclera is not yellow, and papillae of tongue is normal, and breastbone is without tenderness, and cardiopulmonary are without exception, and liver spleen does not touch, lower limb pneumonedema.Chronic aplastic anemia is diagnosed as after multinomial laboratory examination.Greatly alleviate by symptom after two courses for the treatment of of traditional Chinese medicine composition for treating of the present invention, the continual cure recovery from illness course for the treatment of, follows up a case by regular visits to and has no a recurrence in.
Claims (2)
1. treat a Chinese medicine composition for chronic aplastic anemia, it is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 3-8g, Radix Stephaniae Cepharanthae 5-10g, Radix Polygoni Multiflori 5-10g, Herba Microtis taiwanianae 3-10g, Herba Lycopi 3-5g, Herba Sambuci Chiensis 5-8g, Radix Rubiae 10-15g, Radix Seu Caulis Mucunae Sempervirentis 6-9g, Lacca 5-10g, Rhizoma Osmundae 5-12g, Radix cynanchi wilfordii 3-5g, Herba Duchesneae Indicae 3-7g, Radix Malvae 2-5g.
2. the Chinese medicine composition for the treatment of chronic aplastic anemia as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Radix Tylophorae arenicolae 5g, Radix Stephaniae Cepharanthae 7g, Radix Polygoni Multiflori 5g, Herba Microtis taiwanianae 8g, Herba Lycopi 3g, Herba Sambuci Chiensis 7g, Radix Rubiae 10g, Radix Seu Caulis Mucunae Sempervirentis 7g, Lacca 7g, Rhizoma Osmundae 10g, Radix cynanchi wilfordii 3g, Herba Duchesneae Indicae 5g, Radix Malvae 3g.
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| CN105943784A (en) * | 2016-05-17 | 2016-09-21 | 顾维乐 | Traditional Chinese medicine for treating chronic aplastic anemia and preparation method thereof |
| CN105943734A (en) * | 2016-07-01 | 2016-09-21 | 张秀萍 | Traditional Chinese medicine for treating kidney Yang-deficiency type chronic aplastic anemia and preparation method |
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