CN104288675A - Traditional Chinese medicine formula for preventing and treating hepatitis A and preparation method thereof - Google Patents
Traditional Chinese medicine formula for preventing and treating hepatitis A and preparation method thereof Download PDFInfo
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- CN104288675A CN104288675A CN201410495264.9A CN201410495264A CN104288675A CN 104288675 A CN104288675 A CN 104288675A CN 201410495264 A CN201410495264 A CN 201410495264A CN 104288675 A CN104288675 A CN 104288675A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for preventing and treating hepatitis A and a preparation method thereof. The traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 10-20 parts of isatis root, 5-10 parts of willow branc, 3-5 parts of semen raphani, 3-5 parts of pinellia ternate, 3-8 parts of Chinese brake herb, 3-5 parts of cynanchum paniculatum, 3-5 parts of semen plantaginis, 3-5 parts of curcuma aromatic, 3-8 parts of poria cocos, 3-8 parts of felwort, 3-8 parts of oldenlandia diffusa, 5-10 parts of polygonum cuspidatum, 3-8 parts of red peony root, 3-8 parts of rattletop, 5-10 parts of wormwood, 5-10 parts of selaginella uncinata and 3-5 parts of honey-fried licorice root. The preparation method is as follows: weighing the raw materials, adding water to submerge the medicinal materials, and decocting after soaking. By means of conditioning with the traditional Chinese medicines, the effects of clearing away heat and toxic materials, promoting qi circulation and removing obstruction in the collateral, and defeating plague and removing jaundice can be achieved, the pathogenetic condition of hepatitis A is quickly controlled, the traditional Chinese medicine formula has the functions of antiviral, anti-bactericidal and anti-inflammatory, tonifies liver and gall and has certain preventive effects, the patients inapplicable to the vaccine can take the traditional Chinese medicine formula to prevent large-scale infection.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly a kind of Chinese medicine formula preventing and treating hepatitis A and preparation method thereof.
Background technology
Hepatitis A, be called for short hepatitis A, hepatitis A, caused, based on the infectious disease of inflammation pathological changes by hepatitis A virus (HAV), propagate mainly through fecal oral route, clinically with tired, loss of appetite, hepatomegaly, abnormal liver function is main manifestations, there is jaundice in some cases, main manifestations is acute hepatitis, and symptomless infection person is common.Any age all can suffer from primary disease, but is mainly Children and teenager.The general comparatively child of clinical symptoms of adult's hepatitis A attaches most importance to.Winter-spring season is often the peak period of hepatitis A morbidity.The primary disease course of disease is self limiting, and without chronicity, person is extremely rare to cause acute severe hepatitis, and along with inactivated vaccine is in global use, the popular of hepatitis A is controlled effectively.
Hepatitis A based on acute hepatitis, without chronicity, good prognosis.Simultaneously when infection or other Hepadna Virus of superinfection, the state of an illness can increase the weight of even hepatitis gravis can occur.Hepatitis gravis accounts for 0.2% ~ 0.4% of whole hepatitis A case, and case fatality rate is high.Chinese patent (CN103830432A) discloses a kind of Chinese medicine for the treatment of hepatitis A, can treatment hepatitis A to a certain degree, but treatment cycle is long, slowly effective, can not have preventive effect, have certain limitation.
Summary of the invention
The object of this invention is to provide Chinese medicine formula preventing and treating hepatitis A and preparation method thereof, by the conditioning of Chinese medicine, heat-clearing and toxic substances removing, promoting QI circulation for relieving depression, lose pestilence jaundice eliminating, the quick control hepatitis A state of an illness, anti-virus sterilizing antiinflammatory, sharp liver and gall, have certain preventive effect simultaneously, to vaccine, inapplicable patient can take this side, prevents extensive infection.
The invention provides a kind of Chinese medicine formula preventing and treating hepatitis A, formed by the preparation of raw material of following parts by weight: Radix Isatidis 10 ~ 20 parts, 5 ~ 10 parts, Salix babylonica L. branch, Semen Raphani 3 ~ 5 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Herba Pteridis Multifidae 3 ~ 8 parts, Radix Cynanchi Paniculati 3 ~ 5 parts, Semen Plantaginis 3 ~ 5 parts, Radix Curcumae 3 ~ 5 parts, 3 ~ 8 parts, Poria, Radix Gentianae 3 ~ 8 parts, Herba Hedyotidis Diffusae 3 ~ 8 parts, Rhizoma Polygoni Cuspidati 5 ~ 10 parts, Radix Paeoniae Rubra 3 ~ 8 parts, Rhizoma Cimicifugae 3 ~ 8 parts, Herba Artemisiae Scopariae 5 ~ 10 parts, CUIYUNCAO 5 ~ 10 parts, Radix Glycyrrhizae Preparata 3 ~ 5 parts.
More preferably formed by the preparation of raw material of following parts by weight: Radix Isatidis 15 parts, 6 parts, Salix babylonica L. branch, Semen Raphani 4 parts, the Rhizoma Pinelliae 3 parts, Herba Pteridis Multifidae 5 parts, Radix Cynanchi Paniculati 4 parts, Semen Plantaginis 3 parts, Radix Curcumae 4 parts, 5 parts, Poria, Radix Gentianae 6 parts, Herba Hedyotidis Diffusae 6 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Cimicifugae 5 parts, Herba Artemisiae Scopariae 8 parts, CUIYUNCAO 7 parts, Radix Glycyrrhizae Preparata 4 parts.
Preparation method takes raw material of Chinese medicine by above-mentioned weight portion, adds cold water, do not have medical material 2 ~ 5cm, soaks 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20 ~ 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Pharmacology analysis:
Radix Isatidis: bitter, cold, nontoxic.Return liver, stomach warp; Effect heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving, cure mainly maculae caused by violent heat pathogen, high hot headache, major part pestilence, crimson tongue be purple secretly, scarlet fever, erysipelas, mumps, sore throat, skin ulcer are swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.Modern pharmacology proves, Radix Isatidis has obvious inhibitory action to multiple virus and pathogenic bacteria.
Salix babylonica L. branch: bitter in the mouth, cold, nontoxic; Enter bright, the JUE YIN meridian of foot sun; Function is dispeled the wind, diuresis, pain relieving, detumescence; Cure mainly rheumatic arthralgia, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Modern pharmacology proves, Salix babylonica L. branch is used for acute icterohepatitis, and Main Function is jaundice eliminating subcutaneous ulcer, improves poisoning symptom; For acute infectious hepatitis, Main Function falls enzyme, falls wadding; Also preventive effect is had to infectious hepatitis.
Semen Raphani: acrid in the mouth, sweet, property is put down, and returns spleen, stomach, lung meridian.Function helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly food stagnation to stagnate, abdominal distention, belch is had the hiccups, constipation, heavy after dysentery, and expectorant heap soil or fertilizer over and around the roots is breathed with cough.
The Rhizoma Pinelliae: feeble QI, taste is micro-puckery; Function drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.
Herba Pteridis Multifidae: cool in nature, mildly bitter flavor, returns liver, kidney, large intestine channel, has the effects such as clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating, is used for the treatment of dysentery, enteritis, icterohepatitis, spits blood, has blood in stool, the disease such as hematuria.
Radix Cynanchi Paniculati: pungent, temperature; Return liver, stomach warp; Main diseases due to noxious agents produced by various parasites, epidemic, evil gas, pyrexial malaria, main note easily dies, and crys, sad, dimly.Modern pharmacology proves, Radix Cynanchi Paniculati has analgesia, calm and antibacterial action.
Semen Plantaginis: sweet in flavor and cold in property, enters kidney, bladder, liver, lung meridian, function relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm; Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.
Radix Curcumae: acrid in the mouth, hardship, cold in nature.Return liver, the heart, lung meridian, there is the use of regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire.
Poria: sweet in the mouth, light, property is put down, and enters the heart, spleen, lung, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming.Cure mainly lack of appetite gastral cavity painful abdominal mass, vomiting is had loose bowels, palpitation and restlessness, insomnia forgetfulness, edema distension, dysuria, seminal emission turbid urine etc.Modern pharmacological research is reported, Poria has immunostimulant, antitumor, diuresis, calmness, lifting leukocyte, heart tonifying, defying age, protection gastrointestinal, protect the liver and the effect such as resisting pathogenic microbes.
Radix Gentianae: nature and flavor are bitter, puckery, Great Cold, nontoxic.Function heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened; Cure mainly cold and heat between bone, frightened pathogenic factor gas, continue wound absolutely, determines the five internal organs, parasite killing poison; Jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear swells, hypochondriac pain bitter taste, calentura convulsion with spasms.
Herba Hedyotidis Diffusae: bitter in the mouth, light, cold in nature; Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness; Cure mainly dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, be good at the multiple cancerous protuberance for the treatment of.Modern pharmacology proves, Herba Hedyotidis Diffusae treatment acute icterohepatitis is evident in efficacy.
Rhizoma Polygoni Cuspidati: micro-hardship, is slightly cold; Return liver, gallbladder, lung meridian; Function is dispeled the wind, dampness removing, and removing blood stasis with potent drugs stimulates the menstrual flow; Cure mainly rheumatism bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia; Injury from falling down, scalds, malignant boil tinea disease.Arrhythmia and anti-cardiac muscle are lost blood; Blood circulation promoting and blood stasis dispelling.
Radix Paeoniae Rubra: bitter, is slightly cold; Return Liver Channel; Function clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Cure mainly maculae caused by violent heat pathogen, hematemesis and epistaxis, discharging fresh blood stool, conjunctival congestion and swelling pain, carbuncle skin infection, amenorrhea, dysmenorrhea, metrorrhagia and leukorrhagia stranguria with turbid discharge, the stagnant hypochondriac pain of the stasis of blood, hernia abdominal mass is gathered, injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Modern pharmacology research proves, Radix Paeoniae Rubra has antipyretic, antibacterial, spasmolytic, analgesic activity, and humoral and cellular immune response can be suppressed to react, clinical verification shows, radix paeoniae rubrathe for treating acute cholestasis type hepatitis, slow type Serious cholestatic hepatitis of living have obvious pause and transition in rhythm or melody jaundice and choleretic effect.
Rhizoma Cimicifugae: enter lung, spleen, stomach, large intestine channel.Yang invigorating, delivers, rash, removing toxic substances.Control seasonal epidemic pathogens epidemic disease, headache cold and heat, miliaria pruritus due to heat, laryngalgia, burst toxic swelling, gastric heat is had a toothache, dispute skin ulcer, and macule is not saturating; Sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women is collapsed, band, and uterus drops; Carbuncle sore tumefacting virus.
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc.Pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.
CUIYUNCAO: sweet, light, cool.Function clearing away heat-damp and promoting diuresis, hemostasis, cough-relieving.For acute icteric infectious hepatitis, cholecystitis, enteritis, dysentery, oedema due to nephritis, urinary system infection, rheumatic arthritis, hemoptysis of pulmonary tuberculosis; Furuncle and phyma is controlled in external, burn and scald, traumatic hemorrhage, traumatic injury.
Radix Glycyrrhizae Preparata: the Radix Glycyrrhizae of smoking with honey, have antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, primary efficacy is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.
The present invention, by the conditioning of Chinese medicine, heat-clearing and toxic substances removing, promoting QI circulation for relieving depression, loses pestilence jaundice eliminating, the quick control hepatitis A state of an illness, anti-virus sterilizing antiinflammatory, simultaneously sharp liver and gall, and have certain preventive effect, to vaccine, inapplicable patient can take this side, prevents extensive infection.
Outcome measure:
Effective: the basic or major part of clinical symptoms (heating, inappetence, feel sick, frequent vomiting, extremely weak etc.) disappears.
Effective: clinical symptoms is clearly better.
Invalid: all diseases are without improvement.
Therapeutic outcome: 168 use chemoprophylaxis hepatitis A person of the present invention, none example infects; Treating 268 hepatitis A patients, 10 days is a course for the treatment of, and after edible 2 course for the treatment of Chinese medicines of the present invention, effective 255 examples, account for 95.1%, and effective 9 examples, account for 3.4%, and invalid 4 examples, account for 1.5%.
Attached several routine case is described further:
Case 1: Jiang so-and-so, man, 27 years old, because of tired, loss of appetite, low grade fever's admission examination, display hepatomegaly, abnormal liver function etc., are diagnosed as hepatitis A, and separately its family members take medicine of the present invention prevention 1 course for the treatment of, without infecting; Clothes for patients medicine of the present invention took a turn for the better after 2 courses for the treatment of, fully recovered after 3 courses for the treatment of.
Case 2: week so-and-so, female, 10 years old, without inducement occur generate heat, in 37.5 ~ 38.5 DEG C, there is malaise in body temperature fluctuation, Sleep hyperhidrosis is obvious simultaneously.Nausea and vomiting (gastric content) is there is, abdominal discomfort, full abdomen dull pain, yellowish urine before before Yu Yizhou, in Umber, with skin pruritus, without potter's clay sample just, be diagnosed as acute hepatitis A on inspection, take a turn for the better after taking 2 courses for the treatment of of medicine of the present invention, fully recover after 3 courses for the treatment of.
Detailed description of the invention
Embodiment 1:
The invention provides a kind of Chinese medicine formula preventing and treating hepatitis A, formed by the preparation of raw material of following parts by weight: Radix Isatidis 15 parts, 6 parts, Salix babylonica L. branch, Semen Raphani 4 parts, the Rhizoma Pinelliae 3 parts, Herba Pteridis Multifidae 5 parts, Radix Cynanchi Paniculati 4 parts, Semen Plantaginis 3 parts, Radix Curcumae 4 parts, 5 parts, Poria, Radix Gentianae 6 parts, Herba Hedyotidis Diffusae 6 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Cimicifugae 5 parts, Herba Artemisiae Scopariae 8 parts, CUIYUNCAO 7 parts, Radix Glycyrrhizae Preparata 4 parts.
Preparation method takes raw material of Chinese medicine by above-mentioned weight portion, adds cold water, do not have medical material 3cm, soaks 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 30min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Embodiment 2:
The invention provides a kind of Chinese medicine formula preventing and treating hepatitis A, formed by the preparation of raw material of following parts by weight: Radix Isatidis 10 parts, 10 parts, Salix babylonica L. branch, Semen Raphani 3 parts, the Rhizoma Pinelliae 5 parts, Herba Pteridis Multifidae 3 parts, Radix Cynanchi Paniculati 5 parts, Semen Plantaginis 3 parts, Radix Curcumae 5 parts, 3 parts, Poria, Radix Gentianae 8 parts, Herba Hedyotidis Diffusae 3 parts, Rhizoma Polygoni Cuspidati 10 parts, Radix Paeoniae Rubra 3 parts, Rhizoma Cimicifugae 8 parts, Herba Artemisiae Scopariae 5 parts, CUIYUNCAO 10 parts, Radix Glycyrrhizae Preparata 3 parts.
Preparation method takes raw material of Chinese medicine by above-mentioned weight portion, adds cold water, do not have medical material 5cm, soaks 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Embodiment 3:
The invention provides a kind of Chinese medicine formula preventing and treating hepatitis A, formed by the preparation of raw material of following parts by weight: Radix Isatidis 20 parts, 5 parts, Salix babylonica L. branch, Semen Raphani 5 parts, the Rhizoma Pinelliae 3 parts, Herba Pteridis Multifidae 8 parts, Radix Cynanchi Paniculati 3 parts, Semen Plantaginis 5 parts, Radix Curcumae 3 parts, 8 parts, Poria, Radix Gentianae 3 parts, Herba Hedyotidis Diffusae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Radix Paeoniae Rubra 8 parts, Rhizoma Cimicifugae 3 parts, Herba Artemisiae Scopariae 10 parts, CUIYUNCAO 5 parts, Radix Glycyrrhizae Preparata 5 parts.
Preparation method takes raw material of Chinese medicine by above-mentioned weight portion, adds cold water, do not have medical material 2cm, soaks 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.
Claims (3)
1. prevent and treat a Chinese medicine formula for hepatitis A, it is characterized in that being formed by the preparation of raw material of following parts by weight: Radix Isatidis 10 ~ 20 parts, 5 ~ 10 parts, Salix babylonica L. branch, Semen Raphani 3 ~ 5 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Herba Pteridis Multifidae 3 ~ 8 parts, Radix Cynanchi Paniculati 3 ~ 5 parts, Semen Plantaginis 3 ~ 5 parts, Radix Curcumae 3 ~ 5 parts, 3 ~ 8 parts, Poria, Radix Gentianae 3 ~ 8 parts, Herba Hedyotidis Diffusae 3 ~ 8 parts, Rhizoma Polygoni Cuspidati 5 ~ 10 parts, Radix Paeoniae Rubra 3 ~ 8 parts, Rhizoma Cimicifugae 3 ~ 8 parts, Herba Artemisiae Scopariae 5 ~ 10 parts, CUIYUNCAO 5 ~ 10 parts, Radix Glycyrrhizae Preparata 3 ~ 5 parts.
2. prevent and treat the Chinese medicine formula of hepatitis A as claimed in claim 1, it is characterized in that being formed by the preparation of raw material of following parts by weight: Radix Isatidis 15 parts, 6 parts, Salix babylonica L. branch, Semen Raphani 4 parts, the Rhizoma Pinelliae 3 parts, Herba Pteridis Multifidae 5 parts, Radix Cynanchi Paniculati 4 parts, Semen Plantaginis 3 parts, Radix Curcumae 4 parts, 5 parts, Poria, Radix Gentianae 6 parts, Herba Hedyotidis Diffusae 6 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Cimicifugae 5 parts, Herba Artemisiae Scopariae 8 parts, CUIYUNCAO 7 parts, Radix Glycyrrhizae Preparata 4 parts.
3. preparation prevents and treats the method for the Chinese medicine formula of hepatitis A as claimed in claim 1, it is characterized in that being made up of following steps: take raw material of Chinese medicine by above-mentioned weight portion, add cold water, does not have medical material 2 ~ 5cm, soak 1 hour; Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20 ~ 40min to; After cooked, leach medicine juice and decoct as head; Medicinal residues are repeated above-mentioned steps to decoct, after cooked, the medicine juice of twice decoction is merged.
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| 无: "儿童甲型肝病治疗的案例", 《求医网（HTTP://JIBING.QIUYI.CN/XEGB/2013/0305/122001.HTML)》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619730A (en) * | 2016-12-30 | 2017-05-10 | 昆明赛诺制药股份有限公司 | Medicament for treating hepatitis A and preparation method thereof |
| CN106619730B (en) * | 2016-12-30 | 2020-06-16 | 昆明赛诺制药股份有限公司 | Medicine for treating hepatitis A and preparation method thereof |
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