CN105362449A - Traditional Chinese medicine composition for treating gastric-cancer postoperative bleeding and application thereof - Google Patents

Abstract

The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine composition for treating gastric-cancer postoperative bleeding. The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of lentinus lepideus (Fr. : Fr.) Fr., 4-8 parts of henry woodbetony roots, 4-8 parts of aralia dumetorum Hand.-Mazz, 4-8 parts of cluster mallow, 4-8 parts of radix indigoferae stachyoidis, 4-8 parts of melastoma dodecandrum and 4-8 parts of licorice. The medicinal materials are used in a combined, jointly play the effects of 'tonifying qi to control blood, replenishing blood and stopping bleeding, and the traditional Chinese medicine composition focuses on the pathogenesis of qi dysfunction in blood control due to gastric-cancer postoperative bleeding, has a good hemostatic effect and can improve the hemoglobin level and play a blood replenishing role while stopping bleeding.

Description

A kind ofly treat the hemorrhage Chinese medicine composition of postoperative gastric cancer and application thereof

Technical field

The invention belongs to medical art, be specifically related to a kind ofly treat the hemorrhage Chinese medicine composition of postoperative gastric cancer.

Background technology

Gastric cancer is one of most common cancer of China, and its mortality rate is in the first place occupying malignant tumor.It is operation is main Comprehensive Treatment that gastric cancer is the most effectively treated.Due to the lifting of early gastric caacer diagnosis and treatment level thereof, the operation subject range of present gastric cancer also comparatively before corresponding expansion.Although the resection rate of its operative treatment increases, but its post-operative complication is still the frequent problems faced of surgeon, the incidence rate of data display resection of gastric carcinoma infectious-related complication still exists, wherein postoperative gastric cancer is hemorrhage as rare but serious complication, it is still the problem that clinician frequently runs in treatment gastric cancer process, its incidence rate reports about 1%-2% according to domestic literature, but clinician can't lose vigilance because its incidence rate is low.How to reduce hemorrhage incidence rate, reduce postoperative hemorrhage particularly important to the threat of patient vitals.

Hemorrhage for postoperative gastric cancer, doctor trained in Western medicine thinks that it is generally Anastomotic bleeding, relevant with operation technique.Normal employing haemostatic medicament carries out hemostatic treatment, but clinical effectiveness is general, and the patient for haemophilia often needs second operation hemostatic treatment.Second operation patient is painful large, and costly, and danger is higher.Therefore, searching is needed to be used for the treatment of the hemorrhage medicine of postoperative gastric cancer.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of and treat the hemorrhage Chinese medicine composition of postoperative gastric cancer.

The present invention is achieved through the following technical solutions:

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, be made up of the Chinese medicine of following weight portion:

Leopard mushroom 4-8 part, Radix Pedicularis Henryi 4-8 part, white JIUGUNIU 4-8 part, Semen Abutili 4-8 part, Indigofera stachyoides Lindl. 4-8 part, Herba Melastomatis Dodecandri 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition that above-mentioned treatment postoperative gastric cancer is hemorrhage, is made up of the Chinese medicine of following weight portion:

Leopard mushroom 5-7 part, Radix Pedicularis Henryi 5-7 part, white JIUGUNIU 5-7 part, Semen Abutili 5-7 part, Indigofera stachyoides Lindl. 5-7 part, Herba Melastomatis Dodecandri 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine composition that above-mentioned treatment postoperative gastric cancer is hemorrhage, is made up of the Chinese medicine of following weight portion:

6 parts, leopard mushroom, Radix Pedicularis Henryi 6 parts, white JIUGUNIU 6 parts, Semen Abutili 6 parts, Indigofera stachyoides Lindl. 6 parts, Herba Melastomatis Dodecandri 6 parts, 6 parts, Radix Glycyrrhizae.

Or: 5 parts, leopard mushroom, Radix Pedicularis Henryi 7 parts, white JIUGUNIU 5 parts, Semen Abutili 7 parts, Indigofera stachyoides Lindl. 5 parts, Herba Melastomatis Dodecandri 7 parts, 5 parts, Radix Glycyrrhizae.

Or: 7 parts, leopard mushroom, Radix Pedicularis Henryi 5 parts, white JIUGUNIU 7 parts, Semen Abutili 5 parts, Indigofera stachyoides Lindl. 7 parts, Herba Melastomatis Dodecandri 5 parts, 7 parts, Radix Glycyrrhizae.

Or: 4 parts, leopard mushroom, Radix Pedicularis Henryi 8 parts, white JIUGUNIU 4 parts, Semen Abutili 8 parts, Indigofera stachyoides Lindl. 4 parts, Herba Melastomatis Dodecandri 8 parts, 4 parts, Radix Glycyrrhizae.

Or: 8 parts, leopard mushroom, Radix Pedicularis Henryi 4 parts, white JIUGUNIU 8 parts, Semen Abutili 4 parts, Indigofera stachyoides Lindl. 8 parts, Herba Melastomatis Dodecandri 4 parts, 8 parts, Radix Glycyrrhizae.

The application of Chinese medicine composition in the hemorrhage medicine of preparation treatment postoperative gastric cancer that above-mentioned treatment postoperative gastric cancer is hemorrhage.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of postoperative gastric cancer hemorrhage.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Leopard mushroom another name Scaly lentinus, white Lentinus Edodes are the sporophore of Bai Mo section fungus leneinus lepideus Franch LentinuslepideusFr. [AgaricuslepideusFr.].Sweet in the mouth; Property is put down.GUIXIN; Spleen channel.Function fills blood; Benefit conscience.Main insufficiency of vital energy and blood; Deficiency of both the heart and spleen; Fatigue and weak; Insomnia cardiopalmus.

Radix Pedicularis Henryi another name wind catching arrow, cock flower root, mutually leaf Radix Pedicularis Henryi, phoenix tail Radix seu Herba Pedicularis, derive from Scrophulariaceae lousewort plant south of the River Radix seu Herba Pedicularis PedicularishenryiMaxim., be used as medicine with root.Sweet in the mouth, micro-hardship, warm in nature.Function fills blood, the meridian dredging, relieving cough and asthma.For dizziness and tinnitus, palpitation and short breath, bones and muscles pain, bronchitis.

White JIUGUNIU another name JIUGUNIU, Cortex Pini Massonianae JIUGUNIU, Radix Heraclei hemsleyani, honey oil ginseng, NIUJIAOQI.For Araliaceae Cong Zhi Cortex araliae chinensis Araliamelanocarpa (Levl.) Lauener [EleutherococcusmetanocarpaLevl.; A.dumetorumHand.-Mazz.] root.Acrid in the mouth; Micro-sweet; Property is put down.Function invigorating the spleen and replenishing QI; Poison holding is subsided a swelling.The main deficiency of vital energy is dizzy; Tinnitus; Chronic lymphadenitis; Carbuncle sore is not burst for a long time; Chronic suppurative osteomyelisis.

Semen Abutili another name Folium Malvae, sliding dish, Herba Fici Simplicissimae, Herba Capsellae cake leaf, for Malvaceae plant Semen Abutili MalvaverticillataL. is used as medicine with root, stem, Ye Jizi (Fructus Malvae).Stem, leaf: sweet, cold.Root: sweet, temperature.Function stem, leaf: clearing away heat-damp and promoting diuresis; For icterohepatitis.Root: invigorating the spleen and replenishing QI; Weak for the deficiency of vital energy, soreness of the waist and knees, the empty spontaneous perspiration of body, proctoptosis, uterine prolapse, chronic nephritis, diabetes.

Indigofera stachyoides Lindl. another name mountain Flos Carthami, Radix Lespedezae Buergeri, red hardship thorn, derive from pulse family Indigofera stachyoides Lindl. IndigoferastachyoidesLindl., be used as medicine with root.Mildly bitter flavor, puckery, warm in nature.Function promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral, enriching yin and nourishing kidney, hemostasis by invigorating QI.Cure mainly metrorrhagia, traumatic injury and rheumatism, liver cirrhosis, infantile malnutrition, dysentery; Ulcer is QI and blood deficiency with the passing of time.

Herba Melastomatis Dodecandri another name Fructus Pratiae Begonifoliae, blue son, Fructus Fici tikouae, Hydrocotyle sibthorpioides, originate as Genus Melastoma L. of Melastomataceae Herba Melastomatis Dodecandri MelastomadodecandrumLour., be used as medicine with herb or root.Sweet in the mouth, puckery, property is put down.Function heat-clearing and toxic substances removing, expelling wind and removing dampness, tonifying blood and arresting bleeding.For preventing the lonely inflammation of epidemic cerebrospinal, enteritis, dysentery, lung abscess, pelvic inflammatory disease, metrorrhagia, anemia, leucorrhea, lumbago and skelalgia, rheumatic ostalgia, traumatic hemorrhage, venom.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

The traditional Chinese medical science belongs to the sick category such as " gastric abscess ", " stomach painful abdominal mass ", " lump in the abdomen ", " gathering " for gastric cancer, and think that its basic pathogenesis is that deficiency in origin table is real, the deficiency of vital energy is the basis of patients with gastric cancer.The hemorrhage traditional Chinese medical science of postoperative gastric cancer belongs to the category of " blood disorder ", and the present inventor sums up working experience, thinks that postoperative gastric cancer is hemorrhage relevant with QI failing to control blood, qi as the commander of blood, gas can be united blood, blood and gas closely related, therefore " Thorough Knowledge of Medicine Xuezheng Lun, On Blood Syndromes " is said: " with gas, controlling blood must first regulate the flow of vital energy blood." deficiency of vital energy can not take the photograph blood, blood oozing from the body openings or subcuta neous tissue outside arteries and veins, is then hemorrhage, therefore hemorrhage for postoperative gastric cancer, and treatment is upper should give hemostasis by invigorating QI, double with tonifying blood and arresting bleeding.

Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: leopard mushroom, Radix Pedicularis Henryi merit are to fill blood.

Ministerial drug: white JIUGUNIU, Semen Abutili merit are with invigorating the spleen and replenishing QI.

Adjuvant drug: Indigofera stachyoides Lindl. merit is with hemostasis by invigorating QI; Herba Melastomatis Dodecandri merit is with tonifying blood and arresting bleeding.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share the effect of playing " hemostasis by invigorating QI, tonifying blood and arresting bleeding " altogether, the pathogenesis of the hemorrhage QI failing to control blood of the postoperative gastric cancer that links closely, and haemostatic effect is good, and can raise hemoglobin level, while hemostasis, play blood tonification effect.We obviously can improve the TCM syndrome of patient simultaneously, and clinical efficacy is remarkable, is worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, each crude drug weight proportion is as follows:

Leopard mushroom 6g, Radix Pedicularis Henryi 6g, white JIUGUNIU 6g, Semen Abutili 6g, Indigofera stachyoides Lindl. 6g, Herba Melastomatis Dodecandri 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, each crude drug weight proportion is as follows:

5 parts, leopard mushroom, Radix Pedicularis Henryi 7 parts, white JIUGUNIU 5 parts, Semen Abutili 7 parts, Indigofera stachyoides Lindl. 5 parts, Herba Melastomatis Dodecandri 7 parts, 5 parts, Radix Glycyrrhizae.

Embodiment 3

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, each crude drug weight proportion is as follows:

7 parts, leopard mushroom, Radix Pedicularis Henryi 5 parts, white JIUGUNIU 7 parts, Semen Abutili 5 parts, Indigofera stachyoides Lindl. 7 parts, Herba Melastomatis Dodecandri 5 parts, 7 parts, Radix Glycyrrhizae.

Embodiment 4

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, each crude drug weight proportion is as follows:

4 parts, leopard mushroom, Radix Pedicularis Henryi 8 parts, white JIUGUNIU 4 parts, Semen Abutili 8 parts, Indigofera stachyoides Lindl. 4 parts, Herba Melastomatis Dodecandri 8 parts, 4 parts, Radix Glycyrrhizae.

Embodiment 5

Treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, each crude drug weight proportion is as follows:

8 parts, leopard mushroom, Radix Pedicularis Henryi 4 parts, white JIUGUNIU 8 parts, Semen Abutili 4 parts, Indigofera stachyoides Lindl. 8 parts, Herba Melastomatis Dodecandri 4 parts, 8 parts, Radix Glycyrrhizae.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose postoperative gastric cancer hemorrhage (syndrome of qi failing to control blood) patient 150 example, wherein man 92 example, female 58 example, the mean age (67.75 ± 16.34) year.

1.2 differential diagnosis in tcm standards

" syndrome of qi failing to control blood " diagnostic criteria with reference to " haematemesiss " in " new Chinese medicine guideline of clinical investigations ": spitting blood continuously, time light time heavy, color dimness, spiritlessness and weakness, shortness of breath and palpitation, pale complexion, pale tongue, thready and weak pulse.

1.4 Western medicine diagnose standards

The upper gastrointestinal hemorrhage dependent diagnostic standard that the hemorrhage diagnostic criteria of postoperative gastric cancer is formulated with reference to WHO.

1.5 include in and exclusion standard

Inclusive criteria: (1) meets the hemorrhage Western medicine diagnose standard of postoperative gastric cancer; (2) haematemesis syndrome of qi failing to control blood dependent diagnostic standard is met.(3) patient of Western medicine hemostatic treatment is not carried out.Exclusion standard: (1) massive hemorrhage need be transfused blood rescuer; (2) row Western medicine hemostatic treatment person; (3) preoperative coagulation indexes severely subnormal person.(4) to our Chinese medicine allergy sufferers.(5) compliance is poor, can not curer on request.

1.6 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, prescription is as follows: leopard mushroom 6g, Radix Pedicularis Henryi 6g, white JIUGUNIU 6g, Semen Abutili 6g, Indigofera stachyoides Lindl. 6g, Herba Melastomatis Dodecandri 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sub-service is sooner or later a course for the treatment of with 3d.

1.7 observation index

(1) hemostasis is enriched blood effect: 24 hours bleedings before and after treatment; Detect hemoglobin level before and after treatment.

(2) Chinese medicine syndrome integral: with reference to " syndrome of qi failing to control blood " relevant criterion in " new Chinese medicine guideline of clinical investigations ".Extremely weighed by light according to the degree of disease, be respectively 0 point, 2 points, 4 points and 6 points.

1.8 TCM syndrome therapeutic evaluatioies

" new Chinese medicine clinical research medication guide principle " that evaluation criteria was promulgated with reference to 2002.

1. fully recover: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.

Computing formula: nimodipine method: integration x100% before (before treatment the rear integration of integration-treatment)/treatment.

1.9 statistical method

SPSS14.0 version statistical software is adopted to analyze.Measurement data represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 before and after treatment.

2. result

Hemorrhage and situation of enriching blood before and after 2.1 treatments

150 routine bleeding patients, all reach after treatment and stop blooding completely.Average hemoglobin (102.23 ± 13.47) g/L before treatment, rise to (124.37 ± 10.46) g/L after treatment, difference has statistical significance (t=2.875, P<0.05).

TCM syndrome integration and TCM syndrome curative effect before and after 2.2 treatments

Before after treatment, TCM syndrome total mark (6.83 ± 1.62) divides comparatively treatment, (36.41 ± 11.56) point obviously reduce, and difference has statistical significance (t=3.384, P<0.05); 150 routine patients cure 143 examples, effective 6 examples, effective 1 example, invalid 0 example.Curative effect: cure rate 95.3%, total obvious effective rate 99.3%, total effective rate is 100.0%.

2.4 safety analysis

Treatment Patients Before And After Liver and kidney merit and electrocardiogram are without significant change, and drug safety is better.

Claims (8)

1. treat the Chinese medicine composition that postoperative gastric cancer is hemorrhage, be made up of the Chinese medicine of following weight portion:

Leopard mushroom 4-8 part, Radix Pedicularis Henryi 4-8 part, white JIUGUNIU 4-8 part, Semen Abutili 4-8 part, Indigofera stachyoides Lindl. 4-8 part, Herba Melastomatis Dodecandri 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 1 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

Leopard mushroom 5-7 part, Radix Pedicularis Henryi 5-7 part, white JIUGUNIU 5-7 part, Semen Abutili 5-7 part, Indigofera stachyoides Lindl. 5-7 part, Herba Melastomatis Dodecandri 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 2 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

6 parts, leopard mushroom, Radix Pedicularis Henryi 6 parts, white JIUGUNIU 6 parts, Semen Abutili 6 parts, Indigofera stachyoides Lindl. 6 parts, Herba Melastomatis Dodecandri 6 parts, 6 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 2 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

5 parts, leopard mushroom, Radix Pedicularis Henryi 7 parts, white JIUGUNIU 5 parts, Semen Abutili 7 parts, Indigofera stachyoides Lindl. 5 parts, Herba Melastomatis Dodecandri 7 parts, 5 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 2 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

7 parts, leopard mushroom, Radix Pedicularis Henryi 5 parts, white JIUGUNIU 7 parts, Semen Abutili 5 parts, Indigofera stachyoides Lindl. 7 parts, Herba Melastomatis Dodecandri 5 parts, 7 parts, Radix Glycyrrhizae.

6. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 1 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

4 parts, leopard mushroom, Radix Pedicularis Henryi 8 parts, white JIUGUNIU 4 parts, Semen Abutili 8 parts, Indigofera stachyoides Lindl. 4 parts, Herba Melastomatis Dodecandri 8 parts, 4 parts, Radix Glycyrrhizae.

7. the Chinese medicine composition that treatment postoperative gastric cancer according to claim 1 is hemorrhage, is characterized in that, is made up of the Chinese medicine of following weight portion:

8 parts, leopard mushroom, Radix Pedicularis Henryi 4 parts, white JIUGUNIU 8 parts, Semen Abutili 4 parts, Indigofera stachyoides Lindl. 8 parts, Herba Melastomatis Dodecandri 4 parts, 8 parts, Radix Glycyrrhizae.

8. the application of Chinese medicine composition in the hemorrhage medicine for the treatment of postoperative gastric cancer that the treatment postoperative gastric cancer described in claim 1-7 is hemorrhage.