CN105147810A - Traditional Chinese medicine composition for treating gynecological postoperative lumbar pain due to qi stagnation and blood stasis - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating gynecological postoperative lumbar pain due to qi stagnation and blood stasis. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 5-13 parts of buddleja asiatica, 5-13 parts of plumbago zeylanica, 4-8 parts of marsdenia longipes, 4-8 parts of radix pterospermi heterophylli, 4-8 parts of sargentgloryvine stem, 4-8 parts of ramulus euonyrni, 4-8 parts of artemisia anomala, 4-8 parts of fortunella cargarita, 4-8 parts of russula virescens and 4-8 parts of licorice root. The medicinal materials are combined to achieve the effects of promoting circulation of qi and blood to remove stasis and relieving pain, and is closely related with the etiology and pathogenesis of gynecological postoperative lumbar pain due to qi stagnation and blood stasis. The traditional Chinese medicine composition can be used for remarkably relieving patient pains and has a remarkable clinical curative effect.

Description

A kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type gynecological Lumbar pain after operation

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type gynecological Lumbar pain after operation.

Background technology

Operation is one of main treatment means of Gynecology, combined spinal-epidural anesthesia, namely subarachnoid space combines retardance with spinal epidural cavity, have rapid-action, definite effect, local anaesthetics consumption are little, the advantage such as controlled of holding time, be with a wide range of applications at Gynecology.Lumbago is the common complication of combined spinal-epidural anesthesia, is singly that the lumbago incidence rate after waist epidural anesthesia just reaches.Postoperative pain all has impact to systems such as breathing, circulation, digestion, urinary system, endocrine, affects the physical and mental health of patient, delays post-operative recovery process.Common antalgica is bad for gynecological's Lumbar pain after operation effect, not yet has the medicine being exclusively used in gynecological's Lumbar pain after operation at present.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type gynecological Lumbar pain after operation.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, be made up of the Chinese medicine of following weight portion:

Buddleja asiatica 5-13 part, Radix Plumbaginis Zeylanicae 5-13 part, Radix Marsdeniae Longipedis 4-8 part, Radix Pterospermi Heterophylli 4-8 part, Caulis Sargentodoxae 4-8 part, Ramulus Euonymi 4-8 part, Herba Artemisiae Anomalae 4-8 part, Fructus Fortunellae Margaritae 4-8 part, Russula vivesscens (Schaeff.) Franch. 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment qi stagnation and blood stasis type gynecological Lumbar pain after operation, is made up of the Chinese medicine of following weight portion:

Buddleja asiatica 7-11 part, Radix Plumbaginis Zeylanicae 7-11 part, Radix Marsdeniae Longipedis 5-7 part, Radix Pterospermi Heterophylli 5-7 part, Caulis Sargentodoxae 5-7 part, Ramulus Euonymi 5-7 part, Herba Artemisiae Anomalae 5-7 part, Fructus Fortunellae Margaritae 5-7 part, Russula vivesscens (Schaeff.) Franch. 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine composition of above-mentioned treatment qi stagnation and blood stasis type gynecological Lumbar pain after operation, is made up of the Chinese medicine of following weight portion:

Buddleja asiatica 9 parts, Radix Plumbaginis Zeylanicae 9 parts, Radix Marsdeniae Longipedis 6 parts, Radix Pterospermi Heterophylli 6 parts, Caulis Sargentodoxae 6 parts, Ramulus Euonymi 6 parts, Herba Artemisiae Anomalae 6 parts, Fructus Fortunellae Margaritae 6 parts, Russula vivesscens (Schaeff.) Franch. 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of qi stagnation and blood stasis type gynecological Lumbar pain after operation.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Buddleja asiatica another name Herba Gendarussae (Caulis et Folium Gendarussae vulgaris), solely leaf Pu Rhizoma Zingiberis Recens, Erythroculter ilishaeformis number, spend ocean bubble in vain, derive from the Herb of Loganiaceae Genus Buddleja L narrow leaf Herba Buddlejae Lindleyanae BuddlejaasiaticaLour..Acrid in the mouth, hardship, warm in nature.Function expelling wind and removing dampness, promoting flow of QI and blood.Have a pain for women's wind syndrome of head in puerperal pain, cold syndrome of the stomach, rheumatic arthritis, traumatic injury, fracture; Skin pruritus, eczema scrotum, innominate toxic swelling are controlled in external.

Radix Plumbaginis Zeylanicae another name hillside Siberian cocklebur, false jasmine, house steward, dry in and, bird face horse, white snowflake, wild lucerne jasmine, every cloth grass, thousand Semen Arecaes, according to medicine, sky Semen Arecae, white soap medicine, spend soap medicine in vain, see and disappear, spend Rhizoma Rodgersiae in vain, spend JIUGUNIU in vain, Yu Xiaohua, spend The Iron Buddha, fiery miracle, suddenly tiger in vain, be herb or the root of Plumbaginaceae plant Radix Plumbaginis Zeylanicae PlumbagozeylanicaL..Acrid in the mouth; Bitter; Puckery; Warm in nature.Function expelling wind and removing dampness; Promoting flow of QI and blood; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Heart peratodynia; Hepatosplenomegaly; Blood stasis amenorrhea; Osteopatia sprain; Carbuncle scrofula; Scabies pruritus; Venom.

Radix Marsdeniae Longipedis is called little DUIJIESHENG, pulp rattan, the cloud Radix Stemonae, littlely climbs angle, little BAIYAO, is littlely broken angle, is the Herb of dicotyledon medicine asclepiadaceae plant Radix Marsdeniae Longipedis MarsdenialongipesW.T.WangexTsinagetP.T.Li.Sweet in the mouth, micro-hardship, warm in nature.Return liver; Kidney channel.Function expelling wind and removing dampness; Relieving asthma; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Rheumatic heart disease; Bronchial asthma; Traumatic injury damages appoints; Fracture.

Radix Pterospermi Heterophylli another name Sassafras tsumu Hemsl., half of FENGHE, negative and positive leaf, three are not afraid of, ferrum palm, Buddleja asiatica, half Firmiana platanifolia (Linn. f.) Marsili, a kind fiber crops, great Ye Pterospermi Heterophylli.For the root of Sterculiaceae plant Folium potentillae velutinae (Radix Potentillae Fulgentis) tree PterospermumheterophyllumHance or Radix Pterospermi lanceaefolii PterospermumlanceaefoliumRoxb..Acrid in the mouth; Sweet; Slightly warm in nature.Return liver; Spleen channel.Function expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Numb hand and foot; Lumbar muscle strain; Foot gas; Traumatic injury.

Caulis Sargentodoxae another name Caulis seu Radix Schisandrae Henryi, Cortex Ampelopsis Aconitifoliae Radicis, Caulis Sargentodoxae, Rhizoma Homalomenae, Sanguis Draxonis, Radix Zanthoxyli Spinifolii, blood are logical, DAHUOXUE, Huang Shengteng, Spatholobus sinensis chum et T. Chen., blood Caulis Akebiae, Caulis Sargentodoxae, blood sausage, Schisandra glaucescens Diels., red Radix Stauntoniae chinensis, mountain Caulis Sargentodoxae, HUOXUETENG.For the stem of plants of Lardizabalaceae Caulis Sargentodoxae Sargentodoxacuneata (Oliv.) Rehd.etWils..Bitter in the mouth; Property is put down; Nontoxic.Return liver; Large intestine channel.

Function removing toxicity for eliminating carbuncles; Promoting blood circulation and stopping pain; Expelling wind and removing dampness; Parasite killing.Main intestinal carbuncle; Dysentery; Mastalgia; Dysmenorrhea; Amenorrhea; Traumatic injury; Rheumatic arthralgia; Abdominal pain due to worm stagnation.

Insult in Ramulus Euonymi another name winged euonymus, terrible arrow, June, four sides cutting edge of a knife or a sword, castor dustpan bavin, four rib trees, Gallus jabouillei strip, on four sides halberd, JIANZHONGXIAO, anaesthetic.For branch or the aliform appurtenance of the tool fin of Celastraceae plant winged euonymus Euonymusalatus (Thunb.) Sieb..Bitter in the mouth; Pungent; Cold in nature.Return Liver Channel.Function removing blood stasis stimulates the menstrual flow; Removing toxic substances and promoting subsidence of swelling; Parasite killing.Primary symptom abdominal mass is lumpd; Trusted subordinate's pain; Amenorrhea; Dysmenorrhea; Metrorrhagia and metrostaxis; The stagnant stomachache of the stasis of blood in puerperal; Retention of lochia; Hernia; Severe and migratory arthralgia arthralgia pain; Skin ulcer swells; Traumatic pain; Abdominal pain due to worm stagnation; Burn and scald; Venom.

Herba Artemisiae Anomalae calls golden JINU, black rattan dish, Serissa foetida, Herba Senecionis Scandentis, spends tail, charcoal handbag, thousand rice, speckle Chinese date, tenderly white flowers and plants, nine timothys in vain, bitterly connects mother-in-law.For the wounded in the battle herb of feverfew artemisia anomalas ArtemisiaanomalaS.Moore.Bitter in the mouth, warm in nature.Enter the heart, spleen, urinary bladder channel.Function removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.

Fructus Fortunellae Margaritae another name Lu Fructus Citri tangerinae, mountain Fructus Citri tangerinae., be rutaceae Fructus Fortunellae Margaritae Fortunellamargarita(Lour.) and Swingle [CitrusmargaritaLour.], gold play FortunellacrassifoliaSwingle, Fortunella crassifolia Swingle Fortunellajaponica(Thunb.) fruit of Swingle [CitrusjaponicaThunb.].Acrid in the mouth; Sweet; Warm in nature.Return lung meridian.Function is regulated the flow of vital energy resolving depression; Eliminate indigestion and phlegm; Relieving alcoholic intoxication.Main pent-up uncomfortable in chest; Gastral cavity abdomen painful abdominal mass is swollen; Dyspepsia is indigestion and loss of appetite; Cough with copious phlegm; Get sick from drinking too much wine thirsty.

Russula vivesscens (Schaeff.) Franch. calls blue or green face bacterium, blue or green face, Yan face, is the sporophore of Russulaceae fungus green Russula RussulaVirescens (Schaeff.) Fr. [Agari-cusvirescensSchaeff.].Sweet in the mouth; Micro-acid; Cold in nature.Function liver heat removing and eyesight improving; To regulate the flow of vital energy resolving depression.Main liver-heat conjunctival congestion; Poor vision; Women's depressing internal heat in liver; Uncomfortable in chestly not relax.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Doctor trained in Western medicine is thought, under combined spinal-epidural anesthesia, gynecological's Lumbar pain after operation is main relevant with anesthesia procedure.Implement anesthesia time, puncture needle through skin, subcutaneous tissue, muscle and ligament, cause local aseptic inflammation, reflexive muscle spasm and cause effector ceptor sensitivity increase relevant.The traditional Chinese medical science is thought, gynecological's Lumbar pain after operation is not from the stasis of blood, void, stagnant, cold-damp.In art, golden sword coup injury blood network, outside blood oozing from the body openings or subcuta neous tissue arteries and veins, causes obstruction of collaterals by blood stasis; In addition, fear before operation in patients to operation, postoperatively to torment by pain, how depressed feelings will is, and the stagnation of QI is obvious.Therefore, the present inventor thinks, qi depression to blood stasis is the main pathogenesis of gynecological's Lumbar pain after operation, qi depression to blood stasis, stagnation of QI and blood may bring about pain, and treatment is worked as with promoting flow of QI and blood blood stasis dispelling.

Chinese medicine composition of the present invention, its prescription mechanism is as follows:

Monarch drug: Buddleja asiatica, Radix Plumbaginis Zeylanicae merit are with promoting flow of QI and blood.

Ministerial drug: Radix Marsdeniae Longipedis, Radix Pterospermi Heterophylli, Caulis Sargentodoxae merit are with promoting blood circulation, dredging meridian and relieving pain.

Adjuvant drug: Ramulus Euonymi, Herba Artemisiae Anomalae merit are stimulated the menstrual flow with removing blood stasis; Fructus Fortunellae Margaritae, Russula vivesscens (Schaeff.) Franch. merit are with resolving depression of regulating the flow of vital energy.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share, and play the effect of promoting flow of QI and blood blood-activating analgetic altogether, the etiology and pathogenesis of gynecological's Lumbar pain after operation (qi stagnation and blood stasis type) that link closely, can obvious reduction of patient pain, and clinical efficacy significantly, is worthy of popularization.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, each crude drug weight proportion is as follows:

Buddleja asiatica 9g, Radix Plumbaginis Zeylanicae 9g, Radix Marsdeniae Longipedis 6g, Radix Pterospermi Heterophylli 6g, Caulis Sargentodoxae 6g, Ramulus Euonymi 6g, Herba Artemisiae Anomalae 6g, Fructus Fortunellae Margaritae 6g, Russula vivesscens (Schaeff.) Franch. 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, each crude drug weight proportion is as follows:

Buddleja asiatica 7g, Radix Plumbaginis Zeylanicae 7g, Radix Marsdeniae Longipedis 5g, Radix Pterospermi Heterophylli 5g, Caulis Sargentodoxae 5g, Ramulus Euonymi 5g, Herba Artemisiae Anomalae 5g, Fructus Fortunellae Margaritae 5g, Russula vivesscens (Schaeff.) Franch. 5g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, each crude drug weight proportion is as follows:

Buddleja asiatica 11g, Radix Plumbaginis Zeylanicae 11g, Radix Marsdeniae Longipedis 7g, Radix Pterospermi Heterophylli 7g, Caulis Sargentodoxae 7g, Ramulus Euonymi 7g, Herba Artemisiae Anomalae 7g, Fructus Fortunellae Margaritae 7g, Russula vivesscens (Schaeff.) Franch. 7g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, each crude drug weight proportion is as follows:

Buddleja asiatica 13g, Radix Plumbaginis Zeylanicae 13g, Radix Marsdeniae Longipedis 8g, Radix Pterospermi Heterophylli 8g, Caulis Sargentodoxae 8g, Ramulus Euonymi 8g, Herba Artemisiae Anomalae 8g, Fructus Fortunellae Margaritae 8g, Russula vivesscens (Schaeff.) Franch. 8g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, each crude drug weight proportion is as follows:

Buddleja asiatica 5g, Radix Plumbaginis Zeylanicae 5g, Radix Marsdeniae Longipedis 4g, Radix Pterospermi Heterophylli 4g, Caulis Sargentodoxae 4g, Ramulus Euonymi 4g, Herba Artemisiae Anomalae 4g, Fructus Fortunellae Margaritae 4g, Russula vivesscens (Schaeff.) Franch. 4g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose gynecologic surgery lumbago patient (qi stagnation and blood stasis type) 140 example.

1.2 inclusive criteria

(1) women, the age is between 18-65 year;

(2) the lower Gynecological acute abdomwn of row stiffness of the waist connection fiber crops comprises out abdomen hysterectomy, opens abdomen adnexectomy operation etc.; Operating time is at 1.5-3.5 hour;

(3) surgery anesthesia medicine adopts conventional kind, and anesthetic puncture all uses vertical method of needle insertion, equal one-time puncture success.

(4) postoperative without indwelling controlled analgesia pump, there is lumbago patient or postoperative indwelling controlled analgesia pump in postoperative 24 to 48 hours, after pulling out pump, in 24 to 72 hours, occur lumbago patient;

(5) Chinese medical discrimination meets syndrome of qi stagnation and blood stasis patient

1.3 exclusion standard

(1) previously the waist disease such as prolapse of lumbar intervertebral disc, chronic back pain or merging is had to cause the internal disease patient of lumbago;

(2) skin of lumbar region breakage person;

(3) the postoperative person that gets compulsive position

(4) spiritedness Disease.

1.4 differential diagnosis in tcm diagnostic criterias

With reference to " new Chinese medicine guideline of clinical investigations ": qi stagnation and blood stasis type lumbago: sore spot is fixed, or distending pain is uncomfortable, or pain as being stabbed, day at light night is heavy, or continue not understand, movable unfavorable, very then can not change one's position, sore spot tenderness, distending pain in the chest and hypochondrium, the dark lip in face is dark, the hidden green grass or young crops of body of the tongue or have ecchymosis, and the many strings of arteries and veins are puckery or count accurately.

1.5 Therapeutic Method

Give the Chinese medicine of the embodiment of the present invention 1, prescription is as follows: Buddleja asiatica 9g, Radix Plumbaginis Zeylanicae 9g, Radix Marsdeniae Longipedis 6g, Radix Pterospermi Heterophylli 6g, Caulis Sargentodoxae 6g, Ramulus Euonymi 6g, Herba Artemisiae Anomalae 6g, Fructus Fortunellae Margaritae 6g, Russula vivesscens (Schaeff.) Franch. 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, every day potion, sooner or later sub-service is a course for the treatment of with 7d.

1.6 observation index

Pain degree evaluation adopts visual simulation assessment method (VAS scoring): pain degree is from 0 ~ 10 point, and 0 point of expression is painless, and 10 points represent the most bitterly.

1.7 therapeutic evaluation

Curative effect is judged: the calculating of integrated value change is according to formula below: integration x100% before lumbago symptom therapeutic index (n)=(before treatment the rear integration of integration-treatment)/treatment according to integration method.

Clinical recovery: lumbago disappears or the recovery from illness that substantially disappears, n >=90%

Effective: lumbago is obviously improved, 66.7%≤n<90%

Effective: lumbago take a favorable turn, 33.3%≤n<66.7%

Invalid: lumbago is not improved, even increase the weight of, n<33.3%.

1.8 statistical method

Adopt SPSS15.0 version statistics software to process, measurement data represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 between group.

2. result

Before and after 2.1 treatments, VAS scoring is compared

Treating the average VAS scoring of front 140 routine patient is (7.78 ± 2.12) point, and drop to after treatment (0.92 ± 0.13) point, difference has statistical significance (t=2.103, P<0.05).

2.2 clinical efficacy

140 routine patients cure 124 examples, effective 12 examples, effective 4 examples, invalid 0, cure rate 88.6%, total obvious effective rate 97.1%, total effective rate 100.0%.

Claims (3)

1. treat a Chinese medicine composition for qi stagnation and blood stasis type gynecological Lumbar pain after operation, be made up of the Chinese medicine of following weight portion:

Buddleja asiatica 5-13 part, Radix Plumbaginis Zeylanicae 5-13 part, Radix Marsdeniae Longipedis 4-8 part, Radix Pterospermi Heterophylli 4-8 part, Caulis Sargentodoxae 4-8 part, Ramulus Euonymi 4-8 part, Herba Artemisiae Anomalae 4-8 part, Fructus Fortunellae Margaritae 4-8 part, Russula vivesscens (Schaeff.) Franch. 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition for the treatment of qi stagnation and blood stasis type gynecological according to claim 1 Lumbar pain after operation, is characterized in that, be made up of the Chinese medicine of following weight portion:

Buddleja asiatica 7-11 part, Radix Plumbaginis Zeylanicae 7-11 part, Radix Marsdeniae Longipedis 5-7 part, Radix Pterospermi Heterophylli 5-7 part, Caulis Sargentodoxae 5-7 part, Ramulus Euonymi 5-7 part, Herba Artemisiae Anomalae 5-7 part, Fructus Fortunellae Margaritae 5-7 part, Russula vivesscens (Schaeff.) Franch. 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition for the treatment of qi stagnation and blood stasis type gynecological according to claim 3 Lumbar pain after operation, is characterized in that, be made up of the Chinese medicine of following weight portion:

Buddleja asiatica 9 parts, Radix Plumbaginis Zeylanicae 9 parts, Radix Marsdeniae Longipedis 6 parts, Radix Pterospermi Heterophylli 6 parts, Caulis Sargentodoxae 6 parts, Ramulus Euonymi 6 parts, Herba Artemisiae Anomalae 6 parts, Fructus Fortunellae Margaritae 6 parts, Russula vivesscens (Schaeff.) Franch. 6 parts, 6 parts, Radix Glycyrrhizae.