CN105037490A - 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 - Google Patents
一类乙二醛酶i不可逆抑制剂及其制备方法和用途 Download PDFInfo
- Publication number
- CN105037490A CN105037490A CN201510184226.6A CN201510184226A CN105037490A CN 105037490 A CN105037490 A CN 105037490A CN 201510184226 A CN201510184226 A CN 201510184226A CN 105037490 A CN105037490 A CN 105037490A
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- 0 CNC(*CC(N[C@@](CCC(N(C1CCC1)c1ccc2nc[s]c2c1)=O)C(C(CC(O)=O)=C)=O)=*)*C=C Chemical compound CNC(*CC(N[C@@](CCC(N(C1CCC1)c1ccc2nc[s]c2c1)=O)C(C(CC(O)=O)=C)=O)=*)*C=C 0.000 description 3
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物编号 | 乙二醛酶I抑制活性Kd a(nM) |
11 | 20±2 |
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510184226.6A CN105037490B (zh) | 2014-04-17 | 2015-04-17 | 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410154851 | 2014-04-17 | ||
CN2014101548511 | 2014-04-17 | ||
CN201510184226.6A CN105037490B (zh) | 2014-04-17 | 2015-04-17 | 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105037490A true CN105037490A (zh) | 2015-11-11 |
CN105037490B CN105037490B (zh) | 2018-05-29 |
Family
ID=54323509
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN201510185531.7A Active CN105037489B (zh) | 2014-04-17 | 2015-04-17 | 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 |
CN201510184226.6A Active CN105037490B (zh) | 2014-04-17 | 2015-04-17 | 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510185531.7A Active CN105037489B (zh) | 2014-04-17 | 2015-04-17 | 一类乙二醛酶i不可逆抑制剂及其制备方法和用途 |
Country Status (2)
Country | Link |
---|---|
CN (2) | CN105037489B (zh) |
WO (1) | WO2015158306A1 (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101658666A (zh) * | 2008-08-28 | 2010-03-03 | 上海远农医药科技发展有限公司 | 一类谷胱甘肽衍生物及其抗肿瘤医药用途 |
CN103183722A (zh) * | 2011-12-29 | 2013-07-03 | 中国医药集团总公司四川抗菌素工业研究所 | 一种乙二醛酶ⅰ抑制剂及其制备方法和医药用途 |
-
2015
- 2015-04-17 CN CN201510185531.7A patent/CN105037489B/zh active Active
- 2015-04-17 CN CN201510184226.6A patent/CN105037490B/zh active Active
- 2015-04-17 WO PCT/CN2015/076899 patent/WO2015158306A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101658666A (zh) * | 2008-08-28 | 2010-03-03 | 上海远农医药科技发展有限公司 | 一类谷胱甘肽衍生物及其抗肿瘤医药用途 |
CN103183722A (zh) * | 2011-12-29 | 2013-07-03 | 中国医药集团总公司四川抗菌素工业研究所 | 一种乙二醛酶ⅰ抑制剂及其制备方法和医药用途 |
Non-Patent Citations (2)
Title |
---|
ELLYN M. SHARKEY等: "Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I", 《CANCER CHEMOTHER PHARMACOL》 * |
SWATI S. MORE等: "Inhibition of Glyoxalase I: The First Low-Nanomolar Tight-Binding Inhibitors", 《J. MED. CHEM.》 * |
Also Published As
Publication number | Publication date |
---|---|
CN105037489A (zh) | 2015-11-11 |
WO2015158306A1 (zh) | 2015-10-22 |
CN105037490B (zh) | 2018-05-29 |
CN105037489B (zh) | 2019-01-15 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20170406 Address after: 518000 Jiangsu building, Yitian Road, Guangdong, Shenzhen, A3504, Applicant after: Shenzhen pharmaceutical Limited by Share Ltd Address before: Outside the East Shiling Town of Longquanyi District of Chengdu city of Sichuan Province in 610106 Applicant before: Chengdu University |
|
TA01 | Transfer of patent application right | ||
CB03 | Change of inventor or designer information |
Inventor after: Zheng Zhebin Inventor after: Liu Bichong Inventor after: Le Yan Inventor after: Liu Xiao Inventor after: Deng Qishan Inventor after: Shi Qing Inventor after: Huang Xiuhua Inventor before: Zheng Zhebin Inventor before: Liu Bichong Inventor before: Le Yan Inventor before: Liu Xiao Inventor before: Deng Qishan Inventor before: Shi Qing Inventor before: Huang Xiuhua |
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