CN105031494B - It is a kind of to prevent or treat first stream and the drug of hand-foot-and-mouth disease - Google Patents
It is a kind of to prevent or treat first stream and the drug of hand-foot-and-mouth disease Download PDFInfo
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Abstract
The invention discloses a kind of prevention or the drugs for the treatment of first stream and hand-foot-and-mouth disease, the main cloves of the drug, wrinkled giant hyssop, Lemonfragrant Angelica Root, perilla leaf, rhizoma atractylodis, the flower bud of lily magnolia, roud cardamon seed, Chinese cassia tree, folium artemisiae argyi and ching-chieh and auxiliary material are prepared, and the drug can effectively prevent or treat first stream and hand-foot-and-mouth disease.The sachet can pre- child-resistant first stream and hand-foot-and-mouth disease, it is easy to use, children's torso health will not be damaged.
Description
Invention field：
The present invention relates to a kind of prevention or the drugs for the treatment of first stream and hand-foot-and-mouth disease, belong to the technical field of Chinese medicine.
Technical background：
First stream and hand-foot-and-mouth disease are all the diseases for seriously endangering human health.First stream is also known as Influenza A H1N1, is by first
Acute respiration road transmission disease caused by type H1N1 influenza viruses, the virus stain include swine flu, bird flu and human influenza
Three kinds of influenza virus gene segments, early symptom is similar to common cold after people infects first stream, there is fever, cough, laryngalgia, body
Pain has a headache, feels cold and fatigue etc., some there is also diarrhea or vomiting, courbature or it is tired, eyes are rubescent etc..Suffer from part
Person's state of an illness can rapidly develop, and break with tremendous force, and unexpected high fever, body temperature are more than 38 DEG C or even secondary serious pneumonia, acute respiratory distress
Syndrome, empsyxis, pleural effusion, the reduction of whole body haemocyte, renal failure, septicemia, shock and Reye syndromes, breathing
Failure and multiple organ injury, lead to death.Hand-foot-and-mouth disease is occurred frequently in children, therefore has the title of Hand-Food-Mouth Disease, is by a variety of intestines
Common transmittable disease caused by road virus, fallen ill with infant based on.Some cases are showed only as fash or herpangina.Entirely
The course of disease about 5-10 days, majority can self-healing, favourable prognosis, no sequel, a small number of severe cases (especially less than 3 years old person) may occur in which
Encephalitis, encephalomyelitis, meningitis, pulmonary edema etc..Treatment first stream and hand-foot-and-mouth disease common method have general treatment method, disease-resistant at present
Poison treatment and symptomatic treatment, general treatment method use primarily directed to the slight patient of the state of an illness, that is, rest, drink more water, close observation
Change of illness state；Bring down a fever Deng symptomatic treatments can be given to high fever case.Due to there is no specificity antivirus drug, antiviral therapy method
Common neuraminidase inhibitor has Oseltamivir, zanamivir, amantadine and Rimantadine.First influenza virus is to gold at present
Rigid alkanamine and Rimantadine have drug resistance, sensitive to Oseltamivir, zanamivir.However Oseltamivir side effect is big, especially
For children, side effect is better than therapeutic effect.Although the effect of zanamivir, is notable, Small side effects, its oral bio profit
Expenditure is poor, other administering modes such as intranasal administration, intradermal or intravenous injection, administration trouble, safety is poor.It can be seen that antiviral drugs
Children's first stream and hand-foot-and-mouth disease not only effect unobvious are treated, and side effect is big, safety is poor.For a kind of user of the invention
Just, Small side effects, prevention with obvious effects or treatment first stream and the drug of hand-foot-and-mouth disease are of great importance.
Invention content：
The present invention provide it is a kind of prevention or treatment first stream and hand-foot-and-mouth disease drug, the drug can effectively prevent first stream and
Hand-foot-and-mouth disease, and have certain therapeutic effect to first stream and hand-foot-and-mouth disease, and easy to use, significant effect, it is suitable for all kinds of people
Group, especially children, it is safe, it has no toxic side effect.
In order to solve the above technical problems, the present invention is realized using following technical scheme：
A kind of to prevent or treat first stream and the drug of hand-foot-and-mouth disease, the primary medicinal component of the drug is in parts by weight
Calculate, by 1-20 part of cloves, 1-20 parts of wrinkled giant hyssop, 1-20 parts of Lemonfragrant Angelica Root, 1-20 parts of perilla leaf, 1-20 parts of rhizoma atractylodis, 1-20 parts of the flower bud of lily magnolia, in vain
1-20 parts of cool benevolence 1-20 parts, 1-15 parts of Chinese cassia tree, 5-30 parts of folium artemisiae argyi and ching-chieh are made.
Specifically, the drug of prevention above-mentioned or treatment first stream and hand-foot-and-mouth disease, the primary medicinal component of the drug
Calculate in parts by weight, by 5-15 parts of cloves, 5-15 parts of wrinkled giant hyssop, 5-15 parts of Lemonfragrant Angelica Root, 5-15 parts of perilla leaf, 5-15 parts of rhizoma atractylodis,
5-15 parts of 5-15 parts of the flower bud of lily magnolia, 5-15 parts of roud cardamon seed, 2-10 parts of Chinese cassia tree, 10-20 parts of folium artemisiae argyi and ching-chieh are made.
More specifically, it is above-mentioned prevention or treatment first stream and hand-foot-and-mouth disease drug, the drug it is main it is medicinal at
Point calculate in parts by weight, by 10 parts of cloves, 10 parts of wrinkled giant hyssop, 10 parts of Lemonfragrant Angelica Root, 10 parts of perilla leaf, 10 parts of rhizoma atractylodis, 10 parts of the flower bud of lily magnolia,
10 parts of 10 parts of roud cardamon seed, 5 parts of Chinese cassia tree, 15 parts of folium artemisiae argyi and ching-chieh are made.
Prevention above-mentioned or the preparation method for the treatment of first stream and the drug of hand-foot-and-mouth disease are：Said medicine is taken, can be added often
Pharmaceutic adjuvant is advised, auxiliary material can also be not added with, be processed according to the common process of pharmaceutical field, being prepared into pharmaceutical field can connect
The dosage form received.
Specifically, prevention above-mentioned or the preparation method for the treatment of first stream and the drug of hand-foot-and-mouth disease are：Said medicine is taken,
It crushes, is processed according to the common process of pharmaceutical field respectively, be prepared into acceptable dosage form in field of medicaments.
Specifically, prevention above-mentioned or the preparation method for the treatment of first stream and the drug of hand-foot-and-mouth disease are：Said medicine is taken,
0.5-2h is extracted with steam distillation, collects condensate liquid, stratification isolates volatile oil, spare；After extracting volatile oil
The dregs of a decoction add 8-12 times to measure water, decoct 2-4 times, each 0.5-2.5h, and filtering, merging filtrate is concentrated into medicinal extract, above-mentioned volatilization is added
Oil is combined with acceptable pharmaceutic adjuvant in drug, and is processed according to conventional preparation method, is made corresponding
Pharmaceutical preparation.
Specifically, prevention above-mentioned or the preparation method for the treatment of first stream and the drug of hand-foot-and-mouth disease are：Said medicine is taken,
It is extracted with 6-30 times of ethyl alcohol for measuring 60-90%, extracting solution filtering, filtrate recycling ethanol and be concentrated into medicinal extract, with drug can be with
The pharmaceutic adjuvant of receiving is combined, and is processed according to conventional preparation method, and corresponding pharmaceutical preparation is made.
The method of the ethyl alcohol extraction includes soak extraction and refluxing extraction.
The pharmaceutical preparation is sachet, granule, soft extract, hard capsule, tablet, pill, oral solution, powder, sublimed preparation
Or suspension.
The sachet is prepared：Said medicine is taken, low-temperature grinding is packed into cloth at 60-70 targeted fine powders, mixing respectively
Bag to get.
The soft extract is prepared：Said medicine is taken, 1h is extracted with steam distillation, collects condensate liquid, stand and divide
Layer, isolates volatile oil, spare；The dregs of a decoction after extraction volatile oil add 10 times of amount water, decoct 3 times, 2 hours for the first time, second
1 hour, third time 1 hour, filtering, merging filtrate, the medicinal extract that relative density is 1.15~1.25 when being concentrated into 60 DEG C was and above-mentioned
Volatile oil mixing to get.
The capsule is prepared：Said medicine is taken, the alcohol reflux that 8 times of amounts 70% are added extracts 2 times, first time 2
Hour, second 1 hour, filtration, merging filtrate, filtrate recycling ethanol and relative density is 1.15~1.25 when being concentrated into 60 DEG C
Medicinal extract, it is dry under the conditions of 0.07Mpa~0.08Mpa at 60 DEG C, cross 80 mesh sieve, the mixed accessories that the amount of being made 25% is added are mixed
Even, mixed accessories are by microcrystalline cellulose and cornstarch with 1:1 ratio is mixed, and is wetting agent system with 90% ethyl alcohol
Grain is made after particle in 60 DEG C of dryings, is sieved 1 time after 12 mesh, and 60 mesh be used in combination to screen out fine powder, filling capsule to get.
Drug of the present invention by cloves, wrinkled giant hyssop, Lemonfragrant Angelica Root, perilla leaf, rhizoma atractylodis, the flower bud of lily magnolia, roud cardamon seed, Chinese cassia tree, folium artemisiae argyi and
Ching-chieh and auxiliary material are prepared.Wherein, cloves is also known as lilac, is the leaf of lilac, and hardship trembles with fear, plays the role of heat-clearing and damp-drying drug,
For preventing bacillary dysentery, acute icteric hepatitis.Wrinkled giant hyssop is Labiatae herbaceous plant Pogostemon cablin Pogostemincablin
(Blanco) herb of Benth. or wrinkled giant hyssop Agastacherugosus (Fisch.etMey) O.Ktze., it is acrid in flavour and warm in nature, returns spleen, stomach,
Lung channel, fragrant odour, can dampness elimination be amusing, ward off it is dirty and in, relieving summer-heat is delivered, for diseases caused by external factors summer-heat and damp fever with chilliness, have a headache, vomit
Spit or dampness taste caused by abdominal fullness and distention, it is uncomfortable in chest, vomit and diarrhoea, the body tiredness diseases such as tired.Lemonfragrant Angelica Root is also known as the root of Dahurain angelica, is planted for Umbelliferae
Object Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Bent.h et Hook.f.var.formosana
(Boiss.) root of Sh dryings, temperature is pungent, can deliver cold dispelling, wind-damp dispelling, myogenic pain relieving, for cold headache, fever, toothache, nose
The diseases such as deep pool, ulcer sores, pruitus.Perilla leaf is the leaf of the drying of purple perilla platymiscium purple perilla, pungent, tepor, nontoxic, returns spleen
Passed through through, lung channel two, be dispersed in that table is cold, and qi-regulating and battalion control and catch cold, fever in children aversion to cold, headache nasal obstruction, it is simultaneous see cough or
Person uncomfortable in chest of not relaxing.Rhizoma atractylodis are feverfew Atractylis lancea Atractylodes lancea (Thunb.) DC. or Atractylis chinensis
The dry root of Atractylodes chinensis (DC.) Koidz., smell is arduous, fragrant, and warm-natured, returns spleen, stomach, Liver Channel are dry
Wet invigorating the spleen, expelling wind and clearing away cold are used for damp retention in middle-jiao, and abdominal fullness and distention, diarrhea, oedema, tinea pedis impotence is preesed, arthralgia pain due to rheumatism, anemofrigid cold, night
Blind, eyes dusk is puckery.The flower bud of lily magnolia is the bud of magnolia, and pungent, warm, nontoxic, distributed in lung channel, facilitaing lung cold dispelling is sensible, specially controls nasosinusitis, nasal obstruction.
Roud cardamon seed is the fruit of Zingiber herbaceos perennial Amomum cardamomum, and property and flavor of peppery and warm has regulating the flow of QI to ease the stomach, dry cold-dampness, the work(of relieving alcoholism
Effect, the diseases such as the abdominal distension that can treat for stomachache, gas gastric disorder causing nausea.Chinese cassia tree is the drying of canella Chinese cassia tree Cinnamomum cassia Presl
Bark, pungent, sweet, extremely hot in nature returns kidney, spleen, the heart, Liver Channel, there is mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, the work(of warming meridian
Effect, paediatrics be usually used in insufficiency of both the spleen and the kindey diarrhea, hidrosis, swelling, pale complexion, cough and asthma repeatedly, the diseases such as growth retardation.Folium artemisiae argyi is
The dried leaf of feverfew Chinese mugwort Artemisia argyi Levl.et Vant., pungent, bitter, warm-natured, fragrant odour have Wen Jing
The effect of hemostasis, eliminating cold to stop pain, wet down desinsection, cures mainly irregular menstruation, pain such as dysmenorrhoea, and trusted subordinate's crymodynia is spitted blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood,
It has blood in stool, uterine bleeding, diarrhea protracted dysentery, under, eczema, mange, carbuncle swells, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.Ching-chieh is labiate schizonepeta
The drying flower spike of Schizonepeta tenuisfolia Briq., nature and flavor fragrance, expel pathogenic wind from the body surface, facilitaing lung cold dispelling the effect of,
It is usually used in the diseases such as children's cold, nasal obstruction, fever.
Said medicine is carried out prescription, wherein cloves, wrinkled giant hyssop, Lemonfragrant Angelica Root, perilla leaf, rhizoma atractylodis, the flower bud of lily magnolia, White Chloe by the present invention
Benevolence, Chinese cassia tree, folium artemisiae argyi and ching-chieh have the property of pungent-warm, have the benefits of sensible expelling cold, eliminating, facilitaing lung, relieving QI stagnancy in the stomach, the above medicine phases to match,
Expelling cold, eliminating, sensible power more preferably, in addition, roud cardamon seed, Chinese cassia tree, folium artemisiae argyi, ching-chieh separately have the work(of promoting the circulation of qi warm in pain, more have
The power of rash, therefore the rash that can be disappeared with promoting the circulation of qi, keep away the perverse trend of foul epidemic disease poison.All medicine phases, which are equipped with, reaches prophylactic treatment flu, fever and eruption
Disease.
Pharmaceutical dosage form of the present invention includes sachet, and the sachet can continue medicine perfume (or spice) stimulation human body respiration mucous membrane by it
Generate secreting type immune protein ball A, this antibody on viral and bacterium, which have, stronger kills effect so that these viruses and micro- lifes
Object cannot survive in upper respiratory tract mucous membrane, and play the role of keeping off infection.This administering mode and other administering mode phases
Than there is prodigious advantage, particularly with children.Children are in growth and development process, each organ function, enzyme system, it is immune,
And development of central nervous system is not perfect, the metabolism and drainage rate to drug are differed with adult, are also easy to produce not compared with adult
Good reaction.For oral drugs, newborn, infant's gastric acid secretion are less, can influence the dissolving and dissociation of drug, and children
It is even more fastidious to the mouthfeel of drug.For intramuscular injection drug, newborn, infant's muscle mass are few, and nerve ending is not perfect, flesh
Meat administration absorbs not exclusively, and therapeutic effect is not achieved.For intravenous injection, adult injection is all risky, neonatal blood-
Brain barrier is not perfect, and a variety of drugs can pass through, and is allowed to toxicity and increases；The detoxication of enzyme system and liver kidney is not perfect, so
Drug toxicity can be poisoned in child's cylinder accumulation.Therefore, the sachet of the present invention first stream and brothers common for preventing infant
Stomatosis has prodigious advantage, and also has certain therapeutic effect for first stream and hand-foot-and-mouth disease infant.
All medicinal materials contain volatile oil component in side, therefore using the method for low-temperature grinding when preparing sachet,
Retain the drug effect basic substance of drug.To ensure all medicine mixings when crushing, so just can guarantee that curative effect is unified, crushing cannot be too
Slightly, can not be too thin in order to avoid mixing cannot very uniformly, in case drug effect is scattered and disappeared soon very much and drug appears cloth bag and loses, the present invention
People determines that being ground into 60-70 targeted fine powders not only can guarantee that drug was uniformly mixed but also can guarantee that drug effect is not scattered and disappeared quickly by experiment.
When carrying medicinal material using water decoction, it can be vapored away if directly decocting and extracting active ingredient volatile oil therein, therefore medicinal material is first used
Steam distillation extract volatile oil after, then by extract volatile oil after dregs of a decoction water boiling and extraction.The effect of can ensure that drug.It adopts
When extracting medicinal material with ethyl alcohol, since volatile oil component can be dissolved in ethyl alcohol, is directly impregnated using ethyl alcohol or reflux carries
It takes.
Applicant has carried out a large amount of research to the present invention, as follows：
Experimental example 1, pharmacodynamic study
1 experiment material
1.1 experimental animal：Cleaning grade ICR mouse, half male and half female, quality (20 ± 2g) 114；BALB/c suckling mouses, 3-5 days
Age, per 4, nest.
1.2 experimental drugs and reagent：A type H1N1Flu virus (FM1), the viral (enteron aisle of people's hand-foot-and-mouth disease
Virus) EV71H plants, -80 DEG C of refrigerators preserve, ether；Sachet (being prepared according to the preparation method of embodiment 1) of the present invention,
Sachet empty bag (starch for being packed into same weight), control drug sachet (is prepared) by the following method：
Prescription：Wrinkled giant hyssop 10g, folium artemisiae argyi 10g, climbing groundsel 5g, mountain naphthalene 15g, caulis clematidis armandii 20g, santal 5g, cloves 10g.
Technique：Said medicine is taken, dry, pulverize to 100 mesh or so, is uniformly mixed, is packed into beanbag, 6 grams every bag, i.e.,
?.
1.3 laboratory apparatus：Ultra low temperature freezer, MSC18 type A2 type Biohazard Safety Equipments, inverted phase contrast microscope (Japan
Olympus), CO2 incubators (Japanese Yamato companies).
2 experimental methods and result
2.1 A type H1N1The measurement of influenza virus median lethal dose (LD50)：ICR mouse 54,9 are randomly divided by weight
Group, i.e. Normal group, virus 10-1,10-2,10-3,10-4,10-5,10-6,10-7,10-8 concentration group, it is every group 6, female
Hero divides cage to feed.Influenza virus liquid is diluted to 10-1,10-2,10-3,10-4,10-5,10- with physiological saline in 10 times of ratios
6,10-7,10-8 totally 8 concentration gradients, Mice Body is inoculated into micro tack injector by virus liquid in a manner of collunarium respectively
Interior, every 20 μ L of mouse is daily to observe mouse invasion and death condition, continuous 14 days, records every group of death toll, adopts Reed-
It is 10-4.36/20 μ L to the LD50 of mouse that Muench methods, which calculate the virus,.
The sachet of 2.2 present invention tests death prevention rate：48 mouse are randomly divided into 4 groups, every group 12, are distinguished
For Normal group, model control group, sachet group of the present invention, control drug sachet group.Mouse is placed on identical environment but independence
Space in feed 6 days, Normal group and model control group put 5 sachet empty bags around mouse cage, and sachet group of the present invention exists
5 sachets of the invention are put around mouse cage, control drug sachet group puts 5 control drug sachets around mouse cage, and daily one changes.
After 6 days, after mouse ether light anesthesia, model control group, sachet group of the present invention and control drug sachet group are all with 10LD50
Influenza virus collunarium infection, every 20 μ L, Normal group is then with physiological saline collunarium.Continue to feed 8 days later, and observes
Record.Model control group occurs feed amount of drinking water for the 2-3 days after virus infects and reduces, and be slow in action inability, rolls up poly- heap, hair
Object light pool is sent out, the bodily form is become thin, short of breath, and based on abdominal respiration, lip cyanosis, 4d starts infecting mouse death feelings occur
Condition, 5d rises until 8d or so dead mouse peaks；Dead mouse dissect and finds a leaf or leafy or even complete
Lung is serious congested in kermesinus, lobe of the lung swelling.Sachet group of the present invention has dead mouse from 5d after infection.Control drug sachet
Group has dead mouse, the model control group death rate to be apparently higher than Normal group (P from 4d after infection<0.01).Averagely deposit
Live time model control group is significantly lower than Normal group (P<0.01), sachet group of the present invention is apparently higher than model control group (P<
0.01).The death rate, dead intervention rate and increase in life span are calculated as follows.It the results are shown in Table 1.
Death rate %=each groups death toll/each group sum × 100%.
Dead intervention rate %=(the model control group death rate-medication therapy groups the death rate)/model control group death rate ×
100%.
Increase in life span %=(medication therapy groups average Survival number of days-model control group average Survival number of days)/model pair
According to group average Survival number of days × 100%.
Table 1 is to dead mouse intervention effect (n=12)
Note：Compared with Normal group, * P<0.01；
Compared with model control group, #P<0.05；##P<0.01；
The , &P compared with control drug sachet group<0.05.
2.3 present invention infect hand-foot-and-mouth disease virus the protective effect of BALB/c suckling mouses：BALB/c suckling mouses are divided at random by nest
For Normal group, model control group, sachet group of the present invention, control drug sachet group, every group 4, continuous 3d is in normal control
Sachet empty bag is put in group and model control group mouse cage, sachet group of the present invention puts a sachet sachet of the present invention, comparison medicine
Object sachet group puts a control drug sachet, remaining each group all carries out hand-foot-and-mouth disease virus stock solution used in addition to Normal group within the 4th day
Infected, 0.4mL/ only, every time administration or infection after use 75% ethyl alcohol sprinkling suckling mouse wrap up bedding and padding after, put back in cage with mother
Mouse is raised jointly, observes the survival condition of suckling mouse after infection daily, observes 14d altogether, and according to following scale, calculate infection
Severity, 0 point：Health；1 point：The back of a bow, perpendicular hair (being observed after growing hair), become thin, activity is reduced etc.；2 points：Hind leg strength
Weaken；3 points：Unilateral hindlimb is benumbed or paralysis；4 points：Bilateral hindlimb paralysis or paralysis；5 points：It is dying or dead.As follows
The calculating each group death rate and increase in life span are simultaneously for statistical analysis with SPSS softwares.
The death rate=death toll/animal number × 100%
Increase in life span=(test group survival number of days-model control group survival number of days)/model control group survival number of days ×
For 100% model control group in 14 days of observation, animal is dead or in the state of being at death's door, the death rate 100%, infection
Degree integral, the death rate and Normal group relatively all have significant difference；The death rate of sachet group of the present invention is respectively 0,
Significant difference is relatively all had with model group；Increase in life span is 60%, and sachet group gradient of infection of the present invention is substantially reduced, with
Model group relatively all has significant difference.
2 are shown in Table, table 3.
Table 2 infects hand-foot-and-mouth disease virus the influence (n=4) of BALB/c suckling mouse gradient of infection
Note：P is the comparison with model control group
Table 3 infects hand-foot-and-mouth disease virus the protective effect (n=4) of BALB/c suckling mouses
Note：The * P compared with model control group<0.01；
Compared with control drug sachet group, #P<0.05.
Conclusion：By upper result it is found that drug of the present invention is to A type H1N1Influenza virus and people's hand-foot-and-mouth disease virus, which have, to be inhibited
Effect.
2 toxicological experiment of experimental example
1 experimental drug：It is prepared by the following method：
Prescription：Cloves 10g, wrinkled giant hyssop 10g, Lemonfragrant Angelica Root 10g, perilla leaf 10g, rhizoma atractylodis 10g, flower bud of lily magnolia 10g, roud cardamon seed 10g, meat
Osmanthus 5g, folium artemisiae argyi 15g, ching-chieh 10g.
Technique：Said medicine is taken, 1h is extracted with steam distillation, collects condensate liquid, stratification isolates volatilization
Oil, it is spare；The dregs of a decoction after extraction volatile oil add 10 times of amount water, decoct 3 times, 2 hours for the first time, second 1 hour, third time 1
Hour, filtering, merging filtrate, the medicinal extract that relative density is 1.15~1.25 when being concentrated into 60 DEG C, and above-mentioned volatile oil mixing, i.e.,
?.
2 experimental methods
Kunming mouse gives gavage equal 2mg/20g of soft extract of the present invention of small white mouse, does not cause death through prerun, limits
It cannot increase with administered volume in the concentration of drug, median lethal dose (LD50) cannot be measured, therefore carry out maximum tolerance determination
Experiment.
The healthy Kunming mouse 20 of selection, weight (20 ± 2) g, half male and half female gavage this in dividing in 24 hours 2 times
Invention drug soft extract, total amount reach 150g/kg, this dosage is equivalent to 200 times of Coming-of-Age Day dosing.
3 experimental results
Mouse had no that adverse reaction, whole bouncings, weight increase, no death to observation post administration 7 days.
Compared with prior art, the present invention selects cloves, wrinkled giant hyssop, Lemonfragrant Angelica Root, perilla leaf, rhizoma atractylodis, the flower bud of lily magnolia, roud cardamon seed, meat
Osmanthus, folium artemisiae argyi and ching-chieh prescription have the benefits of expelling cold, eliminating.Suitable for first stream and hand-foot-and-mouth disease, sachet of the invention is to preventing
Children's first stream and hand-foot-and-mouth disease, it is easy to use, it is significant in efficacy, it is harmless to children's torso health, reach goal of the invention.
Specific implementation mode：
Embodiment 1：
Prescription：Cloves 10g, wrinkled giant hyssop 10g, Lemonfragrant Angelica Root 10g, perilla leaf 10g, rhizoma atractylodis 10g, flower bud of lily magnolia 10g, roud cardamon seed 10g, meat
Osmanthus 5g, folium artemisiae argyi 15g, ching-chieh 10g.
Technique：Said medicine is taken, under the conditions of 10-15 DEG C, low-temperature grinding is packed at 60-70 targeted fine powders, mixing respectively
Cloth bag, every bag of 6g is to get sachet.
Usage and dosage：Sachet is worn daily and front or is placed in coat pocket, is put in bedside or handbag, it also can be
Sachet is hung indoors, is replaced within 10-15 days primary.
Embodiment 2：
Prescription：Cloves 20g, wrinkled giant hyssop 20g, Lemonfragrant Angelica Root 20g, perilla leaf 20g, rhizoma atractylodis 20g, flower bud of lily magnolia 20g, roud cardamon seed 20g, meat
Osmanthus 15g, folium artemisiae argyi 30g, ching-chieh 20g.Technique：Said medicine is taken, 1h is extracted with steam distillation, collects condensate liquid, stand
Layering, isolates volatile oil, spare；The dregs of a decoction after extraction volatile oil add 10 times of amount water, decoct 3 times, 2 hours for the first time, and second
Secondary 1 hour, third time 1 hour, filtering, merging filtrate, the medicinal extract that relative density is 1.15~1.25 when being concentrated into 60 DEG C was and upper
Volatile oil mixing is stated to get soft extract.
Usage and dosage：It is oral, a 10-15g, 3 times a day.
Embodiment 3：
Prescription：Cloves 1kg, wrinkled giant hyssop 1kg, Lemonfragrant Angelica Root 1kg, perilla leaf 1kg, rhizoma atractylodis 1kg, flower bud of lily magnolia 1kg, roud cardamon seed 1kg, meat
Osmanthus 1kg, folium artemisiae argyi 5kg, ching-chieh 1kg.
Technique：Said medicine is taken, the alcohol reflux that 8 times of amounts 70% are added extracts 2 times, and 2 hours for the first time, 1 is small for the second time
When, filtration, merging filtrate, filtrate recycling ethanol and the medicinal extract that relative density is 1.15~1.25 when being concentrated into 60 DEG C, at 60 DEG C,
It is dry under the conditions of 0.07Mpa~0.08Mpa, 80 mesh sieve is crossed, the mixed accessories mixing of the amount of being made 25% is added, mixed accessories are by micro-
Crystalline cellulose and cornstarch are with 1:1 ratio is mixed, and is wetting agent pelleting with 90% ethyl alcohol, is made after particle in 60
DEG C drying is sieved 1 time after 12 mesh, be used in combination 60 mesh to screen out fine powder, filling capsule, every 0.3g is to get capsule.
Usage and dosage：It is oral, one time 3-5,3 times a day.
Claims (2)
1. the drug of a kind of prevention or treatment first stream and hand-foot-and-mouth disease, it is characterised in that：The primary medicinal component of the drug is pressed
According to listed as parts by weight, by 5-15 parts of cloves, 5-15 parts of wrinkled giant hyssop, 5-15 parts of Lemonfragrant Angelica Root, 5-15 parts of perilla leaf, 5-15 parts of rhizoma atractylodis, pungent
5-15 parts of 5-15 parts smooth, 5-15 parts of roud cardamon seed, 2-10 parts of Chinese cassia tree, 10-20 parts of folium artemisiae argyi and ching-chieh are made.
2. preventing or treating first stream and the drug of hand-foot-and-mouth disease as described in claim 1, it is characterised in that：The drug it is main
Medicinal ingredient is calculated in parts by weight, by 10 parts of cloves, 10 parts of wrinkled giant hyssop, 10 parts of Lemonfragrant Angelica Root, 10 parts of perilla leaf, 10 parts of rhizoma atractylodis, pungent
10 parts of 10 parts smooth, 10 parts of roud cardamon seed, 5 parts of Chinese cassia tree, 15 parts of folium artemisiae argyi and ching-chieh are made.
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