CN105031094A - Prescription used for treating apoplexia and preparation method thereof - Google Patents
Prescription used for treating apoplexia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a prescription used for treating apoplexia. The prescription mainly comprises, by mass, 9-16 parts of uncaria, 11-15 parts of oenothera stricta, 8-14 parts of willow branches, 10-16 parts of wolfberry fruits, 8-15 parts of whorlleaf stonecrop herbs, 9-14 of parts of lycopodium clavatum, 7-12 parts of murraya paniculata roots, 8-13 parts of microsorium fortunei ching, 9-12 parts of ligusticum wallichii, 6-14 parts of long-stalked kadsura, 7-11 parts of mother-of-pearl, 9-13 parts of vicia sativa, 6-10 parts of semen brassicae and 8-12 parts of sweet iris flowers. The prescription is a pure Chinese herb preparation, has wide medicinal herb resources, is low in cost and will not bring economical burden to a patient who takes the prescription for a long time. The prescription is completely in conformity with traditional Chinese medicine principles, has the effects of warming yang and benefiting qi, relaxing the muscles and stimulating the blood circulation and the like, and can dilate cerebral vessels and relieve cerebral tissue damage. In addition, the prescription has the advantages that ingredients are stable, treatment effects are definite and side effects are weak.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of prescription for the treatment of apoplexy and preparation method thereof.
Background technology
Apoplexy is also apoplexy, and apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly fainted, syncope, the distortion of commissure that occurs together, dysphonia and occur that hemiplegia is a class cerebral blood circulation obstacle disease of cardinal symptom.Primary disease morbidity is hurried, and disease sees multiterminal, and change of illness state is rapid, and to become feature similar to the benefaction number of wind, therefore named apoplexy, apoplexy.Apoplexy suddenly to flutter dusk, syncope or facial hemiparalysis, hemiplegia, not smoothgoing, the dysnoesia of stiff tongue speech occur suddenly for principal character.Clinical manifestation has certain limitation nervous symptoms, occurs in side cerebral hemisphere person, has offside three paralysis, i.e. hemiplegia, hemidysesthesia, the hemianopia symptom of offside, or has aphasia simultaneously.Occur in brain stem, cerebellum person and then have homonymy cranial nerve paralysis, contralateral hemiplegia or hemidysesthesia, Ipsilateral limb ataxia.Several cases has headache, vomiting, disturbance of consciousness, even cerebral hernia or death occurs.Acute stage, should give the treatment with calm, relieving convulsion and analgesic, and convalescent period adopts the medicine that can promote nerve metabolism, also combination physical therapy, physical exercise therapy and acupuncture etc. can carry out auxiliary treatment.
Publication No. CN103877194A(application number 201310499552.7) Chinese patent literature disclose a kind of Chinese medicine for the treatment of apoplexy, composition has Radix Astragali 25-35 gram, Flos Carthami 5-10 gram, Rhizoma Chuanxiong 5-15 gram, Pheretima 10-20 gram, Radix Cyathulae 10-20 gram, Radix Salviae Miltiorrhizae 25-40 gram, Ramulus Cinnamomi 5-8 gram, Fructus Crataegi 20-40 gram.Publication No. CN104056188A(application number 201410252105.6) Chinese patent literature disclose a kind of apoplexy also the clear key of god fall apart, crude drug has Calculus Bovis 3-10 gram, Cornu Saigae Tataricae 10-30 gram, Radix Notoginseng 60-80 gram, Radix Curcumae 5-25 gram.Publication No. CN103877392A(application number 201210561552.0) Chinese patent literature disclose a kind of Chinese medicine of prevention of stroke, have Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 15 grams, Oletum Trogopterori 20 grams, Herba Dendrobii 10 grams, Rhizoma Polygonati Odorati 10 grams, Fructus Lycii 15 is restrained into.
About the traditional Chinese medical science formula of apoplexy is of a great variety, effect varies, and in order to improve paralytic's quality of life, effectively controls its development, has and needs to develop the Chinese medicinal formulae that a kind of curative effect is reliable, take safe treatment apoplexy.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of curative effect reliable, take prescription of safe treatment apoplexy and preparation method thereof.
Technical scheme of the present invention is:
Treat a prescription for apoplexy, be prepared from primarily of following bulk drugs, be mass parts: Ramulus Uncariae Cum Uncis 9-16, Radix Oenotherae Odoratae 11-15, Ramulus Salicis Babylonicae 8-14, Fructus Lycii 10-16, Herba Biondiae henryi 8-15, knot careless 9-14, Radix Murrayae 7-12, Lepisorus thunbergianus (Kaulf.) Ching 8-13, Rhizoma Chuanxiong 9-12, Caulis Kadsurae Longipedunculatae 6-14, Concha Margaritifera 7-11, Herba Viviae Sativae 9-13, Semen Sinapis Albae 6-10, Flos Iridis Chinensis 8-12.
In preferred scheme, Ramulus Uncariae Cum Uncis 11-14, Radix Oenotherae Odoratae 12-14, Ramulus Salicis Babylonicae 10-12, Fructus Lycii 12-14, Herba Biondiae henryi 10-13, knot careless 10-13, Radix Murrayae 9-10, Lepisorus thunbergianus (Kaulf.) Ching 9-12, Rhizoma Chuanxiong 10-11, Caulis Kadsurae Longipedunculatae 8-12, Concha Margaritifera 8-10, Herba Viviae Sativae 10-12, Semen Sinapis Albae 7-9, Flos Iridis Chinensis 9-11.
Be more preferably, Ramulus Uncariae Cum Uncis 12.5, Radix Oenotherae Odoratae 13, Ramulus Salicis Babylonicae 11, Fructus Lycii 13, Herba Biondiae henryi 11.5, knot grass 11.5, Radix Murrayae 9.5, Lepisorus thunbergianus (Kaulf.) Ching 10.5, Rhizoma Chuanxiong 10.5, Caulis Kadsurae Longipedunculatae 10, Concha Margaritifera 9, Herba Viviae Sativae 11, Semen Sinapis Albae 8, Flos Iridis Chinensis 10.
Described a kind of prescription for the treatment of apoplexy, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, pulverize and sieve together with step (2) made crude drug, then with step (1) (3) made medicamental pulverata and medicated powder, to sieve mixing, obtain powder.
Described a kind of preparation method for the treatment of the prescription powder of apoplexy, step (4) was pulverized 100-160 mesh sieve and (preferably, was pulverized 120-140 mesh sieve; Be more preferably, pulverized 130 mesh sieves).
Described a kind of prescription for the treatment of apoplexy, be made into pharmaceutically acceptable pill, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into after the vinegar that boils boils, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, 80-120 mesh sieve was pulverized (preferred together with step (2) made crude drug, pulverized 100 mesh sieves), make medicated powder, then mix with step (1) (3) made medicamental pulverata and medicated powder, add refined honey and water, generally make ball, obtain pill.
Described a kind of preparation method for the treatment of the prescription pill of apoplexy, step (3) put into the vinegar that boils boil 20-30 minute (preferred, boil 22-28 minute; Be more preferably, boil 25 minutes).
Described a kind of prescription for the treatment of apoplexy, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, decoct with water twice, the rear little fire of big fire boiling decocts 30-42 minute, and (preferred, 34-38 minute decocted by little fire; Be more preferably, little fire decocts 36 minutes), filter, collect and merge twice gained filtrate, concentrating under reduced pressure becomes clear paste;
(5) after being pulverized by made for step (2) crude drug, then mix with step (1) (3) made medicamental pulverata and medicated powder, then add the made clear paste mixing of step (4), add the mixing of other pharmaceutical excipients, soft material processed, granulate, dry, granulate, tabletting, obtains tablet.
Described a kind of preparation method for the treatment of the prescription tablet of apoplexy, step (4) decocts with water twice, and twice amount of water is the 7-9 of boiled crude drug quality doubly (preferred, amount of water is 8 times of boiled crude drug quality).
Described a kind of prescription for the treatment of apoplexy, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, twice is decocted with water together with step (2) made crude drug, twice amount of water is 8 times of boiled crude drug quality, after big fire boiling, little fire is decocted, filter, collect and merge twice gained filtrate;
(5) step (1) and step (3) made medicamental pulverata and medicated powder are joined in step (4) made filtrate respectively, stir evenly, heat 10-18 minute (preferred, heating 12-16 minute; Be more preferably, heat 14 minutes), obtain decoction.
Described a kind of preparation method for the treatment of the prescription decoction of apoplexy, the rear little fire of step (4) big fire boiling decocts 30-42 minute, and (preferred, 34-38 minute decocted by little fire; Be more preferably, little fire decocts 36 minutes).
A kind of prescription scientific formula for the treatment of apoplexy provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention is pure Chinese medicinal preparation, and medicine source is wide, and cost is low, and long-term taking is without financial burden;
2, this prescription meets Chinese medicine principle completely, has the effect such as warming YANG and invigorating QI, relaxing muscles and tendons to promote blood circulation, and expansible cerebrovascular, alleviates brain tissue impairment;
The advantages such as 3, the present invention has stable components, determined curative effect, and side reaction is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Ramulus Uncariae Cum Uncis: base is former: be Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and the buckle branch belonging to various plants together thereof.Nature and flavor: sweet are cool.Gui Jing: return liver, pericardium channel.Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia, hypertension.
Radix Oenotherae Odoratae: base is former: be the root of onagraceae plant Radix Oenotherae Odoratae.Function cures mainly: antipyretic, cures cold, laryngitis.
Ramulus Salicis Babylonicae: base is former: be the branch of Salicaceous Plants Salix babylonica L..Nature and flavor: bitter, cold.Gui Jing: stomach, Liver Channel.Function cures mainly: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Nature and flavor: sweet are flat.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Herba Biondiae henryi: base is former: be the whole herb with root of Luo Cao section plant biondia hennriyi.Nature and flavor: light, temperature.Gui Jing: liver, kidney channel.Function cures mainly: relaxing muscles and tendons to promote blood circulation, regulates the flow of vital energy and dispels the wind.Control traumatic injury, lower limb cold type of pain is numb, rheumatism numb hand and foot, toothache.
Knot grass: base is former: be the herb of the raw Herba stellariae mediae of pinkwort stone.Nature and flavor: pungent, cool in nature, mild toxicity.Gui Jing: liver, spleen channel.Function cures mainly: suppressing the hyperactive liver, relaxing muscles and tendons to promote blood circulation, dampness removing, removing toxic substances.Main aphasia due to apoplexy, facial hemiparalysis, numb limbs and tense tendons, rheumatic arthralgia, traumatic injury, icterohepatitis, leucorrhea, furuncle
Radix Murrayae: base is former: the root of rutaceae Folium Et Cacumen Murrayae.Gui Jing: enter the heart, liver, lung three warp.Function cures mainly: dispelling the wind and dampness pathogens arthralgia pain, lumbago, traumatic injury, painful and swollen testis, eczema, scabies.
Lepisorus thunbergianus (Kaulf.) Ching: base is former: be the herb of Plants of Polypodiaceae south of the River Microsorium Link band rhizome.Nature and flavor: bitter, cold.Gui Jing: liver, spleen, the heart, lung meridian.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Main pyretic stranguria, dysuria, leucorrhea with red and white discharge, dysentery, jaundice, hemoptysis, epistaxis, bleeding hemorrhoids, scrofula tuberculosis, carbuncle sore tumefacting virus, venom, rheumatalgia, injury and bone fracture.
Rhizoma Chuanxiong: base is former: be the rhizome of samphire Rhizoma Chuanxiong.Nature and flavor: pungent, temperature.Gui Jing: enter liver, gallbladder meridian.Function cures mainly: activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Caulis Kadsurae Longipedunculatae: base is former: be the ratan of Magnolia plant long stalk Fructus Schisandrae Chinensis.Nature and flavor: warm in nature, sweet in the mouth.Function cures mainly: promoting blood circulation by removing wind, Repercusion analgesia.Dispelling the wind and dampness pathogens pain, fracture, stomachache, menoxenia.
Concha Margaritifera: base is former: be the nacreous layer of Pteriidae animal Margarita, geneva pearl pearl shellfish or several mussel shell of Unionidae animal.Nature and flavor: salty, cold.Gui Jing: return liver, heart channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Herba Viviae Sativae: base is former: be the herb of leguminous plant Herba Viviae Sativae.Nature and flavor: Gan Xin, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, and blood and dissolving stasis.To harness the Yellow River subcutaneous ulcer, edema, malaria, epistaxis, cardiopalmus, nocturnal emission, menoxenia.
Semen Sinapis Albae: base is former: be the seed of crucifer Caulis et Folium Sinapis albee.Nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach warp.Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Flos Iridis Chinensis: base is former: the alabastrum of Yang Wei section plant Chinese small iris.Nature and flavor: the micro-hardship of salty acid are cool.Function cures mainly: heat clearing away, removing toxic substances, hemostasis, diuresis.Control sore throat, spit blood, epistaxis, urinary obstruction, gonorrhea, hernia, carbuncle.
embodiment 1treat a prescription for apoplexy, be prepared from (every part of 10g) primarily of following bulk drugs: Ramulus Uncariae Cum Uncis 9 parts, Radix Oenotherae Odoratae 11 parts, Ramulus Salicis Babylonicae 8 parts, Fructus Lycii 10 parts, Herba Biondiae henryi 8 parts, knot grass 9 parts, Radix Murrayae 7 parts, Lepisorus thunbergianus (Kaulf.) Ching 8 parts, Rhizoma Chuanxiong 9 parts, Caulis Kadsurae Longipedunculatae 6 parts, Concha Margaritifera 7 parts, Herba Viviae Sativae 9 parts, Semen Sinapis Albae 6 parts, Flos Iridis Chinensis 8 parts.
Above-mentioned a kind of preparation method for the treatment of the prescription powder of apoplexy is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil 25 minutes, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, pulverized 130 mesh sieves together with step (2) made crude drug, then with step (1) (3) made medicamental pulverata and medicated powder, to sieve mixing, obtain powder.
embodiment 2treat a prescription for apoplexy, be prepared from (every part of 10g) primarily of following bulk drugs: Ramulus Uncariae Cum Uncis 16 parts, Radix Oenotherae Odoratae 15 parts, Ramulus Salicis Babylonicae 14 parts, Fructus Lycii 16 parts, Herba Biondiae henryi 15 parts, knot grass 14 parts, Radix Murrayae 12 parts, Lepisorus thunbergianus (Kaulf.) Ching 13 parts, Rhizoma Chuanxiong 12 parts, Caulis Kadsurae Longipedunculatae 14 parts, Concha Margaritifera 11 parts, Herba Viviae Sativae 13 parts, Semen Sinapis Albae 10 parts, Flos Iridis Chinensis 12 parts.
A kind of preparation method for the treatment of the prescription pill of apoplexy is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into after the vinegar that boils boils 25 minutes, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, 100 mesh sieves were pulverized together with step (2) made crude drug, make medicated powder, mix with step (1) (3) made medicamental pulverata and medicated powder again, add refined honey and water, generally make ball, obtain pill.
Model case: xxx, female, 58 years old.Suffer from apoplexy 7 days, symptom is dizzy, and left lower extremity is unable to be sent out cool, muscular strength 2 grades, distortion of commissure, medical history: hypertension 5 years, and processus aboralis of getting up before week sense is dizzy tired, and after lunch break, find the unable and left distortion of commissure sialorrhea of left lower extremity, examination in hospital, is diagnosed as cerebral infarction.Alleviate to some extent through treatment distortion of commissure, but hemiplegia of limb is without improvement, then proceeds to institute of traditional Chinese medicine's treatment, be diagnosed as apoplexy.
Take a kind of prescription pill for the treatment of apoplexy of the present embodiment gained, every day 2 times, each 3, warm water delivery service, 12 days courses for the treatment of.After taking 4 days, cold extremities alleviates still dizzy, and after taking a course for the treatment of, giddy is eliminated substantially, distortion of commissure is corrected, left lower extremity Myodynamia recovery to 4 grade, and after taking two courses for the treatment of, patient is without malaise symptoms, life can be taken care of oneself, and consolidate and take a course for the treatment of, follow up a case by regular visits to after 1 year, the state of an illness is not repeatedly.
embodiment 3treat a prescription for apoplexy, be prepared from (every part of 10g) primarily of following bulk drugs: Ramulus Uncariae Cum Uncis 11 parts, Radix Oenotherae Odoratae 12 parts, Ramulus Salicis Babylonicae 10 parts, Fructus Lycii 12 parts, Herba Biondiae henryi 10 parts, knot grass 10 parts, Radix Murrayae 9 parts, Lepisorus thunbergianus (Kaulf.) Ching 9 parts, Rhizoma Chuanxiong 10 parts, Caulis Kadsurae Longipedunculatae 8 parts, Concha Margaritifera 8 parts, Herba Viviae Sativae 10 parts, Semen Sinapis Albae 7 parts, Flos Iridis Chinensis 9 parts.
A kind of preparation method for the treatment of the prescription tablet of apoplexy is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil 25 minutes, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, decoct with water twice (twice amount of water is 8 times of boiled crude drug quality), after big fire boiling, little fire decocts 36 minutes, filter, collect and merge twice gained filtrate, concentrating under reduced pressure becomes clear paste;
(5) after being pulverized by made for step (2) crude drug, then mix with step (1) (3) made medicamental pulverata and medicated powder, then add the made clear paste mixing of step (4), add the mixing of other pharmaceutical excipients, soft material processed, granulate, dry, granulate, tabletting, obtains tablet.
Model case: xxx, man, 56 years old.Be affected by the cold before first quarter moon, occur dizziness and tinnitus, occur left limb hemiplegia, aphasia afterwards, like hot aversion to cold, lethargy, examination in hospital, light red tongue, yellow and greasy fur, stringy pulse is empty, and check further through CT, Western medicine diagnose is cerebral infarction, and tcm diagnosis is apoplexy.
Take a kind of prescription tablet for the treatment of apoplexy of the present embodiment gained, adopt every day 2 times, each 4, with warm water delivery service, 12 days courses for the treatment of.After taking one week, spirit takes a turn for the better, and tinnitus disappears, dizzy, limb is cool alleviates, after taking a course for the treatment of, health can be slowly movable, but still need people to help, and can briefly exchange, after taking three courses for the treatment of, life can be taken care of oneself substantially, and limb function recovers normal substantially, and follow up a case by regular visits to after 1 year, condition is good.
embodiment 4treat a prescription for apoplexy, be prepared from (every part of 10g) primarily of following bulk drugs: Ramulus Uncariae Cum Uncis 14 parts, Radix Oenotherae Odoratae 14 parts, Ramulus Salicis Babylonicae 12 parts, Fructus Lycii 14 parts, Herba Biondiae henryi 13 parts, knot grass 13 parts, Radix Murrayae 10 parts, Lepisorus thunbergianus (Kaulf.) Ching 12 parts, Rhizoma Chuanxiong 11 parts, Caulis Kadsurae Longipedunculatae 12 parts, Concha Margaritifera 10 parts, Herba Viviae Sativae 12 parts, Semen Sinapis Albae 9 parts, Flos Iridis Chinensis 11 parts.
A kind of preparation method for the treatment of the prescription decoction of apoplexy is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil 25 minutes, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, twice is decocted with water together with step (2) made crude drug, twice amount of water is 8 times of boiled crude drug quality, after big fire boiling, little fire decocts 36 minutes, filter, collect and merge twice gained filtrate;
(5) step (1) and step (3) made medicamental pulverata and medicated powder are joined in step (4) made filtrate respectively, stir evenly, heat 14 minutes, obtain decoction.
Model case: xxx, man, 65 years old.Medical history: hypertension 5 years, coronary heart disease 2 years.Before 5 days, because of fatigue of playing chess, occur right side limb adynamia time at dusk and fall; urinary incontinence, deliver to examination in hospital, crooked mouth and tongue; dysphonia; figure swallows to choke and coughs, CT prompts for acute cerebral infarction, after rescuing; patient pulls through; the state of an illness is controlled, rear employing Chinese traditional treatment, is diagnosed as apoplexy.
Take a kind of prescription decoction for the treatment of apoplexy of the present embodiment gained, adopt every day 2 times, each 300-400ml, warm, 12 days courses for the treatment of.After taking one week, crooked mouth and tongue improves, and can independently take food, cough without choking, after taking a course for the treatment of, crooked mouth and tongue is eliminated completely, can short distance walking, and simply exchange, after taking two courses for the treatment of, verbalization is gradually clear, and right side upper and lower extremities power strengthens, after taking three courses for the treatment of, language and limb function normal, life can take care of oneself, consolidation take a course for the treatment of after, drug withdrawal, follows up a case by regular visits to after 1 year without recurrence.
embodiment 5treat a prescription for apoplexy, be prepared from (every part of 10g) primarily of following bulk drugs: Ramulus Uncariae Cum Uncis 12.5 parts, Radix Oenotherae Odoratae 13 parts, Ramulus Salicis Babylonicae 11 parts, Fructus Lycii 13 parts, Herba Biondiae henryi 11.5 parts, knot grass 11.5 parts, Radix Murrayae 9.5 parts, Lepisorus thunbergianus (Kaulf.) Ching 10.5 parts, Rhizoma Chuanxiong 10.5 parts, Caulis Kadsurae Longipedunculatae 10 parts, Concha Margaritifera 9 parts, Herba Viviae Sativae 11 parts, Semen Sinapis Albae 8 parts, Flos Iridis Chinensis 10 parts.
A kind of preparation method for the treatment of the prescription powder of apoplexy is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil 25 minutes, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, pulverized 130 mesh sieves together with step (2) made crude drug, then with step (1) (3) made medicamental pulverata and medicated powder, to sieve mixing, obtain powder.
test example 1a kind of clinical practice for the treatment of the prescription (embodiment 5) of apoplexy of gained of the present invention:
In April ,-2014 in February, 2012, filter out 244 routine paralytics at 6 hospital clinics, wherein women 114 example, male 130 example, age 40-72 year, the mean age (51.2 ± 5.3) year, course of disease 2-100 days.Wherein cerebral infarction 166 example, cerebral hemorrhage 78 example.Diagnostic criteria is with reference to the apoplexy diagnostic criteria of State Administration of Traditional Chinese Medicine's formulation in 1994, and all cases is all clarified a diagnosis through CT or MRI.Get rid of and suffer from the serious heart, lung, kidney diaseases and dement; The patients such as Big Area Cerebral Infarction, lacunar infarction, Transient ischemic attacks and Mixed Cerebrovascular disiase; Severe infection, severe diabetes mellitus patient; Data is incomplete, does not complete person's course for the treatment of.
Patient is divided into two groups at random, experimental group 154 example and matched group 90 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and every day takes twice, and each 4-6g(adjusts to some extent depending on concrete condition), 12 days courses for the treatment of, treat 3 courses for the treatment of continuously.Matched group takes other medicine (conventional medication such as ZHONGFENG HUICHUN WAN, XIAOSHUAN TONGLUO PIAN, apoplexy restorative bolus).Treatments period carries out Continuous Observation to two groups of patients, observes and records the rear paralyzed limbs Myodynamia recovery situation for the treatment of.0 grade: paralyse completely; 1 grade: muscle is collapsible, but can not execution; 2 grades: limbs can move at bed surface, but can not lift; 3 grades: limbs can be lifted away from bed surface, but can not resistive drag force: 4 grades: the action that resistive drag force can be made, but calibration ordinary person is poor; 5 grades: muscular strength is normal.
Curative effect situation criterion: clinical cure: clinical symptoms and sign disappear, and take care of oneself, Myodynamia recovery is to 5 grades; Effective: clinical symptoms and sign are obviously improved, muscular strength reaches 3 ~ 4 grades; Effective: clinical symptoms and sign part are improved, and limb function has certain recovery, and muscular strength reaches 1 ~ 2 grade; Invalid: after treatment, clinical symptoms and sign are without improvement, and muscular strength is unchanged.
Table 1 liang group patient treatment outcome
Through the treatment of three courses for the treatment of, experimental group treatment total effective rate is 95.5%, and the total effective rate of matched group is that 76.7%, two groups for the treatment of total effective rates are compared and had statistical significance (P < 0.05).Visible products obtained therefrom of the present invention has comparatively significant therapeutic effect to apoplexy.In therapeutic process, all there is not any untoward reaction phenomenon in two groups of patients.
The rigorous compatibility of formula of the present invention obtains, wherein Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, and Radix Oenotherae Odoratae is antipyretic, Ramulus Salicis Babylonicae wind-expelling pain-stopping, Fructus Lycii nourishing the liver and kidney, Herba Biondiae henryi relaxing muscles and tendons to promote blood circulation, knot careless relaxing muscles and tendons to promote blood circulation, Radix Murrayae eliminating stasis to stop pain, Lepisorus thunbergianus (Kaulf.) Ching clearing away heat-damp and promoting diuresis, Rhizoma Chuanxiong activating QI to alleviate the depression, Caulis Kadsurae Longipedunculatae promoting blood circulation by removing wind, Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, Herba Viviae Sativae blood circulation promoting and blood stasis dispelling, Semen Sinapis Albae removing obstruction in the collateral to relieve pain, Flos Iridis Chinensis heat-clearing and toxic substances removing, all medicines share, and can play the effect such as warming YANG and invigorating QI, relaxing muscles and tendons to promote blood circulation.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a prescription for apoplexy, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Ramulus Uncariae Cum Uncis 9-16, Radix Oenotherae Odoratae 11-15, Ramulus Salicis Babylonicae 8-14, Fructus Lycii 10-16, Herba Biondiae henryi 8-15, knot careless 9-14, Radix Murrayae 7-12, Lepisorus thunbergianus (Kaulf.) Ching 8-13, Rhizoma Chuanxiong 9-12, Caulis Kadsurae Longipedunculatae 6-14, Concha Margaritifera 7-11, Herba Viviae Sativae 9-13, Semen Sinapis Albae 6-10, Flos Iridis Chinensis 8-12.
2. a kind of prescription for the treatment of apoplexy as claimed in claim 1, it is characterized in that, Ramulus Uncariae Cum Uncis 11-14, Radix Oenotherae Odoratae 12-14, Ramulus Salicis Babylonicae 10-12, Fructus Lycii 12-14, Herba Biondiae henryi 10-13, knot careless 10-13, Radix Murrayae 9-10, Lepisorus thunbergianus (Kaulf.) Ching 9-12, Rhizoma Chuanxiong 10-11, Caulis Kadsurae Longipedunculatae 8-12, Concha Margaritifera 8-10, Herba Viviae Sativae 10-12, Semen Sinapis Albae 7-9, Flos Iridis Chinensis 9-11 is (preferred, Ramulus Uncariae Cum Uncis 12.5, Radix Oenotherae Odoratae 13, Ramulus Salicis Babylonicae 11, Fructus Lycii 13, Herba Biondiae henryi 11.5, knot grass 11.5, Radix Murrayae 9.5, Lepisorus thunbergianus (Kaulf.) Ching 10.5, Rhizoma Chuanxiong 10.5, Caulis Kadsurae Longipedunculatae 10, Concha Margaritifera 9, Herba Viviae Sativae 11, Semen Sinapis Albae 8, Flos Iridis Chinensis 10).
3. a kind of prescription for the treatment of apoplexy as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, pulverize and sieve together with step (2) made crude drug, then with step (1) (3) made medicamental pulverata and medicated powder, to sieve mixing, obtain powder.
4. a kind of preparation method for the treatment of the prescription powder of apoplexy as claimed in claim 3, is characterized in that, step (4) pulverized 100-160 mesh sieve (preferred, pulverized 120-140 mesh sieve; Be more preferably, pulverized 130 mesh sieves).
5. a kind of prescription for the treatment of apoplexy as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into after the vinegar that boils boils, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, dry, 80-120 mesh sieve was pulverized (preferred together with step (2) made crude drug, pulverized 100 mesh sieves), make medicated powder, then mix with step (1) (3) made medicamental pulverata and medicated powder, add refined honey and water, generally make ball, obtain pill.
6. a kind of preparation method for the treatment of the prescription pill of apoplexy as claimed in claim 5, is characterized in that, step (3) put into the vinegar that boils boil 20-30 minute (preferred, boil 22-28 minute; Be more preferably, boil 25 minutes).
7. a kind of prescription for the treatment of apoplexy as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, decoct with water twice, the rear little fire of big fire boiling decocts 30-42 minute, and (preferred, 34-38 minute decocted by little fire; Be more preferably, little fire decocts 36 minutes), filter, collect and merge twice gained filtrate, concentrating under reduced pressure becomes clear paste;
(5) after being pulverized by made for step (2) crude drug, then mix with step (1) (3) made medicamental pulverata and medicated powder, then add the made clear paste mixing of step (4), add the mixing of other pharmaceutical excipients, soft material processed, granulate, dry, granulate, tabletting, obtains tablet.
8. a kind of preparation method for the treatment of the prescription tablet of apoplexy as claimed in claim 7, it is characterized in that, step (4) decocts with water twice, and twice amount of water is the 7-9 of boiled crude drug quality doubly (preferred, amount of water is 8 times of boiled crude drug quality).
9. a kind of prescription for the treatment of apoplexy as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Fructus Lycii and Semen Sinapis Albae roguing are cleaned, with sweet wine dipping, load and steam in cup, Steam by water bath exhausts to wine, takes out, dries in the air cool, dries, grinds into powder, put into frying pan, fries to when having fragrance, takes out, dry in the air cool;
(2) get Ramulus Salicis Babylonicae, Herba Biondiae henryi and Caulis Kadsurae Longipedunculatae to clean, cutting, adds in the yellow wine of boiling and the mixed liquor of vinegar, Guan Huo, adds a cover dipping 15 minutes, takes out, is placed in frying pan, and moderate heat adds when propagandizing hotly to dry tack free, takes out, and dries;
(3) Concha Margaritifera is put into the vinegar that boils, boil and (preferably, boil 22-28 minute in 20-30 minute; Be more preferably, boil 25 minutes), take out, be placed in refractory container, heat with high heat, be calcined to crisp, take out, cool, levigation;
(4) Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae, cramp grass, Radix Murrayae, Lepisorus thunbergianus (Kaulf.) Ching, Rhizoma Chuanxiong, Herba Viviae Sativae and Flos Iridis Chinensis remove impurity are cleaned, twice is decocted with water together with step (2) made crude drug, twice amount of water is 8 times of boiled crude drug quality, after big fire boiling, little fire is decocted, filter, collect and merge twice gained filtrate;
(5) step (1) and step (3) made medicamental pulverata and medicated powder are joined in step (4) made filtrate respectively, stir evenly, heat 10-18 minute (preferred, heating 12-16 minute; Be more preferably, heat 14 minutes), obtain decoction.
10. a kind of preparation method for the treatment of the prescription decoction of apoplexy as claimed in claim 9, is characterized in that, after step (4) big fire boiling, little fire is decocted 30-42 minute (preferred, 34-38 minute decocted by little fire; Be more preferably, little fire decocts 36 minutes).
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