CN105030929A - Traditional Chinese medicinal composition for preventing and treating seasonal febrile diseases of poultry and livestock - Google Patents
Traditional Chinese medicinal composition for preventing and treating seasonal febrile diseases of poultry and livestock Download PDFInfo
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- CN105030929A CN105030929A CN201510516851.6A CN201510516851A CN105030929A CN 105030929 A CN105030929 A CN 105030929A CN 201510516851 A CN201510516851 A CN 201510516851A CN 105030929 A CN105030929 A CN 105030929A
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Abstract
The invention discloses a traditional Chinese medicinal composition for preventing and treating seasonal febrile diseases of poultry and livestock. The composition is prepared from the following main components in parts by weight: 10-20 parts of salviae miltiorrhizae, 10-15 parts of moutan bark, 5-6 parts of rheum officinale and 1-2 parts of peppermint. The traditional Chinese medicinal composition has an excellent curative effect on prevention and treatment of seasonal febrile diseases of poultry and livestock and has small side effect and no drug residue.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition preventing and treating livestock and poultry pestilence.
Background technology
Poultry various diseases took place frequently in the last few years, and the anxious hot epidemic febrile disease of the class particularly caused by diseases caused by exogenous pathogenic factor causes massive losses to aquaculture.Poultry epidemic febrile disease has that morbidity is anxious, change is fast, the many features of deteriorated case, often partially contains for thermal image, injuring YIN due to production of dryness, thirsty agitation, a speckle tell the clinical manifestations such as nosebleed.On veterinary clinic, the livestock and poultry pestilence caused by antibacterial and virus causes serious harm to aquaculture.Because antimicrobial drug abuse is general in livestock and poultry breeding industry, bacterial drug resistance is caused constantly to strengthen, as higher in Bacterial Drug Resistance of Patients such as escherichia coli, staphylococcus aureus, Salmonella, bacillus pyocyaneus.For viral infectious, because virus constantly makes a variation, vaccine prevention and control were also often lost efficacy, and virus also can produce drug resistance in addition, as some influenza virus produce drug resistance to amantadine.So clinically, the epidemic prevention and control caused by antibacterial and virus is very difficult for current veterinary drug.Country's improving constantly again food safety attention degree in recent years, in order to prevent residue of veterinary drug, many antimicrobial drugs and antiviral agents prohibit the use.In this case, livestock and poultry pestilence prevention and control arduous task, Chinese medicine becomes important selection.Livestock and poultry pestilence is classified as epidemic febrile disease category by the traditional Chinese medical science, the class acute calenture namely caused by diseases caused by exogenous pathogenic factor.The Seasonal Febrile Disease Theory of the traditional Chinese medical science provides for the prevention and control of livestock and poultry pestilence and well cures thinking.
Summary of the invention
The present invention provides a kind of Chinese medicine composition preventing and treating livestock and poultry pestilence in conjunction with clinical practice under the guidance of Chinese medical theory, this medicine main component has Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Et Rhizoma Rhei, Herba Menthae for the control determined curative effect of livestock and poultry pestilence, and side effect is little, drug residue free.
Prevent and treat a Chinese medicine composition for livestock and poultry pestilence, main components in percentage by weight is counted by weight:
Radix Salviae Miltiorrhizae 10 ~ 20 parts, Cortex Moutan 10 ~ 15 parts, Radix Et Rhizoma Rhei 5 ~ 6 parts, Herba Menthae 1 ~ 2 part.
As technique scheme further preferably, described Chinese herbal main component proportioning is counted by weight:
Radix Salviae Miltiorrhizae 10 ~ 15 parts, Cortex Moutan 10 ~ 13 parts, Radix Et Rhizoma Rhei 5 ~ 6 parts, Herba Menthae 1 ~ 2 part.
For further preferably such scheme, described Chinese herbal main component optimum proportioning by weight evaluation is:
Radix Salviae Miltiorrhizae 13 parts, Cortex Moutan 12 parts, Radix Et Rhizoma Rhei 5 parts, Herba Menthae 2 parts.
According to above-mentioned technology preparation, compositions is made oral liquid or soluble powder, its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid b of twice decoction and medicinal liquid c, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, add ethanol and carry out precipitate with ethanol, add the amount of ethanol and the volume ratio of extractum is 7:3, after precipitate with ethanol, carry out ethanol recovery, obtain extractum d after recovery, density is 1.2, for subsequent use;
E, appropriate for the use of extractum a and d purified water is mixed with the oral liquid with crude drug identical weight; Or the extractum spraying dry of extractum a and d is made soluble powder.
Pharmacology analysis:
Chinese medicine composition of the present invention is well-designed according to Chinese prescription principle, mutual cooperative compensating between medicine.Radix Salviae Miltiorrhizae bitter in the mouth, cold nature, have blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle effect; Radix Et Rhizoma Rhei bitter cold, falls and does not rise, function heat-clearing and toxic substances removing, purging fire and cooling blood, stasis removing, eliminating blood stasis and inducing menstruation; Cortex Moutan toil, is slightly cold, removing heat from blood and promoting blood circulation, makes blood cool and the not stasis of blood, invigorates blood circulation and not absurd row, can rush down the blood fire second of the three ten-day periods of the hot season, can stop up showing tremendous enthusiasm by the removing blood stasis with potent drugs Inner that falls apart again; Herba Menthae acrid in the mouth, property are flat, its can in muscles and bones thoroughly, reach flesh table outward, the logical internal organs of a surname, run through meridians, clothes can thoroughly send out antiperspirant cool, so control heat with cool, be suitable for epidemic febrile disease.These four kinds of Chinese medicines respectively have feature, and blood circulation promoting and blood stasis dispelling is good at by Radix Salviae Miltiorrhizae, eliminating blood stasis to promote regeneration of blood, reducing swelling and alleviating pain, nourishing blood to tranquillize the mind; Clearing away heat and cooling blood is longer than by Cortex Moutan, clear cloudy point of volt fire thoroughly, the two compatibility, removing heat from blood and promoting blood circulation, and the power of clear expelling pathogenic factors from the exterior heat strengthens; The property of Radix Et Rhizoma Rhei is good at pathogenic fire purging removing blood stasis with potent drugs, and with Radix Salviae Miltiorrhizae, Cortex Moutan three compatibility, purging fire and cooling blood is assisted mutually, brokenization is harmonious, and the power of Radix Et Rhizoma Rhei pathogenic fire purging removing blood stasis with potent drugs can strengthen effect of Radix Salviae Miltiorrhizae, Cortex Moutan clearing away heat and cooling blood and promoting blood circulation to remove blood stasis.Herba Menthae gas delicate fragrance is altered, can extending from the interior to the exterior, with Radix Salviae Miltiorrhizae, Cortex Moutan and Radix Et Rhizoma Rhei three compatibility, three's stasis of blood is fallen apart, and blood is alive to be made appended by heat nothing, intrinsic heat just declares loose power to reach in fur to appear in nutrient blood, the natural fibre line of meat with Herba Menthae clearly thoroughly, reach accumulate in thorough clear body stagnant heat, the healthy energy of post-equalization body, pestilence of dispelling is except the object of poison.
Inventor is found by long-term veterinary clinic, during poultry generation epidemic febrile disease, shows as hyperpyrexia more, and spirit is depressed, and the visible ecchymosis of skin, vein generation blood stasis, analyses as main organs extensive bleedings such as the heart, lung, kidney, liver, intestinal, stomaches.With differentiation of syndromes in seasonal febrile diseases according to four phases: WEI,QI,YING and XUE systems, for pathogenic heat are joined the army blood system, force blood to go out, occur ecchymosis; Cause impairment of both QI and blood eventually, occur qi depression to blood stasis, blood vessels are jammed not all right and make animal dead.Thus, the Therapeutic Principle for poultry epidemic febrile disease employing clearing away heat and cooling blood, promoting blood circulation to remove blood stasis effectively can alleviate the loss of aquaculture.
Inventor confirms through clinical experiment, and the Chinese medicine composition be made up of Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Et Rhizoma Rhei, Herba Menthae has effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, can effectively prevent and treat poultry epidemic febrile disease.Adopt preparation method provided by the invention to be prepared simultaneously and can effectively retain the effective elements of the medicine in each taste, avoid the use of organic solvent simultaneously, the toxic side effects reducing medicine can not remain in poultry body, ensure that food safety, the oral liquid of final acquisition or soluble powder can mixed feedings direct with the feedstuff of poultry, convenient and swift, can adjust consumption at any time according to growth of animals or poultry situation, the control for poultry epidemic febrile disease has good effect.
The Chinese medicine composition that the present invention is made up of Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Et Rhizoma Rhei, Herba Menthae, the loss taking the Therapeutic Principle of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis effectively can alleviate poultry epidemic febrile disease clinically to cause.To the control of poultry epidemic febrile disease, there is good efficacy, and side effect is little, drug residue free.
Detailed description of the invention
Embodiment 1
Prevent and treat a Chinese medicine composition for livestock and poultry pestilence, main components in percentage by weight is counted by weight: Radix Salviae Miltiorrhizae 13 parts, Cortex Moutan 12 parts, Radix Et Rhizoma Rhei 5 parts, Herba Menthae 2 parts;
Its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid b of twice decoction and medicinal liquid c, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, add ethanol and carry out precipitate with ethanol, add the amount of ethanol and the volume ratio of extractum is 7:3, after precipitate with ethanol, carry out ethanol recovery, obtain extractum d after recovery, density is 1.2, for subsequent use;
E, the appropriate purified water of extractum a and d is mixed with the oral liquid with crude drug identical weight.
Embodiment 2
Prevent and treat a Chinese medicine composition for livestock and poultry pestilence, main components in percentage by weight is counted by weight: Radix Salviae Miltiorrhizae 10 parts, Cortex Moutan 10 parts, Radix Et Rhizoma Rhei 5 parts, Herba Menthae 1 part;
Its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid b of twice decoction and medicinal liquid c, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, add ethanol and carry out precipitate with ethanol, add the amount of ethanol and the volume ratio 7:3 of extractum, after precipitate with ethanol, carry out ethanol recovery, obtain extractum d after recovery, density is 1.2, for subsequent use;
E, extractum a and d spraying dry are made soluble powder.
Embodiment 3
Prevent and treat a Chinese medicine composition for livestock and poultry pestilence, main components in percentage by weight is counted by weight: Radix Salviae Miltiorrhizae 20 parts, Cortex Moutan 15 parts, Radix Et Rhizoma Rhei 6 parts, Herba Menthae 2 parts;
Its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid b of twice decoction and medicinal liquid c, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, add ethanol and carry out precipitate with ethanol, add the amount of ethanol and the volume ratio 7:3 of extractum, after precipitate with ethanol, carry out ethanol recovery, obtain extractum d after recovery, density is 1.2, for subsequent use;
E, the appropriate purified water of extractum a and d is mixed with the oral liquid with crude drug identical weight.
Embodiment 4
Prevent and treat a Chinese medicine composition for livestock and poultry pestilence, main components in percentage by weight is counted by weight: Radix Salviae Miltiorrhizae 15 parts, Cortex Moutan 13 parts, Radix Et Rhizoma Rhei 6 parts, Herba Menthae 1 part;
Its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid of twice decoction, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, adds ethanol and carries out precipitate with ethanol, adds the amount of ethanol and the volume ratio 7:3 of extractum, carries out ethanol recovery after precipitate with ethanol, after recovery extractum, density is 1.2, for subsequent use;
E, the appropriate purified water of extractum a and d is mixed with the oral liquid with crude drug identical weight.
The result of clinical observation of the present invention is as follows:
Test example 1
Shouguang, Shandong plant, 8 hen houses, every hen house 19000 chickens, between period of disease every day every hen house dead quantity 200-400 only between.Jumpbogroup shows as feed intake and declines, and respiratory symptom is obvious, snore, cough, the phenomenon such as to shout strangely increases, eyelet reddens, shed tears, and feces is dry.Analyse visible tracheorrhagia serious, pulmonary's blood stasis is downright bad, and cardiac muscle is hemorrhage, and kidney enlargement is hemorrhage, pancreatic hemorrhage.
The oral liquid of employing embodiment 1 gives the chicken of every hen house and feedstuff with taking respectively, medication 3 days, and every day every, the death toll of hen house was only down to 40-50.Jumpbogroup feed intake obviously increases, and returns to normal level, and respiratory symptom obviously alleviates, and shouts strangely and obviously reduces.
Test example 2
Shandong region chicken house, 12 hen houses, often give up 20000, and between period of disease, every day often gives up death toll between 300-500.Jumpbogroup is cashed as feed intake declines, and ill chicken spirit is depressed, respiratory symptom seriously, snore, cough, the phenomenon such as to shout strangely increases, feces is dry.Analyse visible tracheorrhagia serious, pulmonary's blood stasis is downright bad, and cardiac muscle is hemorrhage, and kidney enlargement is hemorrhage, pancreatic hemorrhage.
Drink to after adopting the molten water of soluble powder of embodiment 2 chicken in hen house as drinking water, medication is after 4 days, and every day every, the death toll of hen house was only down to 60-70.Jumpbogroup feed intake obviously increases, and returns to normal level, and respiratory symptom obviously alleviates, and shouts strangely and obviously reduces.
Comparative example
Changle, Shandong plant, 6 hen houses, every hen house 18900 chickens, happen suddenly acute epidemic febrile disease, and jumpbogroup spirit is depressed, and feed intake declines to a great extent, and every day every, the dead quantity of hen house only reached more than 700.The main urgent antipyretic and antitoxic powder that adopts of poultry is treated, and coupling is not improved for 3 days; Adopt the oral liquid treatment that embodiment 1 is made subsequently, be used in conjunction 3 days, every day every, hen house death toll was dropped rapidly to about 100; After being used in conjunction 5 days, chicken group recovers normal substantially.
Claims (3)
1. prevent and treat a Chinese medicine composition for livestock and poultry pestilence, it is characterized in that: main components in percentage by weight is counted by weight:
Radix Salviae Miltiorrhizae 10 ~ 20 parts, Cortex Moutan 10 ~ 15 parts, Radix Et Rhizoma Rhei 5 ~ 6 parts, Herba Menthae 1 ~ 2 part;
According to above-mentioned technology preparation, compositions is made oral liquid or soluble powder, its preparation method is:
A, by formula proportion, Radix Salviae Miltiorrhizae powder is broken into coarse powder, crosses 10 mesh sieves, with 90% ethanol percolation of Radix Salviae Miltiorrhizae amount 5 times of weight, collect percolate, carry out ethanol recovery, after recovery extractum a, the relative density 1.2 of extractum, for subsequent use, Radix Salviae Miltiorrhizae decoction dregs is collected;
B, by formula proportion, Cortex Moutan, Radix Et Rhizoma Rhei are knocked down Decocting pot, add the water of 10 times of weight of medical material Radix Et Rhizoma Rhei and Cortex Moutan total amount, boil and boil 1 hour, filter to obtain medicinal liquid b;
C, to get by formula proportion together with Radix Salviae Miltiorrhizae decoction dregs that Herba Menthae and a step obtain and drop into Decocting pot, add up the water of 10 times of weight of medical material amount Radix Et Rhizoma Rhei, Cortex Moutan, Radix Salviae Miltiorrhizae, Herba Menthae, boil and boil 0.5 hour, filter to obtain medicinal liquid c;
D, merged by the medicinal liquid b of twice decoction and medicinal liquid c, carry out concentrating under reduced pressure, being concentrated into extractum density is 1.1, add ethanol and carry out precipitate with ethanol, add the amount of ethanol and the volume ratio of extractum is 7:3, after precipitate with ethanol, carry out ethanol recovery, obtain extractum d after recovery, density is 1.2, for subsequent use;
E, extractum a and d be mixed with the oral liquid with crude drug identical weight by purified water; Or the extractum spraying dry of extractum a and d is made soluble powder.
2. Chinese medicine composition according to claim 1, is characterized in that: main components in percentage by weight is counted by weight:
Radix Salviae Miltiorrhizae 10 ~ 15 parts, Cortex Moutan 10 ~ 13 parts, Radix Et Rhizoma Rhei 5 ~ 6 parts, Herba Menthae 1 ~ 2 part.
3. Chinese medicine composition according to claim 1, is characterized in that: main components in percentage by weight is counted by weight:
Radix Salviae Miltiorrhizae 13 parts, Cortex Moutan 12 parts, Radix Et Rhizoma Rhei 5 parts, Herba Menthae 2 parts.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172334A (en) * | 1987-12-26 | 1989-07-07 | Nisshin Flour Milling Co Ltd | Preventive and remedy for swine pasteurellosis |
| CN101700290A (en) * | 2009-11-24 | 2010-05-05 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and preparation method thereof |
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2015
- 2015-08-21 CN CN201510516851.6A patent/CN105030929B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172334A (en) * | 1987-12-26 | 1989-07-07 | Nisshin Flour Milling Co Ltd | Preventive and remedy for swine pasteurellosis |
| CN101700290A (en) * | 2009-11-24 | 2010-05-05 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李富言等: "《中兽医学专家谈禽病》", 31 March 2014, 中国农业出版社 * |
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Denomination of invention: Traditional Chinese medicinal composition for preventing and treating seasonal febrile diseases of poultry and livestock Effective date of registration: 20190606 Granted publication date: 20190115 Pledgee: Postal Savings Bank of China, Limited by Share Ltd, Weifang branch Pledgor: WEIFANG HAVING BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. Registration number: 2019980000087 |
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Date of cancellation: 20220601 Granted publication date: 20190115 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Weifang branch Pledgor: WEIFANG HUAYING BIOTECHNOLOGY Co.,Ltd. Registration number: 2019980000087 |