CN105030929B - A kind of Chinese medicine composition for preventing and treating livestock and poultry warm disease - Google Patents
A kind of Chinese medicine composition for preventing and treating livestock and poultry warm disease Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for preventing and treating livestock and poultry pestilence, comprising: main components in percentage by weight is by weight are as follows: 10~20 parts of Radix Salviae Miltiorrhizae, 10~15 parts of cortex moutan, 5~6 parts of rheum officinale, 1~2 part of peppermint.The drug has good efficacy, and Small side effects, drug residue free to the prevention and treatment of livestock and poultry warm disease.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence.
Background technique
The a variety of diseases of livestock and poultry took place frequently in recent years, and the especially anxious hot warm disease of one kind as caused by exogenous disease makes aquaculture
At massive losses.Livestock and poultry warm disease has the characteristics that morbidity is anxious, variation is fast, deterioration of a case is more, often contains for thermal image partially, is injuring YIN due to production of dryness, thirsty
The clinical manifestations such as agitation, macular eruption hematemesis.In veterinary clinic, the livestock and poultry pestilence as caused by bacterium and virus causes aquaculture
It seriously endangers.Since antimicrobial abuse is universal in livestock and poultry breeding industry, bacterial drug resistance is caused constantly to enhance, as Escherichia coli,
The Bacterial Drug Resistance of Patients such as staphylococcus aureus, salmonella, Pseudomonas aeruginosa are higher.For viral infectious, not due to virus
Disconnected variation, vaccine prevention and control also tend to fail, and in addition virus can also generate drug resistance, and such as some influenza viruses generate amantadine
Drug resistance.So clinically, the epidemic prevention and control as caused by bacterium and virus is extremely difficult for veterinary drug at present.Country is to food in recent years
The safe attention degree of product is being continuously improved again, and residue of veterinary drug, many antimicrobials and antiviral agent have been forbidden to use in order to prevent.
In this case, livestock and poultry pestilence prevention and control arduous task, traditional Chinese medicine become important selection.Livestock and poultry pestilence is classified as warm disease by Chinese medicine
Scope, i.e. one kind acute fever as caused by exogenous disease.The Seasonal Febrile Disease Theory of Chinese medicine provides well the prevention and control of livestock and poultry pestilence
Cure thinking.
Summary of the invention
The present invention combines clinical practice to provide a kind of Chinese medicine group for preventing and treating livestock and poultry pestilence under the guidance of traditional Chinese medical theory
Object is closed, which has Radix Salviae Miltiorrhizae, the root bark of tree peony, rheum officinale, peppermint curative for effect for the prevention and treatment of livestock and poultry pestilence, and side effect
It is small, drug residue free.
A kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, main components in percentage by weight is by weight are as follows:
10~20 parts of Radix Salviae Miltiorrhizae, 10~15 parts of cortex moutan, 5~6 parts of rheum officinale, 1~2 part of peppermint.
As above-mentioned technical proposal further preferred, the Chinese herbal main component proportion is by weight are as follows:
10~15 parts of Radix Salviae Miltiorrhizae, 10~13 parts of cortex moutan, 5~6 parts of rheum officinale, 1~2 part of peppermint.
For further preferred above scheme, Chinese herbal main component optimum proportioning evaluation by weight are as follows:
13 parts of Radix Salviae Miltiorrhizae, 12 parts of cortex moutan, 5 parts of rheum officinale, 2 parts of peppermint.
According to above-mentioned technology preparation, oral solution or soluble powder, preparation method is made in composition are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, received
Collect percolate, carry out ethyl alcohol recycling, medicinal extract a is obtained after recycling, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot, 10 times of weight of dosing material rheum officinale and cortex moutan total amount by formula rate
Water, boiling boil 1 hour, filter to obtain medical fluid b；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, aggregation medicinal material amount rheum officinale,
Cortex moutan, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid b decocted twice and medical fluid c is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, is added
Ethyl alcohol carries out alcohol precipitation, and the volume ratio of amount and medicinal extract that ethyl alcohol is added is 7:3, carries out ethyl alcohol recycling after alcohol precipitation, medicinal extract is obtained after recycling
D, density 1.2 are spare；
E, by the oral solution of medicinal extract a and d being configured to appropriate purified water with crude drug identical weight；Or by medicinal extract a and d
Medicinal extract spray drying soluble powder is made.
Pharmacology analysis:
The traditional chinese medicine composition of the invention is well-designed according to Chinese prescription principle, mutual cooperative compensating between drug.Radix Salviae Miltiorrhizae taste
Bitter, cold nature has promoting blood circulation, and stasis eliminatings are raw new, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle effect；Rheum officinale bitter cold, drop and
It does not rise, function is clearing heat and detoxicating, purging fire and cooling blood, stasis removing, dispelling stasis of blood and stimulating the menstrual flow；Root bark of tree peony toil, slightly cold, cooling and activating blood, keep blood cool and
The not stasis of blood, promoting blood circulation can rush down blood second of the three ten-day periods of the hot season fire and the scattered interior heap soil or fertilizer over and around the roots of broken stasis of blood are showing tremendous enthusiasm without absurd row；Peppermint acrid flavour, mild-natured, saturating muscle in energy
Bone reaches fleshy exterior outside, declares logical internal organs, runs through channels and collaterals, clothes to send out sweat cool thoroughly so controlling heat with cool be to be suitable for warm disease.This four kinds
Chinese medicine respectively has feature, and Radix Salviae Miltiorrhizae is good at promoting blood circulation, and stasis eliminatings are raw new, swelling and pain relieving, nourishing blood and tranquilization；The root bark of tree peony is longer than clearing heat and cooling blood, clearly
Yin point volt fire thoroughly, the two compatibility, cooling and activating blood, the power enhancing of clear heat symptoms caused by an exopathgen；The property of rheum officinale is good at purging intense heat broken stasis of blood, with Radix Salviae Miltiorrhizae, pellet
Skin three's compatibility, purging fire and cooling blood is mutually assisted, brokenization is harmonious, and the power of rheum officinale purging intense heat broken stasis of blood can enhance Radix Salviae Miltiorrhizae, root bark of tree peony clearing heat and cooling blood and work
Blood dissipates the effect of stasis of blood.Peppermint gas faint scent alters, can extending from the interior to the exterior, with Radix Salviae Miltiorrhizae, the root bark of tree peony and rheum officinale three's compatibility, three's stasis of blood, which dissipates blood work, to be made
Without appended by, intrinsic heat just, to appear, reaches in thorough clear body up in fur from ying blood, the natural fibre line of meat with the power of the clear surname dissipate of peppermint and accumulates it heat
Stagnant heat, the healthy tendency for recovering body, pest of dispelling remove the purpose of poison.
Inventor is had found by long-term veterinary clinic, when warm disease occurs for livestock and poultry, shows as hyperpyrexia, spirit is heavy more
Strongly fragrant, hemostasis occurs for the visible blood cake of skin, vein, analyses as the main organs extensive bleeding such as the heart, lung, kidney, liver, intestines, stomach.To defend
Gas ying blood is dialectical, joins the army blood system for heat symptoms caused by an exopathgen, forces blood outgoing, blood cake occurs；Impairment of both QI and blood is caused eventually, qi depression to blood stasis occurs, blood vessels are stopped up
It fills in not all right and makes animal dead.Thus, livestock and poultry warm disease can effectively be subtracted using clearing heat and cooling blood, the principle of reatment of promoting blood circulation to remove blood stasis
The loss of light aquaculture.
Inventor confirms there is heat-clearing by the Chinese medicine composition that Radix Salviae Miltiorrhizae, the root bark of tree peony, rheum officinale, peppermint form by clinical trial
The effect of cool blood, promoting blood circulation to remove blood stasis, can effectively prevent livestock and poultry warm disease.It is prepared simultaneously using preparation method provided by the invention
The effective elements of the medicine in each taste can effectively be retained, while avoiding the use of organic solvent, reduce the toxic side effect of drug
Drug will not remain in livestock and poultry body, it is ensured that food safety, the oral solution or soluble powder finally obtained can be with livestock and poultry
The direct mixed feeding of feed, it is convenient and efficient, dosage can be adjusted at any time according to growth of animals or poultry situation, had for the prevention and treatment of livestock and poultry warm disease
Good effect.
Present invention Chinese medicine composition made of Radix Salviae Miltiorrhizae, the root bark of tree peony, rheum officinale, peppermint clinically takes clearing heat and cooling blood, promoting blood circulation
The principle of reatment for dissipating the stasis of blood can effectively mitigate loss caused by livestock and poultry warm disease.There is good efficacy to the prevention and treatment of livestock and poultry warm disease, and
Small side effects, drug residue free.
Specific embodiment
Embodiment 1
A kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, main components in percentage by weight is by weight are as follows: and 13 parts of Radix Salviae Miltiorrhizae, cortex moutan
12 parts, 5 parts of rheum officinale, 2 parts of peppermint；
Preparation method are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, received
Collect percolate, carry out ethyl alcohol recycling, medicinal extract a is obtained after recycling, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot, 10 times of weight of dosing material rheum officinale and cortex moutan total amount by formula rate
Water, boiling boil 1 hour, filter to obtain medical fluid b；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, aggregation medicinal material amount rheum officinale,
Cortex moutan, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid b decocted twice and medical fluid c is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, is added
Ethyl alcohol carries out alcohol precipitation, and the volume ratio of amount and medicinal extract that ethyl alcohol is added is 7:3, carries out ethyl alcohol recycling after alcohol precipitation, medicinal extract is obtained after recycling
D, density 1.2 are spare；
E, medicinal extract a and d is configured to the oral solution with crude drug identical weight with appropriate purified water.
Embodiment 2
A kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, main components in percentage by weight is by weight are as follows: and 10 parts of Radix Salviae Miltiorrhizae, cortex moutan
10 parts, 5 parts of rheum officinale, 1 part of peppermint；
Preparation method are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, received
Collect percolate, carry out ethyl alcohol recycling, medicinal extract a is obtained after recycling, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot, 10 times of weight of dosing material rheum officinale and cortex moutan total amount by formula rate
Water, boiling boil 1 hour, filter to obtain medical fluid b；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, aggregation medicinal material amount rheum officinale,
Cortex moutan, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid b decocted twice and medical fluid c is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, is added
Ethyl alcohol carries out alcohol precipitation, and the amount of ethyl alcohol and the volume ratio 7:3 of medicinal extract is added, carries out ethyl alcohol recycling after alcohol precipitation, medicinal extract d is obtained after recycling,
Density is 1.2, spare；
E, soluble powder is made in medicinal extract a and d spray drying.
Embodiment 3
A kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, main components in percentage by weight is by weight are as follows: and 20 parts of Radix Salviae Miltiorrhizae, cortex moutan
15 parts, 6 parts of rheum officinale, 2 parts of peppermint；
Preparation method are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, received
Collect percolate, carry out ethyl alcohol recycling, medicinal extract a is obtained after recycling, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot, 10 times of weight of dosing material rheum officinale and cortex moutan total amount by formula rate
Water, boiling boil 1 hour, filter to obtain medical fluid b；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, aggregation medicinal material amount rheum officinale,
Cortex moutan, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid b decocted twice and medical fluid c is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, is added
Ethyl alcohol carries out alcohol precipitation, and the amount of ethyl alcohol and the volume ratio 7:3 of medicinal extract is added, carries out ethyl alcohol recycling after alcohol precipitation, medicinal extract d is obtained after recycling,
Density is 1.2, spare；
E, medicinal extract a and d is configured to the oral solution with crude drug identical weight with appropriate purified water.
Embodiment 4
A kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, main components in percentage by weight is by weight are as follows: and 15 parts of Radix Salviae Miltiorrhizae, cortex moutan
13 parts, 6 parts of rheum officinale, 1 part of peppermint；
Preparation method are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, received
Collect percolate, carry out ethyl alcohol recycling, medicinal extract a is obtained after recycling, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot, 10 times of weight of dosing material rheum officinale and cortex moutan total amount by formula rate
Water, boiling boil 1 hour, filter to obtain medical fluid b；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, aggregation medicinal material amount rheum officinale,
Cortex moutan, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid decocted twice is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, and ethyl alcohol is added and carries out
Alcohol precipitation, is added the amount of ethyl alcohol and the volume ratio 7:3 of medicinal extract, and ethyl alcohol recycling is carried out after alcohol precipitation, after recycling medicinal extract, density 1.2,
It is spare；
E, medicinal extract a and d is configured to the oral solution with crude drug identical weight with appropriate purified water.
The result of clinical observation of the present invention is as follows:
Test example 1
Shandong Shouguang farm, 8 henhouses, 19000 chickens of every henhouse, the death of daily every henhouse during morbidity
Quantity is between 200-400.Jumpbogroup shows as feed intake decline, and respiratory symptom is obvious, snore, phenomena such as coughing, shouting strangely
Increase, eyelet reddens, sheds tears, and excrement is dry.It is serious to analyse visible tracheorrhagia, lung's hemostasis necrosis, myocardium bleeding, kidney
Enlargement bleeding, hemorrhage of pancreas.
The chicken of every henhouse and feed is given to take together respectively using the oral solution of embodiment 1, medication 3 days, daily every henhouse
Death toll be down to 40-50 only.Jumpbogroup feed intake obviously increases, and restores to normal level, respiratory symptom is substantially reduced, shouts strangely
It significantly reduces.
Test example 2
Shandong region chicken house, 12 henhouses, every house 20000, daily every house death toll is at 300-500 during morbidity
Between.It is that feed intake declines that jumpbogroup, which is cashed, and illness chicken spirit is depressed, and respiratory symptom is serious, snore, cough, shout strangely etc. it is existing
As increasing, excrement is dry.It is serious to analyse visible tracheorrhagia, lung's hemostasis necrosis, myocardium bleeding, kidney enlargement bleeding, pancreas
Bleeding.
It is drunk to the chicken in henhouse as drinking water using after the molten water of the soluble powder of embodiment 2, after medication 4 days, daily
The death toll of every henhouse is down to 60-70 only.Jumpbogroup feed intake obviously increases, and restores to normal level, respiratory symptom is obvious
Mitigate, shouts strangely and significantly reduce.
Comparative example
Shandong Changle farm, 6 henhouses, 18900 chickens of every henhouse, happen suddenly acute warm disease, and jumpbogroup spirit is depressed,
Feed intake declines to a great extent, and the The dead quantity of daily every henhouse is up to more than 700.Poultry is main promptly to be controlled using qingwen baidu powder
It treats, combination is not improved for 3 days；It then using oral liquid treatment made of embodiment 1, is used in conjunction 3 days, daily every henhouse death
Number is dropped rapidly to 100 or so；After being used in conjunction 5 days, chicken group is returned to normal.
Claims (2)
1. a kind of Chinese medicine composition for preventing and treating livestock and poultry pestilence, it is characterised in that: composition proportion is by weight are as follows:
10~15 parts of Radix Salviae Miltiorrhizae, 10~13 parts of cortex moutan, 5~6 parts of rheum officinale, 1~2 part of peppermint；
According to above-mentioned prescription, oral solution or soluble powder, preparation method is made in composition are as follows:
A, Radix Salviae Miltiorrhizae is ground into coarse powder by formula rate, crosses 10 meshes, with 90% ethanol percolation of 5 times of weight of Radix Salviae Miltiorrhizae amount, collected and seep
Filter liquid, carry out ethyl alcohol recycling, after recycling medicinal extract a, the relative density 1.2 of medicinal extract is spare, and the Radix Salviae Miltiorrhizae dregs of a decoction are collected；
B, cortex moutan, rheum officinale are knocked down into Decocting pot by formula rate, the water of 10 times of weight of dosing material rheum officinale and cortex moutan total amount,
Boiling is boiled 1 hour, and medical fluid b is filtered to obtain；
C, Decocting pot is put into together by the Radix Salviae Miltiorrhizae dregs of a decoction that formula rate takes peppermint and a step to obtain, add up medicinal material amount rheum officinale, tree peony
Skin, Radix Salviae Miltiorrhizae, peppermint 10 times of weight water, boiling boil 0.5 hour, filter to obtain medical fluid c；
D, the medical fluid b decocted twice and medical fluid c is merged, is concentrated under reduced pressure, being concentrated into medicinal extract density is 1.1, and ethyl alcohol is added
Alcohol precipitation is carried out, the volume ratio of amount and medicinal extract that ethyl alcohol is added is 7:3, carries out ethyl alcohol recycling after alcohol precipitation, and medicinal extract d is obtained after recycling, close
Degree is 1.2, spare；
E, medicinal extract a and d is configured to the oral solution with crude drug identical weight with purified water；Or medicinal extract a and d are spray-dried and made
At soluble powder.
2. Chinese medicine composition according to claim 1, it is characterised in that: composition proportion is by weight are as follows:
13 parts of Radix Salviae Miltiorrhizae, 12 parts of cortex moutan, 5 parts of rheum officinale, 2 parts of peppermint.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101700290A (en) * | 2009-11-24 | 2010-05-05 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and preparation method thereof |
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| JP2599152B2 (en) * | 1987-12-26 | 1997-04-09 | 日清製粉株式会社 | Agent for prevention and treatment of pasturellosis in pigs |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101700290A (en) * | 2009-11-24 | 2010-05-05 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and preparation method thereof |
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Denomination of invention: Traditional Chinese medicinal composition for preventing and treating seasonal febrile diseases of poultry and livestock Effective date of registration: 20190606 Granted publication date: 20190115 Pledgee: Postal Savings Bank of China, Limited by Share Ltd, Weifang branch Pledgor: WEIFANG HAVING BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. Registration number: 2019980000087 |
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Date of cancellation: 20220601 Granted publication date: 20190115 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Weifang branch Pledgor: WEIFANG HUAYING BIOTECHNOLOGY Co.,Ltd. Registration number: 2019980000087 |