CN105030812A - Compound fungal polysaccharide capsule - Google Patents
Compound fungal polysaccharide capsule Download PDFInfo
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- CN105030812A CN105030812A CN201510353370.8A CN201510353370A CN105030812A CN 105030812 A CN105030812 A CN 105030812A CN 201510353370 A CN201510353370 A CN 201510353370A CN 105030812 A CN105030812 A CN 105030812A
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Abstract
The invention discloses a compound fungal polysaccharide capsule which comprises the following components in parts by weight: 15-25 parts of lentinan, 6-12 parts of agaricus blazei polysaccharide, 2-6 parts of coriolus versicolor polysaccharide, 5-15 parts of lycium barbarum polysaccharide, 1-5 parts of achyranthan, 3-8 parts of astragalus polysaccharide, 2-6 parts of basidiomycete polysaccharide, 2-5 parts of glycyrrhiza polysaccharide, 5-15 parts of gelatin, 5-8 parts of hydroxypropyl methyl cellulose, 8-15 parts of carrageenan, 7-18 parts of alginate, 2-4 parts of carboxymethyl gulcomannan, 1-3 parts of polydimethylsiloxane, 1-3 parts of glycerinum, 3-6 parts of polyethylene glycol, 2-5 parts of magnesium stearate, 0.1-0.5 part of ethylparaben, 2-5 parts of methyl parahydroxybenzoats, 2-5 parts of lauryl sodium sulfate, 0.2-0.6 part of methylsilicone oil, and 60-80 parts of purified water. According to the compound fungal polysaccharide capsule, the multiple fungal polysaccharides are adopted and compounded, and play a synergistic effect through the abovementioned ratio, and therefore, the compound fungal polysaccharide capsule has the functions of resisting viruses and tumors and boosting immunity.
Description
[technical field]
The present invention relates to the technical field of health food and medicine, particularly a kind of technical field of composite fungi amylose capsule.
[background technology]
Polysaccharide is the abbreviation of polysaccharide, has the high polymer that the monosaccharide groups of more than 10 is formed by connecting by major key.Generally be made up of individual even several thousand monosaccharide groups of hundreds of.In the world, fungus polysaccharide is called as and is called " knubble biological reaction instrumentality ", shows by research, active polysaccharide composition β-D (1-73) glucose of medicinal fungus to allos, the even genetic tumor of homology all changes.In addition, it also has the poly-effect of antibacterium, antiviral and anticoagulant, improves liver function and conciliates virulence, improve the utilization rate of animal hypoxia-bearing capability and oxygen, reduce the viscosity of blood, increase myocardial contraction, improve the rhythm of the heart, blood sugar lowering, calmness, ease pain, relieving asthma, cough-relieving, the effect of reducing phlegm.
Active polysaccharide great majority can immune stimulating activity, can strengthen the effect of reticuloendothelial system phagocytic tumor cell, promotes lymphocyte transformation, activated T cell and B cell, and the formation of enhancing antibody.Thus there is antineoplastic activity to a certain extent.But direct lethal effect be there is no for tumor cell.Active polysaccharide can reduce the incidence rate of methyl cholanthrene induced tumor, to some, extensively transfer easily occurs, not easily takes operative treatment and radiotherapeutic leukemia, lymphoma etc., valuable especially.
Owing to there is no b-type amylase in human body, fungus polysaccharide to enter after human body can not digested, decompose, absorb.But the receptors bind directly and on cell membrane, thus pharmacologically active can be there is.The kind of fungus polysaccharide is a lot, and because the monosaccharide kind contained by it is different, molecular structure is different, pharmacologically active is also different.The implication of " compound " is special, and it is never the simple mixing of arbitrarily several or any amount.It improves immune effect and is obviously better than single-activity polysaccharide, and often kind of active polysaccharide all through repetition test and repeatedly selection of clinical, has been selected active higher and have the kind of complementary action, reached more comprehensively, more efficient result.
[summary of the invention]
Object of the present invention solves the problems of the prior art exactly, proposes a kind of composite fungi amylose capsule, selects multiple fungus polysaccharide compound, gives full play to synergism through proportioning, antiviral, antitumor, enhancing immunologic function.
For achieving the above object, the present invention proposes a kind of composite fungi amylose capsule, comprise following component and the mass ratio of each component is: lentinan 15 ~ 25 parts, Agaricus blazeipolysaccharides 6 ~ 12 parts, krestin 2 ~ 6 parts, lycium barbarum polysaccharide 5 ~ 15 parts, Inokopolyose 1 ~ 5 part, astragalus polysaccharides 3 ~ 8 parts, Cupressaceae granulose 2 ~ 6 parts, Angelica Polysaccharide 2 ~ 5 parts, 5 ~ 15 parts, gelatin, hydroxypropyl emthylcellulose 5 ~ 8 parts, carrageenan 8 ~ 15 parts, alginate 7 ~ 18 parts, Carboxyl Methyl Glucomannan 2 ~ 4 parts, polydimethylsiloxane 1 ~ 3 part, glycerol 1 ~ 3 part, Polyethylene Glycol 3 ~ 6 parts, magnesium stearate 2 ~ 5 parts, ethyl hydroxybenzoate 0.1 ~ 0.5 part, methyl parahydroxybenzoate 2 ~ 5 parts, sodium lauryl sulphate 2 ~ 5 parts, methyl-silicone oil 0.2 ~ 0.6 part, purified water 60 ~ 80 parts.
As preferably, the preparation method of described lentinan, Agaricus blazeipolysaccharides, Cupressaceae granulose, krestin adopts extraction extraction, and ultrasonic assistant extracts, select 75% soak with ethanol 1 ~ 2 hour, separation of supernatant, precipitate is soluble in water, high speed dispersion, supernatant is dry, collects dry powder.
As preferably, described hyperacoustic frequency is 20 ~ 80Hz; High speed dispersion rotating speed 1000 ~ 2000rpm, working time 10 ~ 20min.
As preferably, described supernatant drying means is vacuum drying, spraying dry or lyophilization.
As preferably, the extracting method of described lycium barbarum polysaccharide, Inokopolyose, astragalus polysaccharides, Angelica Polysaccharide comprises raw material pulverizing, extraction with aqueous solution: soak by water, centrifugal filtration, filtrate vacuum concentration, then by 75% alcohol settling, centrifugal filtration, ethanol reclaims, extractum, 60 DEG C ~ 80 DEG C hot water dissolvings, resin absorption removal heavy metal, spraying dry, dry powder is collected and is sieved.
As preferably, described alginate is potassium alginate, and described carrageenan adopts the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.
Beneficial effect of the present invention: the present invention selects multiple fungus polysaccharide compound, synergism is given full play to through proportioning, fungus polysaccharide belongs to mushroom polysaccharide: comprise glucosan, mannan, heteropolysaccharide, glycoprotein, peptidoglycan, has many-sided biological activitys such as antitumor, immunomodulating, antithrombotic, defying age, blood sugar lowering, blood fat reducing, antioxidant activity, antithrombase.Antiviral, antitumor, enhancing immunologic function, life-time service has no side effect, and can be used as medicine and health product popularization.
Below in conjunction with detailed description of the invention, the present invention is described in further detail.
[detailed description of the invention]
A kind of composite fungi amylose capsule of the present invention, comprise following component and the mass ratio of each component is: comprise following component and the mass ratio of each component is: lentinan 15 ~ 25 parts, Agaricus blazeipolysaccharides 6 ~ 12 parts, krestin 2 ~ 6 parts, lycium barbarum polysaccharide 5 ~ 15 parts, Inokopolyose 1 ~ 5 part, astragalus polysaccharides 3 ~ 8 parts, Cupressaceae granulose 2 ~ 6 parts, Angelica Polysaccharide 2 ~ 5 parts, 5 ~ 15 parts, gelatin, hydroxypropyl emthylcellulose 5 ~ 8 parts, carrageenan 8 ~ 15 parts, alginate 7 ~ 18 parts, Carboxyl Methyl Glucomannan 2 ~ 4 parts, polydimethylsiloxane 1 ~ 3 part, glycerol 1 ~ 3 part, Polyethylene Glycol 3 ~ 6 parts, magnesium stearate 2 ~ 5 parts, ethyl hydroxybenzoate 0.1 ~ 0.5 part, methyl parahydroxybenzoate 2 ~ 5 parts, sodium lauryl sulphate 2 ~ 5 parts, methyl-silicone oil 0.2 ~ 0.6 part, purified water 60 ~ 80 parts.
The preparation method of described lentinan, Agaricus blazeipolysaccharides, Cupressaceae granulose, krestin adopts extraction extraction, and ultrasonic assistant extracts, and selects 75% soak with ethanol 1 ~ 2 hour, separation of supernatant, precipitate is soluble in water, high speed dispersion, supernatant is dry, collects dry powder.Described hyperacoustic frequency is 20 ~ 80Hz; High speed dispersion rotating speed 1000 ~ 2000rpm, working time 10 ~ 20min.Described supernatant drying means is vacuum drying, spraying dry or lyophilization.The extracting method of described lycium barbarum polysaccharide, Inokopolyose, astragalus polysaccharides, Angelica Polysaccharide comprises raw material pulverizing, extraction with aqueous solution: soak by water, centrifugal filtration, filtrate vacuum concentration, again by 75% alcohol settling, centrifugal filtration, ethanol reclaims, extractum, 60 DEG C ~ 80 DEG C hot water dissolvings, resin absorption removal heavy metal, spraying dry, dry powder is collected and is sieved.Described alginate is potassium alginate, and described carrageenan adopts the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.
Medicament selection of the present invention:
1, fungus polysaccharide
Fungus polysaccharide is a kind of macromolecule polymer, has complicated biological activity and function, has many-sided biological activitys such as antitumor, immunomodulating, antithrombotic, defying age, blood sugar lowering, blood fat reducing, antioxidant activity, antithrombase.
Fungus polysaccharide is not direct killing tumor cell to the therapeutical effect of tumor, but by strengthening the immune defense system of patient, reaches the effect of cancer-resisting.Experiment proves, the polysaccharide proposed from Lentinus Edodes, the Radix Astragali, Cupressaceae bacterium can strengthen the function of T cell, makes the animal of immunologic hypofunction recover normal, has activation especially to the T cell NK cell and LAK cell with killing tumor cell function.
Polysaccharide is again immunized B cells activator, can promote the propagation of B cell as astragalus polysaccharides, lentinan, Cupressaceae granulose, krestin etc., makes it produce a large amount of immune globulin antibody, thus strengthens resistance against diseases.
The material of polysaccharide is powerful tumor necrosis factor (TNF) derivant, macrophage, particularly the cell of toxicity macrophage to tumor has very strong lethality, and it can synthesize and secreting tumor necrosis factor (TNF), makes tumor hemorrhagic necrosis.Inject polysaccharide the 8th day to animal, the generation of TNF peaks, thus plays anticancer function.
Cupressaceae granulose can induce body to produce interferon.Interferon (IFN) is home built antiviral and cancer-resisting substance in body.The Cupressaceae bacterium of adding every milliliter of 10-100 microgram concentration can make normal person produce the raising respectively 8 times of interferon-alpha and IFN-γ and 4 times.
Polyose medicament can produce by activated T cell inducing endogenous interleukin-22, thus avoids toxicity and the side reaction of commodity interleukin-22.Interleukin II (IL-2) is SCIF, produced by the T cell activated, immune t-cell long-term surviving can be safeguarded, the growth of T killer cell and LAK cell can be induced again, therefore become the up-to-date medicine of virus such as treatment tumor and acquired immune deficiency syndrome (AIDS) etc.The sensitivity of cell to interleukin-22 can also be improved, maximum hospital benefit can be produced at lower doses.
2, lentinan
Lentinus Edodes is rich in vitamin B group, ferrum, potassium, provitamin D (changing into vitamin D after Exposure to Sunlight).The edible part of dried thin mushroom accounts for 72%, every 100g eats moisture 13% in part, ash 4.9%, protein 18.64%, fat 4.8%, carbohydrate 71%, calcium 124mg, phosphorus 415mg, ferrum 25.3mg, vitaminB10 .07mg, vitamin B2 1.13mg, nicotinic acid 18.9mg.Wherein in the majority with hemicellulose in carbohydrate, main component is mannitol, trehalose and bacterium sugar, glucose, pentosan, methylpentosan etc.Modern study proves, has the T cell of immunologic function active, can reduce the ability of methyl cholanthrene induced tumor in lentinan scalable human body.Lentinus Edodes has strong inhibitory action to cancerous cell, is 97.5% to the suppression ratio of white mice sarcoma 180, is 80% to the suppression ratio of ehrlich carcinoma.Lentinus Edodes, also containing double stranded RNA, can be induced and produce interferon, have anti-virus ability.
Lentinan is the effective active composition extracted from quality xianggu sporophore, is the principle active component of Lentinus Edodes, is a kind of host immune reinforcing agent, and lentinan has antiviral, antitumor, immunity moderation function and stimulates the effects such as interferon formation.
3, krestin
Coriolous Dersicolor (Fr.) Quel is a kind of mushroom parasitized on withered tree, is one of fungus of most medical value, have heat clearing away, removing toxic substances, antiinflammatory, anticancer, the effect such as to protect the liver.Coriolous Dersicolor (Fr.) Quel is containing abundant protein, fat, polysaccharide, peptidoglycan, glucosan, lignin, aminoacid etc., there is the function of strengthening by means of tonics, the body resistance strengthening and constitution consolidating, many clothes can play effect of life lengthening, wherein protein and amino acid whose content are several times to tens times of general vegetable and fruit, fat content is very low, account for the 0.2%-3.6% of dry product weight, and wherein 74-83% is the unsaturated fatty acid that health is useful.
In Coriolous Dersicolor (Fr.) Quel, main active is krestin, and krestin has immunoloregulation function, is good immunostimulant, has and strengthens immune cell function and identification ability, improves the effects such as the amount of IgM; Krestin has liver protection function simultaneously, significantly can reduce serum transaminase, has obvious repair to liver tissue lesions and hepatic necrosis.
4, Inokopolyose
Radix Achyranthis Bidentatae has invigorating the liver and kidney, bone and muscle strengthening, controls the effects such as waist knee joint is tingle, liver sausage is dizzy, dissipating blood stasis blood, subduing inflammation; Inokopolyose is separation from Radix Achyranthis Bidentatae, extracts a kind of micromolecular polysaccharide compound obtained; pharmacological testing shows that it has and improves body's immunity, leukocyte increasing, Tumor suppression transfer and the liver protecting function, and long-term taking is without any side effects.Inokopolyose has immunocompetent micromolecular polysaccharide, compared with some known polysaccharide, it is little that Inokopolyose has molecular weight, no antigen, good water solubility, human body easily absorbs, chemical extraction steady quality, not only can be used as a kind of disease of Drug therapy immunologic hypofunction, as tumor, hepatitis etc., and can be used as a kind of immunostimulant and be developed to health product.
Inokopolyose goods can strengthen body immunity, the cell number that in increasing serum hemolysin and spleen, antibody is formed, and improve serum immune globulin, excite the phagocytic function of reticuloendothelial system, promote lymphopoiesis, strengthen the activity of NK cell and CTL cell.Confirm through on probation, it can the leukopenia that causes because of chemotherapy of Tumor suppression patient, and the effective percentage that leukocyte is raised reaches 97%.Immune wound can also be recovered simultaneously, play the effect recovering liver function, enhancing human bone marrow hemopoietic function, Tumor suppression growth, there is no side effect.
Embodiment:
Medicated powder formula: lentinan 20 parts, Agaricus blazeipolysaccharides 10 parts, krestin 5 parts, lycium barbarum polysaccharide 12 parts, Inokopolyose 3 parts, astragalus polysaccharides 5 parts, Cupressaceae granulose 5 parts, Angelica Polysaccharide 3 parts,
Capsule shells formula: 15 parts, gelatin, hydroxypropyl emthylcellulose 6 parts, carrageenan 12 parts, alginate 16 parts, Carboxyl Methyl Glucomannan 2.5 parts, polydimethylsiloxane 2 parts, glycerol 2 parts, Polyethylene Glycol 3 parts, magnesium stearate 4 parts, ethyl hydroxybenzoate 0.3 part, methyl parahydroxybenzoate 2 parts, sodium lauryl sulphate 5 parts, methyl-silicone oil 0.3 part, purified water 70 parts.
The preparation method of lentinan, Agaricus blazeipolysaccharides, Cupressaceae granulose, krestin adopts extraction extraction, and ultrasonic assistant extracts, and hyperacoustic frequency is 60Hz; Select 75% soak with ethanol 1.5 hours, separation of supernatant, precipitate is soluble in water, high speed dispersion, high speed dispersion rotating speed 1600rpm, working time 15min.Supernatant vacuum drying, collects dry powder.
The extracting method of lycium barbarum polysaccharide, Inokopolyose, astragalus polysaccharides, Angelica Polysaccharide comprises raw material pulverizing, extraction with aqueous solution: soak by water, centrifugal filtration, filtrate vacuum concentration, again by 75% alcohol settling, centrifugal filtration, ethanol reclaims, extractum, 80 DEG C of hot water dissolvings, resin absorption removal heavy metal, spraying dry, dry powder is collected and is sieved.
By the dry powder proportionally number mixing for standby use made.
By water, capsule shells raw material proportionally number pour in capsule glue pot and fully mix, enter production line and make capsule shells.
The medicated powder of mixing is filled in capsule shells, completes the preparation of fungus polysaccharide capsule.
Above-described embodiment is to explanation of the present invention, is not limitation of the invention, anyly all belongs to protection scope of the present invention to the scheme after simple transformation of the present invention.
Claims (6)
1. a composite fungi amylose capsule, it is characterized in that: comprise following component and the mass ratio of each component is: lentinan 15 ~ 25 parts, Agaricus blazeipolysaccharides 6 ~ 12 parts, krestin 2 ~ 6 parts, lycium barbarum polysaccharide 5 ~ 15 parts, Inokopolyose 1 ~ 5 part, astragalus polysaccharides 3 ~ 8 parts, Cupressaceae granulose 2 ~ 6 parts, Angelica Polysaccharide 2 ~ 5 parts, 5 ~ 15 parts, gelatin, hydroxypropyl emthylcellulose 5 ~ 8 parts, carrageenan 8 ~ 15 parts, alginate 7 ~ 18 parts, Carboxyl Methyl Glucomannan 2 ~ 4 parts, polydimethylsiloxane 1 ~ 3 part, glycerol 1 ~ 3 part, Polyethylene Glycol 3 ~ 6 parts, magnesium stearate 2 ~ 5 parts, ethyl hydroxybenzoate 0.1 ~ 0.5 part, methyl parahydroxybenzoate 2 ~ 5 parts, sodium lauryl sulphate 2 ~ 5 parts, methyl-silicone oil 0.2 ~ 0.6 part, purified water 60 ~ 80 parts.
2. a kind of composite fungi amylose capsule as claimed in claim 1, it is characterized in that: the preparation method of described lentinan, Agaricus blazeipolysaccharides, Cupressaceae granulose, krestin adopts extraction extraction, ultrasonic assistant extracts, select 75% soak with ethanol 1 ~ 2 hour, separation of supernatant, precipitate is soluble in water, high speed dispersion, supernatant is dry, collects dry powder.
3. a kind of composite fungi amylose capsule as claimed in claim 2, is characterized in that: described hyperacoustic frequency is 20 ~ 80Hz; High speed dispersion rotating speed 1000 ~ 2000rpm, working time 10 ~ 20min.
4. a kind of composite fungi amylose capsule as claimed in claim 1, is characterized in that: described supernatant drying means is vacuum drying, spraying dry or lyophilization.
5. a kind of composite fungi amylose capsule as claimed in claim 1, is characterized in that: the extracting method of described lycium barbarum polysaccharide, Inokopolyose, astragalus polysaccharides, Angelica Polysaccharide comprises raw material pulverizing, extraction with aqueous solution: soak by water, centrifugal filtration, filtrate vacuum concentration, then by 75% alcohol settling, centrifugal filtration, ethanol reclaims, extractum, 60 DEG C ~ 80 DEG C hot water dissolvings, resin absorption removal heavy metal, spraying dry, dry powder is collected and is sieved.
6. a kind of composite fungi amylose capsule as claimed in claim 1, is characterized in that: described alginate is potassium alginate, and described carrageenan adopts the mixture of kappa-carrageenan and ι-carrageenan, and the ratio of kappa-carrageenan and ι-carrageenan is 1:1.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106418069A (en) * | 2016-09-12 | 2017-02-22 | 福建万亿店中店电子商务有限责任公司 | Beverage having efficacies of neutralizing effect of alcoholic drinks and protecting liver |
| CN106892996A (en) * | 2017-04-01 | 2017-06-27 | 林婷 | One kind lifting immunity polysaccharide extract and its manufacture method |
| CN108634319A (en) * | 2018-05-23 | 2018-10-12 | 宁波拜尔玛生物科技有限公司 | A kind of composition of adjunct antineoplastic and its application |
| WO2019227885A1 (en) * | 2018-05-30 | 2019-12-05 | 安徽德馨华海生物科技有限公司 | Capsule preparation of achyranthes aspera l. var. rubrafusca (wight) hook polysaccharide, preparation method, and applications |
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| CN104489458A (en) * | 2014-11-29 | 2015-04-08 | 浙江宏辉胶丸有限公司 | Empty capsule adopting coral fungus polysaccharide |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104489458A (en) * | 2014-11-29 | 2015-04-08 | 浙江宏辉胶丸有限公司 | Empty capsule adopting coral fungus polysaccharide |
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| 冯优等: "多糖类药物的研究进展", 《中国生化药物杂志》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106418069A (en) * | 2016-09-12 | 2017-02-22 | 福建万亿店中店电子商务有限责任公司 | Beverage having efficacies of neutralizing effect of alcoholic drinks and protecting liver |
| CN106892996A (en) * | 2017-04-01 | 2017-06-27 | 林婷 | One kind lifting immunity polysaccharide extract and its manufacture method |
| CN108634319A (en) * | 2018-05-23 | 2018-10-12 | 宁波拜尔玛生物科技有限公司 | A kind of composition of adjunct antineoplastic and its application |
| WO2019227885A1 (en) * | 2018-05-30 | 2019-12-05 | 安徽德馨华海生物科技有限公司 | Capsule preparation of achyranthes aspera l. var. rubrafusca (wight) hook polysaccharide, preparation method, and applications |
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