CN105012689A

CN105012689A - Traditional Chinese medicinal preparation for treating chemotherapy-induced oral ulcer

Info

Publication number: CN105012689A
Application number: CN201510397090.7A
Authority: CN
Inventors: 孙凤荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-29
Filing date: 2015-06-29
Publication date: 2015-11-04

Abstract

The present invention discloses a traditional Chinese medicinal decoction for treating chemotherapy-induced oral ulcer. The traditional Chinese medicine believes that oral ulcer belongs to the category of aphtha and canker sore. The common pathogenesis of chemotherapy-induced oral ulcer mostly comprises weakened body resistance, insufficient vital-qi, intolerance by nature, taste damage, transformation failure of spleen, spleen vacuity, blood dryness, outside wind-dryness evil, yin-yang deficiency, deficiency fire uprising and toxic heat accumulation. The invention selects traditional Chinese medicines including silverweed cinquefoil root, lucid ganoderma, rust-coloured crotalaria herb with root, beechey fig leaf, marsh orchis herb, scoparius, Stachys sieboldii Miq., engler abelia fruit or flower, wallich willow root, Cynanchum amplexicaule Hemsl., elecampane, Suchow mosla herb and nard, which are prepared into a soup. Clinical test proves the total efficiency reaching 95%, which is significantly better than 75% in the control group; and the curative effect is substantial.

Description

A kind of Chinese medicine preparation for the treatment of caused by radiotherapy and chemotherapy oral ulcer

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of caused by radiotherapy and chemotherapy oral ulcer.

Background technology

Oral ulcer is that tumor patient is accepting one of toxicity common in chemicotherapy process, clinical manifestation is mainly local pain, erythroplakia, erosion, ulcer, symptoms such as generating heat, weak can be there is in only a few, stomatitis caused by chemotherapy to mostly occur after chemotherapy 5 days, general lasting about 7 days, happening part was many at lip mucosa and left and right buccal mucosa.Life in patients can be had a strong impact on, delay treatment process, even secondary systemic infection.The cell toxicant based chemotherapy medicine of current Clinical practice and radiocurable target are DNA propagation and upgrade histiocyte rapidly, as marrow hemopoietic stem cells, Hair follicle epithelial cells and gastrointestinal epithelial cells etc.Cytotoxic chemotherapy medicine and lonizing radiation, while killing tumor cell, often can injure this type of normal tissue cell in various degree, thus cause multiple toxicity.Oral mucosa belongs to digestive tract top, top layer lining with the flat squamous epithelial cancer of the cladding of non-keratinization, this kind of cell DNA propagation updating decision, to chemotherapeutic and ray all responsive.Therefore, at use chemotherapeutics, particularly when methotrexate and Oral and facial tumor local irradiation, almost invariably can damage oral mucosa epithelial cell, cause ulcer to occur, secondary bacterial infection, the rule for the treatment of of doctor trained in Western medicine to oral ulcer lay particular emphasis on local anti symptom treatment, mainly oral cavity partial application antibiotic etc, but some patients may because of antibiotic select improper, or the generation of bacterial drug resistance, thus cause Endodontic failure.Applicant's clinical practice card is for many years agree, and oral ulcer caused by treatment by Chinese herbs chemotherapy, therapeutic effect is remarkable, the easy economy of method, and has no side effect.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine decoction for the treatment of caused by radiotherapy and chemotherapy oral ulcer.Motherland's medical science is thought: oral ulcer belongs to the traditional Chinese medical science " aphtha ", " mouth infections " category." Shengji Zonglu " is said: " aphtha person, has the Hot-air blowing device part of the body cavity above the diaphragm housing the heart and lungs by heart spleen, a smoked dispute, and is aphtha." indicate aphtha and the dirty relation of heart spleen two.Mostly chemicotherapy oral ulcer is that positive exogenous pathogen is contained, though the etiology and pathogenesis of morbidity is entirely not identical, positive QI-insufficiency, natural disposition is not resistance to, spleen injury, transformation failure of spleen, and insufficiency of the spleen blood is dry, and the outer heresy by wind-dryness, cause deficiency of both YIN and YANG, asthenic fire is superior, and pyretic toxicity gathers, and is the general character of its pathogenesis.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine decoction of this treatment caused by radiotherapy and chemotherapy oral ulcer is made up of the Chinese medicine of following weight portion: Radix potentillae anserinae 15-30 part, Ganoderma lucidum seu Japonicum 1-3 part, Herba Crotalariae Ferrugineae 15-25 part, Caulis et Folium Fici beecheyanae 30-60 part, Herba Orchidis Latifoliae 9-12 part, Flos Caraganae Sinicae 12-18 part, Rhizoma Humatae Tyermanni 9-15 part, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 15-24 part, Radix Salicis Wallichianae 20-30 part, Radix Cynanchi Amplexicaulis 18-30 part, Radix Inulae 3-9 part, Herba Moslae Soochowensis 9-12 part, Radix Et Rhizoma Nardostachyos 3-6 part.

Preferably, Radix potentillae anserinae 22 parts, Ganoderma lucidum seu Japonicum 2 parts, Herba Crotalariae Ferrugineae 20 parts, Caulis et Folium Fici beecheyanae 45 parts, Herba Orchidis Latifoliae 10 parts, Flos Caraganae Sinicae 15 parts, Rhizoma Humatae Tyermanni 12 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 19 parts, Radix Salicis Wallichianae 25 parts, Radix Cynanchi Amplexicaulis 24 parts, Radix Inulae 6 parts, Herba Moslae Soochowensis 11 parts, Radix Et Rhizoma Nardostachyos 5 parts.

Fang Zhong: Radix potentillae anserinae vigorate qi and replenish the blood, invigorating spleen and reinforcing stomach; Ganoderma lucidum seu Japonicum benefiting vital QI and blood, analgesia; Herba Crotalariae Ferrugineae invigorating the spleen and replenishing QI, spleen invigorating, diuretic; Caulis et Folium Fici beecheyanae invigorating the spleen and replenishing QI; Herba Orchidis Latifoliae enriching yin and nourishing kidney, spleen invigorating heart tonifying; Flos Caraganae Sinicae YIN nourishing and blood, stomach invigorating; Rhizoma Humatae Tyermanni wind-damp dispelling, heat-clearing and toxic substances removing; Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) wind-damp dispelling, relieving heat toxin; Radix Salicis Wallichianae wind dispelling, dehumidify antipyretic; Radix Cynanchi Amplexicaulis wind-damp dispelling, heat clearing away, removing toxic substances, detumescence; Radix Inulae promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach; Herba Moslae Soochowensis promoting the circulation of QI to relieve pain, stomach invigorating antiinflammatory; Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, activating spleen and strengthening stomach.

Clinical data

The all cases of physical data are in December, 2011 in December ,-2013 because of the Inpatients in Tumor of caused by radiotherapy and chemotherapy oral ulcer, extract 80 examples and are divided into treatment group and each 40 examples of matched group at random.Matched group man 22 example, female 28 example; Age 23-70 year, 45 years old mean age; Treatment group man 27 example, female 23 example; 25 ~ 67 years old age, 45.5 years old mean age; Two groups of not statistically significants (P < 0.05) in sex, age, Morbidity constitution ratio, have comparability.

Therapeutic Method treatment group adopts Chinese medicine preparation of the present invention, namely takes: Radix potentillae anserinae 22 parts, Ganoderma lucidum seu Japonicum 2 parts, Herba Crotalariae Ferrugineae 20 parts, Caulis et Folium Fici beecheyanae 45 parts, Herba Orchidis Latifoliae 10 parts, Flos Caraganae Sinicae 15 parts, Rhizoma Humatae Tyermanni 12 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 19 parts, Radix Salicis Wallichianae 25 parts, Radix Cynanchi Amplexicaulis 24 parts, Radix Inulae 6 parts, Herba Moslae Soochowensis 11 parts, Radix Et Rhizoma Nardostachyos 5 parts of decoctings make decoction; Every day 1 dose point takes for three times.Matched group adopts doctor trained in Western medicine traditional treatment oral ulcer method vitamin, erythromycin enteric-coated tablet etc. to carry out local application to affected part; Within 15 days, be a course for the treatment of, all treat a course for the treatment of for two groups and add up curative effect.

Criterion of therapeutical effect is cured: edema disappears, and ulcer healing, without pain or sense of discomfort; Effective: ulcer calibration reduces, ulcer point reduces, and pain and sense of discomfort are alleviated, and edema obviously alleviates, invalid: before and after treatment, ulcer is unchanged.

Therapeutic outcome two groups of Comparison of therapeutic refer to table 1

Table 1 liang group comparitive study

22 routine accountings 55.0% are cured by treatment group visible in table 1, invalid 2 routine accountings 5.0%, total effective rate reaches 95.0%, matched group cures 12 routine accountings 30.0%, invalid 10 routine accountings 25.0%, total effective rate reaches 75.0%, and two groups of cure rates, total effective rates have significant difference, and treatment group is obviously better than matched group (P < 0.05).

Detailed description of the invention

Embodiment one: take Radix potentillae anserinae 22 parts, Ganoderma lucidum seu Japonicum 2 parts, Herba Crotalariae Ferrugineae 20 parts, Caulis et Folium Fici beecheyanae 45 parts, Herba Orchidis Latifoliae 10 parts, Flos Caraganae Sinicae 15 parts, Rhizoma Humatae Tyermanni 12 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 19 parts, Radix Salicis Wallichianae 25 parts, Radix Cynanchi Amplexicaulis 24 parts, Radix Inulae 6 parts, Herba Moslae Soochowensis 11 parts, Radix Et Rhizoma Nardostachyos 5 parts, above-mentioned Chinese medicine decocting is made decoction.

Embodiment two: take Radix potentillae anserinae 15 parts, Ganoderma lucidum seu Japonicum 3 parts, Herba Crotalariae Ferrugineae 15 parts, Caulis et Folium Fici beecheyanae 60 parts, Herba Orchidis Latifoliae 9 parts, Flos Caraganae Sinicae 18 parts, Rhizoma Humatae Tyermanni 9 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 15 parts, Radix Salicis Wallichianae 30 parts, Radix Cynanchi Amplexicaulis 18 parts, Radix Inulae 9 parts, Herba Moslae Soochowensis 9 parts, Radix Et Rhizoma Nardostachyos 6 parts, above-mentioned Chinese medicine decocting is made decoction.

Embodiment three: take Radix potentillae anserinae 30 parts, Ganoderma lucidum seu Japonicum 1 part, Herba Crotalariae Ferrugineae 25 parts, Caulis et Folium Fici beecheyanae 30 parts, Herba Orchidis Latifoliae 12 parts, Flos Caraganae Sinicae 12 parts, Rhizoma Humatae Tyermanni 15 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 24 parts, Radix Salicis Wallichianae 20 parts, Radix Cynanchi Amplexicaulis 30 parts, Radix Inulae 3 parts, Herba Moslae Soochowensis 12 parts, Radix Et Rhizoma Nardostachyos 3 parts, above-mentioned Chinese medicine decocting is made decoction.

Claims

1. treat a Chinese medicine preparation for caused by radiotherapy and chemotherapy oral ulcer, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Radix potentillae anserinae 15-30 part, Ganoderma lucidum seu Japonicum 1-3 part, Herba Crotalariae Ferrugineae 15-25 part, Caulis et Folium Fici beecheyanae 30-60 part, Herba Orchidis Latifoliae 9-12 part, Flos Caraganae Sinicae 12-18 part, Rhizoma Humatae Tyermanni 9-15 part, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 15-24 part, Radix Salicis Wallichianae 20-30 part, Radix Cynanchi Amplexicaulis 18-30 part, Radix Inulae 3-9 part, Herba Moslae Soochowensis 9-12 part, Radix Et Rhizoma Nardostachyos 3-6 part.

2. a kind of Chinese medicine preparation for the treatment of caused by radiotherapy and chemotherapy oral ulcer as claimed in claim 1, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: preferred, Radix potentillae anserinae 22 parts, Ganoderma lucidum seu Japonicum 2 parts, Herba Crotalariae Ferrugineae 20 parts, Caulis et Folium Fici beecheyanae 45 parts, Herba Orchidis Latifoliae 10 parts, Flos Caraganae Sinicae 15 parts, Rhizoma Humatae Tyermanni 12 parts, Fructus seu flos abeliae englerianae (Abelia engleriana(Graebn.) Behd.) 19 parts, Radix Salicis Wallichianae 25 parts, Radix Cynanchi Amplexicaulis 24 parts, Radix Inulae 6 parts, Herba Moslae Soochowensis 11 parts, Radix Et Rhizoma Nardostachyos 5 parts.