CN107648506A - A kind of Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy and preparation method thereof - Google Patents

A kind of Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy and preparation method thereof Download PDF

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CN107648506A
CN107648506A CN201711195243.5A CN201711195243A CN107648506A CN 107648506 A CN107648506 A CN 107648506A CN 201711195243 A CN201711195243 A CN 201711195243A CN 107648506 A CN107648506 A CN 107648506A
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chinese medicine
radix
radiotherapy
nasopharyngeal carcinoma
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霍振中
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Nanning Keicheng Mdt Infotech Ltd
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Nanning Keicheng Mdt Infotech Ltd
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Abstract

The invention discloses a kind of Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy, 15 18 parts of the Radix Astragali, 10 13 parts of the fruit of glossy privet, 15 18 parts of radix pseudostellariae, 10 13 parts of oldenlandia diffusa, 10 13 parts of asparagus fern, 10 13 parts of radix rehmanniae recen, 10 13 parts of the stem of noble dendrobium, 10 13 parts of oriental wormwood, 9 12 parts of earthworm, 30 33 parts of reed rhizome, 15 18 parts of the red sage root, 10 13 parts of radix scrophulariae, 10 13 parts of great burdock achene, 10 13 parts of radix scutellariae, 12 15 parts of balloonflower root, 6 10 parts of honey-fried licorice root, 10 13 parts of Paris polyphylla.The present invention is in the case where motherland's Traditional Chinese medical theory instructs, on the basis of forefathers' experience is summarized,《Sweet dew is drunk》On the basis of former side, carry out dialecticalization cut out, with nourishing generate fluid, it is clearing heat and detoxicating, strengthen the body resistance to consolidate the constitution the effect of, can effectively alleviate oral mucositis caused by nasopharyngeal carcinoma radiotherapy.The principle of reatment of traditional simple clearing heat and promoting fluid is breached, is shown according to clinical verification, Chinese medicine of the invention has obvious therapeutic effect to oral mucositis caused by radiotherapy fiery poison, and clinical efficacy is definite, safe and free of toxic and side effects.

Description

A kind of Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy and preparation method thereof
Technical field：
The present invention relates to a kind of Chinese medicine and preparation method thereof, in oral mucositis caused by particularly a kind of alleviation nasopharyngeal carcinoma radiotherapy Medicine and preparation method thereof.
Background technology：
Nasopharyngeal carcinoma is China's common cancer, and wherein Guangdong, Hainan, Guangxi, Fujian, Hunan, Jiangxi Liu Sheng are that nasopharyngeal carcinoma is high Send out area.Radiotherapy is the preferred treatment means of current treatment nasopharyngeal carcinoma.But in Patients During Radiotherapy, patient per easily occur dry, The complication such as sore-throat, poor appetite, oral cavity and the wild skin lesion of radiation, wherein mucous membrane of mouth and skin injury is most common Acute radiation adverse reaction.With the progress of radiotherapy, the mucous membrane in irradiation field may occur in which congested, oedema, typically in radiotherapy Occurs rotten to the corn, ulcer after DT20GY, patient shows as oral cavity, oropharyngeal mucosae pain, substantially aggravated when swallowing, have a medical check-up and see oral cavity, mouth Pharynx mucous membrane is congested, shallow rotten to the corn with oedema or has pseudomembrane etc..Often increase with Radiotherapy dosimetry and aggravate, influence patients ' life quality and put Treatment process, and then influence nasopharyngeal carcinoma radiotherapy curative effect.Effective method how is found, further improves curative effect, mitigates radiotherapy not Good reaction is always the important topic of nasopharyngeal carcinoma clinical research.Cause oral mucosa damage to use local application radiotherapy at present more, Clinic conventional Dobell's sol, water melon frost etc., it is mainly bacteria growing inhibiting that it, which is acted on, promotes the reparation of damage, but said medicine Weaker to tissue infiltration power, the prevention and protective effect to the damage of mucous membrane deep are little.Therefore, its curative effect is poor.
The content of the invention：
The technical problems to be solved by the invention are：There is provided a kind of there is tonifying Qi to promote the production of body fluid, nourishing Yin and clearing heat removing toxic substances and can invigorate blood circulation Stagnation resolvation, the Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy curative for effect.
Its technical scheme is：The Chinese medicine of oral mucositis caused by alleviating nasopharyngeal carcinoma radiotherapy, its drug component and its parts by weight：
Radix Astragali 15-18 part fruit of glossy privet 10-13 part radix pseudostellariae 15-18 part oldenlandia diffusa 10-13 parts
Asparagus fern 10-13 part radix rehmanniae recen 10-13 part stem of noble dendrobium 10-13 part oriental wormwood 10-13 part earthworm 9-12 parts
Reed rhizome 30-33 part red sage root 15-18 part radix scrophulariae 10-13 part great burdock achene 10-13 parts
Radix scutellariae 10-13 part balloonflower root 12-15 part honey-fried licorice root 6-10 part Paris polyphylla 10-13 parts.
A kind of preparation method of the Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy：Its making step is as follows：
1. select marmite or enamel ware decocting；
2. Chinese medicine first uses cold water soak 20 minutes or so before entering to decoct, water consumption of boiling medicine answers dipped powder 1-3cm, after boiling by intense fire Change and be cooked by slow fire 20-30 minutes, one portion per day, every dose of Chinese medicine is decocted twice, takes about 400ml doses altogether, is divided sooner or later after meal after mixing Take.
The heresy of radiotherapy traditional Chinese medical science category fiery poison, easily hinder Tianjin consumption liquid, body fluid can carry QI, gas lose with Tianjin, the Radix Astragali, radix pseudostellariae in above-mentioned prescription Tonifying spleen lung qi, tonifying Qi are promoted the production of body fluid, and body fluid loss, easy deficiency of Yin Sheng Neire, are added and are given birth to the fruit of glossy privet, the dried rhizome of rehmannia, radix scrophulariae, reed rhizome, asparagus fern enriching yin Tianjin heat-clearing.Attacked in the heresy of fiery poison, discomfort in the throat, impairment of dispersing and descending function of the lung, facilitaing lung gas, great burdock achene clearing heat, relieving sore-throat are opened using balloonflower root.Radix scutellariae is apt to Clear part of the body cavity above the diaphragm housing the heart and lungs heat, radix scutellariae can be applied clearing heat and detoxicating；Heat evil easily press from both sides humectation migration it is refractory, the stem of noble dendrobium, oriental wormwood clearing heat and promoting diuresis can be added.Assistant is with white Flower HERBA HEDYOTIS DIFFUSAE, Paris polyphylla anticancer.Prolonged illness hinders Tianjin consumption liquid from silt, heat evil and easily causes qi and blood to condense, and adds with the red sage root, earthworm promoting blood circulationization The stasis of blood.
Beneficial effect：The present invention is in the case where motherland's Traditional Chinese medical theory instructs, on the basis of forefathers' experience is summarized,《It is sweet Dew drink》On the basis of former side, carry out dialecticalization cut out, with nourishing generate fluid, it is clearing heat and detoxicating, strengthen the body resistance to consolidate the constitution the effect of, can effectively delay Oral mucositis caused by solving nasopharyngeal carcinoma radiotherapy.The principle of reatment of traditional simple clearing heat and promoting fluid is breached, is shown according to clinical verification, The Chinese medicine of the present invention has obvious therapeutic effect to oral mucositis caused by radiotherapy fiery poison, and clinical efficacy is definite, safe and nontoxic Side effect.
Embodiment：
Embodiment 1：
The Chinese medicine of oral mucositis caused by alleviating nasopharyngeal carcinoma radiotherapy, its drug component and its weight g：
Radix Astragali 15g fruit of glossy privet 10g radix pseudostellariae 15g oldenlandia diffusas 10g
The g of asparagus fern 10g radix rehmanniae recen 10g stem of noble dendrobium 10g oriental wormwood 10g earthworms 12
Reed rhizome 30g red sage root 15g radix scrophulariae 10g great burdock achenes 10g
The g of radix scutellariae 10g balloonflower root 12g honey-fried licorice root 6g Paris polyphyllas 10.
A kind of preparation method of the Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy：Its making step is as follows：
1. select marmite or enamel ware decocting；
2. Chinese medicine first uses cold water soak 20 minutes or so before entering to decoct, water consumption of boiling medicine answers dipped powder 1-3cm, after boiling by intense fire Change and be cooked by slow fire 20-30 minutes, one portion per day, every dose of Chinese medicine is decocted twice, takes about 400ml doses altogether, is divided sooner or later after meal after mixing Take.
Embodiment 2：
The Chinese medicine of oral mucositis caused by alleviating nasopharyngeal carcinoma radiotherapy, its drug component and its weight g：
Radix Astragali 18g fruit of glossy privet 13g radix pseudostellariae 18g oldenlandia diffusas 13g
The g of asparagus fern 13g radix rehmanniae recen 13g stem of noble dendrobium 13g oriental wormwood 13g earthworms 9
Reed rhizome 33g red sage root 18g radix scrophulariae 13g great burdock achenes 13g
The g of radix scutellariae 13g balloonflower root 15g honey-fried licorice root 10g Paris polyphyllas 13.
A kind of preparation method of the Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy：Its making step is as follows：
1. select marmite or enamel ware decocting；
2. Chinese medicine first uses cold water soak 20 minutes or so before entering to decoct, water consumption of boiling medicine answers dipped powder 1-3cm, after boiling by intense fire Change and be cooked by slow fire 20-30 minutes, one portion per day, every dose of Chinese medicine is decocted twice, takes about 400ml doses altogether, is divided sooner or later after meal after mixing Take.
Embodiment 3：It is yellow.., female, 38 years old, because headache, tinnitus are admitted to hospital for 1 month, diagnose nasopharynx poorly differentiated squamous cell carcinoma （T2N0M0-Phase）, radiotherapy on April 24 in 13 days to 2000 March in 2000, the complex treatment of Chinese medicine plus-minus side, radiotherapy amount pharynx nasalis 7480cGy/62F/47d, neck preventive dose 5040cGy/42F/5W, Patients During Radiotherapy smoothly complete, patient's mouth mucous membrane only moderate Congested, pharyngalgia, can enter soft meal, and the swollen thing of CT promptings is checked after radiotherapy and is disappeared completely.
Embodiment 4：Wei.., man, 63 years old, because of blood sputum drawing back half a year, left side tinnitus was admitted to hospital for 2 months, diagnosed low point of nasopharynx Change squamous cell carcinoma（T3N0M0-Phase）, the radiotherapy on November 2, in 24 days to 1999 of August in 1999, radiotherapy alone, radiotherapy amount nose Pharyngeal 7400cGy/68F/7W, neck preventive dose 6200cGy/39F/6W, there are 2 degree of oral mucosa reaction after underwent within the 2nd week after radiotherapy, the 3rd, there are 3 degree of oral mucosa reaction after underwent within 4 weeks, need anti-inflammatory, nutritional support treatment to ensure that radiotherapy smoothly completes.Body weight subtracts after treatment Light 10KG.
1 clinical data：
70 many cases patients are grouped at random in the Nasopharyngeal Carcinoma Patients accepted for medical treatment in August, 1998 in April, 2000, in being divided into Medicine combination radiotherapy group（Treatment group）With radiation alone group, perspective study is carried out.Enter a group case standard：1 has pathology foundation to turn out to be nose Pharynx cancer, 2 category initial journey radiotherapies, except finding DISTANT METASTASES IN person before 3 radiotherapies and in radiotherapy, except 4 radiotherapies do not reach radical cure amount person, 5 are not It is willing to except cooperation Chinese medicine and follow-up person.Radiotherapy uses 3 60Co Hyperfractionations nasopharynx, basis cranii and neck regions, often Week irradiation 10 times, each pharynx nasalis dosage is 1.2GY, and total amount is up to 65 ~ 75GY, neck 45 ~ 55GY of preventive dose, therapeutic dose 55 ~ 70GY。
2 treatment methods：
Since before treatment 1 ~ 3 day, treatment group take traditional Chinese medicine daily sweet dew drink plus-minus side it is one, terminate to radiotherapy.Control group is simple Hyperfractionation, the same treatment group of method.Withdraw other medicines relevant with this disease during treatment.Radiotherapy terminates progress short term effect and commented Valency.
3 treatment results：
Nasopharyngeal carcinoma patients undergoing radiotherapy 76 is observed altogether, wherein finding DISTANT METASTASES IN in 1 radiotherapy；1 does not reach radical cure amount；4 fail Adhere to that treatment by Chinese herbs is taken in cooperation.Therefore actual evaluable patient totally 70, wherein treatment group 35, control group 35, two groups Sex, age, histological type, to set wild method, exposure dose similar.Treatment group's dosage oral mucosa damage substantially mitigates, performance Reduced for 2,3 degree of reaction cases, time of occurrence delay, 2,3 degree of reactivities are 45.7%（16/35）, and control group is 82.8（29/ 35）.Two groups relatively have significant difference.Radiological dose treatment group when damaging is more common in 3400 ~ 5000cGy, and compares Group is more common in 2400 ~ 3600cGy.
Table：Two groups of oral mucosa damage distributions
Reaction 0 degree 1 degree 2 degree 3 degree
Treatment group（%） 0（0/35） 54.3%（19/35） 28.6%（10/35） 17.1%（6/35）
Control group（%） 0（0/35） 17.1%（6/35） 48.6%（17/35） 34.2%（12/35）
Through Chi-square Test, X2=8.96, P are less than 0.01, there is significant differences.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto, Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.

Claims (2)

1. the Chinese medicine of oral mucositis caused by a kind of alleviation nasopharyngeal carcinoma radiotherapy, it is characterised in that its drug component and its parts by weight：
Radix Astragali 15-18 part fruit of glossy privet 10-13 part radix pseudostellariae 15-18 part oldenlandia diffusa 10-13 parts
9-12 parts of asparagus fern 10-13 part radix rehmanniae recen 10-13 part stem of noble dendrobium 10-13 part oriental wormwood 10-13 parts earthworm
Reed rhizome 30-33 part red sage root 15-18 part radix scrophulariae 10-13 part great burdock achene 10-13 parts
Radix scutellariae 10-13 part balloonflower root 12-15 part honey-fried licorice root 6-10 part Paris polyphylla 10-13 parts.
2. the preparation method of the Chinese medicine of oral mucositis caused by a kind of alleviation nasopharyngeal carcinoma radiotherapy according to claim 1, it is special Sign is：Its making step is as follows：
1. select marmite or enamel ware decocting；
2. Chinese medicine first uses cold water soak 20 minutes or so before entering to decoct, water consumption of boiling medicine answers dipped powder 1-3cm, after boiling by intense fire Change and be cooked by slow fire 20-30 minutes, one portion per day, every dose of Chinese medicine is decocted twice, takes about 400ml doses altogether, is divided sooner or later after meal after mixing Take.
CN201711195243.5A 2017-11-24 2017-11-24 A kind of Chinese medicine of oral mucositis caused by alleviation nasopharyngeal carcinoma radiotherapy and preparation method thereof Pending CN107648506A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113842430A (en) * 2021-11-16 2021-12-28 李桦康 Traditional Chinese medicine formula for regulating and controlling nasopharyngeal carcinoma radioactive oral mucositis and taking method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104306766A (en) * 2014-10-14 2015-01-28 贵港市中医医院 Traditional Chinese medicine prescription for preventing and treating radiation-induced oral mucositis and production method of traditional Chinese medicine prescription

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104306766A (en) * 2014-10-14 2015-01-28 贵港市中医医院 Traditional Chinese medicine prescription for preventing and treating radiation-induced oral mucositis and production method of traditional Chinese medicine prescription

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113842430A (en) * 2021-11-16 2021-12-28 李桦康 Traditional Chinese medicine formula for regulating and controlling nasopharyngeal carcinoma radioactive oral mucositis and taking method

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Application publication date: 20180202