CN104998070A - Traditional Chinese medicine for treating female menstrual edema - Google Patents

Abstract

In order to solve the technical problems, the invention provides traditional Chinese medicine for treating female menstrual edema. According to the traditional Chinese medicine, serrate glorybower herb, herba houttuyniae, semen strychni, ephedra herb, farfugium japonicum, morinda officinalis, anisetree bark, sweetgum fruit, rubus parvifolius, radix polygonati officinalis and powdered antler are used as monarch and ministerial medicine for achieving the effects of invigorating spleen to remove dampness, dispelling cold, inducing diuresis, regulating the menstruation and relieving swelling; pears, apples, pawpaws, white radishes, white gourds, longan arils, red beans, salvia miltiorrhiza, frankincense, rhizoma cyperi, sea tangle, sesames and nori are used as auxiliary medicine for achieving the effects of invigorating the spleen, nourishing the kidney, harmonizing the stomach, promoting blood circulation and removing the edema. The traditional Chinese medicine compound provided by the invention has the advantages that the theory of traditional Chinese medicine is matched and recombined; the medicine effects generate the synergistic effect, so that the effects of regulating the menstruation and removing the edema are achieved; the edema during the menstruation can be effectively treated.

Description

A kind of Chinese medicine for the treatment of female menstrual period edema

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine for the treatment of female menstrual period edema.

Background technology

Edema is local in the outer liquid of body cell caused by moisture accumulation or whole body swelling.Edema is relevant with the pathological changes of a lot of organ of health, causes the cause of disease of edema a lot, complicated and changeable.Environment residing for self, life style, behavior act etc. all may cause edema.Within menstrual onset the last week or two weeks, there is eyelid, the back of the hand in the women of some health, the slight edema of the even two lower limb of ankle, and irritated, insomnia, tired, the symptoms such as headache. during menstrual onset, edema and other symptoms just can disappear gradually, monthly often affect work and life like this.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, the cause of disease of going directly, and healing time is short, control instant effect.The medicine invigorating spleen to remove dampness being the monarch and his subjects with Herba Clerodendri Serrati, Cortex Nothapodytis Radicis, Herba Houttuyniae, Semen Strychni, Herba Ephedrae, Coniogramme japonica (Thunb.) Diels, Radix Morindae Officinalis, Cortex Illicii, Fructus Liquidambaris, Herba Rubi parvifolii, Rhizoma Polygonati Odorati, harts horn carbon, cold expelling diuresis, regulating menstruation detumescence; With pears, Fructus Mali pumilae, Fructus Chaenomelis, white turnip, Fructus Benincasae, Arillus Longan, Semen Phaseoli, Radix Salviae Miltiorrhizae, Olibanum, Rhizoma Cyperi, Thallus Laminariae (Thallus Eckloniae), Semen Sesami, Thallus Porphyrae for assist a ruler in governing a country medicine tonifying speen and tonifying kidney stomach function regulating, promoting the circulation of blood detumescence.Chinese medicine composition of the present invention, compatibility compound theory of Chinese medical science, each efficacy of drugs produces synergism, makes it the effect with regulating menstruation detumescence, thus can effectively treat edema in menstrual period.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of female menstrual period edema, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 10-20 part, Cortex Nothapodytis Radicis 10-20 part, Herba Houttuyniae 10-20 part, Semen Strychni 10-20 part, Herba Ephedrae 10-20 part, Coniogramme japonica (Thunb.) Diels 10-20 part, Radix Morindae Officinalis 10-20 part, Cortex Illicii 10-20 part, Fructus Liquidambaris 10-20 part, Herba Rubi parvifolii 10-20 part, Rhizoma Polygonati Odorati 10-20 part, harts horn carbon 10-20 part, pears 10-20 part, Fructus Mali pumilae 10-20 part, Fructus Chaenomelis 10-20 part, white turnip 10-20 part, Fructus Benincasae 10-20 part, Arillus Longan 10-20 part, Semen Phaseoli 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part, Rhizoma Cyperi 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Sesami 10-20 part, Thallus Porphyrae 10-20 part.

The invention provides a kind of Chinese medicine for the treatment of female menstrual period edema, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 12-18 part, Cortex Nothapodytis Radicis 12-18 part, Herba Houttuyniae 12-18 part, Semen Strychni 12-18 part, Herba Ephedrae 12-18 part, Coniogramme japonica (Thunb.) Diels 12-18 part, Radix Morindae Officinalis 12-18 part, Cortex Illicii 12-18 part, Fructus Liquidambaris 12-18 part, Herba Rubi parvifolii 12-18 part, Rhizoma Polygonati Odorati 12-18 part, harts horn carbon 12-18 part, pears 12-18 part, Fructus Mali pumilae 12-18 part, Fructus Chaenomelis 12-18 part, white turnip 12-18 part, Fructus Benincasae 12-18 part, Arillus Longan 12-18 part, Semen Phaseoli 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Olibanum 12-18 part, Rhizoma Cyperi 12-18 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Semen Sesami 12-18 part, Thallus Porphyrae 12-18 part.

The invention provides a kind of Chinese medicine for the treatment of female menstrual period edema, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 15 parts, Cortex Nothapodytis Radicis 15 parts, Herba Houttuyniae 15 parts, Semen Strychni 15 parts, 15 parts, Herba Ephedrae, Coniogramme japonica (Thunb.) Diels 15 parts, Radix Morindae Officinalis 15 parts, Cortex Illicii 15 parts, Fructus Liquidambaris 15 parts, Herba Rubi parvifolii 15 parts, Rhizoma Polygonati Odorati 15 parts, harts horn carbon 15 parts, pears 15 parts, Fructus Mali pumilae 15 parts, Fructus Chaenomelis 15 parts, white turnip 15 parts, 15 parts, Fructus Benincasae, Arillus Longan 15 parts, 15 parts, Semen Phaseoli, Radix Salviae Miltiorrhizae 15 parts, Olibanum 15 parts, Rhizoma Cyperi 15 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Semen Sesami 15 parts, Thallus Porphyrae 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine of female menstrual period edema, and the dosage form of described Chinese medicine composition is that sweet preparation method of refining pill comprises:

A, by formula proportion, each crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, gets supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1;

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Lac regis apis and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine of female menstrual period edema, and the dosage form of described Chinese medicine composition is that the preparation method of capsule comprises:

A, Radix Salviae Miltiorrhizae is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill;

B, surplus stock is entered in 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine of female menstrual period edema, and pharmaceutical dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, pin powder or slow releasing capsule.

The pharmacology and the property of medicine that the present invention relates to Chinese medicine preparation are as follows:

Herba Clerodendri Serrati:

[meridian distribution of property and flavor]: Xin Gan, temperature.Return spleen; Kidney channel

[function cures mainly] synthetism, pain relieving, preventing the attack (or recurrence) of malaria.Control fracture, traumatic injury, rheumatalgia, malaria.Clearing away heat-damp and promoting diuresis; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main hygropyretic dysentery; Stranguria; Beriberoid pyretic arthralgia; Dysmenorrhea due to blood stasis; Traumatic injury; Laryngopharynx swelling and pain; Swollen ulcer drug; Urticaria; Malaria

1. " register planted by Guangxi medicine ": refute bone, parasite killing, stomach invigorating, clearing away heart-fire, strengthening bone and muscle.Treating malaria disease, dysentery, headache, ophthalmia, traumatic injury.

2. " Guizhou medical herbs ": invigorating spleen to remove dampness, tonify deficiency benefit is damaged.Control weak edema, impairment caused by overstrain.

3. " mountain of papers Chinese herbal medicine ": bone-setting pain stopping, heat-clearing and toxic substances removing.Control fracture, traumatic injury, rheumatalgia, innominate toxic swelling.

Cortex Nothapodytis Radicis:

[nature and flavor] are warm in nature, acrid in the mouth.[return through] lung; Liver Channel

[function cures mainly] expelling wind and removing dampness, cold expelling of regulating the flow of vital energy.Main anemofrigid-damp arthralgia; Edema; Hernia.

Herba Houttuyniae:

Nature and flavor

Not [nature and flavor] " not Lu ": acrid in the mouth, tepor.《 Lv Cliff rock book on Chinese herbal medicine ": cool in nature, nontoxic." the southern regions of the Yunnan Province book on Chinese herbal medicine ": cold in nature, bitter in the mouth is pungent.

[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.

Semen Strychni:

[meridian distribution of property and flavor] bitter in the mouth, cold, poison greatly.Return liver, spleen two warp.

[function cures mainly] removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn paralysis and numbness, injury from falling down, ulcer sore pain; Poliomyelitis sequela, rheumatoid arthritis.Paralysis and numbness, myasthenia gravis etc.

Coniogramme japonica (Thunb.) Diels:

[another name]: Farfugium japonicum (L) Kitam.Liguaria Kaempferi Kino.

Hubei, Hunan claim: golden cup broad-mouthed receptacle for holding liquid, Herba Typhonii gigantei

Fujian claims: Farfugium kaemferi, the ferrum winter Herba Amaranthi tricoloris, large Horse hoof, large Herba Asari, Horse hoof Radix Angelicae Sinensis, a leaf lotus;

[meridian distribution of property and flavor] pungent, sweet, micro-hardship, cool.

[function cures mainly] promoting blood circulation and hemostasis, mass dissipating and swelling eliminating.For spitting of blood of coughing, have blood in stool, menoxenia, traumatic injury, mastitis, carbuncle furuncle and phyma poison.

Herba Ephedrae:

[meridian distribution of property and flavor] acrid in the mouth, micro-hardship, temperature, returns lung, urinary bladder channel.

[function cures mainly] diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.

Radix Morindae Officinalis:

[nature and flavor] acrid in the mouth, sweet; Slightly warm in nature; Return kidney, Liver Channel.

[function] reinforcing the kidney and supporting YANG, expelling wind and removing dampness, strengthening the tendons and bones.Cure mainly that impotence and seminal emission, cold womb are infertile, menoxenia, few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity be soft.

Cortex Illicii:

[meridian distribution of property and flavor] is micro-pungent, puckery, temperature; Slightly poisonous.Return bladder, kidney channel.

[effect]: expelling wind and removing dampness, promoting the circulation of QI to relieve pain.

[curing mainly]: the cards such as treatment rheumatic arthralgia, abdominal pain due to stagnation of QI, married woman's abdominal pain in menstruation.

Fructus Liquidambaris:

[meridian distribution of property and flavor] is bitter, flat.Return liver, kidney channel.

[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.

Herba Rubi parvifolii:

[nature and flavor] are bitter, puckery, cool.

[function cures mainly] has another name called Rubus Parvifolius L.; Clearing away heat and cooling blood, eliminating stagnation, pain relieving, inducing diuresis to remove edema.For cold, fever, laryngopharynx swelling and pain, spitting of blood, spits blood, dysentery, enteritis, hepatitis, hepatosplenomegaly, oedema due to nephritis, urinary system infection, calculus, menoxenia, leucorrhea, rheumatic ostalgia, treating swelling and pain by traumatic injury; Eczema is controlled in external, dermatitis; Take passages: " national Chinese herbal medicine compilation ".

Rhizoma Polygonati Odorati:

[meridian distribution of property and flavor] is sweet, is slightly cold.Attach to the lung and stomach meridians.

[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Harts horn carbon:

[nature and flavor] salty in the mouth, warm in nature.

[function cures mainly] promoting the circulation of blood, detumescence, kidney tonifying.Skin ulcer soup toxic swelling, blood stasis are had a pain, asthenia internal injury, lumbar vertebrae pain.

Pears:

[meridian distribution of property and flavor] sweet in the mouth is sour, cool in nature, enters lung, stomach warp;

[function] containing compositions such as more glycocide and tannic acids, can promote the production of body fluid, heat clearing away, expelling phlegm for arresting cough, have maintenance action to throat.

Fructus Mali pumilae:

[nature and flavor] property is flat, sweet, the micro-acid of sweet in the mouth.

[function] promoting the production of body fluid to quench thirst, clearing heat and relieving fidgetness, invigorating the stomach and promoting digestion, the research of Japanese hirosaki university confirms, the polyphenol in Fructus Mali pumilae can the propagation of anticancer.

Fructus Chaenomelis:

[return through] returns liver, spleen channel.

[function cures mainly] suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness, cures mainly the diseases such as weakness of the spleen and stomach, inappetence, hypogalactia, joint pain, numb limbs and tense tendons.

Fructus Benincasae:

[nature and flavor] slightly sweet flavor, cold nature.

[composition] this product is containing albumen, saccharide, carotene, multivitamin, crude fibre and calcium, phosphorus, ferrum, and potassium salts content is high, and sodium salt content is low.

[function] heat-clearing and toxic substances removing, diuresis and phlem dispersing, relieving restlessness quench the thirst, damp eliminating expelling summer-heat.For irritable feverish sensation of chest and heart, dysuria, lung abscess cough with asthma, cirrhotic ascites, hypertension etc.

White turnip:

[meridian distribution of property and flavor] acrid-sweet flavor, cool in nature, enter lung stomach warp.

[function] digests:

Dyspeptic abdominal distention, dyspepsia, poor appetite, can give birth to and smash juice and drink; Nausea and vomiting, general acid regurgitation water, chronic dysentery, all can shred honey and decoct and finely chew pharynx; Constipation, can cook; Oral ulcer, can smash juice and gargle.

Breathe:

Cough and expectoration, preferably shreds honey and decocts and finely chew pharynx; Pharyngolaryngitis, tonsillitis, hoarseness, aphonia, can smash juice and Sucus Zingberis takes together; Epistaxis, can give birth to and smash juice and a little decoction being taken hot of wine, also can smash juice collunarium; Spitting of blood, with Carnis caprae seu ovis, Carassius auratus with boiling food; Preventing cold, can cook.

Urinary system:

Various urinary system calculus, urinate not smooth, available section processed with honey is oral; Various edema, available Radix Raphani and Fructus Tritici Levis are decocted soup and take.

Fructus Benincasae:

[nature and flavor] slightly sweet flavor, cold nature.

[composition] this product is containing albumen, saccharide, carotene, multivitamin, crude fibre and calcium, phosphorus, ferrum, and potassium salts content is high, and sodium salt content is low.

[function] heat-clearing and toxic substances removing, diuresis and phlem dispersing, relieving restlessness quench the thirst, damp eliminating expelling summer-heat.For irritable feverish sensation of chest and heart, dysuria, lung abscess cough with asthma, cirrhotic ascites, hypertension etc.

Arillus Longan:

[nature and flavor] are warm in nature, and taste is sweet.

[function cures mainly] invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.

Olibanum: regulating QI, invigorates blood circulation, and pain relieving chases after poison.Antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, control wound.

Rhizoma Cyperi:

[nature and flavor] pungent micro-hardship is sweet, flat.

[function cures mainly] regulates the flow of vital energy resolving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.

Semen Phaseoli:

[return through]: lung; The heart; Spleen channel

[effect]: wind and heat dispersing, dampness removing to stop itchin, skin moistening skin care.

[curing mainly]: facial black speck, acne, Zha nose, women's head-ornaments urticaria, tinea versicolor.Swollen sitting and lying of harnessing the river must not, women's head-ornaments health is known swollen: Ramulus Mori ashing, drench juice, and it is full to boil the order of Semen Phaseoli hollow food, and famine is instant most, must not have a meal.(" Mei Shi collection proved recipe ")

Thallus Laminariae (Thallus Eckloniae):

[meridian distribution of property and flavor] gas raw meat, salty in the mouth.Return liver, stomach, kidney channel.

[function cures mainly] has hard masses softening and resolving, expectorant, the function of diuretic.For phlegm retention edema.Have the merit of hard masses softening and resolving, detumescencing diuresis, relaxing the bowels with lubricant drugs expectorant, bronchitis, pulmonary tuberculosis swollen for goiter, lymphonodi cervicales, cough and senile cataract etc., also try out in Therapeutic cancer clinically.

Semen Sesami:

Medicine is through recording

Shennong's Herbal is said, Semen Sesami cures mainly, and " damaging the spleen and stomach void is won, and mends five interior, physical strength profiting, longue meat, life essence-filling, marrow-benefittings.”

" the Master of Preserving Simplicity ": resistance to rheumatism, mends old and feeble.

Compendium of Material Medica: linum gets oil, with Bai Zhewei victory, takes with black person as good.

" Bencao Congxin ": the intestinal that makes us of linum clothes is slided, vital essence is not consolidated person and also should do not eaten.

" book on Chinese herbal medicine is looked for the truth ": instability of kidney-QI and see loose stool, sexual impotence, essence is sliding, leucorrhea, all avoided use.

Health preserving in ancient times scholar TAO Hong-Jing was once said: among eight paddy, and only this is good, celestial family do meal bait it, disconnected paddy is long-living.

At ancient Chinese, Semen Sesami is always regarded as life lengthening food, and Song dynasty famous poet Soviet Union and Eastern Europe is also thought on slope, and Semen Sesami can keep fit body, defying age, steams linum with nine, and with removing the peel Poria, entering whitish honey is less wheaten food, and with the passing of time strength does not wane, and all kinds of diseases and ailments are from going, and this is long-living gist.

Dietary function

Semen Sesami sweet in the mouth, property are flat, enter liver, kidney, lung, spleen channel.

Enrich blood improving eyesight, intestine moistening of dispeling the wind, the lactogenesis that promotes the production of body fluid, the liver benefiting hair care, keep fit effect of body, defying age.

Can be used for that treatment physical weakness, dizziness and tinnitus, hypertension, hyperlipidemia, cough, physical weakness, early whitening of hair, anemia are sallow, deficiency of body fluid, constipation due to dry stool, breast less, the disease such as hematuria.

[purposes] is deficient for Liver and kidney, asthenia of essence and blood, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, myasthenia of limbs; Puerperal blood deficiency, hypogalactia; Blood deficiency and depleted fluid, dryness of the intestine constipation etc.

Thallus Porphyrae:

[performance]: sweet in the mouth, salty, cool in nature.Energy hard masses softening and resolving, removing heat-phlegm, diuresis.

Detailed description of the invention:

Embodiment 1, formula:

Herba Clerodendri Serrati 10g, Cortex Nothapodytis Radicis 10g, Herba Houttuyniae 10g, Semen Strychni 10g, Herba Ephedrae 10g, Coniogramme japonica (Thunb.) Diels 10g, Radix Morindae Officinalis 10g, Cortex Illicii 10g, Fructus Liquidambaris 10g, Herba Rubi parvifolii 10g, Rhizoma Polygonati Odorati 10g, harts horn carbon 10g, pears 10g, Fructus Mali pumilae 10g, Fructus Chaenomelis 10g, white turnip 10g, Fructus Benincasae 10g, Arillus Longan 10g, Semen Phaseoli 10g, Radix Salviae Miltiorrhizae 10g, Olibanum 10g, Rhizoma Cyperi 10g, Thallus Laminariae (Thallus Eckloniae) 10g, Semen Sesami 10g, Thallus Porphyrae 10g.

The preparation method of honey refining pill comprises:

A, by formula proportion, each crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, gets supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1;

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Lac regis apis and be twisted into pill.

animal local excitation is tested:

The allergic reaction on guinea pigs of invention formulation.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

acute toxicity test

Application mice carries out acute toxicity testing and shows: the preparation of Mouse oral gavage Chinese medicine composition of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation tablet of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

Model case and curative effect:

The Qin, female, at 26 years old age, before menstrual period, a couple of days just starts edema, dysmenorrhea, several years.Patient takes medicine fortnight of the present invention, and swelling alleviates, and after three weeks, edema disappears, and movable function takes a turn for the better, and consolidates a week, do not recur so far after next menstruation.

Embodiment 2, formula:

Herba Clerodendri Serrati 15g, Cortex Nothapodytis Radicis 15g, Herba Houttuyniae 15g, Semen Strychni 15g, Herba Ephedrae 15g, Coniogramme japonica (Thunb.) Diels 15g, Radix Morindae Officinalis 15g, Cortex Illicii 15g, Fructus Liquidambaris 15g, Herba Rubi parvifolii 15g, Rhizoma Polygonati Odorati 15g, harts horn carbon 15g, pears 15g, Fructus Mali pumilae 15g, Fructus Chaenomelis 15g, white turnip 15g, Fructus Benincasae 15g, Arillus Longan 15g, Semen Phaseoli 15g, Radix Salviae Miltiorrhizae 15g, Olibanum 15g, Rhizoma Cyperi 15g, Thallus Laminariae (Thallus Eckloniae) 15g, Semen Sesami 15g, Thallus Porphyrae 15g.

The preparation method of capsule comprises:

A, Radix Salviae Miltiorrhizae is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill;

B, surplus stock is entered in 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

acute toxicity test

Application mice carries out acute toxicity testing and shows: the capsule of Mouse oral gavage Chinese medicine composition of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

Embodiment 3, formula:

Herba Clerodendri Serrati 20g, Cortex Nothapodytis Radicis 20g, Herba Houttuyniae 20g, Semen Strychni 20g, Herba Ephedrae 20g, Coniogramme japonica (Thunb.) Diels 20g, Radix Morindae Officinalis 20g, Cortex Illicii 20g, Fructus Liquidambaris 20g, Herba Rubi parvifolii 20g, Rhizoma Polygonati Odorati 20g, harts horn carbon 20g, pears 20g, Fructus Mali pumilae 20g, Fructus Chaenomelis 20g, white turnip 20g, Fructus Benincasae 20g, Arillus Longan 20g, Semen Phaseoli 20g, Radix Salviae Miltiorrhizae 20g, Olibanum 20g, Rhizoma Cyperi 20g, Thallus Laminariae (Thallus Eckloniae) 20g, Semen Sesami 20g, Thallus Porphyrae 20g.

Preparation method is identical with embodiment 1.

long term toxicity test:

Select SD rat, give the Chinese medicine preparation honey pill agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Model case and curative effect:

Liu XX, female, 35 years old age, after bearing child long-term menstrual period edema two weeks, housework is not done, and meets child and goes to school and leaves school and be a problem yet, have a strong impact on quality of life.Patient takes medicine of the present invention every day three times, and each 1 ball (6g), edema disappears, and movable function takes a turn for the better.

Experimental study of the present invention:

The edema patient in menstrual period that 1 object and method 1.1 object are being seen and treated patients year June in January, 2012 to 2013.

1.2 method 1.2.1 inclusive criterias are menstrual woman (age was at 12 years old to 55 years old) 1..

1.2.2 exclusion standard is without endocrine metabolism or other chronic disease affected, also without hepatorenal disease history with take this research of pharmacohistory 1.2.3 affecting menstruation and treat to use Traditional Chinese medicine composition formula of the present invention, by consulting with patient, after obtaining patient's agreement, sign Informed Consent Form and hand-in-glove.1.2.4 by while clinical treatment, take Chinese medicine of the present invention, often take medicine points 3 doses, 3 doses/day, a week (seven days) is a course for the treatment of, takes after two weeks and observes.1.3 observation index two groups patients respectively at before taking medicine, take medicine January after, observe edema phenomenon.The routine patient's osteodynia of 2.1 short-term outcome's matched group 100 is not improved, and dysfunction is not improved; Have clear improvement respectively after taking a course for the treatment of of medicine group 100 routine patient, recovery from dysfunction is normal.

Efficacy assessment standard

1, cure: disappear, movable function recovers normal, and lab testing is normal.

2, take a turn for the better: swelling alleviates, movable function takes a turn for the better.

3, do not heal: swelling is unchanged.

Group of taking medicine therapeutic outcome statistics:

Cure rate 78%, improvement rate 19%, do not heal rate 3%

Wherein: total effective rate=cure rate+improvement rate

Total effective rate is 97%

Therefore a kind of Chinese medicine for the treatment of female menstrual period edema of the present invention is effective.

Claims (5)

1. treat a Chinese medicine for female menstrual period edema, it is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 10-20 part, Cortex Nothapodytis Radicis 10-20 part, Herba Houttuyniae 10-20 part, Semen Strychni 10-20 part, Herba Ephedrae 10-20 part, Coniogramme japonica (Thunb.) Diels 10-20 part, Radix Morindae Officinalis 10-20 part, Cortex Illicii 10-20 part, Fructus Liquidambaris 10-20 part, Herba Rubi parvifolii 10-20 part, Rhizoma Polygonati Odorati 10-20 part, harts horn carbon 10-20 part, pears 10-20 part, Fructus Mali pumilae 10-20 part, Fructus Chaenomelis 10-20 part, white turnip 10-20 part, Fructus Benincasae 10-20 part, Arillus Longan 10-20 part, Semen Phaseoli 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Olibanum 10-20 part, Rhizoma Cyperi 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Sesami 10-20 part, Thallus Porphyrae 10-20 part.

2. a kind of Chinese medicine for the treatment of female menstrual period edema according to claim 1, is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 12-18 part, Cortex Nothapodytis Radicis 12-18 part, Herba Houttuyniae 12-18 part, Semen Strychni 12-18 part, Herba Ephedrae 12-18 part, Coniogramme japonica (Thunb.) Diels 12-18 part, Radix Morindae Officinalis 12-18 part, Cortex Illicii 12-18 part, Fructus Liquidambaris 12-18 part, Herba Rubi parvifolii 12-18 part, Rhizoma Polygonati Odorati 12-18 part, harts horn carbon 12-18 part, pears 12-18 part, Fructus Mali pumilae 12-18 part, Fructus Chaenomelis 12-18 part, white turnip 12-18 part, Fructus Benincasae 12-18 part, Arillus Longan 12-18 part, Semen Phaseoli 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Olibanum 12-18 part, Rhizoma Cyperi 12-18 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Semen Sesami 12-18 part, Thallus Porphyrae 12-18 part.

3. a kind of Chinese medicine for the treatment of female menstrual period edema according to claim 1, is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:

Herba Clerodendri Serrati 15 parts, Cortex Nothapodytis Radicis 15 parts, Herba Houttuyniae 15 parts, Semen Strychni 15 parts, 15 parts, Herba Ephedrae, Coniogramme japonica (Thunb.) Diels 15 parts, Radix Morindae Officinalis 15 parts, Cortex Illicii 15 parts, Fructus Liquidambaris 15 parts, Herba Rubi parvifolii 15 parts, Rhizoma Polygonati Odorati 15 parts, harts horn carbon 15 parts, pears 15 parts, Fructus Mali pumilae 15 parts, Fructus Chaenomelis 15 parts, white turnip 15 parts, 15 parts, Fructus Benincasae, Arillus Longan 15 parts, 15 parts, Semen Phaseoli, Radix Salviae Miltiorrhizae 15 parts, Olibanum 15 parts, Rhizoma Cyperi 15 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Semen Sesami 15 parts, Thallus Porphyrae 15 parts.

4. a kind of Chinese medicine for the treatment of female menstrual period edema according to claim 1-3 any one, is characterized in that: the dosage form of described Chinese medicine composition is that sweet preparation method of refining pill comprises:

A, by formula proportion, each crude drug is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, gets supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1;

B, medicinal residues are soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, add Lac regis apis and be twisted into pill.

5. a kind of Chinese medicine for the treatment of female menstrual period edema according to claim 1-3 any one, is characterized in that: the dosage form of described Chinese medicine composition is that the preparation method of capsule comprises:

A, Radix Salviae Miltiorrhizae is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill;

B, surplus stock is entered in 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill;

C, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.