CN104997936A - Medicine for treating allergic rhinitis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating allergic rhinitis and a preparation method thereof. The medicine is prepared with astragalus membranaceus, rehmannia glutinosa, barbary wolfberry fruits, rhizoma atractylodis macrocephalae, angelica sinensis, chrysanthemum, cocklebur fruits, violet magnolia, radix paeoniae rubra, spina date seeds and notopterygium roots according to a certain weight ratio. The medicine has the functions of dispelling wind, repelling heat and treating wind-cold headache and nasosinusitis, the medicine is used for treating the allergic rhinitis and acts quickly, the curative effect is good, and no relapse occurs.

Description

Medicine of a kind for the treatment of of allergic rhinitis and preparation method thereof

Technical field

The present invention relates to medicine of a kind for the treatment of of allergic rhinitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Allergic dermatitis is also known as allergic rhinitis, that body increases Cucumber sensitivity and the site of pathological change that the occurs abnormality reaction inflammation based on nasal mucosa, most have regular hour and rule in old property outbreak, or with allergen exposure after occur suddenly.Main manifestations is rhinocnesmus, sneeze, flows clear nasal mucus, nasal obstruction and hyposmia or disappearance.At present, because Western medicine effectively cannot effect a radical cure allergic rhinitis, therefore there is great demand in the Chinese medicine of people to effective treatment of allergic rhinitis, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally successfully have found the medicine of effective treatment of allergic rhinitis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment of allergic rhinitis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects the Radix Astragali, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Chrysanthemi, Fructus Xanthii, Flos Magnoliae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi to carry out combination preparation, each efficacy of drugs is made by these drug regimens to produce synergism, thus can effective treatment of allergic rhinitis.

Wherein, select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating the spleen and replenishing QI, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Fructus Lycii is selected to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, seminal emission.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Fructus Xanthii is selected to be that temperature, poisonous, enter lung, Liver Channel, have loose wind, pain relieving, damp eliminating, the function of parasite killing, controls headche due to wind-cold, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four foot spasm and pain, mange, pruritus because its nature and flavor are sweet.Flos Magnoliae is selected to be that temperature, enter lung, stomach warp, dispel the wind, sensible function, controls headache, nasal sinusitis, has a stuffy nose obstructed, toothache because its nature and flavor are pungent.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Semen Ziziphi Spinosae is selected to be that flat, enter the heart, spleen, liver, gallbladder meridian, have nourishing the liver, mind calming, calm the nerves, the function of arresting sweating, controls restlessness of asrhenia type and insomnia because its nature and flavor are sweet, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Rhizoma Et Radix Notopterygii is selected to be that temperature, enter bladder, kidney channel, have loose exterior cold, wind-damp dispelling, the function in sharp joint, cure cold wind and cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore because its nature and flavor are worked hard.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Radix Aconiti Lateralis Preparata is selected to be because its property acrid-sweet flavor, heat, poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excess of YIN network sun, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Radix Astragali 50-60 gram, Radix Rehmanniae Preparata 15-30 gram, Fructus Lycii 10-15 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Radix Angelicae Sinensis 10-15 gram, Flos Chrysanthemi 8-10 gram, Fructus Xanthii 8-10 gram, Flos Magnoliae 8-10 gram, Radix Paeoniae Rubra 8-10 gram, Semen Ziziphi Spinosae 8-10 gram, Rhizoma Et Radix Notopterygii 8-10 gram, Herba Schizonepetae 8-10 gram, Radix Saposhnikoviae 8-10 gram, Radix Glycyrrhizae 8-10 gram, Radix Aconiti Lateralis Preparata 6-10 gram, Cortex Cinnamomi 6-10 gram, Mel 80-90 gram.

Be preferably:

The Radix Astragali 50 grams, Radix Rehmanniae Preparata 25 grams, Fructus Lycii 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 10 grams, Flos Chrysanthemi 8 grams, Fructus Xanthii 8 grams, Flos Magnoliae 9 grams, Radix Paeoniae Rubra 8 grams, Semen Ziziphi Spinosae 8 grams, Rhizoma Et Radix Notopterygii 10 grams, Herba Schizonepetae 10 grams, Radix Saposhnikoviae 10 grams, 10 grams, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 10 grams, Mel 85 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

2, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

3, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;

4, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

5, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

6, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

7, Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

8, Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces;

9, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

10, Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, core is pulled out, dries;

11, Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;

12, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;

13, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

14, Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

15, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add blister to mouth tastes slightly spicy sense again, taking-up ginger decoction leaching 1-3 days, then cooks, then roasts to seventy percent dry, pour in pot urgent stir-fry of useing force into rise to cigarette, till micro-drum splits, taking-up cools;

16, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

Two, prepare

Preparation method:

(1) by the described Radix Astragali, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Chrysanthemi, Fructus Xanthii, Flos Magnoliae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, put into container for stirring and be evenly ground into fine powder;

(2) Mel is refined into the tender honey of 110-115 DEG C;

(3) stick together grinding for the spice of fine powder adds Mel mixing system, then rubbing pill, 9 grams, every ball.

Medicine of the present invention has dispelling wind, the heat that disappears, control headche due to wind-cold, the function of nasal sinusitis, is used for the treatment of allergic rhinitis instant effect, good effect, does not recur.

In prescription, the Radix Astragali has removing the relative excess fire, except damp and hot function is monarch drug, and Fructus Lycii nourishing kidney, lung moistening, tonifying liver, improving eyesight, Flos Magnoliae has the function of expelling pathogenic wind and restoring the functions of orifices in face, and the two is ministerial drug; Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening is detoxified, the function of coordinating the actions of various ingredients in a prescription, and for making medicine, all medicines take stopgap measures with being left, said medicine is combined, makes it efficacy of drugs and produce synergism, thus can the recurrence of effective treatment of allergic rhinitis.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups and often organize 10, wherein one group is overdose test group, and another group is normal amount test group, overdose group is 0.5 gram/kg, normal amount group is 0.2 gram/kg, and administering mode is by administration by gavage administration after pill dilution, twice daily, serve on 7 days, observe administration reaction every day, result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 30 examples for medical treatment.

2, diagnostic criteria

Allergic rhinitis is clinical has the symptoms such as sneeze, stream clear water sample tears, nasal obstruction, rhinocnesmus to occur, and with the eye symptom such as ophthalmic pruritus, conjunctival congestion.The common nasal mucosa of sign is pale, edema, nasal cavity watery secretion.Skin prick test is positive, and/or Specificity IgE is positive.

3, Therapeutic Method

Above-mentioned pill is taken to patient, every day 2 times, each ball, early, evening bfore meals, 7 days courses for the treatment of, take 2 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: allergic rhinitis focus is eliminated, recovery from illness.

Take a turn for the better: sneeze, snivel are effectively controlled, nasal obstruction, rhinocnesmus symptom alleviate, and allergic inflammation progressively takes a turn for the better.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy Allergic Rhinitis 30 example of the present invention, effective 23 examples of result, obvious effective rate is 76.67%, and take a turn for the better 4 examples, and improvement rate is 13.33%, and invalid 3 examples, total effective rate is 90%.

Claims (3)

1. the medicine of a treatment of allergic rhinitis, it is characterized in that: it is made up of the crude drug in following weight range: Radix Astragali 50-60 gram, Radix Rehmanniae Preparata 15-30 gram, Fructus Lycii 10-15 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Radix Angelicae Sinensis 10-15 gram, Flos Chrysanthemi 8-10 gram, Fructus Xanthii 8-10 gram, Flos Magnoliae 8-10 gram, Radix Paeoniae Rubra 8-10 gram, Semen Ziziphi Spinosae 8-10 gram, Rhizoma Et Radix Notopterygii 8-10 gram, Herba Schizonepetae 8-10 gram, Radix Saposhnikoviae 8-10 gram, Radix Glycyrrhizae 8-10 gram, Radix Aconiti Lateralis Preparata 6-10 gram, Cortex Cinnamomi 6-10 gram, Mel 80-90 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

The Radix Astragali 50 grams, 25 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 10 grams, Flos Chrysanthemi 8 grams, Fructus Xanthii 8 grams, Flos Magnoliae 9 grams, Radix Paeoniae Rubra 8 grams, Semen Ziziphi Spinosae 8 grams, Rhizoma Et Radix Notopterygii 10 grams, Herba Schizonepetae 10 grams, Radix Saposhnikoviae 10 grams, 10 grams, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 10 grams, Mel 85 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

One, get the raw materials ready

1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

2, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

3, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;

4, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

5, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

6, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

7, Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

8, Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces;

9, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

10, Semen Ziziphi Spinosae: bamboo basket put into by former medicine, sinks in clear water cylinder, and core is kept afloat, and shell is heavy water-bed, core is pulled out, dries;

11, Rhizoma Et Radix Notopterygii: pick decontamination, cleans, runs through, and section, dries;

12, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;

13, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

14, Radix Glycyrrhizae: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

15, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add blister to mouth tastes slightly spicy sense again, taking-up ginger decoction leaching 1-3 days, then cooks, then roasts to seventy percent dry, pour in pot urgent stir-fry of useing force into rise to cigarette, till micro-drum splits, taking-up cools;

16, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

Two, prepare:

Preparation method:

(1) by the described Radix Astragali, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Flos Chrysanthemi, Fructus Xanthii, Flos Magnoliae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, put into container for stirring and be evenly ground into fine powder;

(2) Mel is refined into the tender honey of 110-115 DEG C;

(3) stick together grinding for the spice of fine powder adds Mel mixing system, then rubbing pill, 9 grams, every ball.