CN104983483A - Multifunctional rodent fixator and use method thereof - Google Patents
Multifunctional rodent fixator and use method thereof Download PDFInfo
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- CN104983483A CN104983483A CN201510417697.7A CN201510417697A CN104983483A CN 104983483 A CN104983483 A CN 104983483A CN 201510417697 A CN201510417697 A CN 201510417697A CN 104983483 A CN104983483 A CN 104983483A
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- fixing head
- tail
- fuselage cover
- rotation
- fixator
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- 241000283984 Rodentia Species 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 26
- 239000008280 blood Substances 0.000 claims abstract description 34
- 210000004369 blood Anatomy 0.000 claims abstract description 34
- 230000007246 mechanism Effects 0.000 claims abstract description 27
- 230000001681 protective effect Effects 0.000 claims description 24
- 238000001990 intravenous administration Methods 0.000 claims description 19
- 230000000153 supplemental effect Effects 0.000 claims description 19
- 230000033001 locomotion Effects 0.000 claims description 18
- 230000005540 biological transmission Effects 0.000 claims description 13
- 238000006073 displacement reaction Methods 0.000 claims description 10
- 241001247821 Ziziphus Species 0.000 claims description 9
- 210000001015 abdomen Anatomy 0.000 claims description 5
- 239000000523 sample Substances 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 49
- 238000002474 experimental method Methods 0.000 abstract description 21
- 210000003462 vein Anatomy 0.000 abstract description 12
- 210000000078 claw Anatomy 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 241000700159 Rattus Species 0.000 abstract 4
- 230000001276 controlling effect Effects 0.000 abstract 1
- 230000036544 posture Effects 0.000 abstract 1
- 210000003128 head Anatomy 0.000 description 33
- 241000699670 Mus sp. Species 0.000 description 28
- 210000003414 extremity Anatomy 0.000 description 22
- 238000001959 radiotherapy Methods 0.000 description 19
- 241000699666 Mus <mouse, genus> Species 0.000 description 17
- 238000011160 research Methods 0.000 description 9
- 238000010171 animal model Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 238000013461 design Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000003187 abdominal effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000005252 bulbus oculi Anatomy 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 230000004807 localization Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003439 radiotherapeutic effect Effects 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 240000004244 Cucurbita moschata Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 206010061225 Limb injury Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The invention discloses a multifunctional rodent fixator and a use method thereof. The multifunctional rodent fixator comprises a fixator body shell, a base plate, a rotatable fixing plate located on the upper portion of the fixator body shell, four claw binding devices located on the rotatable fixing plate, limb fixing cableways located below the claw binding devices, a tail fixing device connected to one end of the fixator body shell, a lead plate protection cover arranged on the fixator body shell, a ray guide and positioning device arranged on the top of the protection over, a pitching angle adjusting mechanism arranged in the base plate, a rotating angle adjusting mechanism for controlling the rotating angle of the rotatable fixing plate and an auxiliary supporting rotating mechanism. By means of the multifunctional rodent fixator, just one researcher can fix an experimental rat to an experiment table easily, conveniently and firmly, the fixator is suitable for rats of various shapes, the pitching of the fixing angle and the rotating angle of experiment animals can be adjusted, and the requirements for various experiment postures are met; tails of the rats can be stably fixed, caudal vein blood enrichment and regulating can be achieved with one hand, and four pieces of caudal veins of a rat can be selected and exchanged freely.
Description
Technical field
The invention belongs to animal experiment study equipment technical field, relate to that a kind of operation is simple and reliable and can meet multi-functional rodent holder and the using method thereof of multiple Research Requirements.
Background technology
In current mouse experiment, first research worker needs to be fixed mice, at present, as follows to the situation of the method and apparatus that mice is fixed:
1. the method for fixing mice is divided into two kinds: one to be utilize cylindrical vessel, carries out squash type fix by space in constriction container to mice; Two is fix by mice extremity being carried out binding with rope, then by rope bondage in position, preset, or be connected with slide block by rope, make it to slide with it in circular cylinder with fixing.But said method operation is more complicated, in most cases need two experimenters to coordinate simultaneously and just can complete the fixing of mice, not only waste of manpower, and fixed effect is unsatisfactory.
2. for laboratory animal tail vein injection with get blood, apply existing fixed form, what be difficult to realize to laboratory animal afterbody is stable fixing, more can not realize selecting tail veins when animal trunk is fixing.In current operation, research worker often can be reversed to find suitable blood vessel to afterbody when animal trunk is fixing, causes afterbody damage, congestion or necrosis most probably; In addition, owing to needing hands to hold afterbody getting in blood or injection process, cause the needle angle of another hands to be restricted, because tail vein is tiny, blood vessel wall is thin and skin-proximal, usually therefore prick and wear blood vessel and even the health of operator is constituted a threat to.The structure of animal model expends time in, energy and financial resources, if do not mate the massive losses making animal model damage scientific research beyond doubt due to experiment auxiliary appliance.
3. radiotherapy is in the research of " action effect in animal tumor model ", most radiotherapy instrument derives from human clinical therapy and applies rear superseded instrument, its ray beam size of launching is more suitable for the mankind, radiotherapy can the size of focus point uneven, because mice volume is small, build mouse tumor model in Neoplastic organ or organize less, when applying radiotherapy instrument and carrying out radiotherapy, be difficult to realize the irradiation to each position of mouse body, more can not positioning tumor focus carry out fixed point radiotherapy accurately, mice is caused to accept excessive radiotherapy and dead or do not concentrate because of radiotherapy site and cause experimental result not have the problems such as scientific thus.
4. current animal experiment technique is widely used in biomedicine and drug research etc., and current laboratory animal operating board mostly is dull and stereotyped fixed model, and namely mice is fixed on operating board by level, cannot regulate mice position.But many zooperies there are certain requirements mice position, after carrying out specific part lavation or some surgery, in order to ensure liquid (peritoneal lavage fluid, pus, blood etc.), drain is unobstructed and make mice keep a part higher than other positions, or for the needs of surgical exposure, require that mice changes position etc. at any time in art.Therefore, a kind of novel experimental operation table that can adjust animal position is at any time needed badly.
5., in mouse experiment, pluck eyeball and get blood and be widely used as the operation of normal experiment.But often because mice fixed position is not good and fixingly loosely occur getting blood difficulty, drop of blood waste, pollute and animal is hurted sb.'s feelings event during this operation.Therefore need exploitation that mice can be made to be fixed into lateral position safely, and ensure that blood vertically instills the animal experiment device of blood collecting containers.
Summary of the invention
The present invention, in order to solve above-mentioned problems of the prior art, provides a kind of multi-functional rodent holder.This laboratory table can realize an only research worker can carry out easy firm fixing to experiment mice, and is applicable to the mice of various size difference, realizes pitching and the rotary mediation of laboratory animal fixed angle, meets kinds of experiments position demand; Mus tail Absorbable organic halogens is fixed, and one hand can realize tail vein liquid enrichment and regulation and control, and selects arbitrarily to exchange to four caudal veins; In the research of mouse tumor model radiotherapeutic effect, realize locating the targeting of tumor focus; Reduce manpower, operate simple for use, reduce the damage to animal model, improve experiment success rate and make result of the test have more science.
The present invention takes following technical scheme for addressing this problem:
A kind of multi-functional rodent holder is van-type rodent holder or drum-type rodent holder.This holder comprises fuselage cover and chassis, be positioned at the rotation fixing head above fuselage cover, four of being positioned on rotation fixing head tie up pawl device and are positioned at the extremity tied up below pawl device and fix cableway, be connected to the tail fixing device of fuselage cover one end, the stereotype protective cover be arranged on above fuselage cover guides and positioner with the ray being arranged on protective cover top, be arranged on the luffing angle governor motion in chassis, and control the anglec of rotation governor motion and the supplemental support rotating mechanism that rotate the fixing head anglec of rotation.
Tail fixing device comprises tail intravenous procedures platform and tail intravenous set blood fixture, and tail intravenous procedures platform is connected by fixed hinge with between fuselage cover end wall, can the used time does not pack up.Be provided with collapsible pair of bar bracing frame below tail intravenous procedures platform, collapsible pair of bar bracing frame upper end is connected by fixed hinge with tail intravenous procedures platform, and lower end is connected by fixed hinge with fuselage cover end wall.Collapsible pair of bar bracing frame is provided with ratchet, locked by ratchet one-way during use.Tail intravenous procedures platform is provided with the tail intravenous set blood fixture be made up of multiple snap ring, and user can select snap ring to fix Mus tail according to the difference of Mus tail length and concrete condition voluntarily.This laboratory table also comprises afterbody collection blood handwheel, and afterbody collection blood handwheel is independently arranged, and can carry out the operation of collection blood to Mus tail.Afterbody collection blood handwheel top is provided with finger ring, and wheel body mid portion has the groove of applicable Mus tail diameter, and finger ring and wheel body are all connected on handwheel support.Finger ring can be placed on operator's finger, and operator can dip the sterilised liqs such as ethanol with rubber pulley, by directly realizing making full use of of sterilised liq in groove at afterbody by the action of press-fit push-and-pull, realizes afterbody sterilization and venous blood enrichment at one stroke.
Anglec of rotation governor motion comprises the bearing block be arranged on fuselage cover, is positioned at bearing above bearing block and intermeshing worm gear and worm screw.Anglec of rotation governor motion adopts Worm Wheel System design, has auto-lock function.Worm gear connects with the power transmission shaft rotated on fixing head, and power transmission shaft is bolted in bottom with rotation fixing head, and the axle center of power transmission shaft is higher than the surface rotating fixing head, coaxial with the snap ring be positioned on tail fixing device; Thus make rotating shaft axle center coaxial with rodent afterbody, be that axle rotates to reach animal bodies with afterbody, realize the object choosing tail vein.Worm screw one end and the anglec of rotation be positioned at outside fuselage cover adjust knob and are connected, and control worm screw by anglec of rotation adjustment knob.The power transmission shaft of anglec of rotation governor motion has bearing block to support and the protection of fuselage top panel, ensure that the accurate and stable of Worm Wheel System.
Supplemental support rotating mechanism is two annulus connected by sliding bearing, the lower end of supplemental support rotating mechanism internal ring is provided with brace table with rotation fixing head junction, rotating fixing head uses bolt to be rigidly connected by brace table and internal ring, can rotate with rotation animal fixing head.Supplemental support rotating mechanism outer shroud and fuselage cover are rigidly connected by connector, play load-bearing and fixation to rotating animal fixing head.The semicircle of supplemental support rotating mechanism outer shroud is provided with graduated disc, supplemental support rotating mechanism internal ring is provided with and deeply rules as pointer, the convenient angle to animal upset adjusts accurately.
Luffing angle governor motion is connected on bearing block, comprises driving-chain and is positioned at the luffing angle adjusting knob outside fuselage cover.Angle of pitch adjusting knob and the anglec of rotation adjust knob and are arranged at homonymy, facilitate experimenter to operate.Luffing angle governor motion adopts single side chain kind of drive, carries out transmission by the length adjusting driving-chain, and driving-chain one end connects luffing angle adjusting lever, and the other end connects the bearing pin in the middle of two pairs of support bars.Experimenter adjusts the length of driving-chain by rotating the angle of pitch adjusting knob of adjusting lever one end, thus realizes regulating the luffing angle of integral body above.Be provided with ratchet in angle of pitch adjusting knob, unidirectional locking can be realized.
Be provided with support bracket between fuselage cover lower surface near caudal end part and chassis, support bracket forms by by the top support bracket of pinned connection and lower prop.Support bracket can rotate with the change of fuselage attitude, and supports the deadweight of integral body, meets experimenter's demand to mice position in experimental implementation.
Fuselage cover bottom is provided with clean sliding door, and the personnel of being convenient to operation clean fuselage interior.
Rodent extremity are fixed by tiing up pawl device, and tiing up pawl device is Split type structure, tie up split on pawl device and are provided with extremity buckle for tiing up pawl, and tie up under pawl device and fixed by latch between split; Under tiing up pawl device, split is provided with acupressure probe and baffle plate, and acupressure probe handled easily personnel drag thus fixing mice as required.Tie up the lower end of split under pawl device and form circular lead angle, and be fixed on extremity by Fixed latches and fix on cableway, circular lead angle is conducive to dragging force, and baffle plate can the ratchet of confutation sour jujube plate.It is groove-like structure that extremity fix cableway, be connected with rotation fixing head by bolt, extremity are fixed in cableway and are provided with left and right twice sour jujube shape track, be respectively equipped with shallow grooves, sliding for tiing up the circular lead angle of split under pawl device, between two slideways, being also provided with dark groove, and connected by Fixed latches and tie up split and slideway bottom under pawl device, stop split slide block under tiing up pawl device to be free to slide, assist to tie up pawl device and overcome action of gravity and make it drop.The ratchet of sour jujube shape track forms to slide hinder with the baffle plate of split bottom under pawl device of tiing up remained static, thus realization fixedly secures the object of animal foot.
Rotate middle side part on fixing head and be provided with abdomen fixation device, abdomen fixation device comprises bellyband and is connected to the buckle at bellyband two ends, and buckle is fixed in the draw-in groove of rotation fixing head both sides formation.Rodent abdominal part is fixed by animal bellyband, and the main material of described bellyband is elastomeric material, and two ends are fixed by snap in rotation animal fixing head both sides, avoid the limb injury that animal is caused because of self gravitation reason in the process rotated.
The top of stereotype protective cover is formed with microscler slit space, be provided with scalable radical occlusion device and ray in slit space to guide and positioner, ray guiding and positioner are positioned at the middle part of scalable radical occlusion device, are bolted with scalable radical occlusion device; Ray guides and positioner comprises apparatus main body and leading screw and feed rod, apparatus main body is provided with ray bullport and locating hole, and leading screw and feed rod are through apparatus main body both sides, and leading screw one end is connected with the adjustment of displacement knob be arranged on stereotype protective cover end wall.Use lead screw transmission, there is precision high, the advantage that location is accurate.High-brightness light emitting diode can be used to carry out lesion localization, and according to the regular length of ray bullport and locating hole, operation adjustment of displacement knob guides radiotherapy machine location.Scalable radical occlusion device, for coordinating ray to guide and positioner use, can stop that additional radiation drops into the tissue outside required irradiated lesion.
The advantage that the present invention has and good effect are:
First, multi-functional rodent holder of the present invention, the extremity buckle tied up on pawl device in split is adopted to be entangled firm by mice extremity, with be connected to extremity fix on cableway tie up pawl device under split combine closely, under tiing up pawl device by push-and-pull, split realizes the personalization of different building shape mice stable fixing, mice claw and rotation fixing head are departed from this device and extremity are in extended state, mice can not be grabbed and climb twisting, trunk can keep this figure all the time, reduce the swing of Mus afterbody, be convenient to Mus tail fix, the experimental implementation demand that fixing animal stablized by many need can be met.
Second, the both sides upper limb of animal and both sides lower limb are separately fixed in two tracks up and down of extremity movable rail by tiing up pawl device by the present invention, realize the fixing supine prostrate of animal and lateral position, coordinate body pitching to regulate the rotation rotating fixing head with animal to regulate to realize the stable of the various position of animal and fix, meet liquid drain in body, eyeball gets blood, the experiment demand such as surgical field of view exposure and radiotherapy localization.
3rd; reconcile knob by the angle rotating fixing head to regulate rotation fixing head; 360 degree of rotatable fixed positions that to achieve with Mus tail be axle; there is bellyband protection that mice can not be caused damage to it because of self gravitation; at Mus tail operating board, place can select caudal vein; use collection blood handwheel can realize afterbody sterilization also fixing with the rapid enrichment of venous blood simultaneously, realize needle angle freely, be convenient to injection and get blood.
4th, in the research of animal tumor model radiotherapeutic effect, to be guided by ray and detent mechanism can position mouse tumor focus, ray can be made precisely to irradiate in disease site by the drive mechanism of feed screw nut, the large I of emitting radiation bundle is not by the impact of radiotherapy machine, meet the accurate range requirement of various radiotherapy, and can avoid other body parts is exposed under lonizing radiation, greatly improve radiotherapy efficiency, avoid the death that excessive radiotherapy causes, make the science of experimental result stronger.
In sum, all operations is simple, saving resource, can complete repertoire and operate, substantially increase operating efficiency by a people, decreasing manpower and quality time that existence conditions wastes, providing convenience for carrying out scientific experiments.
Accompanying drawing explanation
Fig. 1 is the structural perspective of multi-functional rodent holder of the present invention;
Fig. 2 is the structural perspective after multi-functional rodent holder of the present invention removes protective cover;
Fig. 3 is the sectional side elevation after multi-functional rodent holder of the present invention removes protective cover;
Fig. 4 is the top view of stereotype protective cover of the present invention;
Fig. 5 is the sectional view along A-A line in Fig. 4;
Fig. 6 is the structural perspective tiing up pawl device of the present invention;
Fig. 7 is the profile tiing up pawl device of the present invention; Fig. 8 is the structural perspective of afterbody collection blood handwheel of the present invention;
Critical piece symbol description in accompanying drawing:
1: tie up pawl device 101: tie up pawl device shell
102: sour jujube shape track 103: tie up split under pawl device
104: tie up split 105 on pawl device: extremity buckle
106: Fixed latches 107: acupressure probe
108: circular lead angle 109: baffle plate
2: abdomen fixation device 201: buckle
202: bellyband 3: rotate fixing head
4: anglec of rotation governor motion 401: power transmission shaft
402: worm gear 403: bearing
404: worm screw 405: bearing block
406: supplemental support rotating mechanism internal ring
407: support column 408: fuselage top panel
409: anglec of rotation adjustment knob 5: fuselage cover
501: supplemental support rotating mechanism outer shroud
502: chassis 6: tail fixing device
601: the first fixed hinges 602: tail intravenous procedures platform
603: snap ring 604: collapsible pair bar bracing frame
605: ratchet 606: the second fixed hinge
7: luffing angle governor motion 701: top support bracket
702: lower prop 703: hinge
704: support bar 705: bearing pin
706: driving-chain 707: luffing angle adjusting lever
8: stereotype protective cover 801: protective cover end wall
802: scalable radical occlusion device 803: ray guides and positioner
804: ray bullport 805: locating hole
806: leading screw 807: adjustment of displacement knob
9: afterbody collection blood handwheel 901: finger ring
902: handwheel support 903: wheel body.
Detailed description of the invention
Referring to the drawings and specific embodiments, multi-functional rodent holder of the present invention is described in detail.Specific embodiment described below is only preferred forms of the present invention, and can not be interpreted as limitation of the present invention.
Fig. 1 is the structural perspective of multi-functional rodent holder of the present invention; Fig. 2 is the structural perspective after multi-functional rodent holder of the present invention removes protective cover; Fig. 3 is the sectional side elevation after multi-functional rodent holder of the present invention removes protective cover; As shown in Figure 1 to Figure 3, multi-functional rodent holder of the present invention is van-type rodent holder or drum-type rodent holder.This holder comprises fuselage cover 5 and chassis, be positioned at the rotation fixing head 3 above fuselage cover, four of being positioned on rotation fixing head 3 tie up pawl device 1 and are positioned at the extremity tied up below pawl device and fix cableway, be connected to the tail fixing device of fuselage cover one end, the stereotype protective cover be arranged on above fuselage cover guides and positioner with the ray being arranged on protective cover top, be arranged on the luffing angle governor motion in chassis, and control the anglec of rotation governor motion and the supplemental support rotating mechanism that rotate the fixing head anglec of rotation.
Tie up pawl device 1 and slip cableway assembly thereof to be fixed with it from rotation fixing head 3 bottom by bolt, bellyband 201 and buckle 202 thereof are fixed on by draw-in groove and rotate fixing head 3 both sides, rotate fixing head 3 to be connected with the power transmission shaft 401 in anglec of rotation governor motion 4 by bolt, power transmission shaft 401 and worm gear 402 grafting, worm gear 402 and worm screw 404 engage each other, worm screw 404 one end and the anglec of rotation be placed in outside fuselage cover 5 adjust knob 409 and are connected, power transmission shaft 401 is by bearing 403 and bearing block 405 grafting, bearing block 405 is secured by bolts on the support column 407 of fuselage interior both sides setting, fuselage top panel 408 is connected with fuselage cover by clamp.Rotate fixing head 3 to be connected with supplemental support rotating mechanism internal ring 406 by bolt, supplemental support rotating mechanism internal ring 406 is connected with supplemental support rotating mechanism outer shroud 501 by sliding bearing, supplemental support rotating mechanism outer shroud 501 and fuselage cover 5 are welded as a whole, tail intravenous procedures platform 602 is connected with fuselage cover by the first fixed hinge 601, collapsible pair of bar bracing frame 604 is connected with fuselage cover with tail intravenous procedures platform at its two ends respectively by the second fixed hinge 606, on collapsible pair of bar bracing frame 602, folding hinge installs one direction fixed ratchet wheel 605 by bearing pin, tail intravenous procedures platform is bolted six buckles and snap ring 603.Fuselage cover 5 lower front part is provided with support bracket 701, be connected with the support bracket 702 on chassis 8 by bearing pin, two pairs of support bar 704 two ends in luffing angle governor motion 7 are connected with fuselage cover 5 bottom and chassis 8 respectively by hinge 703, two pairs of support bars are connected by bearing pin 705, driving-chain 706 two ends are individually fixed in support bar bearing pin 705 and luffing angle adjusting lever 707, luffing angle adjusting lever 707 one end is provided with luffing angle adjusting knob 708, be placed in outside fuselage cover 5, in knob, be provided with ratchet.
Fig. 4 is the top view of stereotype protective cover of the present invention; Fig. 5 is the sectional view along A-A line in Fig. 4.As shown in Figure 4 and Figure 5, the top of stereotype protective cover 8 is formed with microscler slit space, be provided with scalable radical occlusion device 802 and ray in slit space to guide and positioner 803, ray guiding and positioner are positioned at the middle part of scalable radical occlusion device, are bolted with scalable radical occlusion device; Ray guides and positioner adopts screw nut driven mode, comprises apparatus main body, leading screw, feed rod and is positioned at the adjustment of displacement knob of leading screw one end.Be provided with interconnective ray bullport 804 and locating hole 805 in apparatus main body, ray bullport and locating hole are connected on leading screw 806.Leading screw one end is connected with the adjustment of displacement knob 807 be arranged on stereotype protective cover end wall 801.
Ray guides and the apparatus main body of positioner is positioned in the middle of scalable radical occlusion device, be bolted with scalable radical occlusion device, leading screw and feed rod are arranged at the both sides of apparatus main body, its two ends are connected to the front and rear wall of radiation lid, apparatus main body is only limited to be embedded in the straight-line displacement campaign in slit space, feed rod is connected for rigidly fixing with radiation lid rear wall, and leading screw two ends are connected with radiation lid front and rear wall by axle sleeve, and leading screw one end is provided with locating hole adjusting device.
Fig. 6 is the structural perspective tiing up pawl device of the present invention; Fig. 7 is the profile tiing up pawl device of the present invention.As shown in Figure 6 and Figure 7, tie up pawl device shell 101 to be bolted with rotation fixing head 3, extremity buckle 105 is plugged on to be tied up on pawl device on split 104, under tiing up on pawl device split 104 and tiing up pawl device, split 103 is connected by pin, under tiing up pawl device, split 103 top is processed with acupressure probe 107, bottom is processed with circular lead angle 108 and baffle plate 109, and bottom is connected with sour jujube shape track 102 by Fixed latches 106.
Fig. 8 is the structural perspective of afterbody collection blood handwheel of the present invention.As shown in Figure 8, Mus tail integrates blood handwheel 9 top as finger ring 901, and be plugged on handwheel support 902, handwheel 903 is connected with handwheel support 903 by axle.
Multi-functional rodent holder of the present invention, the operational requirements of rodent involved in Most experiments room can be met, simultaneously, consider the habit of laboratory animal and the operating habit of operator, the present invention starts with from each details, solves the problem faced in experimental implementation now.Tie up pawl device and consider that the range of activity of the extremity of rodent and active behavior design, owing to usually shrinking extremity when rodent moves, the present invention will tie up pawl device and be designed to monodirectional locking; For to the safeguard protection of animal in rotary course, be designed with bellyband especially and bound by the abdominal part of animal, this not only makes animal fixing more stable, and has played the effect avoiding animal to cause extremity to lose because of self gravitation; Angle of pitch governor motion meets many requirements rodent being carried out to operation and postoperative operation equally; Rotate animal fixing head and afterbody operation panel coordinate that to achieve with animal afterbody be axle center pivot, handled easily personnel select tail vein blood vessel; The spinfunction rotating animal fixing head achieves 360 degree and rotates without dead angle, and it can the worm and gear tumbler of self-locking and the design of tuning drive gear and graduated disc, facilitates the operation of experimenter; Achieve the coordinating of extremity cableway, animal rotating mechanism and body pitching zoopery operate in many operation positions stable fixing; Afterbody operating board can fold, and for space saved by this machine, the design of six afterbody buckles, makes operator to operate safely, accurately, improve the success rate of experiment, and six afterbody buckles can experimentally require to select wherein several being fixed.The design of stereotype protective cover makes to use heavy-duty machines to become possibility to mice radiotherapy, not only can carry out precise positioning to the radiotherapy focus of mice, can also by changing the size of pore size control x radiation x area.
The use procedure of multi-functional rodent holder of the present invention is as follows:
1. tail intravenous procedures: when positive clinostatism fixes animal, first will tie up split on pawl device to take out, use extremity buckle respectively by animal foot bondage, then split under pawl device is tied up in press-in, strained by sour jujube plate track, thus fixing mice extremity, finally use bellyband bondage animal abdominal part, animal is steadily fixed on and rotates on fixing head.Afterbody operating board is lifted, use ratchet is fixed, animal afterbody is placed along afterbody operating board, by regulating anglec of rotation control knob, find the easy-operating vein blood vessel of afterbody, after vein blood vessel is selected, finger rubber wheel is dipped sterilised liq, the operation of collection blood is carried out to afterbody, after collection blood end of operation, first nearly the buckle in animal root of the tail portion is pressed stuck, then selected the position of fixing afterbody hypomere by buckle according to experimental implementation demand, after blood or entry needle insertion will be got, nearly the buckle in Mus root of the tail portion is again pressed and is unclamped, start to carry out getting blood and injection operation.
2. experiment operates with many Postural immobilization: during fixing mice, first will tie up split on pawl device to take out successively, as required by animal foot bondage one by one, or two upper limb bondage together, two lower limb bondage together, to tie up split on pawl device again inserts in lower split, strained by sour jujube plate track, bellyband is finally used to fix animal abdominal part, animal is steadily fixed on and rotates on fixing head, coordinate the pitching of body pitching mechanism to reconcile and rotate the rotation adjustment of animal fixing head rotating mechanism, realize supine position, ventricumbent position, the firm of the positions such as left and right sides clinostatism is fixed.According to operation practical situation or requirement of experiment, rotation fixing head is adjusted to optimal performance angle, the angle of inclination of angle of pitch adjusting knob to animal is used to regulate, tie up pawl device to coordinate with extremity track and choose suitable position, realize eyeball and get blood, body inner product liquid drainage, surgical field of view exposure and radiotherapy localization etc., thus facilitate normally carrying out of experimental implementation.
3, rodent carries out radiotherapy: adopt positive clinostatism to be fixed by animal, fixing means is as described in 1, for stereotype protective cover buckled by machine, high-brightness light emitting diode is used to be positioned over locating hole, now ray bullport serves as observation port, operator are by operation adjustment of displacement knob, after the hot spot that laser pen projects is overlapped by the lesion marking place of radiation exposure with animal, close and take off laser pen, by means of the characteristic that screw nut driven precision is high, by adjustment of displacement knob triple turn again, now under ray bullport, center is the focus that will accept radiotherapy.
4, the application of independent handwheel devices is simple, and personnel directly realize making full use of of sterilised liq in groove at afterbody by the action of press-fit push-and-pull by experiment, realizes afterbody sterilization and venous blood enrichment at one stroke.
Multi-functional rodent holder of the present invention, can meet above-mentioned experimental implementation demand one by one, equally can also comprehensively aforesaid operations with the use of, meet more complicated experiment demand.
Claims (10)
1. a multi-functional rodent holder, it is characterized in that: this laboratory table comprises fuselage cover and chassis, be positioned at the rotation fixing head above fuselage cover, four of being positioned on rotation fixing head tie up pawl device and are positioned at the extremity tied up below pawl device and fix cableway, be connected to the tail fixing device of fuselage cover one end, the stereotype protective cover be arranged on above fuselage cover guides and positioner with the ray being arranged on protective cover top, be arranged on the luffing angle governor motion in chassis, and control the anglec of rotation governor motion and the supplemental support rotating mechanism that rotate the fixing head anglec of rotation, tail fixing device comprises tail intravenous procedures platform and tail intravenous set blood fixture, tail intravenous procedures platform is connected by the first fixed hinge with between fuselage cover end wall, collapsible pair of bar bracing frame is provided with below tail intravenous procedures platform, collapsible pair of bar bracing frame upper end is connected with tail intravenous procedures platform, lower end is connected with fuselage cover end wall, collapsible pair of bar bracing frame is provided with ratchet, and tail intravenous procedures platform is provided with the tail intravenous set blood fixture be made up of multiple snap ring.
2. multi-functional rodent holder according to claim 1, it is characterized in that: this laboratory table also comprises afterbody collection blood handwheel, afterbody collection blood handwheel is independently arranged, top is provided with finger ring, wheel body mid portion has the groove of applicable Mus tail diameter, and finger ring and wheel body are all connected on handwheel support.
3. multi-functional rodent holder according to claim 2, is characterized in that: anglec of rotation governor motion comprises the bearing block be arranged on fuselage cover, is positioned at bearing above bearing block and intermeshing worm gear and worm screw; Worm gear connects with the power transmission shaft rotated on fixing head, and power transmission shaft is bolted in bottom with rotation fixing head, and the axle center of power transmission shaft is higher than the surface rotating fixing head, coaxial with the snap ring be positioned on tail fixing device; Worm screw one end and the anglec of rotation be positioned at outside fuselage cover adjust knob and are connected.
4. multi-functional rodent holder according to claim 1, is characterized in that:
Supplemental support rotating mechanism is two annulus connected by sliding bearing, the lower end of supplemental support rotating mechanism internal ring is provided with brace table with rotation fixing head junction, rotating fixing head uses bolt to be rigidly connected by brace table and internal ring, and supplemental support rotating mechanism outer shroud and fuselage cover are rigidly connected by connector; The semicircle of supplemental support rotating mechanism outer shroud is provided with graduated disc, supplemental support rotating mechanism internal ring is provided with and deeply rules as pointer.
5. multi-functional rodent holder according to claim 3, it is characterized in that: luffing angle governor motion is connected on bearing block, adopt single side chain kind of drive, the luffing angle adjusting knob comprising driving-chain, luffing angle adjusting lever, support bar and be positioned at outside fuselage cover; Driving-chain one end connects luffing angle adjusting lever, and the other end connects the bearing pin in the middle of two pairs of support bars; Ratchet is provided with in angle of pitch adjusting knob.
6. multi-functional rodent holder according to claim 5, is characterized in that: be provided with support bracket between fuselage cover lower surface near caudal end part and chassis, and support bracket forms by by the top support bracket of pinned connection and lower prop.
7. multi-functional rodent holder according to claim 1, is characterized in that: fuselage cover bottom is provided with the clean sliding door that handled easily personnel clean fuselage interior.
8. multi-functional rodent holder according to claim 1, is characterized in that: tiing up pawl device is Split type structure, ties up split on pawl device and is provided with extremity buckle for tiing up pawl, and ties up under pawl device and fixed by latch between split; Under tiing up pawl device, split is provided with acupressure probe and baffle plate, tie up the lower end of split under pawl device and form circular lead angle, and be fixed on extremity by Fixed latches and fix on cableway, it is groove-like structure that extremity fix cableway, be connected with rotation fixing head by bolt, extremity are fixed in cableway and are provided with left and right twice sour jujube shape track, and the ratchet of sour jujube shape track forms to slide hinder with the baffle plate of split bottom under pawl device of tiing up remained static.
9. multi-functional rodent holder according to claim 1, it is characterized in that: rotate middle side part on fixing head and be provided with abdomen fixation device, abdomen fixation device comprises bellyband and is connected to the buckle at bellyband two ends, and buckle is fixed in the draw-in groove of rotation fixing head both sides formation.
10. multi-functional rodent holder according to claim 1, it is characterized in that: the top of stereotype protective cover is formed with microscler slit space, be provided with scalable radical occlusion device and ray in slit space to guide and positioner, ray guiding and positioner are positioned at the middle part of scalable radical occlusion device, are bolted with scalable radical occlusion device, ray guides and positioner adopts screw nut driven mode, comprise apparatus main body, leading screw, feed rod and be positioned at the adjustment of displacement knob of leading screw one end, apparatus main body is positioned in the middle of scalable radical occlusion device, be bolted with scalable radical occlusion device, ray bullport and locating hole is provided with in apparatus main body, ray bullport and locating hole are connected on leading screw, leading screw and feed rod are arranged at the both sides of apparatus main body, its two ends are all connected on protective cover end wall, apparatus main body is made to be only limited to straight-line displacement campaign in slit space, feed rod is connected for rigidly fixing with protective cover end wall, leading screw two ends are connected with protective cover end wall by axle sleeve.
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| CN106798971A (en) * | 2017-04-05 | 2017-06-06 | 青岛大学附属医院 | A kind of tumour radiotherapy experimental provision |
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| CN105999452A (en) * | 2016-04-22 | 2016-10-12 | 山东大学齐鲁医院 | Stoma enema auxiliary device |
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| CN106725982B (en) * | 2017-01-18 | 2018-10-26 | 兰州大学 | A kind of mouse blood-taking device |
| CN106798971A (en) * | 2017-04-05 | 2017-06-06 | 青岛大学附属医院 | A kind of tumour radiotherapy experimental provision |
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| CN113171204B (en) * | 2021-05-10 | 2023-07-04 | 兰州大学 | But angle regulation's for experiments rat shank fixing device |
| CN115568971A (en) * | 2021-07-06 | 2023-01-06 | 中国科学院深圳先进技术研究院 | Fixing device and fixing method for female mouse |
| WO2023279459A1 (en) * | 2021-07-06 | 2023-01-12 | 中国科学院深圳先进技术研究院 | Female mouse fixing device and fixing method |
| CN114259377A (en) * | 2021-12-21 | 2022-04-01 | 郭宏 | Special accumulated liquid prevention four-limb operation device for general surgery department |
| CN114259377B (en) * | 2021-12-21 | 2024-04-26 | 郭宏 | Special effusion-preventing limb operation device for general surgery department |
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Effective date of registration: 20180426 Address after: 300381 Tianjin Nankai District Lingao Creative Industrial Park 3 phase A building management service center 206-3 Patentee after: Tianjin Hai Rui Biological Technology Co., Ltd. Address before: 300070 Medical University Of Tianjin, 22, Observatory Road, Heping District, Tianjin Patentee before: Dai Liang |
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