CN103598926A - Fixing apparatus for volume uniform radiation test of laboratory mice - Google Patents
Fixing apparatus for volume uniform radiation test of laboratory mice Download PDFInfo
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- CN103598926A CN103598926A CN201310574795.2A CN201310574795A CN103598926A CN 103598926 A CN103598926 A CN 103598926A CN 201310574795 A CN201310574795 A CN 201310574795A CN 103598926 A CN103598926 A CN 103598926A
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Abstract
The invention discloses a fixing apparatus for volume uniform radiation test of laboratory mice and belongs to fixing apparatus for animal experiments. The fixing apparatus comprises a cylindrical casing with the bottom end closed and the top end open, a circular cover plate capable of being connected fixedly in a detachable manner and capping the top opening of the cylindrical casing, and multiple water-drop-shaped chambers which are placed in the circular casing for containing the laboratory mice and in the shape fitting with shapes of the laboratory mice. The chambers are in radial arrangement with the centripetal tip ends and outwards round ends, the round ends are tangent with the wall of the casing, and through holes which are designed in size enabling tails of the mice to pass through and run through the wall of the casing and the walls of the chambers are formed below the tangent lines respectively. Multiple laboratory mice can be fixed completely at one time and then subjected to uniform radiation, so that consistency of experimental radiation dose is guaranteed while experiment efficiency is increased. The fixing apparatus is simple in structure, low in cost, convenient to operate and use and easy to produce and promote.
Description
Technical field
The present invention relates to a kind of zoopery radiation fixture, relate in particular to a kind of for the experimental mouse fixture that homogeneous radiation is tested in batches.
Background technology
Now, be deeply applied to gradually the fields such as national defense and military, industrial and agricultural production and medical science life sciences due to nuclear technology, the chance that people contact with lonizing radiation is increasing, also increased by the probability of radiation damage thereupon.Meanwhile, malignant tumor becomes the first killer who threatens human health day by day, and along with scientific and technological development, in recent decades, radiation therapy technology has also been made significant headway.So, be no matter research and development high-efficiency low-toxicity, antiradiation drug easy to use, or the radiation therapy technology of Improvement malignant tumor, all very necessary, therefore scientific research personnel need to carry out animal radiation experiments in a large number.
Mice, rat are all conventional living animals in experiment, and action has uncontrollability, often interference emission experimentation.Therefore, need to utilize various fixtures to limit its action.In radiation experiments in the past, conventionally mice or rat are positioned in wide mouthed bottle or glass container, carry out coherent radiation research.In existing technology, mostly can only be for single mice or rat experiment for the fixture of mice or rat radiation experiments, less for the fixture of batch mice or rat experiment.For example, utility model patent ［Fan Sai army, Xu Jiaying, Qin Liqiang, Deng. a kind of fixture .CN201987699U for rat irradiation experiment, 2011.09.28. Xu adds English, Fan Saijun, Qin Liqiang, Deng. a kind of mouse fixing .CN201977959U for radiation experiments, 2011.09.21. ］ although can be by many mices or rat side by side in embedding device, carry out the total body radiation of laboratory animal, but due to square being inversely proportional to of absorbed dose and radiation length, because laboratory animal is different from radiographic source distance, its uniformity and flatness of accepting radiation dose is all very undesirable.Utility model patent ［ Liu Yong, Hu Weigang, Xu Qing. a kind of medical mouse tumor irradiates stationary pipes and fixture .CN202283289U, 2012.06.27. ］ although realized the batch irradiation of 12 mices, but be only the partial radiation to mice shank, and respectively fill the arrangement that is square of Mus pipe, also can not make mice receive equal radiation dose.Therefore, the batch uniform experiments radiation fixture for experimental mouse needs further to further investigate and develop.
Summary of the invention
The invention provides a kind of for the experimental mouse fixture that homogeneous radiation is tested in batches.Object is in irradiation experiment, to fix and limit the action of mice or rat.
The technical solution used in the present invention is: a kind of for the experimental mouse fixture that homogeneous radiation is tested in batches, comprise the cylinder shell that bottom closed upper end is uncovered; Cover in cylinder shell upper port and the detachable circular cover being fixedly connected with; Be placed in cylinder shell for holding experimental mouse, a plurality of drops dress Mus cavitys that shape coordinates with experimental mouse body; Dress Mus cavity all most advanced and sophisticated centripetal, nose circle is outwards petal-shaped radiation and arranges, and nose circle is tangent with housing tube wall, has the through hole that connects housing tube wall and fill Mus cavity tube wall in the bottom of each phase tangent line, and hole size can make experimental mouse tail pass through.
Further, in housing tube wall upper end, have equally distributed at least 3 screwed holes, have the hole coordinating with screwed hole at the periphery of circular lid sheet frame, circular cover is detachably fixed on housing by the bolt penetrating in screwed hole.
Preferably, described circular cover is less to radiation ray absorbed dose, almost the netted material of negligible thermoplastic.
Preferably, described cylinder shell and dress Mus cavity are the material that inner wall smooth is transparent.
Because technique scheme is used, the present invention compared with prior art, has the following advantages:
1, this fixture application drops dress Mus cavity, its shape matches with the body of experimental mouse, can form small space, realizes being completely fixed experimental mouse; Dress Mus cavity is petal-shaped radiation to be arranged, and can disposablely to many experimental mouse, carry out homogeneous radiation experiment, has both guaranteed the concordance of experiment radiation dose, has improved again conventional efficient.
2, experimental mouse tail can both can coordinate positioning experiment Mus by the through hole on dress Mus cavity nose circle bottom tube wall and housing tube wall, can carry out the experiments such as experimental mouse tail vein injection, blood sampling again simultaneously.
3, circular cover is the netted material of thermoplastic, less to radiation ray absorbed dose, almost negligible; Meanwhile, network structure also can be used as passage, maintains the eupnea of experiment mice.
4, cylinder shell and dress Mus cavity are the material that inner wall smooth is transparent.Smooth material has avoided mice to cause damage owing to grabbing to sting to collide; Transparent material can be seen mutually mice, and impatient, the oppressive emotion of mice of having avoided experiment to cause, also facilitates experimenter's Real Time Observation experiment mice state simultaneously.
5, this fixture structure is simple, with low cost, easy and simple to handle, easy to use, is beneficial to production, is easy to promote; And all material is capable of washing disinfecting all, conveniently reuses.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the present invention is further described.
Fig. 1-1st, the present invention does not add the structural representation of cover plate.
Fig. 1-2 is the top view that the present invention does not add circular cover.
Fig. 1-3rd, the present invention adds the structural representation of circular cover.
Fig. 2-1, Fig. 2-2, Fig. 2-3rd, further embodiment of this invention structural representation.
In figure: 1, cylinder shell, 2, circular cover, 3, dress Mus cavity, 4, housing tube wall, 5, through hole, 6, screwed hole and bolt.
The specific embodiment
Embodiment 1: for the mice fixture that homogeneous radiation is tested in batches.
As shown in Fig. 1-1, Fig. 1-2 and Fig. 1-3, for the mice fixture that homogeneous radiation is tested in batches, comprise the cylinder shell 1 that bottom closed upper end is uncovered; Cover in cylinder shell 1 upper port and the detachable circular cover being fixedly connected with 2; Be placed in cylinder shell 1 for holding experimental mouse, 12 drops dress Mus cavitys 3 that shape coordinates with experimental mouse body; It is tangent that dress Mus cavity 3 equal tips are centripetal, nose circle is outwards petal-shaped radiation arrangement and nose circle and housing tube wall 4, has the through hole 5 that connects housing tube wall 4 and fill Mus cavity 3 in the bottom of each phase tangent line; The mousetail that greatly can make of through hole 5 passes through, and both can coordinate location mice, can carry out the experiments such as mouse tail vein injection, blood sampling again simultaneously.In housing tube wall 4 upper ends, have equally distributed three screwed holes 6, have the hole coordinating with screwed hole at the periphery of circular cover 2 frames, circular cover 2 is detachably fixed on housing by the bolt 6 penetrating in screwed hole.
According to the common physical size of mice, the length of the dress Mus cavity 3 of the present embodiment is 8cm, highly for 3cm.The radius of cylinder shell 1 is consistent with the length of dress Mus cavity 3, is 8cm; The height of cylinder shell 1 is consistent with the height of dress Mus cavity 3, is 3cm.
Circular cover is the netted material of thermoplastic.The netted material of thermoplastic is less to radiation ray absorbed dose, almost negligible; Meanwhile, network structure also can be used as passage, maintains the eupnea of experiment mice.Cylinder shell and dress Mus cavity are the material that inner wall smooth is transparent.Smooth material has avoided mice to cause damage owing to grabbing to sting to collide; Transparent material can be seen mutually mice, and impatient, the oppressive emotion of mice of having avoided experiment to cause, also facilitates experimenter's Real Time Observation experiment mice state simultaneously.
Using method is: before experiment, first extract three bolts in screwed hole, take off circular cover; Mice is put into drops dress Mus cavity according to head successively towards home position, and mouse tail passes from through hole; Cover circular cover, fix three bolts, fixedly mice, makes mice freely activity in dress Mus cavity; Radiation source irradiates center is pointed to the home position of circular cover, started to carry out the experiment of batch mice homogeneous radiation.
Embodiment 2: for the rat fixture that homogeneous radiation is tested in batches.
As shown in Fig. 2-1, Fig. 2-2 and Fig. 2-3, for the rat fixture that homogeneous radiation is tested in batches, comprise the cylinder shell 1 that bottom closed upper end is uncovered; Cover in cylinder shell 1 upper port and the detachable circular cover being fixedly connected with 2; Be placed in cylinder shell 1 for holding experimental mouse, six drops dress Mus cavitys 3 that shape coordinates with experimental mouse body; It is tangent that dress Mus cavity 3 equal tips are centripetal, nose circle is outwards petal-shaped radiation arrangement and nose circle and housing tube wall 4, has the through hole 5 that connects housing tube wall 4 and fill Mus cavity 3 in the bottom of each phase tangent line; The rat tail that greatly can make of through hole 5 passes through.In housing tube wall 4 upper ends, have equally distributed three screwed holes 6, have the hole coordinating with screwed hole at the periphery of circular cover 2 frames, circular cover 2 is detachably fixed on housing by the bolt 6 penetrating in screwed hole.
According to the common physical size of rat, the length of the present embodiment dress Mus cavity 3 is 20cm, highly is 8cm.The radius of cylinder shell 1 is consistent with the length of dress Mus cavity 3, is 20cm; The height of cylinder shell 1 is consistent with the height of dress Mus cavity 3, is 8cm.
Using method is with embodiment 1.
Claims (7)
1. for the experimental mouse fixture that homogeneous radiation is tested in batches, it is characterized in that: comprise the cylinder shell that bottom closed upper end is uncovered (1); Cover in cylinder shell (1) upper port and the detachable circular cover being fixedly connected with (2); Be placed in cylinder shell (1) for holding experimental mouse, a plurality of drops dress Mus cavitys (3) that shape coordinates with experimental mouse body; Dress Mus cavity (3) all most advanced and sophisticated centripetal, nose circle is outwards petal-shaped radiation arrangement, and nose circle and housing tube wall (4) are tangent, in the bottom of each phase tangent line, have the through hole (5) that connects housing tube wall (4) and dress Mus cavity (3) tube wall, through hole (5) size can make experimental mouse tail pass through.
2. according to claim 1 for the experimental mouse fixture that homogeneous radiation is tested in batches, it is characterized in that: in housing tube wall (4) upper end, have equally distributed at least 3 screwed holes (6), periphery at circular cover (2) frame has the hole coordinating with screwed hole, and circular cover (2) is detachably fixed on housing by the bolt (6) penetrating in screwed hole.
3. according to claim 1 for the experimental mouse fixture that homogeneous radiation is tested in batches, it is characterized in that: described circular cover (2) is less to radiation ray absorbed dose, almost the netted material of negligible thermoplastic.
4. according to claim 1 for the experimental mouse fixture that homogeneous radiation is tested in batches, it is characterized in that: described cylinder shell (1) and dress Mus cavity (3) are the material that inner wall smooth is transparent.
5. according to claim 1 for the experimental mouse fixture that homogeneous radiation is tested in batches, it is characterized in that: the radius of described cylinder shell (1) is consistent with the length of dress Mus cavity (3), the height of cylinder shell (1) is consistent with the height of dress Mus cavity (3).
According to described in claim 1 or 4 or 5 for the experimental mouse fixture of homogeneous radiation experiment in batches, it is characterized in that: when described dress Mus cavity (3) is when placing mice, its length is 8cm, highly is 3cm.
According to described in claim 1 or 4 or 5 for the experimental mouse fixture of homogeneous radiation experiment in batches, it is characterized in that: when described dress Mus cavity (3) is when placing rat, its length is 20cm, highly is 8cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310574795.2A CN103598926A (en) | 2013-11-13 | 2013-11-13 | Fixing apparatus for volume uniform radiation test of laboratory mice |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310574795.2A CN103598926A (en) | 2013-11-13 | 2013-11-13 | Fixing apparatus for volume uniform radiation test of laboratory mice |
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| CN103598926A true CN103598926A (en) | 2014-02-26 |
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| CN201310574795.2A Pending CN103598926A (en) | 2013-11-13 | 2013-11-13 | Fixing apparatus for volume uniform radiation test of laboratory mice |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983483A (en) * | 2015-07-16 | 2015-10-21 | 代亮 | Multifunctional rodent fixator and use method thereof |
| CN109124810A (en) * | 2018-09-26 | 2019-01-04 | 华蓥市铜堡初级中学 | A kind of animal blood taking platform |
| CN109363795A (en) * | 2018-09-29 | 2019-02-22 | 东南大学 | Microwave irradiation device and method suitable for open field |
| CN110522531A (en) * | 2019-09-03 | 2019-12-03 | 河南中医药大学 | A kind of retaining frame device of Brain Radiation Injury model mice experiment |
| RU198451U1 (en) * | 2020-03-27 | 2020-07-10 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | FIVE-BOX LABORATORY MOUSE LOCATION CAMERA |
| WO2022105619A1 (en) * | 2020-11-23 | 2022-05-27 | 南京中硼联康医疗科技有限公司 | Animal irradiation system and irradiation fixing apparatus thereof |
| RU217307U1 (en) * | 2023-02-09 | 2023-03-27 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Tablet for modeling the effects of radiation therapy of tumors on small laboratory animals under local exposure to ionizing radiation |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983483A (en) * | 2015-07-16 | 2015-10-21 | 代亮 | Multifunctional rodent fixator and use method thereof |
| CN104983483B (en) * | 2015-07-16 | 2017-01-04 | 代亮 | Multi-functional rodent holder and using method |
| CN109124810A (en) * | 2018-09-26 | 2019-01-04 | 华蓥市铜堡初级中学 | A kind of animal blood taking platform |
| CN109363795A (en) * | 2018-09-29 | 2019-02-22 | 东南大学 | Microwave irradiation device and method suitable for open field |
| CN109363795B (en) * | 2018-09-29 | 2020-07-31 | 东南大学 | Microwave irradiation device and method suitable for open field |
| CN110522531A (en) * | 2019-09-03 | 2019-12-03 | 河南中医药大学 | A kind of retaining frame device of Brain Radiation Injury model mice experiment |
| CN110522531B (en) * | 2019-09-03 | 2022-03-25 | 河南中医药大学 | Protective frame device for radioactive brain injury model mouse experiment |
| RU198451U1 (en) * | 2020-03-27 | 2020-07-10 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | FIVE-BOX LABORATORY MOUSE LOCATION CAMERA |
| WO2022105619A1 (en) * | 2020-11-23 | 2022-05-27 | 南京中硼联康医疗科技有限公司 | Animal irradiation system and irradiation fixing apparatus thereof |
| RU217307U1 (en) * | 2023-02-09 | 2023-03-27 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Tablet for modeling the effects of radiation therapy of tumors on small laboratory animals under local exposure to ionizing radiation |
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Inventor after: Yang Yang Inventor after: Jiao Liuhong Inventor after: Zhao Yong Inventor after: Luo Xiaomei Inventor after: Zhu Bin Inventor before: Yang Yang Inventor before: Luo Xiaomei Inventor before: Wang Lulu Inventor before: Zhu Bin Inventor before: Sun Yang Inventor before: Ma Wenqing |
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Effective date of registration: 20160715 Address after: 221004 No. 226 Copper Mountain Road, Jiangsu, Xuzhou Applicant after: Huaihai Hospital Affiliated to Xuzhou Medical College Address before: 221004 No. 226 Copper Mountain Road, Jiangsu, Xuzhou Applicant before: 97 Hospital of People's Liberation Army |
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Application publication date: 20140226 |