CN104983483B - Multi-functional rodent holder and using method - Google Patents

Multi-functional rodent holder and using method Download PDF

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Publication number
CN104983483B
CN104983483B CN201510417697.7A CN201510417697A CN104983483B CN 104983483 B CN104983483 B CN 104983483B CN 201510417697 A CN201510417697 A CN 201510417697A CN 104983483 B CN104983483 B CN 104983483B
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CN
China
Prior art keywords
tail
pawl
fixed plate
fixed
rotation
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CN201510417697.7A
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Chinese (zh)
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CN104983483A (en
Inventor
代亮
张志东
姚远
宋紫暄
申天宇
李彦静
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代亮
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Priority to CN201510417697.7A priority Critical patent/CN104983483B/en
Publication of CN104983483A publication Critical patent/CN104983483A/en
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Publication of CN104983483B publication Critical patent/CN104983483B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00Appliances for supporting or fettering animals for operative purposes

Abstract

The invention discloses a kind of multi-functional rodent holder and using method, including fuselage cover and chassis, it is positioned at the rotation fixed plate above fuselage cover, it is positioned at four rotated in fixed plate tie up pawl device and be positioned at and tie up the extremity below pawl device and fix cableway, it is connected to the tail fixing device of fuselage cover one end, it is arranged on the stereotype protective cover above fuselage cover and is arranged on ray guiding and the positioner at protective cover top, the luffing angle governor motion being arranged in chassis, and control to rotate the anglec of rotation governor motion of the fixed plate anglec of rotation and auxiliary support rotary mechanism.This laboratory table can realize only one research worker can carry out easy firm fixing to experiment mice, and is applicable to the mice of various size difference, it is achieved the pitching of laboratory animal fixed angle and rotary mediation, meets kinds of experiments position demand.Rat-tail can stably be fixed, and one hand can realize tail vein liquid enrichment and regulation and control, and arbitrarily selects four caudal veins to exchange.

Description

Multi-functional rodent holder and using method
Technical field
The invention belongs to animal experiment study equipment technical field, operation is simple and reliable and can meet multiple to relate to one The multi-functional rodent holder of Research Requirements and using method thereof.
Background technology
In current mouse experiment, research worker is fixed firstly the need of to mice, at present, is fixed mice The situation of method and apparatus as follows:
1. the method fixing mice is divided into two kinds: one to be to utilize cylindrical vessel, by space in constriction container to mice Carry out squash type to fix;Two is fixing by mice extremity carrying out binding with rope, then by rope bondage in position, preset, or Person is connected with slide block by rope, is allowed to slide with circular cylinder with fixing.But said method operation is more complicated, most feelings Need two experimenters to coordinate just under condition simultaneously and can complete the fixing of mice, not only waste of manpower, and fixed effect and pay no attention to Think.
2. for laboratory animal tail vein injection with take blood, apply existing fixed form, be difficulty with experiment dynamic The stable of thing afterbody is fixed, and more can not realize selecting tail veins in the case of animal trunk is fixing.Current behaviour In work, afterbody is often reversed to find suitable blood vessel, most probably in the case of animal trunk is fixing by research worker Cause afterbody damage, congestion or necrosis;Additionally, due to need a hands to hold afterbody in taking blood or injection process, cause another The needle angle of one hands is restricted, owing to tail vein is tiny, blood vessel wall is thin and skin-proximal, and the most therefore pierce through blood vessel Even the health of operator is constituted a threat to.The structure of animal model expends time, energy and financial resources, if owing to experiment is auxiliary Equipment is helped not mate so that animal model damages the massive losses of scientific research beyond doubt.
3. radiotherapy is in the research of " action effect in animal tumor model ", and most radiotherapy instrument derives from people The instrument eliminated after the application of class clinical treatment, its ray beam size launched is more suitable for the mankind, and radiotherapy can the size of focus point Uneven, owing to mice volume is small, Neoplastic organ or tissue in the mouse tumor model of structure are less, in application radiotherapy When instrument carries out radiotherapy, it is difficulty with the irradiation to each position of mouse body, more can not positioning tumor focus go forward side by side accurately Row fixed point radiotherapy, thus causes mice to accept excessive radiotherapy and dead or do not concentrate because of radiotherapy site and cause experimental result not have The problems such as science.
4. current animal experiment technique is widely used in biomedicine and drug research etc., and current laboratory animal is grasped Station mostly is flat board fixed model, i.e. mice and is fixed on operating board by level, it is impossible to be adjusted mice position.But it is many Mice position be there are certain requirements by zoopery, after carrying out specific part lavation or some surgery, for ensureing liquid (abdominal cavity Irrigating solution, pus, blood etc.) drain is unobstructed and makes mice keep a part to be higher than other positions, or the need for surgical exposure Want, it is desirable to mice changes position etc. in art at any time.Therefore, a kind of novel experiment behaviour that can adjust animal position at any time is needed badly Station.
5., in mouse experiment, pluck eyeball and take blood and be widely used as the operation of normal experiment.But it is past during this operation Toward owing to mice fixed position is the best and fixing loosely occurs taking blood difficulty, drop of blood waste, pollute and animal is hurted sb.'s feelings event.Cause This needs exploitation that mice can be made to be fixed into safely lateral position, and ensures that blood vertically instills the zoopery of blood collecting containers and sets Standby.
Summary of the invention
The present invention is to solve above-mentioned problems of the prior art, it is provided that a kind of multi-functional rodent is fixed Device.This laboratory table can realize only one research worker can carry out easy firm fixing to experiment mice, and is applicable to each Plant the mice of size difference, it is achieved the pitching of laboratory animal fixed angle and rotary mediation, meet kinds of experiments position demand;Mus Tail can stably be fixed, and one hand can realize tail vein liquid enrichment and regulation and control, and arbitrarily selects four caudal veins to exchange; In mouse tumor model radiotherapeutic effect is studied, it is achieved the targeting of tumor focus is positioned;Reduce manpower, operate with easy to be easy OK, reduce the damage to animal model, improve experiment success rate and make result of the test the most scientific.
The present invention solves that this problem takes following technical scheme:
A kind of multi-functional rodent holder, be van-type rodent holder or drum-type rodent solid Determine device.This holder includes fuselage cover and chassis, is positioned at the rotation fixed plate above fuselage cover, is positioned in rotation fixed plate Four tie up pawl device and be positioned at and tie up the extremity below pawl device and fix cableway, be connected to the tail fixing device of fuselage cover one end, It is arranged on the stereotype protective cover above fuselage cover and is arranged on ray guiding and the positioner at protective cover top, being arranged on the end Luffing angle governor motion in dish, and control to rotate the anglec of rotation governor motion of the fixed plate anglec of rotation and auxiliary support Rotating mechanism.
Tail fixing device includes tail intravenous procedures platform and tail intravenous set blood fixing device, outside tail intravenous procedures platform is with fuselage Connected by fixed hinge between shell end wall, can pack up in the not used time.It is provided with collapsible double-rod below tail intravenous procedures platform to support Frame, collapsible double-rod bracing frame upper end is connected by fixed hinge with tail intravenous procedures platform, and lower end is passed through with fuselage cover end wall Fixed hinge connects.On collapsible double-rod bracing frame, ratchet is installed, can be locked by ratchet one-way during use.Tail intravenous procedures Platform is provided with the tail intravenous set blood fixing device being made up of multiple snap rings, and user can be according to the difference of rat-tail length with concrete Situation selects snap ring to fix rat-tail voluntarily.This laboratory table also includes that afterbody collection blood handwheel, afterbody collection blood handwheel are independently arranged, can be right Rat-tail carries out collecting blood operation.Afterbody collection blood handwheel top is provided with finger ring, and wheel body mid portion has the groove of applicable rat-tail diameter, Finger ring and wheel body are all connected on handwheel support.Finger ring can be placed on operator's finger, and operator can dip in rubber pulley Take the sterilised liqs such as ethanol, by the abundant profit of sterilised liq in being directly realized by groove by the action of press-fit push-and-pull at afterbody With, realize afterbody sterilization at one stroke and be enriched with venous blood.
Anglec of rotation governor motion includes the bearing block being arranged on fuselage cover, is positioned at the bearing above bearing block and phase The worm gear engaged mutually and worm screw.Anglec of rotation governor motion uses Worm Wheel System design, has auto-lock function.Worm gear and rotation The power transmission shaft turned in fixed plate connects, and power transmission shaft is bolted in bottom with rotating fixed plate, and the axle center of power transmission shaft is higher than Rotate the surface of fixed plate, coaxial with the snap ring being positioned on tail fixing device;So that rotary shaft axle center is moved with Rodents Thing afterbody is coaxial, to reach animal bodies with afterbody for axle rotation, it is achieved choose the purpose of tail vein.Worm screw one end be positioned at The anglec of rotation outside fuselage cover adjusts knob and connects, and can adjust knob by the anglec of rotation and control worm screw.The anglec of rotation is adjusted The power transmission shaft of joint mechanism has bearing block to support and fuselage top panel is protected, it is ensured that Worm Wheel System accurately and stable.
Auxiliary support rotary mechanism is two annulus connected by sliding bearing, under auxiliary support rotary mechanism internal ring End is provided with support platform with rotating fixed plate junction, rotates fixed plate and uses bolt to be rigidly connected with internal ring by supporting platform, Can rotate with rotating animal fixed plate.Auxiliary support rotary mechanism outer shroud is rigidly connected by connector with fuselage cover, Play load-bearing and the fixation rotating animal fixed plate.The semicircle of auxiliary support rotary mechanism outer shroud is provided with scale Dish, is provided with deep line on auxiliary support rotary mechanism internal ring and carries out accurately as pointer, the convenient angle to animal upset Adjust.
Luffing angle governor motion is connected on bearing block, including driving-chain and be positioned at the luffing angle outside fuselage cover Adjusting knob.Angle of pitch adjusting knob and the anglec of rotation adjust knob and are arranged at homonymy, facilitate experimenter to operate.Luffing angle Governor motion uses single side chain kind of drive, carries out transmission by the length adjusting driving-chain, and driving-chain one end connects pitching Angle adjustment lever, the other end connects two to the bearing pin in the middle of support bar.Experimenter can be by rotating the pitching of adjusting lever one end Angle adjusting knob adjusts the length of driving-chain, thus realizes the luffing angle to integral body above and regulate.The angle of pitch regulates It is provided with ratchet in knob, unidirectional locking can be realized.
Being provided with support bracket between fuselage cover lower surface near caudal end part and chassis, support bracket is connected by by bearing pin Top support bracket and lower prop composition.Support bracket can rotate with the change of fuselage attitude, and supports whole The deadweight of body fuselage, meets experimenter's demand to mice position in experimental implementation.
Fuselage cover bottom is provided with cleaning sliding door, and the personnel of being convenient to operation clean fuselage interior.
Rodent extremity are fixed by tiing up pawl device, and tiing up pawl device is Split type structure, tie up split on pawl device and are provided with for tiing up The extremity buckle of pawl, and tie up and fixed by latch between split under pawl device;Tie up split under pawl device and be provided with acupressure probe and baffle plate, finger pressure Plate facilitates operator to drag as required thus fixing mice.Tie up the lower end of split under pawl device and form circular lead angle, and pass through Fixed latches is fixed on extremity and fixes on cableway, and circular lead angle is conducive to dragging force, and baffle plate can be with the ratchet of confutation spine plate.Four It is groove-like structure that limb fixes cableway, is connected with rotating fixed plate by bolt, and extremity are provided with left and right twice spine in fixing cableway Shape track, is respectively equipped with shallow grooves, slides for tiing up the circular lead angle of split under pawl device, is additionally provided with deep groove, and leads between two slideways Crossing Fixed latches connection and tie up split and slideway bottom under pawl device, prevention is tied up split slide block under pawl device and slidably, is assisted to tie up pawl device Action of gravity is overcome to make it not fall out.The ratchet of spine shape track with remain static tie up the baffle plate of split bottom under pawl device Constituting slides hinders, thus realizes fixedly securing the purpose of animal foot.
Rotating middle side part in fixed plate and be provided with abdomen fixation device, abdomen fixation device includes bellyband and is connected to bellyband The buckle at two ends, buckle is fixed on and rotates in the draw-in groove that fixed plate both sides are formed.Rodent abdominal part is solid by animal bellyband Fixed, the main material of described bellyband is elastomeric material, and two ends are fixed by snap in rotating animal fixed plate both sides, it is to avoid animal is in rotation The limb injury caused because of self gravitation reason during Zhuaning.
The top of stereotype protective cover is formed with elongated slit space, be provided with in slit space scalable radical occlusion device and Ray guides and positioner, and ray guiding and positioner are positioned at the middle part of scalable radical occlusion device, block dress with scalable Put and be bolted;Ray guides and positioner includes apparatus main body and leading screw and feed rod, and apparatus main body is provided with Ray bullport and hole, location, leading screw and feed rod through apparatus main body both sides, leading screw one end be arranged on stereotype protective cover end wall On adjustment of displacement knob connect.Use lead screw transmission, there is precision high, the advantage that location is accurate.High-brightness luminous two pole can be used Pipe carries out lesion localization, and according to the regular length of ray bullport with hole, location, operation adjustment of displacement knob guides radiotherapy machine Location.Scalable radical occlusion device, for coordinating ray to guide and positioner use, can stop that additional radiation input is required and irradiate disease Tissue outside stove.
The present invention has the advantage that with good effect:
First, the multi-functional rodent holder of the present invention, use the extremity buckle tied up on pawl device in split by little Mus extremity entangle firm, combine closely with being connected to the split under pawl device of tiing up that extremity fix on cableway, tie up split under pawl device by push-and-pull Realizing stably fixing the personalization of different building shape mice, this device makes mice claw depart from rotation fixed plate and extremity are in Extended state so that mice can not grab and climb twisting, trunk can keep this figure all the time, reduces the swing in rat-tail portion, it is simple to rat-tail Fixing, many need can be met and stably fix the experimental implementation demand of animal.
Second, the both sides upper limb of animal and both sides lower limb can be separately fixed at extremity active rail by tiing up pawl device by the present invention In two tracks up and down in road, it is achieved supine prostrate that animal is fixing and lateral position, coordinate body pitching regulation and animal The regulation that rotates rotating fixed plate realizes the stable fixing of the various position of animal, meets internal liquid drain, eyeball takes blood, operation The experiment demands such as visual field exposure and radiotherapy localization.
3rd, reconciling knob by the angle rotating fixed plate can be adjusted rotating fixed plate, it is achieved that with rat-tail For 360 degree of rotatable fixed positions of axle, there is bellyband protection that it will not be caused damage, in rat-tail by mice because of self gravitation Caudal vein can be selected at operating board, use collection blood handwheel can realize afterbody sterilization simultaneously and be enriched with rapidly with venous blood And fix, it is achieved needle angle is freely, it is simple to injects and takes blood.
4th, in the research of animal tumor model radiotherapeutic effect, guided by ray and detent mechanism can be sick to mouse tumor Stove positions, and ray can be made precisely to be irradiated in disease site by the drive mechanism of feed screw nut, emitting radiation bundle big I is not affected by radiotherapy machine, meets the accurate range requirement of various radiotherapy, and can avoid the exposure of other body parts Under lonizing radiation, greatly improve radiotherapy efficiency, it is to avoid the death that excessive radiotherapy is caused so that the science of experimental result Property is higher.
In sum, all operations is simple, saves resource, can be completed repertoire by a people and operate, fully improve Operating efficiency, decreases manpower and quality time that existence conditions is wasted, provides convenience for carrying out scientific experiments.
Accompanying drawing explanation
Fig. 1 is the structural perspective of the multi-functional rodent holder of the present invention;
Fig. 2 is the structural perspective after the multi-functional rodent holder of the present invention removes protective cover;
Fig. 3 is the sectional side elevation after the multi-functional rodent holder of the present invention removes protective cover;
Fig. 4 is the top view of the stereotype protective cover of the present invention;
Fig. 5 is the sectional view of line A-A along Fig. 4;
Fig. 6 is the structural perspective tiing up pawl device of the present invention;
Fig. 7 is the profile tiing up pawl device of the present invention;Fig. 8 is the structural perspective of the afterbody collection blood handwheel of the present invention;
Critical piece symbol description in accompanying drawing:
1: tie up pawl device 101: tie up pawl device shell
102: spine shape track 103: tie up split under pawl device
104: tie up split 105 on pawl device: extremity buckle
106: Fixed latches 107: acupressure probe
108: circular lead angle 109: baffle plate
2: abdomen fixation device 201: buckle
202: bellyband 3: rotate fixed plate
4: anglec of rotation governor motion 401: power transmission shaft
402: worm gear 403: bearing
404: worm screw 405: bearing block
406: auxiliary support rotary mechanism internal ring
407: support column 408: fuselage top panel
409: anglec of rotation adjustment knob 5: fuselage cover
501: auxiliary support rotary mechanism outer shroud
502: chassis 6: tail fixing device
601: the first fixed hinges 602: tail intravenous procedures platform
603: snap ring 604: collapsible double-rod bracing frame
605: ratchet 606: the second fixed hinge
7: luffing angle governor motion 701: top support bracket
702: lower prop 703: hinge
704: support bar 705: bearing pin
706: driving-chain 707: luffing angle adjusting lever
8: stereotype protective cover 801: protective cover end wall
802: scalable radical occlusion device 803: ray guides and positioner
804: ray bullport 805: hole, location
806: leading screw 807: adjustment of displacement knob
9: afterbody collection blood handwheel 901: finger ring
902: handwheel support 903: wheel body.
Detailed description of the invention
With specific embodiment, the multi-functional rodent holder of the present invention is carried out specifically referring to the drawings Bright.Specific embodiments described below is only the preferred forms of the present invention, and is not considered as limiting the invention.
Fig. 1 is the structural perspective of the multi-functional rodent holder of the present invention;Fig. 2 is that the multi-functional of the present invention nibbles Tooth class animal holder removes the structural perspective after protective cover;Fig. 3 is that the multi-functional rodent holder of the present invention goes Fall the sectional side elevation after protective cover;As shown in Figure 1 to Figure 3, the multi-functional rodent holder of the present invention, is van-type Rodents Animal holder or drum-type rodent holder.This holder includes fuselage cover 5 and chassis, is positioned on fuselage cover The rotation fixed plate 3 of side, is positioned at four rotated in fixed plate 3 and ties up pawl device 1 and be positioned at and tie up the extremity below pawl device and fix cableway, It is connected to the tail fixing device of fuselage cover one end, is arranged on the stereotype protective cover above fuselage cover and is arranged on protective cover The ray at top guides and positioner, the luffing angle governor motion being arranged in chassis, and controls to rotate fixed plate rotation The anglec of rotation governor motion of gyration and auxiliary support rotary mechanism.
Tie up pawl device 1 and slip cableway assembly thereof from rotate fixed plate 3 bottom by bolt fixed thereto, bellyband 201 and Buckle 202 is fixed on rotation fixed plate 3 both sides by draw-in groove, rotates fixed plate 3 by bolt and anglec of rotation governor motion 4 Power transmission shaft 401 connect, power transmission shaft 401 and worm gear 402 grafting, worm gear 402 engages each other with worm screw 404, worm screw 404 one end and Being placed in the adjustment knob 409 of the anglec of rotation outside fuselage cover 5 to connect, power transmission shaft 401 is inserted with bearing block 405 by bearing 403 Connecing, bearing block 405 is secured by bolts on the support column 407 that fuselage interior both sides are arranged, and fuselage top panel 408 passes through clamp It is connected with fuselage cover.Rotating fixed plate 3 to be connected with auxiliary support rotary mechanism internal ring 406 by bolt, auxiliary supports and rotates Mechanism's internal ring 406 is connected with auxiliary support rotary mechanism outer shroud 501 by sliding bearing, assists support rotary mechanism outer shroud 501 Being welded as a whole with fuselage cover 5, tail intravenous procedures platform 602 is connected with fuselage cover by the first fixed hinge 601, collapsible Double-rod bracing frame 604 is connected with tail intravenous procedures platform and fuselage cover at its two ends respectively by the second fixed hinge 606, can Fold folding hinge on double-rod bracing frame 602, by bearing pin, one direction fixed ratchet wheel 605 is installed, tail intravenous procedures platform passes through spiral shell Bolt fixes six buckles and snap ring 603.Fuselage cover 5 lower front part is provided with support bracket 701, by holding of bearing pin and chassis 8 Weight support 702 is connected, two pairs of support bar 704 two ends in luffing angle governor motion 7 by hinge 703 respectively with fuselage outside Shell 5 bottom and chassis 8 connect, and two pairs of support bars are connected by bearing pin 705, and driving-chain 706 two ends are individually fixed in support lever pin Axle 705 and luffing angle adjusting lever 707, luffing angle adjusting lever 707 one end is provided with luffing angle adjusting knob 708, is placed in machine Outside body shell 5, in knob, it is provided with ratchet.
Fig. 4 is the top view of the stereotype protective cover of the present invention;Fig. 5 is the sectional view of line A-A along Fig. 4.Such as Fig. 4 and Fig. 5 Shown in, the top of stereotype protective cover 8 is formed with elongated slit space, is provided with scalable radical occlusion device 802 in slit space Guiding and positioner 803 with ray, ray guiding and positioner are positioned at the middle part of scalable radical occlusion device, with scalable screening Blocking means is bolted;Ray guide and positioner use screw nut driven mode, including apparatus main body, leading screw, Feed rod and be positioned at the adjustment of displacement knob of leading screw one end.Interconnective ray bullport 804 He it is provided with in apparatus main body Hole 805, location, ray bullport and hole, location are connected on leading screw 806.Leading screw one end be arranged on stereotype protective cover end wall 801 On adjustment of displacement knob 807 connect.
Ray guides and the apparatus main body of positioner is positioned in the middle of scalable radical occlusion device, leads to scalable radical occlusion device Crossing bolt to connect, leading screw and feed rod are arranged at the both sides of apparatus main body, and its two ends are connected to wall before and after radiation lid so that Apparatus main body is only limited to the straight-line displacement campaign being embedded in slit space, and feed rod is connected for rigidly fixing with radiation lid rear wall, silk Thick stick two ends are connected with radiation lid front and rear wall by axle sleeve, and leading screw one end is provided with hole, location adjusting means.
Fig. 6 is the structural perspective tiing up pawl device of the present invention;Fig. 7 is the profile tiing up pawl device of the present invention.Such as Fig. 6 and Tu Shown in 7, tiing up pawl device shell 101 and be bolted with rotating fixed plate 3, extremity buckle 105 is plugged on ties up split 104 on pawl device On, tie up split 104 on pawl device and be connected by pin with tiing up split 103 under pawl device, tie up split 103 top under pawl device and be machined with finger pressure Plate 107, bottom is machined with circular lead angle 108 and baffle plate 109, and bottom is connected with spine shape track 102 by Fixed latches 106.
Fig. 8 is the structural perspective of the afterbody collection blood handwheel of the present invention.As shown in Figure 8, rat-tail collection blood handwheel 9 top is for referring to Ring 901, is plugged on handwheel support 902, and handwheel 903 is connected with handwheel support 903 by axle.
The multi-functional rodent holder of the present invention, can meet Rodents involved in Most experiments room and move The operational requirements of thing, simultaneously, it is contemplated that the habit of laboratory animal and the operating habit of operator, the present invention is from each details Start with, solve the difficulty and problem faced in experimental implementation now.Tie up pawl device and allow for the extremity of rodent Range of activity and active behavior and design, owing to generally shrinking extremity when rodent moves, the present invention will tie up pawl device It is designed as monodirectional locking;For to animal safeguard protection in rotary course, it is specifically designed bellyband and the abdominal part of animal is tied up Fixed, this not only makes animal fixing more stable, and has played the effect avoiding animal to cause extremity to lose because of self gravitation; Angle of pitch governor motion meets many requirements that rodent carries out operation and postoperative operation equally;Rotate animal to fix Plate achieves pivoting with animal afterbody as axle center with coordinating of afterbody operation panel, facilitates operator to tail vein blood Selecting of pipe;Rotating the spinfunction of animal fixed plate to achieve 360 degree and rotate without dead angle, it can the worm and gear rotation of self-locking Device and tuning drive gear and the design of graduated disc, facilitate the operation of experimenter;Extremity cableway, animal rotating mechanism and fuselage The cooperation of pitching achieves the stable of many operation positions in zoopery operation and fixes;Afterbody operating board can fold, for this Machine saves space, the design of six afterbody buckles so that operator safely, accurately operate can improve experiment Success rate, six afterbody buckles can select the most several being fixed according to requirement of experiment.The design of stereotype protective cover makes With heavy-duty machines, mice radiotherapy is possibly realized, is possible not only to the radiotherapy focus of mice is carried out precise positioning, it is also possible to pass through Change the size of pore size control x radiation x area.
The use process of the multi-functional rodent holder of the present invention is as follows:
1. tail intravenous procedures: when positive clinostatism fixes animal, first will tie up split on pawl device and take out, and use extremity buckle respectively By animal foot bondage, it is then pressed into tiing up split under pawl device, is strained by spine plate track, thus fixing mice extremity, finally make With bellyband bondage animal abdominal part, animal is steadily fixed in rotation fixed plate.Afterbody operating board is lifted, uses ratchet solid Fixed, animal afterbody is placed along afterbody operating board, by regulation anglec of rotation control knob, finds the easy-operating venous blood of afterbody Pipe, after vein blood vessel selects, dips sterilised liq by finger rubber wheel, and afterbody carries out collecting blood operation, and collection blood has operated Bi Hou, the most nearly buckle in animal root of the tail portion press stuck, are then selected under fixing afterbody by buckle according to experimental implementation demand The position of section, after taking blood or entry needle insertion, the nearly buckle of rat-tail root is again pressed and is unclamped, and proceeds by and takes blood and note Penetrate operation.
2. experiment operates with many Postural immobilization: during fixing mice, first will tie up split on pawl device and take out successively, as required By animal foot bondage one by one, or double upper limb bondage is together, and double lower limb bondages together, then will tie up the lower split of split insertion on pawl device In, strained by spine plate track, finally use bellyband to fix animal abdominal part, animal is steadily fixed in rotation fixed plate, joins The pitching closing body pitching mechanism is reconciled and rotates the rotation regulation of animal fixed plate rotating mechanism, it is achieved supine position, The firm of the positions such as ventricumbent position, left and right sides clinostatism is fixed.According to operation practical situation or requirement of experiment, fixed plate will be rotated and adjust To optimal performance angle, use angle of pitch adjusting knob that the angle of inclination of animal is adjusted, tie up pawl device and join with extremity track Suitable position is chosen in conjunction, it is achieved eyeball takes blood, internal hydrops drain, surgical field of view exposure and radiotherapy localization etc., thus convenient real Test being normally carried out of operation.
3, rodent carries out radiotherapy: using positive clinostatism to be fixed by animal, fixing means, as described in 1, is buckled for machine Stereotype protective cover, uses high-brightness light emitting diode to be positioned over hole, location, and now ray bullport serves as observation port, and operator are led to Cross operation adjustment of displacement knob, after being overlapped at the lesion marking that the hot spot that laser pen projects is irradiated by lonizing radiation with animal, close Close and take off laser pen, by means of the characteristic that screw nut driven precision is high, by adjustment of displacement knob triple turn again, now penetrating Under line bullport, center is the focus that will accept radiotherapy.
4, the application of independent handwheel devices is simple, direct by the action of press-fit push-and-pull at afterbody by experimenter Realize making full use of of sterilised liq in groove, realize afterbody sterilization at one stroke and be enriched with venous blood.
The multi-functional rodent holder of the present invention, can meet above-mentioned experimental implementation demand one by one, equally can also Summary operation with the use of, meet more complicated experiment demand.

Claims (8)

1. a multi-functional rodent holder, it is characterised in that: this holder includes fuselage cover and chassis, is positioned at machine Rotation fixed plate above body shell, is positioned at four rotated in fixed plate and ties up pawl device and be positioned at and tie up the extremity below pawl device and fix Cableway, is connected to the tail fixing device of fuselage cover one end, is arranged on the stereotype protective cover above fuselage cover and is arranged on The ray at protective cover top guides and positioner, the luffing angle governor motion being arranged in chassis, and controls to rotate admittedly Determine anglec of rotation governor motion and the auxiliary support rotary mechanism of the plate anglec of rotation;Tail fixing device includes tail intravenous procedures platform With tail intravenous set blood fixing device, being connected by the first fixed hinge between tail intravenous procedures platform and fuselage cover end wall, tail is quiet Being provided with collapsible double-rod bracing frame below arteries and veins operating board, collapsible double-rod bracing frame upper end is connected with tail intravenous procedures platform, lower end Being connected with fuselage cover end wall, collapsible double-rod bracing frame is provided with ratchet, tail intravenous procedures platform is provided with by multiple snap rings The tail intravenous set blood fixing device of composition;Auxiliary support rotary mechanism is two annulus connected by sliding bearing, auxiliary The lower end of support rotating mechanism internal ring is provided with support platform with rotating fixed plate junction, rotates fixed plate and uses bolt by supporting Platform is rigidly connected with internal ring, and auxiliary support rotary mechanism outer shroud is rigidly connected by connector with fuselage cover;Support in auxiliary The semicircle of rotating mechanism outer shroud is provided with graduated disc, is provided with and deeply rules as pointer on auxiliary support rotary mechanism internal ring;Rotation Turning middle side part in fixed plate and be provided with abdomen fixation device, abdomen fixation device includes bellyband and is connected to the card at bellyband two ends Button, buckle is fixed on and rotates in the draw-in groove that fixed plate both sides are formed.
Multi-functional rodent holder the most according to claim 1, it is characterised in that: this holder also includes afterbody Collection blood handwheel, afterbody collection blood handwheel is independently arranged, and top is provided with finger ring, and wheel body mid portion has the recessed of applicable rat-tail diameter Groove, finger ring and wheel body are all connected on handwheel support.
Multi-functional rodent holder the most according to claim 2, it is characterised in that: anglec of rotation governor motion bag Include the bearing block being arranged on fuselage cover, be positioned at the bearing above bearing block and intermeshing worm gear and worm screw;Worm gear with The power transmission shaft rotated in fixed plate connects, and power transmission shaft is bolted in bottom with rotating fixed plate, and the axle center of power transmission shaft is high In the surface of rotation fixed plate, coaxial with the snap ring being positioned on tail fixing device;Worm screw one end be positioned at outside fuselage cover The anglec of rotation adjust knob connect.
Multi-functional rodent holder the most according to claim 3, it is characterised in that: luffing angle governor motion is even It is connected on bearing block, uses single side chain kind of drive, including driving-chain, luffing angle adjusting lever, support bar be positioned at outside fuselage Luffing angle adjusting knob outside shell;Driving-chain one end connects luffing angle adjusting lever, and the other end connects two in support bar Between bearing pin;It is provided with ratchet in angle of pitch adjusting knob.
Multi-functional rodent holder the most according to claim 4, it is characterised in that: the nearly tail of fuselage cover lower surface Being provided with support bracket at end and between chassis, support bracket is propped up by the top support bracket connected by bearing pin and bottom load-bearing Frame forms.
Multi-functional rodent holder the most according to claim 1, it is characterised in that: fuselage cover bottom is provided with Operator are facilitated to clean the cleaning sliding door of fuselage interior.
Multi-functional rodent holder the most according to claim 1, it is characterised in that: tiing up pawl device is Split type structure, Tie up split on pawl device and be provided with the extremity buckle for tiing up pawl, and tie up and fixed by latch between split under pawl device;Tie up lower point of pawl device Body is provided with acupressure probe and baffle plate, ties up the lower end of split under pawl device and forms circular lead angle, and it is solid to be fixed on extremity by Fixed latches On standing wire road, it is groove-like structure that extremity fix cableway, is connected with rotating fixed plate by bolt, and extremity are provided with in fixing cableway Left and right twice spine shape track, the ratchet of spine shape track constitutes slip with the baffle plate tiing up split bottom under pawl device remained static Hinder.
Multi-functional rodent holder the most according to claim 1, it is characterised in that: the top shape of stereotype protective cover Becoming to have elongated slit space, be provided with scalable radical occlusion device and ray guides and positioner in slit space, ray draws Lead and positioner is positioned at the middle part of scalable radical occlusion device, be bolted with scalable radical occlusion device;Ray guide and Positioner uses screw nut driven mode, including apparatus main body, leading screw, feed rod and the adjustment of displacement being positioned at leading screw one end Knob, apparatus main body is positioned in the middle of scalable radical occlusion device, is bolted with scalable radical occlusion device, sets in apparatus main body Being equipped with ray bullport and hole, location, ray bullport and hole, location to be connected on leading screw, leading screw and feed rod are arranged at device master The both sides of body, its two ends are both connected on protective cover end wall so that the straight-line displacement fortune that apparatus main body is only limited in slit space Dynamic, feed rod is connected for rigidly fixing with protective cover end wall, and leading screw two ends are connected with protective cover end wall by axle sleeve.
CN201510417697.7A 2015-07-16 2015-07-16 Multi-functional rodent holder and using method CN104983483B (en)

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CN106798971A (en) * 2017-04-05 2017-06-06 青岛大学附属医院 A kind of tumour radiotherapy experimental provision
CN108209856A (en) * 2017-12-14 2018-06-29 中国科学院昆明动物研究所 Animal eye examination stereotaxic instrument
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