CN104981752A - 对用于复杂系统的优化的输入参数组合的快速识别 - Google Patents

对用于复杂系统的优化的输入参数组合的快速识别 Download PDF

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Publication number
CN104981752A
CN104981752A CN201480005166.0A CN201480005166A CN104981752A CN 104981752 A CN104981752 A CN 104981752A CN 201480005166 A CN201480005166 A CN 201480005166A CN 104981752 A CN104981752 A CN 104981752A
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complex system
drug
input parameters
drugs
optimized
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CN201480005166.0A
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Chinese (zh)
Inventor
何志明
丁显廷
汪洋
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication of CN104981752A publication Critical patent/CN104981752A/zh
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2119/00—Details relating to the type or aim of the analysis or the optimisation
    • G06F2119/22—Yield analysis or yield optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/20—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Mathematical Physics (AREA)
  • Databases & Information Systems (AREA)
  • General Health & Medical Sciences (AREA)
  • Mathematical Analysis (AREA)
  • Pure & Applied Mathematics (AREA)
  • Public Health (AREA)
  • Mathematical Optimization (AREA)
  • Computational Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Software Systems (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Computation (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Algebra (AREA)
  • Operations Research (AREA)
  • Computing Systems (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Physiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Computer Hardware Design (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Geometry (AREA)
CN201480005166.0A 2013-01-17 2014-01-17 对用于复杂系统的优化的输入参数组合的快速识别 Pending CN104981752A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361753842P 2013-01-17 2013-01-17
US61/753,842 2013-01-17
PCT/US2014/012111 WO2014113714A1 (en) 2013-01-17 2014-01-17 Rapid identification of optimized combinations of input parameters for a complex system

Publications (1)

Publication Number Publication Date
CN104981752A true CN104981752A (zh) 2015-10-14

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CN201480005166.0A Pending CN104981752A (zh) 2013-01-17 2014-01-17 对用于复杂系统的优化的输入参数组合的快速识别

Country Status (9)

Country Link
US (2) US20150356269A1 (enExample)
EP (1) EP2946263A4 (enExample)
JP (3) JP2016507105A (enExample)
KR (1) KR102272849B1 (enExample)
CN (1) CN104981752A (enExample)
AU (2) AU2014207327A1 (enExample)
CA (1) CA2898324A1 (enExample)
SG (1) SG11201505579TA (enExample)
WO (1) WO2014113714A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109074422A (zh) * 2016-04-13 2018-12-21 技能细胞公司 制备生物合成装置的方法及其在诊断中的用途

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Publication number Priority date Publication date Assignee Title
WO2021014343A1 (en) * 2019-07-23 2021-01-28 Reagene Innovations Pvt. Ltd. Artificial intelligence guided identification of affordable re-purposed drugs for leukemias
EP4046161A4 (en) * 2019-10-18 2023-11-29 National University of Singapore METHOD FOR PREDICTING APPROPRIATE THERAPY

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US20040009536A1 (en) * 2001-07-30 2004-01-15 George Grass System and method for predicting adme/tox characteristics of a compound
CN102047255A (zh) * 2008-03-26 2011-05-04 赛拉诺斯股份有限公司 用于评估临床结果的方法和系统
US20120078521A1 (en) * 2010-09-27 2012-03-29 General Electric Company Apparatus, system and methods for assessing drug efficacy using holistic analysis and visualization of pharmacological data
CN102822834A (zh) * 2010-04-07 2012-12-12 诺华探索公司 用于预测治疗结果的基于计算机的系统

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US4368509A (en) * 1979-08-24 1983-01-11 Li Chou H Self-optimizing machine and method
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US7124031B1 (en) * 2000-05-11 2006-10-17 Medco Health Solutions, Inc. System for monitoring regulation of pharmaceuticals from data structure of medical and labortory records
US20020165762A1 (en) * 2001-05-02 2002-11-07 Clinical Discovery Israel Ltd. Method for integrated analysis of safety, efficacy and business aspects of drugs undergoing development
US20040138826A1 (en) * 2002-09-06 2004-07-15 Carter Walter Hansbrough Experimental design and data analytical methods for detecting and characterizing interactions and interaction thresholds on fixed ratio rays of polychemical mixtures and subsets thereof
AU2003269395A1 (en) * 2002-09-16 2004-04-30 Optimata, Ltd. An interactive technique for optimizing drug development from the pre-clinical phases through phase-iv
JP3987059B2 (ja) * 2004-07-30 2007-10-03 株式会社東芝 最適値探索支援装置、最適値探索支援方法、及び記録媒体
JP2007041784A (ja) * 2005-08-02 2007-02-15 Toshiba Corp 最適値探索支援装置、最適値探索支援方法、及びプログラム
JP4670826B2 (ja) * 2007-03-26 2011-04-13 トヨタ自動車株式会社 制御パラメータの実験計画設定方法、その実験計画設定方法をコンピュータに実行させるためのプログラム、およびそのプログラムを記録したコンピュータ読取可能な記録媒体
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009536A1 (en) * 2001-07-30 2004-01-15 George Grass System and method for predicting adme/tox characteristics of a compound
CN102047255A (zh) * 2008-03-26 2011-05-04 赛拉诺斯股份有限公司 用于评估临床结果的方法和系统
CN102822834A (zh) * 2010-04-07 2012-12-12 诺华探索公司 用于预测治疗结果的基于计算机的系统
US20120078521A1 (en) * 2010-09-27 2012-03-29 General Electric Company Apparatus, system and methods for assessing drug efficacy using holistic analysis and visualization of pharmacological data

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109074422A (zh) * 2016-04-13 2018-12-21 技能细胞公司 制备生物合成装置的方法及其在诊断中的用途
CN109074422B (zh) * 2016-04-13 2022-05-13 技能细胞公司 制备生物合成装置的方法及其在诊断中的用途

Also Published As

Publication number Publication date
JP2016507105A (ja) 2016-03-07
CA2898324A1 (en) 2014-07-24
EP2946263A4 (en) 2016-08-31
KR102272849B1 (ko) 2021-07-02
JP2019029027A (ja) 2019-02-21
AU2014207327A1 (en) 2015-08-06
US20210358636A1 (en) 2021-11-18
SG11201505579TA (en) 2015-08-28
EP2946263A1 (en) 2015-11-25
KR20150110567A (ko) 2015-10-02
WO2014113714A1 (en) 2014-07-24
JP2022048275A (ja) 2022-03-25
US20150356269A1 (en) 2015-12-10
AU2019257388A1 (en) 2019-11-14

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Application publication date: 20151014