CN104981250A - 用于治疗贫血的方法 - Google Patents

用于治疗贫血的方法 Download PDF

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Publication number
CN104981250A
CN104981250A CN201380067832.9A CN201380067832A CN104981250A CN 104981250 A CN104981250 A CN 104981250A CN 201380067832 A CN201380067832 A CN 201380067832A CN 104981250 A CN104981250 A CN 104981250A
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CN
China
Prior art keywords
gdf11
actriia
antagonist
seq
actriib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380067832.9A
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English (en)
Chinese (zh)
Inventor
维多利亚·松
拉杰什·乔普拉
奥利维尔·赫尔米内
伊凡·克鲁兹莫拉
迈克尔·杜赛特
蒂亚戈·特罗瓦蒂马切尔
奥雷利·弗里克
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Celgene Corp
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Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Priority to CN202011541918.9A priority Critical patent/CN112933223A/zh
Priority to CN202011542063.1A priority patent/CN112957462A/zh
Publication of CN104981250A publication Critical patent/CN104981250A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380067832.9A 2012-10-24 2013-10-23 用于治疗贫血的方法 Pending CN104981250A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202011541918.9A CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011542063.1A CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718128P 2012-10-24 2012-10-24
US61/718,128 2012-10-24
PCT/US2013/066353 WO2014066487A2 (en) 2012-10-24 2013-10-23 Methods for treating anemia

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202011542063.1A Division CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011541918.9A Division CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Publications (1)

Publication Number Publication Date
CN104981250A true CN104981250A (zh) 2015-10-14

Family

ID=50545463

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201380067832.9A Pending CN104981250A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011542063.1A Pending CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011541918.9A Pending CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Family Applications After (2)

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CN202011542063.1A Pending CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011541918.9A Pending CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Country Status (9)

Country Link
US (1) US20150266950A1 (enExample)
EP (2) EP2911682A4 (enExample)
JP (3) JP6401172B2 (enExample)
CN (3) CN104981250A (enExample)
AU (4) AU2013334660B2 (enExample)
CA (1) CA2889286A1 (enExample)
HK (1) HK1214504A1 (enExample)
NZ (1) NZ747350A (enExample)
WO (1) WO2014066487A2 (enExample)

Cited By (2)

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CN107011430A (zh) * 2017-04-07 2017-08-04 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN112601538A (zh) * 2018-05-09 2021-04-02 科乐斯疗法公司 激活素受体iia型变体及其使用方法

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US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
EP2599495A1 (en) 2007-02-01 2013-06-05 Acceleron Pharma, Inc. Activin-ActRIIa Antagonists and Uses for Treating or Preventing Breast Cancer
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CA2699936A1 (en) 2007-09-18 2009-03-26 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
HUE051137T2 (hu) 2008-08-14 2021-03-01 Acceleron Pharma Inc GDF-csapdák
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
US8178488B2 (en) 2009-06-08 2012-05-15 Acceleron Pharma, Inc. Methods for increasing thermogenic adipocytes
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CN103298832A (zh) 2010-11-08 2013-09-11 阿塞勒隆制药公司 Actriia结合剂及其用途
EP2911682A4 (en) * 2012-10-24 2016-03-23 Celgene Corp METHOD FOR TREATING ANEMIA
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
KR102520970B1 (ko) * 2014-03-21 2023-04-12 악셀레론 파마 인코포레이티드 액티빈 b 및/또는 gdf11을 억제함으로써 적혈 혈액 세포 수준을 증가시키고 비효율적인 적혈구 생성을 치료하는 방법
CN107135646B (zh) 2014-06-13 2022-03-15 阿塞勒隆制药公司 用于治疗溃疡的方法和组合物
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
JP2018501307A (ja) * 2014-12-03 2018-01-18 セルジーン コーポレイション アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用
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AU2016261913B2 (en) * 2015-05-13 2021-08-12 Acceleron Pharma Inc. Treatment of beta-thalassemia using ActRII ligand traps
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KR20200109330A (ko) 2018-01-12 2020-09-22 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011430A (zh) * 2017-04-07 2017-08-04 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN107011430B (zh) * 2017-04-07 2020-09-01 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN112601538A (zh) * 2018-05-09 2021-04-02 科乐斯疗法公司 激活素受体iia型变体及其使用方法
CN112601538B (zh) * 2018-05-09 2025-08-19 科乐斯疗法公司 激活素受体iia型变体及其使用方法

Also Published As

Publication number Publication date
CN112957462A (zh) 2021-06-15
AU2013334660A1 (en) 2015-05-14
EP3527219A1 (en) 2019-08-21
JP2018184430A (ja) 2018-11-22
AU2013334660B2 (en) 2018-08-09
US20150266950A1 (en) 2015-09-24
EP2911682A2 (en) 2015-09-02
EP2911682A4 (en) 2016-03-23
CA2889286A1 (en) 2014-05-01
JP6401172B2 (ja) 2018-10-10
JP2016503398A (ja) 2016-02-04
AU2020203198A1 (en) 2020-06-11
AU2020203198B2 (en) 2021-12-23
WO2014066487A2 (en) 2014-05-01
NZ747350A (en) 2020-07-31
JP2020183390A (ja) 2020-11-12
AU2022201923A1 (en) 2022-04-14
CN112933223A (zh) 2021-06-11
HK1214504A1 (zh) 2016-07-29
WO2014066487A3 (en) 2014-06-19
AU2018256635A1 (en) 2018-11-22

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