AU2013334660B2 - Methods for treating anemia - Google Patents

Methods for treating anemia Download PDF

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Publication number
AU2013334660B2
AU2013334660B2 AU2013334660A AU2013334660A AU2013334660B2 AU 2013334660 B2 AU2013334660 B2 AU 2013334660B2 AU 2013334660 A AU2013334660 A AU 2013334660A AU 2013334660 A AU2013334660 A AU 2013334660A AU 2013334660 B2 AU2013334660 B2 AU 2013334660B2
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AU
Australia
Prior art keywords
glu
leu
val
pro
gly
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AU2013334660A
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AU2013334660A1 (en
Inventor
Rajesh Chopra
Ivan CRUZMOURA
Michael DUSSIOT
Aurelie FRICOT
Olivier Hermine
Victoria Sung
Thiago TROVATIMACIEL
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Celgene Corp
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Celgene Corp
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Publication of AU2013334660B2 publication Critical patent/AU2013334660B2/en
Priority to AU2018256635A priority Critical patent/AU2018256635A1/en
Priority to AU2020203198A priority patent/AU2020203198B2/en
Priority to AU2022201923A priority patent/AU2022201923A1/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2013334660A 2012-10-24 2013-10-23 Methods for treating anemia Active AU2013334660B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2018256635A AU2018256635A1 (en) 2012-10-24 2018-11-02 Methods for treating anemia
AU2020203198A AU2020203198B2 (en) 2012-10-24 2020-05-15 Methods for treating anemia
AU2022201923A AU2022201923A1 (en) 2012-10-24 2022-03-21 Methods for treating anemia

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718128P 2012-10-24 2012-10-24
US61/718,128 2012-10-24
PCT/US2013/066353 WO2014066487A2 (en) 2012-10-24 2013-10-23 Methods for treating anemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018256635A Division AU2018256635A1 (en) 2012-10-24 2018-11-02 Methods for treating anemia

Publications (2)

Publication Number Publication Date
AU2013334660A1 AU2013334660A1 (en) 2015-05-14
AU2013334660B2 true AU2013334660B2 (en) 2018-08-09

Family

ID=50545463

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2013334660A Active AU2013334660B2 (en) 2012-10-24 2013-10-23 Methods for treating anemia
AU2018256635A Abandoned AU2018256635A1 (en) 2012-10-24 2018-11-02 Methods for treating anemia
AU2020203198A Active AU2020203198B2 (en) 2012-10-24 2020-05-15 Methods for treating anemia
AU2022201923A Abandoned AU2022201923A1 (en) 2012-10-24 2022-03-21 Methods for treating anemia

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2018256635A Abandoned AU2018256635A1 (en) 2012-10-24 2018-11-02 Methods for treating anemia
AU2020203198A Active AU2020203198B2 (en) 2012-10-24 2020-05-15 Methods for treating anemia
AU2022201923A Abandoned AU2022201923A1 (en) 2012-10-24 2022-03-21 Methods for treating anemia

Country Status (9)

Country Link
US (1) US20150266950A1 (enExample)
EP (2) EP3527219A1 (enExample)
JP (3) JP6401172B2 (enExample)
CN (3) CN104981250A (enExample)
AU (4) AU2013334660B2 (enExample)
CA (1) CA2889286A1 (enExample)
HK (1) HK1214504A1 (enExample)
NZ (1) NZ747350A (enExample)
WO (1) WO2014066487A2 (enExample)

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US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
CA2677007A1 (en) 2007-02-01 2008-08-07 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating or preventing breast cancer
TWI782836B (zh) 2007-02-02 2022-11-01 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
CA3039330C (en) 2007-02-09 2021-11-09 Acceleron Pharma Inc. Activin-actriia antagonists and uses for promoting bone growth in cancer patients
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US11123430B2 (en) 2015-11-04 2021-09-21 Acceleron Pharma Inc. Methods for increasing red blood cell levels and treating ineffective erythropoiesis
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Also Published As

Publication number Publication date
NZ747350A (en) 2020-07-31
WO2014066487A3 (en) 2014-06-19
JP2016503398A (ja) 2016-02-04
CA2889286A1 (en) 2014-05-01
JP2018184430A (ja) 2018-11-22
AU2020203198A1 (en) 2020-06-11
EP3527219A1 (en) 2019-08-21
EP2911682A4 (en) 2016-03-23
CN112957462A (zh) 2021-06-15
EP2911682A2 (en) 2015-09-02
WO2014066487A2 (en) 2014-05-01
JP2020183390A (ja) 2020-11-12
JP6401172B2 (ja) 2018-10-10
CN112933223A (zh) 2021-06-11
AU2022201923A1 (en) 2022-04-14
AU2018256635A1 (en) 2018-11-22
CN104981250A (zh) 2015-10-14
HK1214504A1 (zh) 2016-07-29
AU2020203198B2 (en) 2021-12-23
AU2013334660A1 (en) 2015-05-14
US20150266950A1 (en) 2015-09-24

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