CN104968366B - 包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 - Google Patents

包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 Download PDF

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CN104968366B
CN104968366B CN201380066162.9A CN201380066162A CN104968366B CN 104968366 B CN104968366 B CN 104968366B CN 201380066162 A CN201380066162 A CN 201380066162A CN 104968366 B CN104968366 B CN 104968366B
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seq
protein
pila
conjugated
amino acid
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CN104968366A (zh
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F.切迪亚
W.P.豪斯多尔夫
V.弗兰特
C.伊塞巴埃特
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GlaxoSmithKline Biologicals SA
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Priority claimed from GBGB1218660.7A external-priority patent/GB201218660D0/en
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Priority claimed from US13/827,203 external-priority patent/US20140105927A1/en
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CN201380066162.9A 2012-10-17 2013-10-15 包含一种或多种肺炎链球菌荚膜糖缀合物和含有来自流感嗜血杆菌的蛋白E和/或PilA的蛋白组分的免疫原性组合物 Active CN104968366B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261714942P 2012-10-17 2012-10-17
US201261714956P 2012-10-17 2012-10-17
US61/714956 2012-10-17
GB1218660.7 2012-10-17
US61/714942 2012-10-17
GBGB1218660.7A GB201218660D0 (en) 2012-10-17 2012-10-17 Immunogenic composition
US13/826932 2013-03-14
US13/826696 2013-03-14
US13/827203 2013-03-14
US13/826,696 US9561268B2 (en) 2012-10-17 2013-03-14 Immunogenic composition
US13/826,932 US20140193451A1 (en) 2012-10-17 2013-03-14 Immunogenic composition
US13/827,203 US20140105927A1 (en) 2012-10-17 2013-03-14 Immunogenic composition
PCT/EP2013/071472 WO2014060383A1 (en) 2012-10-17 2013-10-15 Immunogenic composition comprising 1 or more streptococcus pneumoniae capsular saccharide conjugates and a protein component comprising protein e and/or pila fromhaemophilus influenzae.

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CN104968366B true CN104968366B (zh) 2017-12-01

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CN201380066113.5A Expired - Fee Related CN104853768B (zh) 2012-10-17 2013-10-15 免疫原性组合物

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201218660D0 (en) 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CN104306965B (zh) * 2014-10-31 2017-05-10 康希诺生物股份公司 预防肺炎链球菌感染性疾病的免疫原性组合物及制备方法
IL303998A (en) * 2015-07-21 2023-08-01 Pfizer Immunogenic preparations containing conjugated capsular sugar antigens, kits containing them and their uses
GB201518684D0 (en) * 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201603029D0 (en) * 2016-02-22 2016-04-06 Glaxosmithkline Biolog Sa Vaccine
CN106432512B (zh) * 2016-09-30 2022-03-01 康希诺生物股份公司 一种增强多糖抗原免疫原性蛋白载体及其制备方法与应用
JP7446227B2 (ja) * 2018-01-19 2024-03-08 オービーアイ ファーマ,インコーポレイテッド Crm197タンパク質の発現方法
CN110540597B (zh) * 2018-12-20 2021-04-30 湖北工业大学 基于流感嗜血杆菌表面蛋白的乳胶微球免疫层析试纸的制备方法
MX2022013456A (es) * 2020-05-01 2022-11-16 Sinocelltech Ltd Metodo para mejorar la inmunogenicidad de un antigeno proteinico/peptidico.
KR20220142219A (ko) * 2021-04-14 2022-10-21 한국생명공학연구원 장내 미생물에서 단백질 분비를 유도하는 신호서열
EP4169513A1 (en) 2021-10-19 2023-04-26 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising sting agonists
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063802A2 (en) * 2003-12-23 2005-07-14 Children's Hospital, Inc. Haemophilus influenzae type iv pili
CN101374859A (zh) * 2006-01-17 2009-02-25 阿恩·福斯格伦 新的表面外露流感嗜血菌蛋白质(蛋白质E;pE)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056359A2 (en) * 1999-03-19 2000-09-28 Smithkline Beecham Biologicals S.A. Vaccine against streptococcus pneumoniae
GB0108364D0 (en) * 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
SI1296715T2 (sl) * 2000-06-29 2016-03-31 Smithkline Beecham Biologicals S.A. Multivalentni sestavek cepiva
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0130215D0 (en) * 2001-12-18 2002-02-06 Glaxosmithkline Biolog Sa Vaccine
EP2298794A3 (en) * 2005-07-08 2011-04-06 Nationwide Children's Hospital, Inc. Chimeric vaccine for haemophilus influenzae-induced disease
KR101579947B1 (ko) * 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신
CA2748149C (en) * 2008-12-24 2018-03-06 Netherlands Vaccine Institute Modified steptococcus pneumonia pneumolysin (ply) polypeptides
KR101512053B1 (ko) * 2009-09-03 2015-04-28 화이자 백신스 엘엘씨 Pcsk9 백신
JP5894083B2 (ja) * 2009-12-22 2016-03-23 サノフィ パストゥール リミテッドSanofi Pasteur Limited 免疫原性組成物
JP6046632B2 (ja) * 2010-12-03 2016-12-21 サノフィ パストゥール リミテッドSanofi Pasteur Limited 肺炎球菌に対する免疫用組成物
JP5944480B2 (ja) * 2011-03-22 2016-07-05 セルム・インスティテュート・オブ・インディア・ピーブイティー.・リミテッド 多糖を調製するための新規な方法
TW201302779A (zh) * 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗
AU2012257771C1 (en) * 2011-05-17 2015-12-03 Glaxosmithkline Biologicals S.A. Vaccine against Streptococcus pneumoniae

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063802A2 (en) * 2003-12-23 2005-07-14 Children's Hospital, Inc. Haemophilus influenzae type iv pili
CN101374859A (zh) * 2006-01-17 2009-02-25 阿恩·福斯格伦 新的表面外露流感嗜血菌蛋白质(蛋白质E;pE)

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CA2888321A1 (en) 2014-04-24
IL238079A0 (en) 2015-05-31
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MX2015004949A (es) 2015-07-06
BR112015008418A2 (pt) 2017-07-04
WO2014060389A3 (en) 2014-09-12
CN104968366A (zh) 2015-10-07
WO2014060383A1 (en) 2014-04-24
JP6412500B2 (ja) 2018-10-24
BR112015008419A8 (pt) 2019-09-10
AU2013331781A1 (en) 2015-05-07
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EP2908854A2 (en) 2015-08-26
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BR112015008419A2 (pt) 2017-07-04
AU2013331781A8 (en) 2015-05-14
AU2013333975A1 (en) 2015-05-07
WO2014060385A1 (en) 2014-04-24
BR112015008417A8 (pt) 2019-09-10
BR112015008419B1 (pt) 2022-11-08
JP2015534962A (ja) 2015-12-07
EP2908855B1 (en) 2017-06-28
EA201590490A1 (ru) 2015-10-30
EA201590491A1 (ru) 2016-01-29
BR112015008417A2 (pt) 2017-07-04
CA2888310A1 (en) 2014-04-24
KR20150072444A (ko) 2015-06-29
IL238053A0 (en) 2015-05-31
JP6236086B2 (ja) 2017-11-22
ES2640320T3 (es) 2017-11-02
CN104853768B (zh) 2019-04-19
MX365842B (es) 2019-06-17
MX2015005002A (es) 2015-07-17
EP2908856B1 (en) 2019-02-20
EP2908855A1 (en) 2015-08-26
KR20150058571A (ko) 2015-05-28
SG11201502635SA (en) 2015-05-28

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