CN104961955A - Method for preparing polyethylene material for medical trachea cannula - Google Patents
Method for preparing polyethylene material for medical trachea cannula Download PDFInfo
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- CN104961955A CN104961955A CN201510370832.7A CN201510370832A CN104961955A CN 104961955 A CN104961955 A CN 104961955A CN 201510370832 A CN201510370832 A CN 201510370832A CN 104961955 A CN104961955 A CN 104961955A
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- trachea cannula
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- medical
- medical trachea
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/06—Polyethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/18—Applications used for pipes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
Abstract
The invention discloses a method for preparing a polyethylene material for a medical trachea cannula. The method comprises the steps of 1, preparing all the components by weight; 2, evenly mixing all the components in a mixing and stirring machine; 3, placing evenly mixed materials into a reaction still, heating the reaction still under the vacuum condition to 100-120 DEG C, stirring the materials for 10-20 min, cooling the materials to 30-40 DEG C, stirring the materials for 5-10 min, and obtaining a mixed material; 4, placing the mixed material in a double-screw extruder at a temperature of 180-190 DEG C to obtain sample bars through extrusion, and conducting water cooling, air drying and grain-sized dicing to obtain the polyethylene material. The preparing method is short in process, simple in operation, low in cost, environment-friendly and high in economical effectiveness. Compared with the prior art, the polyethylene material for the medical trachea cannula prepared with the method has the advantage that biocompatibility and safety performance are excellent and better than those of related products existing in the current market.
Description
Technical field
The invention belongs to polymeric material field, relate to a kind of preparation method of Medical trachea cannula polythene material.
Technical background
Plastics, as a kind of very important material, are widely applied at medicine and hygiene fields.It both can be made into disposable medical instrument as dropping bottle, syringe etc., can be used for again non-once medical facilities as gauger, surgery instrument etc., and medical plastic field is current plastics industry one of market having development potentiality most.
Along with the sustainable growth of population in the world quantity, particularly aging populations and the increase of number suffering from chronic disease, facilitate the sustainable growth of medical services market, special medical apparatus obtains widespread demand.Due to macromolecular material excellent specific property and also can reduce costs, at present, medical treatment product and apparatus are from large-scale diagnostic instrments, disposable medical article so that meticulous artificial organ all be unable to do without macromolecular material, and macromolecular material becomes one of important raw and processed materials of medical treatment product and apparatus gradually.And at present, in respiratory system field, the plastics relevant to respirator are one of fields that plastic applications is the most concentrated in medicine equipment, trachea cannula uses one of maximum plastics in medical instruments field, and these goods are mostly prepared from by materials such as polyethylene, polyvinyl chloride, polyethylene, rubber.Trachea cannula refers to that the technology by a special endotracheal tube inserts tracheae through glottis is called trachea cannula, and this technology can attract for airway patency, ventilation oxygen-supplying, respiratory tract and prevent from inhaling etc. by mistake provide top condition.Emergency trachea intubation technique has become cardiopulmonary resuscitation and with the important measures in the Severe acute disease patient rescue process of respiratory dysfunction.Endotracheal intubation is important rescue technology conventional in rescue service, most widely used general, the most effective one of means the most efficiently in management of respiratory, be the basic skills that medical worker must skillfully grasp, vital effect is played to rescue patient vitals, reduction case fatality rate.And can the tracheal strips secretory product of sucking-off in time or foreign matter, prevent foreign matter from entering respiratory tract, keep respiratory passage unblocked, carry out effective artificial or mechanical ventilation, in time whether direct relation that the success of rescuing becomes no, can patient the prognosis situation of safe transit and patient to prevent patient's anoxic and carbon dioxide retention trachea cannula.The product of this class is the easily-consumed products that quantity is larger, and China consumes the value of this series products every year at about several hundred million yuans, and market is very huge.Current China can autonomous production respirator and associated plastic goods thereof, but due to factors such as product finenesses, product is mainly used in small and medium-sized cities and vast Rural areas or outlet, and mainly apply as metropolitan markets such as Beijing-Tianjin Shanghai or external imported product, therefore the market space is still very large.Due to contact with liquid or and human contact, the basic demand of medical grade plastic materials has chemical stability and biological safety.In simple terms, the moiety in plastic material can not be separated out and enter liquid or human body, can not cause toxicity and the damage of histoorgan, is nontoxic to human body.For improving blood compatibility, the histocompatibility of goods, need the modifying surface to goods.The plastic tool anti-infection property of interposing catheter and life-time service is also one of research and development direction of current medical grade plastic materials.In sum, a kind of property separated out is low, security is high Medical trachea cannula plastic material is badly in need of providing to be this area technical problem urgently to be resolved hurrily.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of preparation method of Medical trachea cannula polythene material is provided.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of Medical trachea cannula polythene material, said method comprising the steps of: step one, polyethylene 80-90 part is taken according to weight part, chloroprene rubber 24-30 part, polyvinylpyrrolidone 2-5 part, chitosan 2-8 part, ethene-α-ethylene-octene copolymer 4-7 part, dicumyl peroxide 3-7 part, acetyl citrate 4-14 part, two maleinamic acid 6-12 part, divinyl tetramine 2-6 part, Yelkin TTS 4-6 part, two maleinamic acid 6-12 part, fimbrin 3-8 part, toxilic acid tin octylate 3-6 part, thiol methyl tin 2-5 part, dispersion agent 11-14 part, antiseptic-germicide 14-20 part, step 2, each component to be mixed in mixing and blending machine, step 3, the material after mixing is put into reactor, be heated to 100-120 DEG C under vacuum, stir 10-20 minute, be cooled to 30-40 DEG C, stir 5-10 minute, obtain mixture,
Step 4, mixture is placed in twin screw extruder at 180-190 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described dispersion agent is the one in polyvinyl lactam, sodium lauryl sulphate, fatty acid polyglycol ester.Vacuum tightness described in step 3 is 2-5MPa.In step 4, upper screw speed is 340 ~ 370r/min.
Described antiseptic-germicide is nano silver inorganic antimicrobial agent or primary ammonium phosphate.
The present invention has following beneficial effect: preparation method's flow process of the present invention is shorter, simple to operate, and cost is low, environmentally friendly, high financial profit.Compared with prior art, the Medical trachea cannula polythene material that the method for the invention provides is prepared has excellent biocompatibility and security, be all better than the performance of existing related products on the market, and its intensity is high, good mechanical property.
Embodiment
embodiment 1
A preparation method for Medical trachea cannula polythene material, said method comprising the steps of: step one, take polyethylene 80 parts, chloroprene rubber 24 parts, polyvinylpyrrolidone 2 parts, chitosan 2 parts, ethene-α-ethylene-octene copolymer 4 parts, dicumyl peroxide 3 parts, acetyl citrate 4 parts, two maleinamic acid 6 parts, divinyl tetramine 2 parts, 4 parts, Yelkin TTS, two maleinamic acid 6 parts, fimbrin 3 parts, toxilic acid tin octylate 3 parts, thiol methyl tin 2 parts, dispersion agent 11 parts, antiseptic-germicide 14 parts according to weight part; Step 2, each component to be mixed in mixing and blending machine; Step 3, the material after mixing is put into reactor, be heated to 100-120 DEG C under vacuum, stir 10-20 minute, be cooled to 30-40 DEG C, stir 5-10 minute, obtain mixture;
Step 4, mixture is placed in twin screw extruder at 180-190 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described dispersion agent is the one in polyvinyl lactam, sodium lauryl sulphate, fatty acid polyglycol ester.Vacuum tightness described in step 3 is 2-5MPa.In step 4, upper screw speed is 340 ~ 370r/min.
Described antiseptic-germicide is nano silver inorganic antimicrobial agent or primary ammonium phosphate.
embodiment 2
A preparation method for Medical trachea cannula polythene material, said method comprising the steps of: step one, take polyethylene 90 parts, chloroprene rubber 30 parts, polyvinylpyrrolidone 5 parts, chitosan 8 parts, ethene-α-ethylene-octene copolymer 7 parts, dicumyl peroxide 7 parts, acetyl citrate 14 parts, two maleinamic acid 12 parts, divinyl tetramine 6 parts, 6 parts, Yelkin TTS, two maleinamic acid 12 parts, fimbrin 8 parts, toxilic acid tin octylate 6 parts, thiol methyl tin 5 parts, dispersion agent 14 parts, antiseptic-germicide 20 parts according to weight part; Step 2, each component to be mixed in mixing and blending machine; Step 3, the material after mixing is put into reactor, be heated to 100-120 DEG C under vacuum, stir 10-20 minute, be cooled to 30-40 DEG C, stir 5-10 minute, obtain mixture;
Step 4, mixture is placed in twin screw extruder at 180-190 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described dispersion agent is the one in polyvinyl lactam, sodium lauryl sulphate, fatty acid polyglycol ester.Vacuum tightness described in step 3 is 2-5MPa.In step 4, upper screw speed is 340 ~ 370r/min.
Described antiseptic-germicide is nano silver inorganic antimicrobial agent or primary ammonium phosphate.
embodiment 3
A preparation method for Medical trachea cannula polythene material, said method comprising the steps of: step one, take polyethylene 85 parts, chloroprene rubber 28 parts, polyvinylpyrrolidone 4 parts, chitosan 6 parts, ethene-α-ethylene-octene copolymer 6 parts, dicumyl peroxide 5 parts, acetyl citrate 10 parts, two maleinamic acid 8 parts, divinyl tetramine 4 parts, 5 parts, Yelkin TTS, two maleinamic acid 8 parts, fimbrin 5 parts, toxilic acid tin octylate 4 parts, thiol methyl tin 3 parts, dispersion agent 13 parts, antiseptic-germicide 16 parts according to weight part; Step 2, each component to be mixed in mixing and blending machine; Step 3, the material after mixing is put into reactor, be heated to 100-120 DEG C under vacuum, stir 10-20 minute, be cooled to 30-40 DEG C, stir 5-10 minute, obtain mixture;
Step 4, mixture is placed in twin screw extruder at 180-190 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described dispersion agent is the one in polyvinyl lactam, sodium lauryl sulphate, fatty acid polyglycol ester.Vacuum tightness described in step 3 is 2-5MPa.In step 4, upper screw speed is 340 ~ 370r/min.
Described antiseptic-germicide is nano silver inorganic antimicrobial agent or primary ammonium phosphate.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (5)
1. the preparation method of a Medical trachea cannula polythene material, it is characterized in that, said method comprising the steps of: step one, polyethylene 80-90 part is taken according to weight part, chloroprene rubber 24-30 part, polyvinylpyrrolidone 2-5 part, chitosan 2-8 part, ethene-α-ethylene-octene copolymer 4-7 part, dicumyl peroxide 3-7 part, acetyl citrate 4-14 part, two maleinamic acid 6-12 part, divinyl tetramine 2-6 part, Yelkin TTS 4-6 part, two maleinamic acid 6-12 part, fimbrin 3-8 part, toxilic acid tin octylate 3-6 part, thiol methyl tin 2-5 part, dispersion agent 11-14 part, antiseptic-germicide 14-20 part, step 2, each component to be mixed in mixing and blending machine, step 3, the material after mixing is put into reactor, be heated to 100-120 DEG C under vacuum, stir 10-20 minute, be cooled to 30-40 DEG C, stir 5-10 minute, obtain mixture,
Step 4, mixture is placed in twin screw extruder at 180-190 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
2. the preparation method of a kind of Medical trachea cannula polythene material according to claim 1, is characterized in that, described dispersion agent is the one in polyvinyl lactam, sodium lauryl sulphate, fatty acid polyglycol ester.
3. the preparation method of a kind of Medical trachea cannula polythene material according to claim 1, is characterized in that, vacuum tightness described in step 3 is 2-5MPa.
4. the preparation method of a kind of Medical trachea cannula polythene material according to claim 1, is characterized in that, in step 4, upper screw speed is 340 ~ 370r/min.
5. the preparation method of a kind of Medical trachea cannula polythene material according to claim 1, is characterized in that, described antiseptic-germicide is nano silver inorganic antimicrobial agent or primary ammonium phosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510370832.7A CN104961955A (en) | 2015-06-30 | 2015-06-30 | Method for preparing polyethylene material for medical trachea cannula |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510370832.7A CN104961955A (en) | 2015-06-30 | 2015-06-30 | Method for preparing polyethylene material for medical trachea cannula |
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| Publication Number | Publication Date |
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| CN104961955A true CN104961955A (en) | 2015-10-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510370832.7A Pending CN104961955A (en) | 2015-06-30 | 2015-06-30 | Method for preparing polyethylene material for medical trachea cannula |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664327A (en) * | 2016-03-21 | 2016-06-15 | 车昊 | Trachea cannula core and preparation method thereof |
| CN106188907A (en) * | 2016-08-30 | 2016-12-07 | 何仁英 | A kind of biological material being applicable to flexible pipe for medical purpose and preparation method thereof |
| CN106366421A (en) * | 2016-09-22 | 2017-02-01 | 江南大学 | Polymer-modified nano-lecithin composite material and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1227580A (en) * | 1996-08-06 | 1999-09-01 | 埃克森化学专利公司 | Method for processing polyethylene and polyethylene elastomer polyblend |
| CN101724284A (en) * | 2008-10-31 | 2010-06-09 | 中国石油化工股份有限公司 | Anti-bacterial thermoplastic composite and preparation method thereof |
| CN104387655A (en) * | 2014-11-24 | 2015-03-04 | 苏州市贝克生物科技有限公司 | Medical nano-zinc oxide antibacterial PE and preparation method thereof |
-
2015
- 2015-06-30 CN CN201510370832.7A patent/CN104961955A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1227580A (en) * | 1996-08-06 | 1999-09-01 | 埃克森化学专利公司 | Method for processing polyethylene and polyethylene elastomer polyblend |
| CN101724284A (en) * | 2008-10-31 | 2010-06-09 | 中国石油化工股份有限公司 | Anti-bacterial thermoplastic composite and preparation method thereof |
| CN104387655A (en) * | 2014-11-24 | 2015-03-04 | 苏州市贝克生物科技有限公司 | Medical nano-zinc oxide antibacterial PE and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664327A (en) * | 2016-03-21 | 2016-06-15 | 车昊 | Trachea cannula core and preparation method thereof |
| CN105664327B (en) * | 2016-03-21 | 2017-12-19 | 车昊 | A kind of trachea cannula tube core and preparation method thereof |
| CN107929902A (en) * | 2016-03-21 | 2018-04-20 | 周中南 | Trachea cannula tube core and preparation method thereof |
| CN106188907A (en) * | 2016-08-30 | 2016-12-07 | 何仁英 | A kind of biological material being applicable to flexible pipe for medical purpose and preparation method thereof |
| CN106366421A (en) * | 2016-09-22 | 2017-02-01 | 江南大学 | Polymer-modified nano-lecithin composite material and preparation method thereof |
| CN106366421B (en) * | 2016-09-22 | 2018-09-21 | 江南大学 | A kind of polymer-modified nanometer lecithin composite material and preparation method |
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Application publication date: 20151007 |