CN109608791A - A kind of anti-oxidant medical PVC material and preparation method thereof - Google Patents
A kind of anti-oxidant medical PVC material and preparation method thereof Download PDFInfo
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- CN109608791A CN109608791A CN201910013992.4A CN201910013992A CN109608791A CN 109608791 A CN109608791 A CN 109608791A CN 201910013992 A CN201910013992 A CN 201910013992A CN 109608791 A CN109608791 A CN 109608791A
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- pvc material
- medical pvc
- heat stabilizer
- oxidant
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/04—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08L27/06—Homopolymers or copolymers of vinyl chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of anti-oxidant medical PVC materials, by weight including 100 parts of Corvic, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, heat stabilizer 3-5 parts main, 6-10 parts of auxiliary heat stabilizer, 2-5 parts of antioxidant, 2-5 parts of lubricant and 2-3 parts of filler.A kind of anti-oxidant medical PVC material that the present invention obtains, its by by Corvic, polycarbonate together with three kinds of mixed with polymers of thermoplastic polyurethane, to improve the bright degree of medical PVC, antioxidant is added, can prevent PVC material from degrading because heated flavescence.
Description
Technical field
The present invention relates to a kind of medical PVC, especially a kind of anti-oxidant medical PVC material and preparation method thereof.
Background technique
PVC granular material in medical use is one of the primary raw material for being widely used in disposable medical instrument both at home and abroad at present.Due to tool
There is good combination property, the superior advantage of cost performance is more and more widely used in medical instruments field.Such as it cures by oxygen therapy
Mask, atomizing face mask and nasal oxygen tube etc..But since PVC medical material is to belong to thermal sensitivity plastics, using steam sterilizing mistake
It will cause PVC material degradation under the action of high temperature (121 °C) and long-time (30 minutes) in journey to turn yellow, plasticizer causes
The tacky problem of equipment surfaces, to influence to use.
Summary of the invention
There is provided the purpose of the present invention is to solve above-mentioned the deficiencies in the prior art a kind of anti-oxidant medical PVC material and
Preparation method.
To achieve the goals above, a kind of anti-oxidant medical PVC material designed by the present invention includes polychlorostyrene by weight
100 parts of vinyl, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, main heat stabilizer
3-5 parts, 6-10 parts of auxiliary heat stabilizer, 2-5 parts of antioxidant, 2-5 parts of lubricant and 2-3 parts of filler；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
The proportion of the antioxidant is as follows:
(1) triphenyl phosphite: diphenyl-iso-octyl phosphite ester is 3:1；
(2) phosphorous acid benzene di-isooctyl: trisnonyl phenyl phosphite 1:1；
(3) trisnonyl phenyl phosphite: trioctyl trimellitate (TOTM): phosphorous acid benzene di-isooctyl is 2:1:1.
The invention also discloses a kind of preparation methods of anti-oxidant medical PVC material, by weight by Corvic
100 parts, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, 6-10 parts of auxiliary heat stabilizer,
2-5 parts of antioxidant, 2-5 parts of lubricant mixed in mixer；By mixture and it is main heat stabilizer 3-5 parts in proportion
Extruding pelletization is carried out on equidirectional parallel double-screw extruder, while being proportionally added into 2-3 parts of filler at side feed material, finally
Material is granulated through extruder plasticizing and is cooled to 40 ~ 50 DEG C, can be prepared by a kind of anti-oxidant medical PVC material.
The processing time in the mixer is 20-30min, speed 30-50rpm/min.
The processing temperature of the double screw extruder is 1 section: 145 DEG C；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5
Section: 145 DEG C.
A kind of anti-oxidant medical PVC material that the present invention obtains, by by Corvic, polycarbonate and thermoplastic
Property polyurethane three kinds of mixed with polymers together, to improve the bright degree of medical PVC, add antioxidant, PVC can be prevented
Material is degraded flavescence due to heated.
Specific embodiment
Below with reference to embodiment, the present invention is further described.
Embodiment 1:
A kind of anti-oxidant medical PVC material provided in this embodiment includes 100 parts of Corvic, poly- carbonic acid by weight
10 parts of ester, 30 parts of thermoplastic polyurethane, 70 parts of plasticizer, 3 parts of main heat stabilizer, 6 parts of auxiliary heat stabilizer, antioxidant 2
Part, 2 parts of lubricant and 2 parts of filler；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
The proportion of the antioxidant is triphenyl phosphite: diphenyl-iso-octyl phosphite ester is 3:1.
The invention also discloses a kind of preparation methods of anti-oxidant medical PVC material, by weight by Corvic
100 parts, 10 parts of polycarbonate, 30 parts of thermoplastic polyurethane, 70 parts of plasticizer, 6 parts of auxiliary heat stabilizer, 2 parts of antioxidant,
2 parts of lubricant are mixed in mixer；By 3 parts of mixture and main heat stabilizer, in proportion in corotating twin-screw
Extruding pelletization is carried out on extruder, while being proportionally added into 2 parts of filler at side feed material, and last material is made through extruder plasticizing
Grain is cooled to 40 ~ 50 DEG C, can be prepared by a kind of anti-oxidant medical PVC material.
The processing time in the mixer is 20-30min, speed 30-50rpm/min.
The processing temperature of the double screw extruder is 1 section: 145 DEG C；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5
Section: 145 DEG C.
After tested, a kind of anti-oxidant medical PVC material made from the embodiment, biological experimental data are acute not generate
General toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 2:
A kind of anti-oxidant medical PVC material provided in this embodiment, the difference from embodiment 1 is that the medical PVC material,
It by weight include 100 parts of Corvic, 15 parts of polycarbonate, 40 parts of thermoplastic polyurethane, 80 parts of plasticizer, main heat
5 parts of stabilizer, 10 parts of auxiliary heat stabilizer, 5 parts of antioxidant, 5 parts of lubricant and 3 parts of filler.
After tested, a kind of anti-oxidant medical PVC material made from the embodiment, biological experimental data are acute not generate
General toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 3:
A kind of anti-oxidant medical PVC material provided in this embodiment, the difference from embodiment 1 is that the medical PVC material,
It by weight include 100 parts of Corvic, 12 parts of polycarbonate, 35 parts of thermoplastic polyurethane, 75 parts of plasticizer, main heat
4 parts of stabilizer, 8 parts of auxiliary heat stabilizer, 2 parts of antioxidant, 2 parts of lubricant and 3 parts of filler.
After tested, a kind of anti-oxidant medical PVC material made from the embodiment, biological experimental data are acute not generate
General toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 4:
A kind of anti-oxidant medical PVC material provided in this embodiment, the difference from embodiment 1 is that the antioxidant is matched
Than being phosphorous acid benzene di-isooctyl: trisnonyl phenyl phosphite 1:1.
After tested, a kind of anti-oxidant medical PVC material made from the embodiment, biological experimental data are acute not generate
General toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 5:
A kind of anti-oxidant medical PVC material provided in this embodiment, the difference from embodiment 1 is that the antioxidant is matched
Than being trisnonyl phenyl phosphite: trioctyl trimellitate (TOTM): phosphorous acid benzene di-isooctyl is 2:1:1.
After tested, a kind of anti-oxidant medical PVC material made from the embodiment, biological experimental data are acute not generate
General toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Claims (5)
1. a kind of anti-oxidant medical PVC material, it is characterised in that: by weight include 100 parts of Corvic, poly- carbonic acid
10-15 parts of ester, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, heat stabilizer 3-5 parts main, auxiliary heat stabilizer 6-
10 parts, 2-5 parts of antioxidant, 2-5 parts of lubricant and 2-3 parts of filler；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
2. anti-oxidant medical PVC material according to claim 1, it is characterised in that: the proportion of the antioxidant is as follows:
(1) triphenyl phosphite: diphenyl-iso-octyl phosphite ester is 3:1；
(2) phosphorous acid benzene di-isooctyl: trisnonyl phenyl phosphite 1:1；
(3) trisnonyl phenyl phosphite: trioctyl trimellitate (TOTM): phosphorous acid benzene di-isooctyl is 2:1:1.
3. a kind of preparation method of anti-oxidant medical PVC material as described in claim 1, it is characterised in that: first by weight
Part by 100 parts of Corvic, 10-15 part of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, assist
6-10 parts of heat stabilizer, 2-5 parts of antioxidant, 2-5 parts of lubricant mixed in mixer；Then by mixture and master
3-5 parts of heat stabilizer carry out extruding pelletization on equidirectional parallel double-screw extruder in proportion, while at side feed material in proportion
It is added filler 2-3 parts, last material is granulated through extruder plasticizing and is cooled to 40 ~ 50 DEG C, can be prepared by a kind of anti-oxidant medical
PVC material.
4. the preparation method of anti-oxidant medical PVC material according to claim 3, it is characterised in that: in the mixer
The processing time be 20-30min, speed 30-50rpm/min.
5. the preparation method of anti-oxidant medical PVC material according to claim 3, it is characterised in that: the twin-screw squeezes
The processing temperature of machine is 1 section: 145 DEG C out；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5 sections: 145 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910013992.4A CN109608791A (en) | 2019-01-08 | 2019-01-08 | A kind of anti-oxidant medical PVC material and preparation method thereof |
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| CN201910013992.4A CN109608791A (en) | 2019-01-08 | 2019-01-08 | A kind of anti-oxidant medical PVC material and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111154202A (en) * | 2020-03-10 | 2020-05-15 | 奥特路（漳州）光学科技有限公司 | Anti-ultraviolet antibacterial environment-friendly medical eye patch main frame material and manufacturing method thereof |
| CN112920525A (en) * | 2021-01-26 | 2021-06-08 | 浙江天原医用材料有限公司 | High-toughness high-transparency medical catheter PVC material and preparation method thereof |
| CN115124796A (en) * | 2022-08-19 | 2022-09-30 | 无锡宏义高分子材料科技有限公司 | PVC material for safe antioxidant medicine package and preparation method thereof |
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| CN101979434A (en) * | 2010-11-24 | 2011-02-23 | 成都市新津事丰医疗器械有限公司 | Low-temperature resistant medicinal PVC modified material |
| CN105949669A (en) * | 2016-06-21 | 2016-09-21 | 林春梅 | Low-precipitation medical plastic catheter material and preparation method thereof |
| CN206285311U (en) * | 2016-07-18 | 2017-06-30 | 上海市肺科医院 | A kind of novel transfusion device |
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2019
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Patent Citations (4)
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| CN1428368A (en) * | 2001-12-28 | 2003-07-09 | 海尔科化工程塑料国家工程研究中心股份有限公司 | Infection-resisting high-molecular material, its preparation method and application |
| CN101979434A (en) * | 2010-11-24 | 2011-02-23 | 成都市新津事丰医疗器械有限公司 | Low-temperature resistant medicinal PVC modified material |
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Non-Patent Citations (1)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111154202A (en) * | 2020-03-10 | 2020-05-15 | 奥特路（漳州）光学科技有限公司 | Anti-ultraviolet antibacterial environment-friendly medical eye patch main frame material and manufacturing method thereof |
| CN112920525A (en) * | 2021-01-26 | 2021-06-08 | 浙江天原医用材料有限公司 | High-toughness high-transparency medical catheter PVC material and preparation method thereof |
| CN112920525B (en) * | 2021-01-26 | 2024-06-04 | 浙江天原医用材料有限公司 | High-toughness high-permeability medical catheter PVC material and preparation method thereof |
| CN115124796A (en) * | 2022-08-19 | 2022-09-30 | 无锡宏义高分子材料科技有限公司 | PVC material for safe antioxidant medicine package and preparation method thereof |
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Application publication date: 20190412 |
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