CN109504001A - A kind of antibacterial medical PVC material and preparation method thereof - Google Patents
A kind of antibacterial medical PVC material and preparation method thereof Download PDFInfo
- Publication number
- CN109504001A CN109504001A CN201910013993.9A CN201910013993A CN109504001A CN 109504001 A CN109504001 A CN 109504001A CN 201910013993 A CN201910013993 A CN 201910013993A CN 109504001 A CN109504001 A CN 109504001A
- Authority
- CN
- China
- Prior art keywords
- parts
- pvc material
- medical pvc
- antibacterial
- antibacterial medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/04—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08L27/06—Homopolymers or copolymers of vinyl chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2227—Oxides; Hydroxides of metals of aluminium
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C08K2003/321—Phosphates
- C08K2003/325—Calcium, strontium or barium phosphate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C08K2003/321—Phosphates
- C08K2003/328—Phosphates of heavy metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a kind of antibacterial medical PVC materials, by weight including 100 parts of Corvic, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, heat stabilizer 3-5 parts main, 6-10 parts of auxiliary heat stabilizer, 2-5 parts of antibacterial agent, 2-5 parts of lubricant and 2-3 parts of filler.A kind of antibacterial medical PVC material that the present invention obtains, by together with three kinds of mixed with polymers of thermoplastic polyurethane, to improve the bright degree of medical PVC, adding antibacterial agent, the anti-microbial property of PVC material can be improved Corvic, polycarbonate.
Description
Technical field
The present invention relates to a kind of medical PVC, especially a kind of antibacterial medical PVC material and preparation method thereof.
Background technique
PVC granular material in medical use is one of the primary raw material for being widely used in disposable medical instrument both at home and abroad at present.Due to tool
There is good combination property, the superior advantage of cost performance is more and more widely used in medical instruments field.Such as it cures by oxygen therapy
Mask, atomizing face mask and nasal oxygen tube etc..But since the anti-microbial property of PVC is inadequate, so will affect trouble after long-term use
Person's health.
Summary of the invention
There is provided the purpose of the present invention is to solve above-mentioned the deficiencies in the prior art a kind of antibacterial medical PVC material and its
Preparation method.
To achieve the goals above, a kind of antibacterial medical PVC material designed by the present invention includes polychlorostyrene second by weight
100 parts of olefine resin, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, main heat stabilizer 3-5
Part, 6-10 parts of auxiliary heat stabilizer, 2-5 parts of antibacterial agent, 2-5 parts of lubricant and 2-3 parts of filler；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
The proportion of the antibacterial agent is as follows:
It (1) by weight include zeolite 25-30 parts, 10-15 parts of nano zine oxide, 5-10 parts of calcium phosphate, poly hexamethylene biguanide
5-10 parts of hydrochloride, 15-20 parts of silane coupling agent；
(2) resist by weight including zeolite 15-20 parts, 10-15 parts of nano zine oxide, 10-15 parts of basic zirconium phosphate, organosilicon quaternary ammonium salt
30-50 parts of microbial inoculum, 15-20 parts of silane coupling agent.
The invention also discloses a kind of preparation methods of antibacterial medical PVC material, by weight by Corvic
100 parts, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, 6-10 parts of auxiliary heat stabilizer,
2-5 parts of antibacterial agent, 2-5 parts of lubricant mixed in mixer；Mixture and main heat stabilizer 3-5 parts are existed in proportion
Extruding pelletization is carried out on equidirectional parallel double-screw extruder, while 2-3 parts of filler are proportionally added at side feed material, last object
Material is granulated through extruder plasticizing and is cooled to 40 ~ 50 DEG C, can be prepared by a kind of antibacterial medical PVC material.
The processing time in the mixer is 20-30min, speed 30-50rpm/min.
The processing temperature of the double screw extruder is 1 section: 145 DEG C；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5
Section: 145 DEG C.
A kind of antibacterial medical PVC material that the present invention obtains, by by Corvic, polycarbonate and thermoplasticity
Three kinds of mixed with polymers of polyurethane together, to improve the bright degree of medical PVC, add antibacterial agent, PVC material can be improved
Anti-microbial property.
Specific embodiment
Below with reference to embodiment, the present invention is further described.
Embodiment 1:
A kind of antibacterial medical PVC material provided in this embodiment includes 100 parts of Corvic, polycarbonate by weight
10 parts, 30 parts of thermoplastic polyurethane, 70 parts of plasticizer, 3 parts of main heat stabilizer, 6 parts of auxiliary heat stabilizer, 2 parts of antibacterial agent, profit
2 parts and 2 parts of filler of lubrication prescription；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
The antibacterial agent includes 25 parts of zeolite, 10 parts of nano zine oxide, 5 parts of calcium phosphate, polyhexamethylene pair by weight
5 parts of guanidine hydrochloride, 15 parts of silane coupling agent.
The invention also discloses a kind of preparation methods of antibacterial medical PVC material, by weight by Corvic
100 parts, 10 parts of polycarbonate, 30 parts of thermoplastic polyurethane, 70 parts of plasticizer, 6 parts of auxiliary heat stabilizer, 2 parts of antibacterial agent, profit
2 parts of lubrication prescription are mixed in mixer；3 parts of mixture and main heat stabilizer are squeezed out in corotating twin-screw in proportion
Extruding pelletization is carried out on machine, while being proportionally added into 2 parts of filler at side feed material, and last material is granulated cold through extruder plasticizing
But to 40 ~ 50 DEG C, it can be prepared by a kind of antibacterial medical PVC material.
The processing time in the mixer is 20-30min, speed 30-50rpm/min.
The processing temperature of the double screw extruder is 1 section: 145 DEG C；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5
Section: 145 DEG C.
After tested, a kind of antibacterial medical PVC material made from the embodiment, biological experimental data are acute complete not generate
Body toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 2:
A kind of antibacterial medical PVC material provided in this embodiment, the difference from embodiment 1 is that the medical PVC material, is pressed
Parts by weight include that 100 parts of Corvic, 15 parts of polycarbonate, 40 parts of thermoplastic polyurethane, 80 parts of plasticizer, main heat are steady
Determine 5 parts of agent, 10 parts of auxiliary heat stabilizer, 5 parts of antibacterial agent, 5 parts of lubricant and 3 parts of filler.
After tested, a kind of antibacterial medical PVC material made from the embodiment, biological experimental data are acute complete not generate
Body toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 3:
A kind of antibacterial medical PVC material provided in this embodiment, the difference from embodiment 1 is that the medical PVC material, is pressed
Parts by weight include that 100 parts of Corvic, 12 parts of polycarbonate, 35 parts of thermoplastic polyurethane, 75 parts of plasticizer, main heat are steady
Determine 4 parts of agent, 8 parts of auxiliary heat stabilizer, 1 part of antibacterial agent, 2 parts of lubricant and 2 parts of filler.
After tested, a kind of antibacterial medical PVC material made from the embodiment, biological experimental data are acute complete not generate
Body toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Embodiment 4:
A kind of antibacterial medical PVC material provided in this embodiment, the difference from embodiment 1 is that the antibacterial agent is by weight
Including 20 parts of zeolite, 15 parts of nano zine oxide, 15 parts of basic zirconium phosphate, 50 parts of silicone Quaternary Ammonium Salt Antimicrobial Agent, 20 parts of silane coupling agent.
After tested, a kind of antibacterial medical PVC material made from the embodiment, biological experimental data are acute complete not generate
Body toxicity, cytotoxicity is less than 2 grades, and intradermal stimulation display is without obvious erythema or oedema；Degree of allergic reaction meets less than 2 grades
Relevant regulations in GB15593 blood transfusion (liquid) utensil soft polyvinyl chloride plastic.
Claims (5)
1. a kind of antibacterial medical PVC material, it is characterised in that: by weight include 100 parts of Corvic, polycarbonate
10-15 parts, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, heat stabilizer 3-5 parts main, auxiliary heat stabilizer 6-10
Part, 2-5 parts of antibacterial agent, 2-5 parts of lubricant and 2-3 parts of filler；
The plasticizer be dihexyl phthalate, hexamethylene -1,2- dicarboxylic acids diisononyl esters, trioctyl trimellitate (TOTM),
One or more of three n-octyl of acetyl tributyl citrate；
The main heat stabilizer is calcium zinc stabilizer or organic tin stabilizer；
The auxiliary heat stabilizer is epoxidized soybean oil；
The lubricant is methyl-silicone oil or ethyl silicon oil；
The filler is one of nano-titanium dioxide, silica and aluminium oxide.
2. antibacterial medical PVC material according to claim 1, it is characterised in that: the proportion of the antibacterial agent is as follows:
It (1) by weight include zeolite 25-30 parts, 10-15 parts of nano zine oxide, 5-10 parts of calcium phosphate, poly hexamethylene biguanide
5-10 parts of hydrochloride, 15-20 parts of silane coupling agent；
(2) resist by weight including zeolite 15-20 parts, 10-15 parts of nano zine oxide, 10-15 parts of basic zirconium phosphate, organosilicon quaternary ammonium salt
30-50 parts of microbial inoculum, 15-20 parts of silane coupling agent.
3. a kind of preparation method of antibacterial medical PVC material as described in claim 1, it is characterised in that: first by weight
By 100 parts of Corvic, 10-15 parts of polycarbonate, 30-40 parts of thermoplastic polyurethane, 70-80 parts of plasticizer, auxiliary heat
6-10 parts of stabilizer, 2-5 parts of antibacterial agent, 2-5 parts of lubricant mixed in mixer；Then mixture and main heat is steady
Determine 3-5 parts of agent and carry out extruding pelletization on equidirectional parallel double-screw extruder in proportion, while being proportionally added at side feed material
2-3 parts of filler, last material is granulated through extruder plasticizing and is cooled to 40 ~ 50 DEG C, can be prepared by a kind of antibacterial medical PVC material
Material.
4. the preparation method of antibacterial medical PVC material according to claim 3, it is characterised in that: in the mixer
The processing time is 20-30min, speed 30-50rpm/min.
5. the preparation method of antibacterial medical PVC material according to claim 3, it is characterised in that: the twin-screw extrusion
The processing temperature of machine is 1 section: 145 DEG C；2 sections: 155 DEG C；3 sections: 160 DEG C, 4 sections: 150 DEG C, 5 sections: 145 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910013993.9A CN109504001A (en) | 2019-01-08 | 2019-01-08 | A kind of antibacterial medical PVC material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910013993.9A CN109504001A (en) | 2019-01-08 | 2019-01-08 | A kind of antibacterial medical PVC material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109504001A true CN109504001A (en) | 2019-03-22 |
Family
ID=65756384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910013993.9A Pending CN109504001A (en) | 2019-01-08 | 2019-01-08 | A kind of antibacterial medical PVC material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109504001A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111019265A (en) * | 2019-12-25 | 2020-04-17 | 上海新上化高分子材料有限公司 | High-efficiency antibacterial medical polyvinyl chloride elastomer |
| CN111909448A (en) * | 2020-07-02 | 2020-11-10 | 中国人民解放军西部战区总医院 | Medical material, auxiliary support for acupuncture points and preparation method thereof |
| CN112480569A (en) * | 2020-11-30 | 2021-03-12 | 南通大学附属医院 | Lubricating cold compress nipple, preparation method and packaging device thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428368A (en) * | 2001-12-28 | 2003-07-09 | 海尔科化工程塑料国家工程研究中心股份有限公司 | Infection-resisting high-molecular material, its preparation method and application |
| JP2017115265A (en) * | 2015-12-24 | 2017-06-29 | 帝人株式会社 | Flame-retardant antibacterial fabric, method for producing the same and fiber product |
| CN108410317A (en) * | 2018-03-12 | 2018-08-17 | 合肥华盖生物科技有限公司 | A kind of medical instrument surface layer antibiotic paint and preparation method thereof |
-
2019
- 2019-01-08 CN CN201910013993.9A patent/CN109504001A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428368A (en) * | 2001-12-28 | 2003-07-09 | 海尔科化工程塑料国家工程研究中心股份有限公司 | Infection-resisting high-molecular material, its preparation method and application |
| JP2017115265A (en) * | 2015-12-24 | 2017-06-29 | 帝人株式会社 | Flame-retardant antibacterial fabric, method for producing the same and fiber product |
| CN108410317A (en) * | 2018-03-12 | 2018-08-17 | 合肥华盖生物科技有限公司 | A kind of medical instrument surface layer antibiotic paint and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 丁彤等: "《中国化工产品大全 上》", 31 January 2005, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111019265A (en) * | 2019-12-25 | 2020-04-17 | 上海新上化高分子材料有限公司 | High-efficiency antibacterial medical polyvinyl chloride elastomer |
| CN111909448A (en) * | 2020-07-02 | 2020-11-10 | 中国人民解放军西部战区总医院 | Medical material, auxiliary support for acupuncture points and preparation method thereof |
| CN112480569A (en) * | 2020-11-30 | 2021-03-12 | 南通大学附属医院 | Lubricating cold compress nipple, preparation method and packaging device thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109504001A (en) | A kind of antibacterial medical PVC material and preparation method thereof | |
| CN107556659A (en) | A kind of super-elastic medical PVC pump line material and preparation method thereof | |
| CN105237906A (en) | High-resilience antibacterial medical polyvinyl chloride (PVC) plastic and preparation method thereof | |
| CN111019265B (en) | High-efficiency antibacterial medical polyvinyl chloride elastomer | |
| CN105907082A (en) | TPU film used for medical product and preparation method of TPU film | |
| CN105237903B (en) | A kind of transparent medical PVC material for being applied to wide ripple lucifuge and preparation method thereof | |
| CN110715118A (en) | Antibacterial durable double-layer PE pipe and manufacturing method thereof | |
| CN109777001A (en) | A kind of high tenacity medical PVC material and preparation method thereof | |
| CN111100407A (en) | Anti-adhesion medical antibacterial PVC material | |
| CN104893183A (en) | Hard antibacterial pharmaceutical PVC (polyvinyl chloride) sheet and production method thereof | |
| CN109608791A (en) | A kind of anti-oxidant medical PVC material and preparation method thereof | |
| CN102304257A (en) | Medical PVC material adopted for steam sterilization, and preparation method thereof | |
| CN105778333A (en) | Medical antibacterial light-resistant polyvinyl chloride plastic | |
| CN105801941B (en) | Styrene butadiene rubber/natural rubber/negative oxygen ion powder blended closed-cell secondary foaming material and preparation method thereof | |
| CN106947240A (en) | A kind of medical antibacterial polymer composite and preparation method and application | |
| CN103073811B (en) | Antibacterial polyvinyl chloride composition and preparation method thereof | |
| CN108559123A (en) | A kind of bio-medical PVC material and preparation method thereof | |
| CN105778339A (en) | Medical environment-friendly high-elasticity PVC (PolyVinyl Chloride) particle | |
| CN107828158A (en) | A kind of medical tube with flame-proof antibiotic function and preparation method thereof | |
| CN104448668A (en) | TPE material for medical infusion device tube and preparation method thereof | |
| CN105017680A (en) | Preparation method of polyvinyl chloride material used for medical trachea cannulas | |
| CN104877182A (en) | Method for preparing medical plastic | |
| CN110713677A (en) | PVC modified material for antibacterial, mildewproof and anti-UV elastic floor adhesive and preparation method thereof | |
| CN105175939B (en) | High-oxygen-permeability medical PVC (polyvinyl chloride) material and preparation method of high-oxygen-permeability medical PVC material | |
| CN108976632B (en) | PVC composition for disposable syringe rubber plug and preparation method of rubber plug |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190322 |