CN104448668A - TPE material for medical infusion device tube and preparation method thereof - Google Patents
TPE material for medical infusion device tube and preparation method thereof Download PDFInfo
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- CN104448668A CN104448668A CN201310414940.0A CN201310414940A CN104448668A CN 104448668 A CN104448668 A CN 104448668A CN 201310414940 A CN201310414940 A CN 201310414940A CN 104448668 A CN104448668 A CN 104448668A
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Abstract
The invention discloses a TPE material for medical infusion device tube and a preparation method thereof. The TPE materials includes the following raw materials by weight: 100 portions of SEBS, 30 portions of co-polypropylene, 20 portions of oleamide and 1 portion of an antioxidant. The medical infusion device tube prepared from the TPE material has no adsorption effect on many drugs, so that drug dosage accuracy and the therapeutic effect are guaranteed; and the problem of participation of released paclitaxel injection and the polyoxyethylene castor oil in plasticizing agent in the reaction are avoided, so as to ensure the use effect of anti-cancer drug such as paclitaxel. In addition, the medical infusion device tube can avoid the problem of migration of processing aid or plasticizer into the blood or in medical liquid, and the important indexes including pH value variation, reducing substances, heavy metal content, cell toxicity, UV absorbance, sensitization response and hemolytic reaction are superior to those of the similar polyvinyl chloride products, so as to ensure the safety of patients.
Description
Technical field
The present invention relates to a kind of TPE material for medical Transfusion device flexible pipe and preparation method thereof.
Background technology
What the material of traditional medical Transfusion device flexible pipe generally adopted is PVC(polyvinyl chloride) material, but service condition both domestic and external and research data show: there is infringement to HUMAN HEALTH and environment in polyvinyl chloride (PVC) RESINS and additive DE HP thereof.
1987, vinylchlorid was defined as human carcinogen by IARC.No matter be when polyvinyl chloride (PVC) RESINS is synthesized, still add man-hour, always more or less produce vinylchlorid.Research finds: Long Term Contact vinyl chloride monomer can cause the symptoms such as neurasthenia, chloracne and Raynand's disease, is referred to as vinyl chloride disease.
Research shows: plasticised vinyl chloride resin DEHP has generation toxic side effect to the multiple organ of humans and animals, more worrying, and DEHP hydrolysis can generate phthalic acid list (ethyl hexyl) ester (MEHP), and its toxic side effect is far away higher than DEHP.Calendar year 2001, the polyvinyl chloride of DEHP plasticising is classified as the material of carcinogenesis by IARC, should not as medical material.
Summary of the invention
Object of the present invention, provides a kind of TPE material for medical Transfusion device flexible pipe and preparation method thereof exactly in order to solve the problem.
The object of the present invention is achieved like this:
A kind of TPE material for medical Transfusion device flexible pipe of the present invention, comprises the raw material by following weight proportion:
Above-mentioned a kind of TPE material for medical Transfusion device flexible pipe, wherein, described oxidation inhibitor is that antioxidant 1010 and irgasfos 168 are composite by equal proportion.
Present invention also offers a kind of preparation method of the TPE material for medical Transfusion device flexible pipe.Comprise the following steps:
(1) raw material is taken by weight ratio: SEBS100 part, Co-polypropylene 30 parts, amine hydroxybenzene 20 parts, 1 part, oxidation inhibitor;
(2) SEBS and Co-polypropylene are joined in high-speed mixer, mix 2 ~ 3 minutes;
(3) by stirring arm adjustment of rotational speed to 1500 rev/min in high-speed mixer, and start to be heated to 80-85 DEG C, then amine hydroxybenzene and oxidation inhibitor are slowly added, remix discharging after 5 minutes;
(4) raw material of mixing is put into dual-screw-stem machine extruding pelletization, the rotating speed of dual-screw-stem machine is 30-50 rev/min, feeding section temperature is 160 DEG C ~ 170 DEG C, compression section temperature is 170 DEG C ~ 180 DEG C, metering zone temperature is 180 DEG C ~ 190 DEG C, machine neck temperature is 190 DEG C ~ 200 DEG C, die temperature 190 DEG C ~ 200 DEG C.
The SEBS adopted in the raw material of TPE material of the present invention has that good biocompatibility, antioxidant property are good, nontoxic, environmental protection is easily processed and can the advantage such as 100% recycling;
The medical Transfusion device flexible pipe adopting TPE material of the present invention to prepare to multi-medicament without adsorption, the accuracy of drug dose and the result for the treatment of of medicine have had guarantee, there will not be the problem discharging the polyoxyethylenated castor oil contained in paclitaxel injection and softening agent and participate in reacting, thus ensure that the result of use of the cancer therapy drugs such as taxol.Can not be there is processing aid or plasticizer migration in addition to the problem in blood or liquid in this medical Transfusion device flexible pipe, the important indicators such as pH value variable quantity, reducing substance, heavy metal content, cytotoxicity, ultraviolet absorptivity, sensitivity response and hemolytic reaction all surmount polyvinyl chloride like product, ensure that the treatment safety of patient.
Embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Take the raw material of following weight proportion: the SEBS of 100 weight parts, the Co-polypropylene of 30 weight parts, the amine hydroxybenzene of 20 weight parts, the oxidation inhibitor (antioxidant 1010 and 168 is respectively 0.5 weight part) of 1 weight part; SEBS and Co-polypropylene are joined in high-speed mixer, mixes 2 ~ 3 minutes; By stirring arm adjustment of rotational speed to 1500 rev/min in high-speed mixer, and start to be heated to 82 DEG C, then amine hydroxybenzene and oxidation inhibitor are slowly added, remix discharging after 5 minutes; The raw material of mixing is put into dual-screw-stem machine extruding pelletization, the rotating speed of dual-screw-stem machine is 30-50 rev/min, feeding section temperature is 160 DEG C ~ 170 DEG C, compression section temperature is 170 DEG C ~ 180 DEG C, metering zone temperature is 180 DEG C ~ 190 DEG C, machine neck temperature is 190 DEG C ~ 200 DEG C, die temperature 190 DEG C ~ 200 DEG C.The TPE material of the present invention for medical Transfusion device flexible pipe can be obtained.
Carried out performance test to the TPE material that embodiment 1 obtains, test result is as shown in the table:
Above embodiment is used for illustrative purposes only, but not limitation of the present invention, person skilled in the relevant technique, without departing from the spirit and scope of the present invention, various conversion or modification can also be made, therefore all equivalent technical schemes also should belong to category of the present invention, should be limited by each claim.
Claims (3)
1. for a TPE material for medical Transfusion device flexible pipe, it is characterized in that, comprise the raw material by following weight proportion:
2. a kind of TPE material for medical Transfusion device flexible pipe as claimed in claim 1, it is characterized in that, described oxidation inhibitor is that antioxidant 1010 and irgasfos 168 are composite by equal proportion.
3. the preparation method for the TPE material of medical Transfusion device flexible pipe as claimed in claim 1.Comprise the following steps:
(1) raw material is taken by weight ratio: SEBS100 part, Co-polypropylene 30 parts, amine hydroxybenzene 20 parts, 1 part, oxidation inhibitor;
(2) SEBS and Co-polypropylene are joined in high-speed mixer, mix 2 ~ 3 minutes;
(3) by stirring arm adjustment of rotational speed to 1500 rev/min in high-speed mixer, and start to be heated to 80-85 DEG C, then amine hydroxybenzene and oxidation inhibitor are slowly added, remix discharging after 5 minutes;
(4) raw material of mixing is put into dual-screw-stem machine extruding pelletization, the rotating speed of dual-screw-stem machine is 30-50 rev/min, feeding section temperature is 160 DEG C ~ 170 DEG C, compression section temperature is 170 DEG C ~ 180 DEG C, metering zone temperature is 180 DEG C ~ 190 DEG C, machine neck temperature is 190 DEG C ~ 200 DEG C, die temperature 190 DEG C ~ 200 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310414940.0A CN104448668A (en) | 2013-09-12 | 2013-09-12 | TPE material for medical infusion device tube and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310414940.0A CN104448668A (en) | 2013-09-12 | 2013-09-12 | TPE material for medical infusion device tube and preparation method thereof |
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| CN104448668A true CN104448668A (en) | 2015-03-25 |
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| CN201310414940.0A Pending CN104448668A (en) | 2013-09-12 | 2013-09-12 | TPE material for medical infusion device tube and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596490A (en) * | 2017-09-20 | 2018-01-19 | 苏州创新达成塑胶模具有限公司 | A kind of constant temperature intravenous |
| CN107987455A (en) * | 2017-12-15 | 2018-05-04 | 常州恒方大高分子材料科技有限公司 | A kind of transparent SEBS materials of high performance-price ratio medical soft and preparation method thereof |
| CN108102406A (en) * | 2017-12-15 | 2018-06-01 | 深圳恒方大高分子材料科技有限公司 | It is a kind of can the absorption of anti-bubble TPE infusion tube materials and preparation method thereof |
| CN109384962A (en) * | 2018-11-15 | 2019-02-26 | 宿迁市春明医疗器材有限公司 | A kind of medical Transfusion device material |
| CN109735042A (en) * | 2018-12-28 | 2019-05-10 | 成都兢鹏生化科技有限公司 | A kind of medical AMTPS material, medical instrument and preparation method |
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| CN101486818A (en) * | 2008-01-18 | 2009-07-22 | 常州弘拓塑胶材料有限公司 | Thermoplastic elastomer materials |
| CN101550257A (en) * | 2009-05-14 | 2009-10-07 | 威海洁瑞医用制品有限公司 | Thermoplastic elastomer composite material |
| CN101798433A (en) * | 2010-03-16 | 2010-08-11 | 成都市新津事丰医疗器械有限公司 | Non-PVC material for medical infusion products and preparation method thereof |
| CN102911475A (en) * | 2012-09-25 | 2013-02-06 | 惠州市怡佳电线电缆材料有限公司 | Medical artificial rubber material and preparation method thereof |
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| CN101486818A (en) * | 2008-01-18 | 2009-07-22 | 常州弘拓塑胶材料有限公司 | Thermoplastic elastomer materials |
| CN101550257A (en) * | 2009-05-14 | 2009-10-07 | 威海洁瑞医用制品有限公司 | Thermoplastic elastomer composite material |
| CN101798433A (en) * | 2010-03-16 | 2010-08-11 | 成都市新津事丰医疗器械有限公司 | Non-PVC material for medical infusion products and preparation method thereof |
| CN102911475A (en) * | 2012-09-25 | 2013-02-06 | 惠州市怡佳电线电缆材料有限公司 | Medical artificial rubber material and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596490A (en) * | 2017-09-20 | 2018-01-19 | 苏州创新达成塑胶模具有限公司 | A kind of constant temperature intravenous |
| CN107987455A (en) * | 2017-12-15 | 2018-05-04 | 常州恒方大高分子材料科技有限公司 | A kind of transparent SEBS materials of high performance-price ratio medical soft and preparation method thereof |
| CN108102406A (en) * | 2017-12-15 | 2018-06-01 | 深圳恒方大高分子材料科技有限公司 | It is a kind of can the absorption of anti-bubble TPE infusion tube materials and preparation method thereof |
| CN109384962A (en) * | 2018-11-15 | 2019-02-26 | 宿迁市春明医疗器材有限公司 | A kind of medical Transfusion device material |
| CN109735042A (en) * | 2018-12-28 | 2019-05-10 | 成都兢鹏生化科技有限公司 | A kind of medical AMTPS material, medical instrument and preparation method |
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