CN101962460A - Radiation resistant medical vinylene chloride plastics free from phthalate - Google Patents
Radiation resistant medical vinylene chloride plastics free from phthalate Download PDFInfo
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- CN101962460A CN101962460A CN 201010520377 CN201010520377A CN101962460A CN 101962460 A CN101962460 A CN 101962460A CN 201010520377 CN201010520377 CN 201010520377 CN 201010520377 A CN201010520377 A CN 201010520377A CN 101962460 A CN101962460 A CN 101962460A
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Abstract
The invention relates to radiation resistant medical vinylene chloride plastics free from phthalate, comprising the following components in parts by weight: 100 parts of polyvinyl chloride resin, 25-95 parts of environmental-friendly plasticizer, 0.1-8 parts of gamma ray absorbent, 4.5-9 parts of efficient heat stabilizer and 0.3-1.5 parts of lubricant; the environmental-friendly plasticizer is one out of cyclohexane 1,2-dioctyl phthalate DINCH, SOFT-N-SAFE, EBN or TBC; the gamma ray absorbent can be 2-nitro-2'-hydroxy-5'-methyl azobenzene; the efficient heat stabilizer is one out of powder, paste or liquid calcium zinc heat stabilizer; and the lubricant is stearic acid PNBCA or oxidized polyethlene wax. The radiation resistant medical vinylene chloride plastics free from phthalate are used for producing disposable medical supplies. As the plastics of the invention are free from phthalate and can effectively absorb gamma rays, thus enjoying safety in use.
Description
Technical field
The present invention relates to a kind of medical polyvinyl plastics field that is used to produce disposable medical article, particularly relate to the medical polyvinyl plastics that a kind of anti-irradiation does not contain phthalic ester.
Background technology
Products such as medical blood transfusion tube, tubing, infusion bag, conduit, intubate and the oxygen mask of prior art are mainly all made by medical polyvinyl plastics.Medical polyvinyl plastics has a wide range of applications in medical facilities, mainly is because medical polyvinyl plastics itself has good physical properties.These physical propertiess comprise: accessibility and this class material and vein (intravenous that medical polyvinyl plastics is made, IV) favorable compatibility between injection liquid and the blood, so aspect medical, this plastics excellent property, easy to use, very popular with users.Yet pure pvc material, its hardness and flexibility all can't satisfy medical demand, need to add softening agent it is carried out modification.The effect of softening agent is: the accessibility that increases flexibility, elongation or the processing (processing) of polymkeric substance.Plasticized polyvinyl chloride class material also has more transparent characteristics, and has better chemical stability and economy.
At present, the most frequently used softening agent of polyvinyl chloride is dimixo-octyl phthalate (DOP).In recent years, more about the wholesomeness dispute of DOP, biomedical bound pair was queried human safety with phthalic ester plastifying igelite, thought that it can produce a series of influences of the carcinogenic effect that comprises active organism to animal.Decision bans use of o-benzoic acid ester plasticizers such as DINP in July, 2005 in European Union; Japan also will add in the food sanitation amendment in the toy with the soft PVC manufacturing, prohibit the regulation that contains the phthalic acid composition.In addition, to medical polyvinyl plastics, usually need the requirement of lucifuge, particularly requirement will absorb gamma-rays, because gamma-rays has destruction to the medicine that is contained in the medical apparatus, this has not only reduced the drug effect of medicine, and can produce color and precipitation, have a strong impact on the quality of medicine, even increased the toxicity of medicine.Based on this situation, select the new plasticizer that its toxicity is lower than DOP, migration precipitation is littler than DOP, and select suitable gamma-rays absorption agent, to be used to the preparing medical polyvinyl plastics that anti-irradiation does not contain phthalic ester, be very urgent problem.In order to ensure the safety of human body in medical procedure, people wish that urgently a kind of anti-irradiation does not contain the medical polyvinyl plastics appearance of phthalic ester.
Summary of the invention
Technical problem to be solved by this invention is, the medical polyvinyl plastics that overcomes prior art contains phthalic ester, can not effectively absorb gamma-rays, the defective that meeting exerts an influence in medical procedure to human body, because of adding the effective compatible of gamma-rays absorption agent and igelite and reaction, produce absorption and intercept gamma-ray intrusion, provide a kind of anti-irradiation not contain the medical polyvinyl plastics of phthalic ester, this medical polyvinyl plastics does not contain phthalic ester, can effectively absorb gamma-rays, medical apparatus with this medical polyvinyl plastics production does not contain phthalic ester, can effectively absorb gamma-rays, use this medical apparatus that does not contain phthalic ester can guarantee the safety of human body in medical procedure.
The technical solution adopted for the present invention to solve the technical problems is: anti-irradiation does not contain the medical polyvinyl plastics of phthalic ester, is prepared from by the component blend of following parts by weight:
100 parts of polyvinyl chloride (PVC) RESINS;
25～95 parts of environment-friendly plasticizers;
3～6 parts in gamma-rays absorption agent;
4.5～9 parts of efficient thermo-stabilizers;
0.3～1.5 part of lubricant;
Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters,
Any in SOFT-N-SAFE, EBN or the tri-n-butyl citrate.
In technique scheme, the medical polyvinyl plastics that anti-irradiation does not contain phthalic ester is prepared from by the component blend of following preferred weight umber:
100 parts of polyvinyl chloride (PVC) RESINS;
40～70 parts of environment-friendly plasticizers;
3.5～5 parts in gamma-rays absorption agent;
5～8 parts of efficient thermo-stabilizers;
0.5～1.2 part of lubricant;
Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters,
Any in SOFT-N-SAFE, EBN or the tri-n-butyl citrate.
Described gamma-rays absorption agent be 2-nitro-2 '-hydroxyl-5 '-methyl-benzene, 2,4, more than one in 6-three (2, the 4-dihydroxy phenyl)-1,3,5-triazines, 2,4 dihydroxy benaophenonels or 2 (2-dihydroxyl-5-phenmethyl) benzotriazole.
Described efficient thermo-stabilizer is more than one in powder, paste or the liquid calcium zinc heat stabilizer.
Described lubricant is n-butyl stearate and/or oxidized polyethlene wax.
The invention has the beneficial effects as follows:
1, table 1 is the test report that medical polyvinyl plastics of the present invention does not contain phthalic acid series ester class, this part test report explanation does not contain phthalic ester (serial ester class) by the medical polyvinyl plastics that the component blend of above-mentioned parts by weight is prepared from, and sees Table 1.The medical apparatus of producing with this medical polyvinyl plastics (as blood transfusion tube, tubing, infusion bag, conduit, intubate and oxygen mask etc.) does not just contain phthalic ester certainly yet, uses this medical apparatus that does not contain phthalic ester can guarantee the safety of human body in medical procedure.
The anti-irradiation of table 1 does not contain the examining report of the medical polyvinyl plastics of phthalic ester
2, table 2 is survey reports that anti-irradiation of the present invention does not contain the medical polyvinyl plastics of phthalic ester.Table 2 explanation: the medical apparatus with this medical polyvinyl plastics manufacturing has good properties.This medical apparatus (as blood transfusion tube, tubing, infusion bag, conduit, intubate and oxygen mask etc.) that does not contain phthalic ester aspect acute general toxicity project, does not have acute general toxic reaction being used for the process that human body carries out medical treatment; Aspect the cytotoxicity project, cell-cytotoxic reaction: 1 grade; Aspect the sensitization of skin project, no sensitization of skin reaction; Aspect intracutaneous stimulation project, no intracutaneous stimulates.See Table 2.
The anti-irradiation of table 2 does not contain the survey report of the medical polyvinyl plastics of phthalic ester
3, table 3 is physical properties assays that three anti-irradiation that embodiment produced of the present invention do not contain the medical polyvinyl plastics of phthalic ester.Table 3 explanation: the medical polyvinyl plastics that this anti-irradiation does not contain phthalic ester has good physical properties, its flexibility is good, the elongation height, convenient to its processing (processing), have more transparent characteristics, can effectively absorb gamma-rays, and have better chemical stability and economy.See Table 3.
Three anti-irradiation that embodiment produced of table 3 do not contain the physico-chemical property assay of the medical polyvinyl plastics of phthalic ester:
Embodiment
Embodiment 1, and the described a kind of anti-irradiation of present embodiment does not contain the medical polyvinyl plastics of phthalic ester, is prepared from by the component blend of following parts by weight:
100 parts of polyvinyl chloride (PVC) RESINS;
60 parts of environment-friendly plasticizers;
4.5 parts in gamma-rays absorption agent;
7 parts of efficient thermo-stabilizers;
1 part of lubricant;
Described polyvinyl chloride (PVC) RESINS is the polyvinyl chloride (PVC) RESINS of suspension method preparation, and its polymerization degree is 1000～1300.Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters.Described gamma-rays absorption agent be 2 nitros-2 '-hydroxyl-5 '-methyl-benzene.Described efficient thermo-stabilizer is the liquid calcium zinc heat stabilizer.Described lubricant is a n-butyl stearate.
The preparation method of present embodiment is: carry out polyreaction in the component input high speed reactor with above-mentioned parts by weight, temperature of reaction is 90～120 ℃, enter twin screw extruder by the automatic transport pipeline, extrusion temperature is 100～180 ℃, through pelletizing automatically, cooling, detection and finished product packing operation, obtain the medical polyvinyl plastics that the described a kind of anti-irradiation of present embodiment does not contain phthalic ester again.
Embodiment 2, and the described a kind of anti-irradiation of present embodiment does not contain the medical polyvinyl plastics of phthalic ester, are prepared from by the component blend of following parts by weight:
100 parts of polyvinyl chloride (PVC) RESINS;
25 parts of environment-friendly plasticizers;
3 parts in gamma-rays absorption agent;
9 parts of efficient thermo-stabilizers;
1.5 parts of lubricants;
Described polyvinyl chloride (PVC) RESINS is the polyvinyl chloride (PVC) RESINS of suspension method preparation, and its polymerization degree is 1000～1300.Described environment-friendly plasticizer is
SOFT-N-SAFE,
SOFT-N-SAFE is by a kind of novel acetylated monoglyceride of deriving out in the hydrogenated castor oil, and this product is produced by Danisco (China) company limited.Described gamma-rays absorption agent is 2,4,6-three (2, the 4-dihydroxy phenyl)-1,3,5-triazines.Described efficient thermo-stabilizer is the paste calcium zinc heat stabilizer.Described lubricant is an oxidized polyethlene wax.
The preparation method of present embodiment is: carry out polyreaction in the component input high speed reactor with above-mentioned parts by weight, temperature of reaction is 90～120 ℃, enter twin screw extruder by the automatic transport pipeline, extrusion temperature is 100～180 ℃, through pelletizing automatically, cooling, detection and finished product packing operation, obtain the medical polyvinyl plastics that the described a kind of anti-irradiation of present embodiment does not contain phthalic ester again.
Embodiment 3, and the described a kind of anti-irradiation of present embodiment does not contain the medical polyvinyl plastics of phthalic ester, are prepared from by the component blend of following parts by weight:
100 parts of polyvinyl chloride (PVC) RESINS;
95 parts of environment-friendly plasticizers;
6 parts in gamma-rays absorption agent;
4.5 parts of efficient thermo-stabilizers;
0.3 part of lubricant;
Described polyvinyl chloride (PVC) RESINS is the polyvinyl chloride (PVC) RESINS of suspension method preparation, and its polymerization degree is 1000～1300.Described environment-friendly plasticizer is tri-n-butyl citrate (also can be EBN, EBN is by LG Corp of South Korea production).Described gamma-rays absorption agent is 2,4 dihydroxy benaophenonels or 2 (2-dihydroxyl-5-phenmethyl) benzotriazoles.Described efficient thermo-stabilizer is the powder calcium zinc heat stabilizer.Described lubricant is n-butyl stearate and oxidized polyethlene wax.
The preparation method of present embodiment is: carry out polyreaction in the component input high speed reactor with above-mentioned parts by weight, temperature of reaction is 90～120 ℃, enter twin screw extruder by the automatic transport pipeline, extrusion temperature is 100～180 ℃, through pelletizing automatically, cooling, detection and finished product packing operation, obtain the medical polyvinyl plastics that the described a kind of anti-irradiation of present embodiment does not contain phthalic ester again.
The above only is three preferred embodiments of the present invention, is not to be used for limiting the present invention, all its similar embodiment, and for example: anti-irradiation does not contain the medical polyvinyl plastics of phthalic ester, is prepared from by the component blend of following parts by weight:
100 parts of polyvinyl chloride (PVC) RESINS;
25～95 parts of environment-friendly plasticizers;
3～6 parts in gamma-rays absorption agent;
4.5～9 parts of efficient thermo-stabilizers;
0.3～1.5 part of lubricant;
Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters,
Any etc. in SOFT-N-SAFE, EBN or the tri-n-butyl citrate, these features all should be covered by the protection domain of patent of the present invention.
Claims (5)
1. anti-irradiation does not contain the medical polyvinyl plastics of phthalic ester, it is characterized in that: the component blend by following parts by weight is prepared from:
100 parts of polyvinyl chloride (PVC) RESINS;
25～95 parts of environment-friendly plasticizers;
3～6 parts in gamma-rays absorption agent;
4.5～9 parts of efficient thermo-stabilizers;
0.3～1.5 part of lubricant;
Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters,
Any in SOFT-N-SAFE, EBN or the tri-n-butyl citrate.
2. anti-irradiation according to claim 1 does not contain the medical polyvinyl plastics of phthalic ester, it is characterized in that: the component blend by following preferred weight umber is prepared from:
100 parts of polyvinyl chloride (PVC) RESINS;
40～70 parts of environment-friendly plasticizers;
3.5～5 parts in gamma-rays absorption agent;
5～8 parts of efficient thermo-stabilizers;
0.5～1.2 part of lubricant;
Described environment-friendly plasticizer is a hexanaphthene 1,2-dioctyl phthalate diisononyl esters,
Any in SOFT-N-SAFE, EBN or the tri-n-butyl citrate.
3. anti-irradiation according to claim 1 and 2 does not contain the medical polyvinyl plastics of phthalic ester, it is characterized in that: described gamma-rays absorption agent be 2-nitro-2 '-hydroxyl-5 '-methyl-benzene, 2,4,6-three (2, the 4-dihydroxy phenyl)-1,3, more than one in 5-triazine, 2,4 dihydroxy benaophenonels or 2 (2-dihydroxyl-5-phenmethyl) benzotriazole.
4. anti-irradiation according to claim 1 and 2 does not contain the medical polyvinyl plastics of phthalic ester, it is characterized in that: described efficient thermo-stabilizer is more than one in powder, paste or the liquid calcium zinc heat stabilizer.
5. anti-irradiation according to claim 1 and 2 does not contain the medical polyvinyl plastics of phthalic ester, it is characterized in that: described lubricant is n-butyl stearate and/or oxidized polyethlene wax.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201010520377 CN101962460A (en) | 2010-10-25 | 2010-10-25 | Radiation resistant medical vinylene chloride plastics free from phthalate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010520377 CN101962460A (en) | 2010-10-25 | 2010-10-25 | Radiation resistant medical vinylene chloride plastics free from phthalate |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617951A (en) * | 2012-04-01 | 2012-08-01 | 山东万图高分子材料有限公司 | Polyvinyl chloride (PVC)-based material plasticized by non-benzene plasticizer, and preparation method thereof |
| CN103113694A (en) * | 2013-02-25 | 2013-05-22 | 高邮市汉升高分子材料有限公司 | Preparation method of anti-gamma ray medical flexible polyvinyl chloride mask material |
| CN105482309A (en) * | 2015-12-31 | 2016-04-13 | 东莞市祺龙电业有限公司 | Radiation-proofing PVC modified material and preparation method thereof |
| US10626248B2 (en) | 2012-12-29 | 2020-04-21 | Saint-Gobain Performance Plastics Corporation | Flexible tube |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102617951A (en) * | 2012-04-01 | 2012-08-01 | 山东万图高分子材料有限公司 | Polyvinyl chloride (PVC)-based material plasticized by non-benzene plasticizer, and preparation method thereof |
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| US10626248B2 (en) | 2012-12-29 | 2020-04-21 | Saint-Gobain Performance Plastics Corporation | Flexible tube |
| CN103113694A (en) * | 2013-02-25 | 2013-05-22 | 高邮市汉升高分子材料有限公司 | Preparation method of anti-gamma ray medical flexible polyvinyl chloride mask material |
| CN105482309A (en) * | 2015-12-31 | 2016-04-13 | 东莞市祺龙电业有限公司 | Radiation-proofing PVC modified material and preparation method thereof |
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Application publication date: 20110202 |