CN1064086A - Special material for medical polyvinyl chloride and preparation method thereof - Google Patents
Special material for medical polyvinyl chloride and preparation method thereof Download PDFInfo
- Publication number
- CN1064086A CN1064086A CN 91106340 CN91106340A CN1064086A CN 1064086 A CN1064086 A CN 1064086A CN 91106340 CN91106340 CN 91106340 CN 91106340 A CN91106340 A CN 91106340A CN 1064086 A CN1064086 A CN 1064086A
- Authority
- CN
- China
- Prior art keywords
- medical
- pvc
- organotin
- polyvinyl chloride
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920000915 polyvinyl chloride Polymers 0.000 title description 16
- 239000004800 polyvinyl chloride Substances 0.000 title description 16
- 239000000463 material Substances 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title 1
- 229920003023 plastic Polymers 0.000 claims abstract description 3
- 239000004033 plastic Substances 0.000 claims abstract description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims description 12
- 239000004593 Epoxy Substances 0.000 claims description 9
- 235000012424 soybean oil Nutrition 0.000 claims description 9
- 239000003549 soybean oil Substances 0.000 claims description 9
- 239000000314 lubricant Substances 0.000 claims description 5
- 239000004014 plasticizer Substances 0.000 claims description 2
- BRWZYZWZBMGMMG-UHFFFAOYSA-J dodecanoate tin(4+) Chemical compound [Sn+4].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O BRWZYZWZBMGMMG-UHFFFAOYSA-J 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 abstract description 9
- 238000012545 processing Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 230000000295 complement effect Effects 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000002932 luster Substances 0.000 description 3
- 238000005453 pelletization Methods 0.000 description 3
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- -1 dimercapto 2-ethyl hexyl ethanoate dioctyltin Chemical compound 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 1
- XQBCVRSTVUHIGH-UHFFFAOYSA-L [dodecanoyloxy(dioctyl)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCCCCCC)(CCCCCCCC)OC(=O)CCCCCCCCCCC XQBCVRSTVUHIGH-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- HRKQOINLCJTGBK-UHFFFAOYSA-N dihydroxidosulfur Chemical compound OSO HRKQOINLCJTGBK-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to the field of plastic processing application, and discloses a formula of medical PVC, which adopts the synergistic and complementary action of a plurality of stabilizers, and importantly, uses an organic tin stabilizer to obtain obvious positive effect. Low production cost, easily obtained raw materials, good product quality, especially excellent biochemical performance, good transparency and color, and is suitable for popularization and application at home and abroad, and can be used for medical appliances or food packaging and the like.
Description
The present invention is a kind of prescription of medical PVC, and this formulation material is mainly used in medical apparatus, also can be used for other containers for medical use and food product pack, belongs to plastics processing and application technology.
Because polyvinyl chloride resin has the good biological safety and the transparency, cheap, so be widely used in the production of various medical apparatus, most widely used general on disposable medical appliances such as disposable blood transfusion and infusion device and bags of blood especially.
Yet the existing disadvantage of polyvinyl chloride resin is to be heated easily to decompose, and in molding process, is heated and can emits HCL, makes performance become bad.So polyvinyl chloride resin all adds an amount of thermo-stabilizer in use.
Most widely used general also effective stabilizer is the organism of lead, barium, cadmium in polyvinyl chloride resin, but these heavy metal compounds all are deleterious, and they are harmful, are not suitable for using in medical article.
At present, employed stablizer all is that Ca/Zn type stablizer and epoxy soybean oil are used in the medical PVC prescription, and the representative formula of flexible PVC is as follows:
100 parts of PVC
30～80 parts of DOP
0.01～5 part of Ca/Zn stablizer
0～10 part of epoxy soybean oil
0～5 part of lubricant
By the prepared PP Pipe Compound of above prescription, its thermostability and irradiation stability are relatively poor, and appearance color has yellow when making goods, and the transparency is also relatively poor.
Improvement technology to above conventional formulation was once arranged, as European patent EP-0,165 in 1985, No. 579 applications and Romanian patent RO-88, No. 824 applications.The former has added unsaturated fatty acids diacid dialkyl ester (R on the basis of conventional formulation
1OCOCR
3=CR
4COOR
2) 0.1～50 part, the latter has added barium sulfate.
Above-mentioned two inventions have improved the radiation hardness stability preferably.But the thermostability and the transparency of the goods that all prescriptions of prior art are produced are all undesirable.
The objective of the invention is existing prescription is improved, on the basis that does not influence medical function, improve the thermostability of mixing material and the transparency and the color and luster of goods.
Above-mentioned purpose realizes by following design: well-known, organotin can make the PVC stabilization and help keeping original color and luster, but its lubrication is poor, must be aided with other stablizer and lubricant.So this medical PVC compound disclosed in this invention contains plasticizer DOP, stablizer (Ca/Zn), epoxy soybean oil and lubricant etc., unusual part of the present invention just is to have added organotin, this class organotin must be thioalcohol type or bay acid type, its add-on is 0.01～5 part, optimum content is 0.05～0.3 part, and concrete prescription is:
100 parts of PVC
0～80 part of DOP
0.01～5 part of Ca/Zn stablizer
0～10 part of epoxy soybean oil
0～5 part of lubricant
0.01～5 part of organotin stabilizer
The medical PVC PP Pipe Compound, not only requiring has good physical and mechanical properties, the more important thing is that the biological chemical performance of medical field requirement is relatively stricter.And the product appearance of producing with PP Pipe Compound requires smoothly, transparent, colourless, and this is that health care is desired.
The present invention be directed to the existing in prior technology problem, with the sanitary grade PVC is raw material, with health level DOP is softening agent, its key problem in technology is to adopt performance complement, three kinds of stablizers with synergy are used, make every well behaved medical PVC PP Pipe Compound with appropriate proportioning and processing method, three kinds of stablizers that adopted are Ca/Zn one package stabilizer, organotin stabilizer and epoxy soybean oil.
System is with addition of worker's technology:
(1) technological process such as Fig. 1
(2) processing condition:
Mix with GH-10 type high-speed mixer:
Rotating speed is that 1250 rev/mins of mixing times are 5～7 minutes
With PLD-651 type extrusion molding instrument extruding pelletization:
Extrusion temperature is 175 ℃
The inventive method has obtained very significantly positively effect through verification experimental verification.And following advantage is arranged, and low as cost, raw material is easy to get, good product quality, and the biological chemical performance excellence, especially visual appearance is good, clear, colorless, its modified effect is seen attached list, and remarkable in economical benefits, and this technology is suitable for applying both at home and abroad.
Below be two formulation examples:
Example 1:
Use homogenizer with PVC, DOP, Ca/Zn one package stabilizer, dimercapto 2-ethyl hexyl ethanoate dioctyltin, epoxy soybean oil with 100: 55: 1.5: 0.2: 5 ratio height is mixed and is closed 5～7 minutes, and extruding pelletization makes the medical PVC PP Pipe Compound under 175 ℃ condition.
Example 2:
Use homogenizer with PVC, DOP, Ca/Zn one package stabilizer, Bis(lauroyloxy)dioctyltin, epoxy soybean oil with 100: 55: 1.5: 0.2: 5 ratio height is mixed and is closed 5～7 minutes, and extruding pelletization makes the medical PVC PP Pipe Compound under 175 ℃ condition.
Its performance is seen attached list.
| Conventional formulation | Example 1. | Example 2. | |
| PVC DOP Ca/Zn stablizer epoxy soybean oil dimercapto 2-ethyl hexyl ethanoate dioctyltin Bis(lauroyloxy)dioctyltin | 100 55 2 5 － － | 100 55 1.5 5 0.2 － | 100 55 1.5 5 － 0.2 |
| * heat-stable time (hr) transparent color and luster | 3 is yellowish little turbid | 5.5 water white transparency | 5.4 water white transparency |
* annotate: according to the ASTM standard: congo red method is surveyed the stability of PVC.
Claims (4)
1, a kind of PVC compound of medical plastic ware use contains plasticizer DOP, stablizer (Ca/Zn), epoxy soybean oil and lubricant etc., it is characterized in that having added organotin.
2, PVC compound according to claim 1 is characterized in that organotin is tin mercaptides or tin laurate.
3, PVC compound as claimed in claim 1 or 2, the content that it is characterized in that organotin is 0.01～5 part.
4, PVC compound as claimed in claim 1 or 2, the optimum content that it is characterized in that said organotin is 0.05～0.3 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91106340 CN1064086A (en) | 1991-02-11 | 1991-02-11 | Special material for medical polyvinyl chloride and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91106340 CN1064086A (en) | 1991-02-11 | 1991-02-11 | Special material for medical polyvinyl chloride and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1064086A true CN1064086A (en) | 1992-09-02 |
Family
ID=4907767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91106340 Pending CN1064086A (en) | 1991-02-11 | 1991-02-11 | Special material for medical polyvinyl chloride and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1064086A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101948594A (en) * | 2010-10-25 | 2011-01-19 | 江苏技术师范学院 | High-impact-resistance water supply pipe aggregate and preparation method thereof |
| CN101962460A (en) * | 2010-10-25 | 2011-02-02 | 欧阳伟 | Radiation resistant medical vinylene chloride plastics free from phthalate |
| CN101962461A (en) * | 2010-10-25 | 2011-02-02 | 欧阳伟 | Phthalate-free medical polrvinyl chloride (PVC) plastic |
| CN101550259B (en) * | 2009-05-14 | 2011-02-09 | 威海洁瑞医用制品有限公司 | Medical multifunctional polyvinyl chloride composite material |
| CN102304257A (en) * | 2011-08-25 | 2012-01-04 | 上海恒方大高分子材料科技有限公司 | Medical PVC material adopted for steam sterilization, and preparation method thereof |
| CN102321316A (en) * | 2011-08-25 | 2012-01-18 | 上海恒方大高分子材料科技有限公司 | Medical polyvinyl chloride (PVC) material for gamma-ray irradiation disinfection and preparation method thereof |
| CN102321317A (en) * | 2011-08-25 | 2012-01-18 | 上海恒方大高分子材料科技有限公司 | High-transparent medical PVC pellet and preparation method thereof |
| CN102321315A (en) * | 2011-08-25 | 2012-01-18 | 成都市新津事丰医疗器械有限公司 | Sac body material of medical disposable cooling sacs |
| CN101544801B (en) * | 2008-03-27 | 2012-01-25 | 中国石油化工股份有限公司 | Polyvinyl chloride modifying material and preparation method thereof |
| CN103087442A (en) * | 2012-08-24 | 2013-05-08 | 苏州宝津塑业有限公司 | Method using Fe<3+> as PVC (Polyvinyl Chloride) assistant |
| CN105153582A (en) * | 2015-09-02 | 2015-12-16 | 苏州新区佳合塑胶有限公司 | PVC (polyvinyl chloride) transparent hard sheet |
-
1991
- 1991-02-11 CN CN 91106340 patent/CN1064086A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101544801B (en) * | 2008-03-27 | 2012-01-25 | 中国石油化工股份有限公司 | Polyvinyl chloride modifying material and preparation method thereof |
| CN101550259B (en) * | 2009-05-14 | 2011-02-09 | 威海洁瑞医用制品有限公司 | Medical multifunctional polyvinyl chloride composite material |
| CN101948594A (en) * | 2010-10-25 | 2011-01-19 | 江苏技术师范学院 | High-impact-resistance water supply pipe aggregate and preparation method thereof |
| CN101962460A (en) * | 2010-10-25 | 2011-02-02 | 欧阳伟 | Radiation resistant medical vinylene chloride plastics free from phthalate |
| CN101962461A (en) * | 2010-10-25 | 2011-02-02 | 欧阳伟 | Phthalate-free medical polrvinyl chloride (PVC) plastic |
| CN101962461B (en) * | 2010-10-25 | 2015-05-06 | 欧阳伟 | Phthalate-free medical polrvinyl chloride (PVC) plastic |
| CN102321317A (en) * | 2011-08-25 | 2012-01-18 | 上海恒方大高分子材料科技有限公司 | High-transparent medical PVC pellet and preparation method thereof |
| CN102321315A (en) * | 2011-08-25 | 2012-01-18 | 成都市新津事丰医疗器械有限公司 | Sac body material of medical disposable cooling sacs |
| CN102321316A (en) * | 2011-08-25 | 2012-01-18 | 上海恒方大高分子材料科技有限公司 | Medical polyvinyl chloride (PVC) material for gamma-ray irradiation disinfection and preparation method thereof |
| CN102321315B (en) * | 2011-08-25 | 2013-04-17 | 成都市新津事丰医疗器械有限公司 | Sac body material of medical disposable cooling sacs |
| CN102321316B (en) * | 2011-08-25 | 2013-04-24 | 上海恒方大高分子材料科技有限公司 | Medical polyvinyl chloride (PVC) material for gamma-ray irradiation disinfection and preparation method thereof |
| CN102321317B (en) * | 2011-08-25 | 2013-07-31 | 上海恒方大高分子材料科技有限公司 | High-transparent medical PVC pellet and preparation method thereof |
| CN102304257A (en) * | 2011-08-25 | 2012-01-04 | 上海恒方大高分子材料科技有限公司 | Medical PVC material adopted for steam sterilization, and preparation method thereof |
| CN103087442A (en) * | 2012-08-24 | 2013-05-08 | 苏州宝津塑业有限公司 | Method using Fe<3+> as PVC (Polyvinyl Chloride) assistant |
| CN105153582A (en) * | 2015-09-02 | 2015-12-16 | 苏州新区佳合塑胶有限公司 | PVC (polyvinyl chloride) transparent hard sheet |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |