CN105566799B - A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines - Google Patents
A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines Download PDFInfo
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- CN105566799B CN105566799B CN201410523976.7A CN201410523976A CN105566799B CN 105566799 B CN105566799 B CN 105566799B CN 201410523976 A CN201410523976 A CN 201410523976A CN 105566799 B CN105566799 B CN 105566799B
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Abstract
A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines, belongs to medical PVC plastics arts.It is characterized in that, parts by weight composition is：100 parts of Corvic, 1.0 ~ 3.0 parts of Environment-friendlyheat heat stabilizer, 30 ~ 70 parts of citric acid ester plasticizer, 1 ~ 5 part of epoxidized soybean oil, 0.1 ~ 0.4 part of glycol glycidyl ethers, 0.05 ~ 0.2 part of lubricant；The Corvic is the polyvinyl chloride resin that average degree of polymerization is 1000 ~ 2500.Using environment-friendly type citrate as primary plasticizer, epoxidized soybean oil is extender plasticizer, carrys out plasticized PVC by the compound Plasticising system that the glycol glycidyl ethers of auxiliary stabilization form to chlorine-containing polymer, high transparency PVC woven hoses are made.The raw materials used equal asepsis environment-protecting of auxiliary agent, is environment-friendly composition.
Description
Technical field
A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines, belongs to medical PVC plastics technology neck
Domain.
Background technology
Nineteen eighty-two National Cancer Institute demonstrates dioctyl phthalate（DOP）It can make the liver for nibbling class animal
Carcinogenic, the growth and development on baby and children is particularly on human body influences bigger.Citric acid ester type product can be used as plastic plastification
Agent, food additives, washing assisant, cosmetic additive agent etc., be it is a kind of it is nontoxic, pollution-free, non-stimulated, biological degradability is good
Green chemical products.Citric acid ester plasticizer is approved as nontoxic plasticizer by U.S. Food and Drug Administration (FDA),
Available for packaging for foodstuff, medical apparatus, toy for children and personal hygiene article etc..The states such as America and Europe, Japan and Korea S use epoxy
The environment-friendly plasticizers such as esters, citric acid ester type replace the DOP to be used for the PVC products such as packaging for foodstuff, medical supplies, toy for children
In.And still using DOP as primary plasticizer in China's polyvinyl chloride (PVC) medical product, the use of asepsis environment-protecting class plasticizer is to changing
The health status of kind medical PVC article user, the development for accelerating medical environmental-protection PVC industries are of great significance.With adjacent benzene two
The plasticization effect of formic acid dioctyl ester is compared, and the citric acid ester plasticizer plasticization effect of equal parts is slightly worse, the transparency of material
It is low, limit the use of the plasticizer.
Patent document CN200910015222.X《A kind of medical multifunctional polyvinyl chloride composite material》Disclose a kind of doctor
Use composite material.The medical composite material is made of PVC resin powder, nano modified material, plasticizer, stabilizer, lubricant, is matched somebody with somebody
Every 100 weight parts PVC resin powder is added with 0.5 ~ 3 part of nano modified material, 20 ~ 40 parts of phthalic acid ester, trimellitic acid in side
10 ~ 30 parts of ester, 10 ~ 30 parts of citrate, 5 ~ 10 parts of epoxidized soybean oil (ESBO), 0.5 ~ 1 part of calcium stearate (CaSt), stearic acid
0.1 ~ 0.5 part of zinc (ZnSt), 0.1 ~ 0.5 part of silicone oil.The program has reached higher transparency but has used the neighbour containing phenyl ring
Phthalic acid ester, trimellitic acid esters plasticizer, although both plasticizer are with good plasticising performance and processing performance, quilt
Widely use.But phthalic acid ester is a kind of typical environmental hormone and the genotoxicity material of the mankind, to the property of children
Gland development is harmful；Trimellitic acid esters plasticizer can cause eye damage, moderate skin irritatin, respiratory tract, intestines and stomach thorn
Swash, to health, all there are potential hazard.
102321317 B of patent CN《A kind of high transparency medical PVC pellet and preparation method thereof》Disclose a kind of medical
Pellet.The pellet by 100 parts by weight of PVC resins, 40 ~ 70 parts by weight of plasticizer DOP, efficient calcium/zinc heat stabilizer 0.3 ~
0.8 parts by weight, 1 ~ 5 parts by weight of auxiliary heat stabilizer and 0.1 ~ 0.5 parts by weight of highly-efficient lubricant composition.It is medical in the patent
Although bright material has equally reached higher transparency but used plasticizer DOP, to dye body health, there are more serious harm.
The content of the invention
The technical problem to be solved in the present invention is：Overcome the deficiencies of the prior art and provide it is a kind of it is environment-protecting and non-poisonous, have it is excellent
The transparent environment-friendly type high transparency PVC composition for being used to make medical infusion lines.
The technical solution adopted by the present invention to solve the technical problems is：The environment-friendly type that this is used to make medical infusion lines is high
Transparent PVC composition, it is characterised in that parts by weight, which form, is：100 parts of Corvic, Environment-friendlyheat heat stabilizer 1.0 ~ 3.0
Part, 30 ~ 70 parts of citric acid ester plasticizer, 1 ~ 5 part of epoxidized soybean oil, 0.1 ~ 0.4 part of glycol glycidyl ethers, lubricant
0.05 ~ 0.2 part；The Corvic is the polyvinyl chloride resin that average degree of polymerization is 1000 ~ 2500.
The present invention selects the polyvinyl chloride resin that average degree of polymerization is 1000 ~ 2500, and particle gas porosity and the present invention of resin select
Plasticizer be adapted, it is big to the plasticizer absorption of the present invention, the plasticizer selected of the present invention is more preferably played effectiveness.
The ageing whiteness that shows is high, apparent density is small, the transparency is good.
The present invention is using environment-friendly type citrate as primary plasticizer, and epoxidized soybean oil is extender plasticizer, to chloride polymerization
Thing carrys out plasticized PVC by the compound Plasticising system that the glycol glycidyl ethers of auxiliary stabilization form, and it is medical to prepare high transparency
PVC woven hose group compounds.Citrate is a kind of good nontoxic plasticizer, its cold resistance, light resistance, have excellent water-resistance, tool
Have the advantages that compatibility is good, plasticizing efficiency is high, nontoxic, volatility is small；Epoxidized soybean oil and PVC compatibilities are more preferable, except plasticising
Effect is outer, additionally it is possible to assigns PVC product excellent thermal stability；Glycol glycidyl ethers have chlorine-containing polymer auxiliary surely
Tailor-made to use, the above-mentioned plasticizer of addition collocation and extender plasticizer of the component can improve the transparency of PVC woven hoses, reduce Huang
Colour index, the light transmittance of woven hose are improved significantly.The raw materials used equal asepsis environment-protecting of auxiliary agent of the present invention, is combined for environment-friendly type
Thing.
Preferably, the average degree of polymerization of the PVC resins is 1200.Select the PVC trees that average degree of polymerization is 1200
Possessed apparent density and particle gas porosity have optimal uptake, Neng Goubao to the compound Plasticising system of the present invention during fat
Compound Plasticising system is demonstrate,proved to play effectiveness completely.
Preferably, the citric acid ester plasticizer is trioctyl lemon acid, and dosage is 40 ~ 60 parts.Inventor
Find in the course of the research, in citric acid ester plasticizer, the molecular size of trioctyl lemon acid is more suitable for PVC resins
Particle gas porosity, trioctyl lemon acid can preferably be absorbed by polyvinyl chloride resin when same dose citric acid ester plasticizer adds,
Play more obvious plasticization effect.
Preferably, the Environment-friendlyheat heat stabilizer is calcium zinc heat stabilizer, and dosage is 1.5 ~ 2.0 parts.Calcium zinc heat stabilizer is
The non-toxic stabilizer of comparative maturity at present, and have liquid calcium zinc heat stabilizer and solid calcium zinc heat stabilizer, it can obtain very well
Utilization.When dosage can obtain more preferable thermostable effect in the present invention for 1.5 ~ 2.0 parts.
Preferably, the dosage of the epoxidized soybean oil is 2 ~ 3 parts.Epoxidized soybean oil is a kind of extender plasticizer, this hair
Bright middle citrate is arranged in pairs or groups for primary plasticizer, makes citrate in the polyvinyl chloride resin of average degree of polymerization of the present invention, is disperseed more equal
It is even, enhance the speedup effect of citrate.Reach optimal auxiliary plasticization effect in dosage for 2 ~ 3 parts.
Preferably, the dosage of the glycol glycidyl ethers is 0.2 ~ 0.3 part.Glycol glycidyl ethers in the present invention
Dosage be 0.2 ~ 0.3 part when, to chlorine-containing polymer have auxiliary stabilization it is the most obvious, the light transmittance of woven hose reaches most
It is good.
Preferably, the lubricant is methyl-silicone oil, and the dosage of methyl-silicone oil is 0.05 ~ 0.15 part.Methyl-silicone oil has
Remarkable heat resistance, weatherability, hydrophobicity, physiological inertia and less surface tension is higher also with low viscosity-temperature coefficient
Resistance to compression.It can better adapt to the polyvinyl chloride resin for the larger molecular weight that the present invention selects.
The preparation method of environment-friendly type high transparency PVC composition for making medical infusion lines is：Above-mentioned material is pressed one
Certainty ratio weighs, by polyvinyl chloride resin, calcium zinc stabilizer, trioctyl lemon acid, epoxidized soybean oil, glycol glycidyl ethers, methyl
Silicone oil is in high-speed mixer（Rotating speed is 1000 ~ 1400 turns）Middle mixing 10 ~ 12 minutes, treats that liquid phase component is inhaled by polyvinyl chloride resin completely
Receive, mixing material soap-free emulsion polymeization and it is dispersed after be put into slow-speed mixer cooling, material temperature be less than 60 DEG C after blowing.The thing that will be mixed
Expect to be granulated in double screw extruder, the finally extrusion molding in single screw extrusion machine by pellet, medical PVC woven hose is made.
Compared with prior art, the environment-friendly type high transparency PVC composition for making medical infusion lines of the invention is had
Some beneficial effects are：Using environment-friendly type citrate as primary plasticizer, epoxidized soybean oil is extender plasticizer, to chlorine-containing polymer
The compound Plasticising system being made of the glycol glycidyl ethers of auxiliary stabilization carrys out plasticized PVC, and it is defeated that high transparency PVC is made
Liquid pipe, and it is safe and non-toxic.Trioctyl lemon acid is a kind of good nontoxic plasticizer, its cold resistance, light resistance, water resistance are excellent
It is good, have the advantages that compatibility is good, plasticizing efficiency is high, nontoxic, volatility is small；Epoxidized soybean oil and PVC compatibilities are more preferable, except
Outside plasticization, additionally it is possible to assign PVC product excellent thermal stability；Glycol glycidyl ethers have chlorine-containing polymer auxiliary
Help stabilization, the addition of the component can improve the transparency of PVC woven hoses, the light transmittance of woven hose bring up to 88.5% with
On, preferred solution can reach more than 90.5%.The raw materials used equal asepsis environment-protecting of auxiliary agent, is environment-friendly composition.
Embodiment
The environment-friendly type high transparency PVC composition for being used to make medical infusion lines below by specific embodiment to the present invention
It is described further, wherein embodiment 1 is most preferred embodiment.
Each embodiment proportioning component of the medical high transparency PVC woven hose group compounds of the environment-friendly type is as shown in table 1.
Table 1 is used for the formula for making the environment-friendly type high transparency PVC composition of medical infusion lines（In parts by weight）
。
The component proportion of each comparative example is as shown in table 2：
The formula of 2 comparative example medical PVC woven hose of table（In parts by weight）
。
Embodiment and comparative example are weighed by formula, embodiment first adds polyvinyl chloride resin, calcium zinc stabilizer, methyl-silicone oil
In warmed-up high-speed mixer, start stirring（Rotating speed is 700 ~ 1400 turns）, when material temperature is up to 80 DEG C by plasticizer citric acid
Blowing after being mixed 10 ~ 12 minutes in three monooctyl esters addition high-speed mixer, cooling.By the material mixed in double screw extruder
It is granulated, it is as shown in table 3 is granulated parameter setting.By mixing material using Brabendar plasticizing instrument plasticizings, the melt after plasticizing is molded into
The thin slice of 0.5mm, tests its optical property.Brabendar plasticizing process is：160 DEG C of temperature, rotor speed 60rpm, feeding quantity
57g, fusion time 4min；Mould pressing process：2min, 180 DEG C of temperature, 10 ~ 15MPa of pressure, pressurize 2min are plasticized by plasticizing process.
3 comminutor parameter setting of table
。
The performance test results of embodiment and comparative example are as shown in table 4, table 5：
4 embodiment of table and the performance of comparative example PVC medical infusion lines compositions compare
。
The biochemical property test result of 5 embodiment of table and comparative example
。
The performance of the embodiment of the present invention is more suitable for medical it can be seen from each comparative example and embodiment, is dived to human body
Endangering smaller.Epoxidized soybean oil, glycol glycidyl ethers have auxiliary stabilization, and glycol glycidyl ethers are to combination
The thing transparency has a great influence, and the addition of glycol glycidyl ethers can significantly improve the light transmittance of material, reduces mist degree.Epoxy
Soybean oil, glycol glycidyl ethers compound use effect are more preferable.Cannot good body using the small polyvinyl chloride resin of average degree of polymerization
Reveal the composite effect of citrate, epoxidized soybean oil and glycol glycidyl ethers, transparency is still undesirable.Lubricant methyl
Silicone oil is chosen so that the effectiveness of compound Plasticising system preferably plays.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (5)
1. a kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines, it is characterised in that parts by weight, which form, is：
100 parts of Corvic, 1.0 ~ 3.0 parts of Environment-friendlyheat heat stabilizer, 40 ~ 60 parts of trioctyl lemon acid, 1 ~ 5 part of epoxidized soybean oil,
0.1 ~ 0.4 part of glycol glycidyl ethers, 0.05 ~ 0.15 part of methyl-silicone oil；The Corvic is that average degree of polymerization is
1000 ~ 2500 polyvinyl chloride resin.
2. a kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines according to claim 1, its feature
It is：The average degree of polymerization of the PVC resins is 1200.
3. a kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines according to claim 1, its feature
It is：The Environment-friendlyheat heat stabilizer is calcium zinc heat stabilizer, and dosage is 1.5 ~ 2.0 parts.
4. a kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines according to claim 1, its feature
It is：The dosage of the epoxidized soybean oil is 2 ~ 3 parts.
5. a kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines according to claim 1, its feature
It is：The dosage of the glycol glycidyl ethers is 0.2 ~ 0.3 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410523976.7A CN105566799B (en) | 2014-10-08 | 2014-10-08 | A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines |
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|---|---|---|---|
| CN201410523976.7A CN105566799B (en) | 2014-10-08 | 2014-10-08 | A kind of environment-friendly type high transparency PVC composition for being used to make medical infusion lines |
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| CN105566799A CN105566799A (en) | 2016-05-11 |
| CN105566799B true CN105566799B (en) | 2018-05-04 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106977832A (en) * | 2016-04-23 | 2017-07-25 | 佛山瑞箭体育器材有限公司 | Woven hose environment-friendly type high transparency PVC composition |
| CN106215247A (en) * | 2016-08-01 | 2016-12-14 | 苏州创新达成塑胶模具有限公司 | A kind of medical plastic intubates |
| CN106751141A (en) * | 2016-11-28 | 2017-05-31 | 浙江凯越塑胶工业有限公司 | A kind of medical grade or food grade plastic composite and preparation method thereof |
| CN109535592A (en) * | 2018-11-15 | 2019-03-29 | 宿迁市春明医疗器材有限公司 | A kind of medical infusion lines tubing |
| CN111667967B (en) * | 2020-07-11 | 2022-12-16 | 北矿科技股份有限公司 | High-fluidity samarium-iron-nitrogen flexible bonded permanent magnet for injection molding and preparation method thereof |
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| JP2004097599A (en) * | 2002-09-11 | 2004-04-02 | Kawasumi Lab Inc | Blood circuit for high pressure steam sterilization treatment |
| CN102807717A (en) * | 2011-05-30 | 2012-12-05 | 贝恩医疗设备(广州)有限公司 | Special non-o-benzene polyvinyl chloride plastic for blood transfusion, and preparation process thereof |
| CN103467878A (en) * | 2013-08-12 | 2013-12-25 | 北京伏尔特技术有限公司 | Medical pipe |
| CN104072915A (en) * | 2014-07-10 | 2014-10-01 | 上海新上化高分子材料有限公司 | Radiation-resistant sterile medical polyvinyl chloride material and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004097599A (en) * | 2002-09-11 | 2004-04-02 | Kawasumi Lab Inc | Blood circuit for high pressure steam sterilization treatment |
| CN102807717A (en) * | 2011-05-30 | 2012-12-05 | 贝恩医疗设备(广州)有限公司 | Special non-o-benzene polyvinyl chloride plastic for blood transfusion, and preparation process thereof |
| CN103467878A (en) * | 2013-08-12 | 2013-12-25 | 北京伏尔特技术有限公司 | Medical pipe |
| CN104072915A (en) * | 2014-07-10 | 2014-10-01 | 上海新上化高分子材料有限公司 | Radiation-resistant sterile medical polyvinyl chloride material and preparation method thereof |
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