CN105232465A - Fenbendazole liposome preparation and preparing method thereof - Google Patents
Fenbendazole liposome preparation and preparing method thereof Download PDFInfo
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- CN105232465A CN105232465A CN201510764088.9A CN201510764088A CN105232465A CN 105232465 A CN105232465 A CN 105232465A CN 201510764088 A CN201510764088 A CN 201510764088A CN 105232465 A CN105232465 A CN 105232465A
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Abstract
The invention discloses a fenbendazole liposome preparation and a preparing method thereof. The fenbendazole liposome preparation is prepared through a phosphate method with soya bean lecithin and cholesterol as film materials. The fenbendazole liposome preparation has good preparation nature and good target performance, the treatment effect can be improved, and the fenbendazole liposome preparation has the advantages that long-time acting is achieved, medicine toxicity is reduced, and drug stability is improved.
Description
Technical field
The present invention relates to a kind of novel formulation of fenbendazole, particularly relate to a kind of fenbendazole Liposomal formulation and preparation method thereof.
Background technology
Liposome is the continuous double-layer lipid molecule including a water-containing space; The Main Ingredients and Appearance of liposome is natural phospholipid and steroid, because of but biological accommodable, biodegradable, nontoxic and non-immunogenicity.Now existing polytype liposome, they all contain the interval of water and fat, and therefore water solublity and lipophilic molecule and ion easily wrap in liposome particles; The character of this uniqueness makes liposome become the general carrier of multi-medicament.Liposome is a kind of targeted drug carrier, belongs to a kind of novel form of targeting drug delivery system.It is in nano level microgranule that drug powder or solution can be embedded in diameter by it, this microgranule has class cellularity, enter the autoimmune function mainly being activated body in human or animal body by reticuloendothelial system phagocytic, and change the distribution in vivo of encapsulated medicine, drug main will be put aside in the histoorgans such as lung, spleen, liver and bone marrow, thus improve the therapeutic index of medicine, reduce the therapeutic dose of medicine and reduce the toxicity of medicine.Liposomal formulation prepared by this method has very hyposmosis coefficient to bilayer, thus makes medicine have very high envelop rate.
Fenbendazole is benzimidazole anthelmintic, it not only has height anthelmintic activity to gastrointestinal nematode parasites adult and larva, and have good result to net filaria, fasciola and cestode, also has extremely strong killing egg effect, mainly act on gram positive bacteria and mycoplasma, have inhibitory action in various degree to part gram negative bacteria, spirillum, coccidiosis and fungus.As medicine, fenbendazole is widely used in the control, particularly its strong anti-mycoplasma characteristic of livestock and poultry mycoplasma disease, bacterial disease, spirochetosis and parasitic disease etc., becomes the choice drug for the treatment of livestock and poultry mycoplasma disease; As feedstuff medicated premix, fenbendazole is widely used in the feedstuff of chicken, pig, cattle etc., promotes animal growth, improves efficiency of feed utilization, increases fanning economics.Clinical common formulations has peroral dosage form and injection; But it is shorter that this medicine regular dosage form eliminates the half-life, medication is frequent, and widely distributed in vivo.
Summary of the invention
The object of this invention is to provide a kind of fenbendazole Liposomal formulation and preparation method thereof, to increase substantially the drug effect of fenbendazole medicine, as respiratory system diseases such as the airsacculitis in order to treat chicken, lower drug toxicity and improve drug substance stable performance.
The object of the invention is with following technical proposals realize:
A kind of fenbendazole Liposomal formulation, is characterized in that being prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 10 ~ 90 parts, 5 ~ 40 parts, cholesterol; Further, be prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 7 ~ 14mL, are placed in 65 ~ 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100 ~ 200mmol/L, every milligram of fenbendazole adds the phosphate buffer of 10 ~ 15mL, stirs and makes fenbendazole solution, be placed in 65 ~ 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 65 ~ 70 DEG C of stirred in water bath aquation 10 ~ 20min; Magnetic agitation 30 ~ 60min subsequently, mixing, to obtain final product.
Further; Comprise the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 10mL, are placed in 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100mmol/L, every milligram of fenbendazole adds the phosphate buffer of 12.5mL, stirs and makes fenbendazole solution, be placed in 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 70 DEG C of stirred in water bath aquation 15min; Magnetic agitation 60min subsequently, mixing, to obtain final product.
Fenbendazole Liposomal formulation envelop rate provided by the invention up to 80.2%, uniform particle sizes and be on average less than 50nm, there is good preparation nature and targeting, medicine retention time in blood circulation is long, improve formulation products quality and curative effect, decrease toxic and side effects, improve bioavailability, used fat material toxicity is little, good biocompatibility, does not have immunoreation; And preparation method is simple, applicable industrialized great production easy to operate.
Detailed description of the invention
embodiment 1
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 10 ~ 90 parts, 5 ~ 40 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 7 ~ 14mL, are placed in 65 ~ 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100 ~ 200mmol/L, every milligram of fenbendazole adds the phosphate buffer of 10 ~ 15mL, stirs and makes fenbendazole solution, be placed in 65 ~ 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 65 ~ 70 DEG C of stirred in water bath aquation 10 ~ 20min; Magnetic agitation 30 ~ 60min subsequently, mixing, to obtain final product.
embodiment 2
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 100mg and cholesterol 50mg to mix, add dehydrated alcohol 20ml, be placed in 65 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 2mg adds the phosphate buffer water 20ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 65 DEG C of stirred in water bath aquation 10min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 30min, mixing, to obtain final product.
embodiment 3
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 60 parts, 20 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 300mg and cholesterol 100mg to mix, add dehydrated alcohol 50ml, be placed in 65 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 5mg adds the phosphate buffer water 60ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 65 DEG C of stirred in water bath aquation 15min.Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 45min, mixing, to obtain final product.
embodiment 4
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 90 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 720mg and cholesterol 200mg to mix, add dehydrated alcohol 80ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 8mg adds the phosphate buffer water 100ml of 0.2mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 40min, mixing, to obtain final product.
embodiment 5
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 1000mg and cholesterol 500mg to mix, add dehydrated alcohol 210ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 20mg adds the phosphate buffer water 200ml of 0.15mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 65 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 6
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 10 parts, 5 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 200mg and cholesterol 100mg to mix, add dehydrated alcohol 21ml, be placed in 68 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 20mg adds the phosphate buffer water 200ml of 0.2mol/L, stirs and makes fenbendazole solution, be placed in 68 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 67 DEG C of stirred in water bath aquation 18min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 50min, mixing, to obtain final product.
embodiment 7
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 25 parts, 15 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 500mg and cholesterol 300mg to mix, add dehydrated alcohol 64ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 20mg adds the phosphate buffer water 300ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 66 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 69 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 8
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 30 parts, 10 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 600mg and cholesterol 200mg to mix, add dehydrated alcohol 72ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 20mg adds the phosphate buffer water 200ml of 0.15mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 65 DEG C of stirred in water bath aquation 15min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 30min, mixing, to obtain final product.
embodiment 9
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 80 parts, 35 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 800mg and cholesterol 350mg to mix, add dehydrated alcohol 115ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 130ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 10min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 30min, mixing, to obtain final product.
embodiment 10
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 70 parts, 30 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 700mg and cholesterol 300mg to mix, add dehydrated alcohol 110ml, be placed in 65 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 140ml of 0.2mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 15min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 40min, mixing, to obtain final product.
embodiment 11
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 40 parts, 15 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 400mg and cholesterol 150mg to mix, add dehydrated alcohol 44ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 150ml of 0.15mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 12
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 85 parts, 40 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 850mg and cholesterol 400mg to mix, add dehydrated alcohol 125ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 110ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 13
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 85 parts, 40 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 850mg and cholesterol 400mg to mix, add dehydrated alcohol 125ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 110ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 14
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) take soybean lecithin 500mg and cholesterol 250mg to mix, add dehydrated alcohol 75ml, be placed in 70 DEG C of water-baths, be stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) fenbendazole taking 10mg adds the phosphate buffer water 125ml of 0.1mol/L, stirs and makes fenbendazole solution, be placed in 65 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of preheating, add in the beaker containing phospholipid and cholesterol ester plasma membrane, 70 DEG C of stirred in water bath aquation 20min; Be placed on magnetic stirring apparatus by beaker subsequently, room temperature, stir 60min, mixing, to obtain final product.
embodiment 15
A kind of fenbendazole Liposomal formulation, is prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
The preparation method of fenbendazole Liposomal formulation as above, comprises the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 10mL, are placed in 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100mmol/L, every milligram of fenbendazole adds the phosphate buffer of 12.5mL, stirs and makes fenbendazole solution, be placed in 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 70 DEG C of stirred in water bath aquation 15min; Magnetic agitation 60min subsequently, mixing, to obtain final product.
test example
blood medicine analysis design mothod
Randomly draw the sick chicken 30 infecting coccidiosis, be divided into three groups, body weight is at 1-2kg.Example 4-5 preparation and matched group preparation (commercially available fenbendazole pre-mixing agent), give chicken oral example 4 preparation, example 5 preparation and matched group preparation respectively, dosage is 40mg effective ingredient amount/kg body weight, different time is taken a blood sample, blood plasma antibacterial activity is measured with Microbiological Assay, with standard substance (fenbendazole) for reference, calculate the blood drug level (ug/ml) of different time after medication.Result is as shown in table 1:
Table 1
Minimum inhibitory concentration (MIC) value of fenbendazole to chicken coccidiosis is 0.025 ~ 0.5(ug/ml).This shows, the fenbendazole Liposomal formulation slow release effect prepared by the present invention is obvious, and in body, the persistent period is long, can reduce administration number of times.
Claims (4)
1. a fenbendazole Liposomal formulation, is characterized in that being prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 10 ~ 90 parts, 5 ~ 40 parts, cholesterol.
2. a fenbendazole Liposomal formulation, is characterized in that being prepared from by the raw material of following weight portion: fenbendazole 1 part, soybean lecithin 50 parts, 25 parts, cholesterol.
3. the preparation method of the fenbendazole Liposomal formulation as described in any one of claim 1 ~ 2, is characterized in that comprising the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 7 ~ 14mL, are placed in 65 ~ 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100 ~ 200mmol/L, every milligram of fenbendazole adds the phosphate buffer of 10 ~ 15mL, stirs and makes fenbendazole solution, be placed in 65 ~ 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 65 ~ 70 DEG C of stirred in water bath aquation 10 ~ 20min; Magnetic agitation 30 ~ 60min subsequently, mixing, to obtain final product.
4. the preparation method of fenbendazole Liposomal formulation as claimed in claim 3, is characterized in that comprising the following steps:
(1) by soybean lecithin and cholesterol mixing, add dehydrated alcohol, every 100mg soybean lecithin and cholesterol add dehydrated alcohol 10mL, are placed in 70 DEG C of water-baths, are stirred to dissolve, removal of solvent under reduced pressure, obtain immobilized artificial membrane;
(2) add to fenbendazole the phosphate buffer that concentration is 100mmol/L, every milligram of fenbendazole adds the phosphate buffer of 12.5mL, stirs and makes fenbendazole solution, be placed in 70 DEG C of water-baths, and insulation is stand-by;
(3) get the fenbendazole solution of the preheating that step (2) obtains, add the immobilized artificial membrane that step (1) obtains, 70 DEG C of stirred in water bath aquation 15min; Magnetic agitation 60min subsequently, mixing, to obtain final product.
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| CN201510764088.9A CN105232465A (en) | 2015-11-11 | 2015-11-11 | Fenbendazole liposome preparation and preparing method thereof |
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| CN201510764088.9A CN105232465A (en) | 2015-11-11 | 2015-11-11 | Fenbendazole liposome preparation and preparing method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108210460A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of preparation method of albendazole liposomes preparation |
| CN115040479A (en) * | 2022-04-20 | 2022-09-13 | 南昌大学抚州医学院 | Preparation method and application of fenbendazole liposome |
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| WO1994012154A1 (en) * | 1992-11-23 | 1994-06-09 | Cortecs Limited | Lipid containing formulation and method for its preparation |
| CN1422611A (en) * | 2001-11-21 | 2003-06-11 | 新疆医科大学第一附属医院 | Albendazole lipid and method for preparing said lipid by neutralization method |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012154A1 (en) * | 1992-11-23 | 1994-06-09 | Cortecs Limited | Lipid containing formulation and method for its preparation |
| CN1422611A (en) * | 2001-11-21 | 2003-06-11 | 新疆医科大学第一附属医院 | Albendazole lipid and method for preparing said lipid by neutralization method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210460A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of preparation method of albendazole liposomes preparation |
| CN115040479A (en) * | 2022-04-20 | 2022-09-13 | 南昌大学抚州医学院 | Preparation method and application of fenbendazole liposome |
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Application publication date: 20160113 |