CN108210460A - A kind of preparation method of albendazole liposomes preparation - Google Patents
A kind of preparation method of albendazole liposomes preparation Download PDFInfo
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- CN108210460A CN108210460A CN201611148608.4A CN201611148608A CN108210460A CN 108210460 A CN108210460 A CN 108210460A CN 201611148608 A CN201611148608 A CN 201611148608A CN 108210460 A CN108210460 A CN 108210460A
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- albendazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Abstract
The present invention relates to a kind of preparation methods of albendazole liposomes preparation, include the following steps：（1）The preparation of diethyl ether solution：In parts by weight, it weighs soybean lecithin and cholesterol is dissolved in anhydrous ether successively, stirring and dissolving obtains diethyl ether solution completely, spare；（2）The preparation of albendazole solution：It weighs albendazole to be dissolved in phosphate buffer solution, is placed in stirring and dissolving at 60 ~ 70 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；（3）Albendazole solution with diethyl ether solution is mixed, is shaken, is ultrasonically treated, vacuum distillation removal organic solvent, then stirred in water bath aquation, finally stirs and evenly mixs at room temperature, obtains product.Liposomal formulation prepared by this method can increase substantially the drug effect of albendazole drug, such as the treatment other parasites of cysticercosis such as strongyloides intestinalis, lower drug toxicity and improve drug substance stable performance.
Description
Technical field
The invention belongs to albendazole liposomes preparation technique fields, and in particular to a kind of albendazole liposomes preparation
Preparation method.
Background technology
Liposome is the continuous double-layer lipid molecule for including a water-containing space.The main ingredient of liposome be natural phospholipid and
Steroids, thus be biological accommodable, biodegradable, nontoxic and non-immunogenicity.Have a plurality of types of fat now
Plastid, their intervals all containing water and fat, therefore water-soluble and lipophilic molecule and ion are easily packed in liposome particles
In.This unique property makes carrier of the liposome as a variety of medicament universals.Liposome is a kind of targeted drug carrier, is belonged to
A kind of novel form of targeting drug delivery system.Drug powder or solution can be embedded in a diameter of nano level particle by it, this
Kind of particle has class eucaryotic cell structure, into human or animal's body in itself exempting from for body is mainly activated by reticuloendothelial system phagocytic
Epidemic disease function, and change the internal distribution for being encapsulated drug, drug is made mainly to be put aside in the histoorgans such as lung, spleen, liver and marrow,
So as to improve the therapeutic index of drug, reduce the therapeutic dose of drug and reduce the toxicity of drug.
Albendazole is the broad-spectrum de-worming medicine of a high-efficiency low-toxicity.It can be clinically used for ascarifuge, pinworm, tapeworm, whipworm, hook
Worm, excrement strongylid etc..After being metabolized as sulfoxide type or sulfone class in vivo, inhibit absorption of the parasite to glucose, cause polypide sugared
Original exhausts or inhibits fumaric reductase system, hinders the generation of ATP, makes parasite that can not survive and breed.It is not only right
Gastrointestinal nematode parasites adult and larva have height anthelmintic activity, and have good result to net tail nematode, fasciola and tapeworm, also
Have extremely strong killing egg effect, mainly act on gram-positive bacteria and mycoplasma, to part Gram-negative bacteria, conveyor screw,
Coccidia and fungi have different degrees of inhibiting effect.As medicine, albendazole be widely used in livestock and poultry mycoplasma disease,
The prevention of bacteriosis, spirochetosis and parasitic disease etc., particularly its strong mycoplasma characteristic, become treatment
The choice drug of livestock and poultry mycoplasma disease.As feed medicated premix, albendazole is widely used in the feed of chicken, pig, ox etc.
In, promote animal growth, improve efficiency of feed utilization, increase fanning economics.
Since albendazole is insoluble in water, the slightly soluble in acetone, ether or chloroform is almost insoluble in ethanol, therefore
Limit the absorption of the existing dosage form of albendazole.
Invention content
The object of the present invention is to provide fat prepared by a kind of preparation method of albendazole liposomes preparation, this method
Liposome preparation has bilayer very hyposmosis coefficient, thus drug is made to have very high envelop rate, can increase substantially acetysalicylic acid phenobarbital
Up to the drug effect of azoles drug, such as the treatment other parasites of cysticercosis such as strongyloides intestinalis, lower drug toxicity and raising drug is steady
Qualitative energy.
To achieve the above object, the technical solution adopted by the present invention is as follows：
The present invention provides a kind of preparation methods of albendazole liposomes preparation, include the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 10~90 parts of soybean lecithins are weighed and 5~40 parts of cholesterol are molten successively
Solution is placed in stirring and dissolving at 50 ~ 65 DEG C of temperature and obtains diethyl ether solution completely in 50~120 parts of anhydrous ethers, spare；
（2）The preparation of albendazole solution：It weighs 1 ~ 2 part of albendazole and is dissolved in a concentration of 100~200mmol/L phosphate-buffereds
It in solution, is placed in stirring and dissolving at 60 ~ 70 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 100~200mmol/L phosphate buffer solutions is 1；（L0~100）；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shaking are ultrasonically treated 5
~10min, vacuum distillation removal organic solvent, then in 65~70 DEG C of stirred in water bath 10~20min of aquation, most after room temperature
30~60min of lower stirring, mixing obtain product.
According to the preparation method of above-mentioned albendazole liposomes preparation, step（1）In, in parts by weight, weigh 75 parts
Soybean lecithin and 25 parts of cholesterol are dissolved in successively in 80 parts of anhydrous ethers, and it is complete to be placed in stirring and dissolving at 50 ~ 65 DEG C of temperature
Diethyl ether solution is obtained, it is spare；
Step（2）In, it weighs 1 part of albendazole and is dissolved in a concentration of 100mmol/L phosphate buffer solutions, be placed in 65 DEG C of temperature
Lower stirring and dissolving obtains albendazole solution completely, heat preservation, spare；The albendazole and 100mmol/L phosphate-buffereds are molten
The mass ratio of liquid is 1；50；
Step（3）In, by step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, surpasses
Sonication 10min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 15min, is finally stirred at room temperature
40min is mixed, mixing obtains product.
Compared with prior art, beneficial effects of the present invention：
Albendazole liposomes preparation envelop rate height provided by the invention, uniform particle sizes, drug retention time in blood circulation
It is long, formulation products quality is improved, reduces toxic side effect, improves bioavilability.And preparation method is simple, easy to operate
It is suitble to industrialized production.
Specific embodiment
Present disclosure is further described by the following examples, but is not limited to these embodiments, following raw material
It is commercially available.
Embodiment 1
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 10~90 parts of soybean lecithins are weighed and 5~40 parts of cholesterol are molten successively
Solution is placed in stirring and dissolving at 50 ~ 65 DEG C of temperature and obtains diethyl ether solution completely in 50~120 parts of anhydrous ethers, spare；
（2）The preparation of albendazole solution：It weighs 1 ~ 2 part of albendazole and is dissolved in a concentration of 100~200mmol/L phosphate-buffereds
It in solution, is placed in stirring and dissolving at 60 ~ 70 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 100~200mmol/L phosphate buffer solutions is 1；（L0~100）；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shaking are ultrasonically treated 5
~10min, vacuum distillation removal organic solvent, then in 65~70 DEG C of stirred in water bath 10~20min of aquation, most after room temperature
30~60min of lower stirring, mixing obtain product.
Embodiment 2
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 75 parts of soybean lecithins are weighed and 25 parts of cholesterol are dissolved in 80 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 50 ~ 65 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：1 part of albendazole is weighed to be dissolved in a concentration of 100mmol/L phosphate buffer solutions,
It is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole and 100mmol/L
The mass ratio of phosphate buffer solution is 1；50；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
10min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 15min, is finally stirred at room temperature
40min, mixing obtain product.
Embodiment 3
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 80 parts of soybean lecithins are weighed and 30 parts of cholesterol are dissolved in 110 successively
In part anhydrous ether, it is placed in stirring and dissolving under temperature 60 C and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.5 parts of albendazoles and is dissolved in a concentration of 150mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 150mmol/L phosphate buffer solutions is 1；80；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
8min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 10min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 4
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 70 parts of soybean lecithins are weighed and 25 parts of cholesterol are dissolved in 100 successively
In part anhydrous ether, it is placed in stirring and dissolving at 55 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.4 parts of albendazoles and is dissolved in a concentration of 200mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving under temperature 60 C and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 200mmol/L phosphate buffer solutions is 1；70；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
8min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 20min, is finally stirred at room temperature
40min, mixing obtain product.
Embodiment 5
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 60 parts of soybean lecithins are weighed and 20 parts of cholesterol are dissolved in 60 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.8 parts of albendazoles and is dissolved in a concentration of 180mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 180mmol/L phosphate buffer solutions is 1；40；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
6min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 10min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 6
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 60 parts of soybean lecithins are weighed and 10 parts of cholesterol are dissolved in 60 parts successively
In anhydrous ether, it is placed in stirring and dissolving under temperature 50 C and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：2 parts of albendazoles are weighed to be dissolved in a concentration of 200mmol/L phosphate buffer solutions,
It is placed in stirring and dissolving under temperature 70 C and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole and 200mmol/L
The mass ratio of phosphate buffer solution is 1；100；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
8min, vacuum distillation removal organic solvent, then in 70 DEG C of stirred in water bath aquation 20min, is finally stirred at room temperature
40min, mixing obtain product.
Embodiment 7
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 80 parts of soybean lecithins are weighed and 30 parts of cholesterol are dissolved in 110 successively
In part anhydrous ether, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.6 parts of albendazoles and is dissolved in a concentration of 120mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving under temperature 60 C and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 120mmol/L phosphate buffer solutions is 1；60；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
5min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 20min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 8
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 10 parts of soybean lecithins are weighed and 40 parts of cholesterol are dissolved in 50 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：2 parts of albendazoles are weighed to be dissolved in a concentration of 140mmol/L phosphate buffer solutions,
It is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole and 140mmol/L
The mass ratio of phosphate buffer solution is 1；60；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
10min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 15min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 9
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 90 parts of soybean lecithins are weighed and 5 parts of cholesterol are dissolved in 50 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 55 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.9 parts of albendazoles and is dissolved in a concentration of 130mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 130mmol/L phosphate buffer solutions is 1；40；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
5min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 10min, is finally stirred at room temperature
40min, mixing obtain product.
Embodiment 10
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 40 parts of soybean lecithins are weighed and 5 parts of cholesterol are dissolved in 50 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 55 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.4 parts of albendazoles and is dissolved in a concentration of 110mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 110mmol/L phosphate buffer solutions is 1；60；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
6min, vacuum distillation removal organic solvent, then in 68 DEG C of stirred in water bath aquation 20min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 11
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 60 parts of soybean lecithins are weighed and 15 parts of cholesterol are dissolved in 90 parts successively
In anhydrous ether, it is placed in stirring and dissolving at 62 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：2 parts of albendazoles are weighed to be dissolved in a concentration of 140mmol/L phosphate buffer solutions,
It is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole and 140mmol/L
The mass ratio of phosphate buffer solution is 1；70；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
6min, vacuum distillation removal organic solvent, then in 70 DEG C of stirred in water bath aquation 20min, is finally stirred at room temperature
50min, mixing obtain product.
Embodiment 12
A kind of preparation method of albendazole liposomes preparation, includes the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 40 parts of soybean lecithins are weighed and 20 parts of cholesterol are dissolved in 110 successively
In part anhydrous ether, it is placed in stirring and dissolving at 55 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
（2）The preparation of albendazole solution：It weighs 1.2 parts of albendazoles and is dissolved in a concentration of 160mmol/L phosphate buffer solutions
In, it is placed in stirring and dissolving at 65 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 160mmol/L phosphate buffer solutions is 1；80；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, is ultrasonically treated
8min, vacuum distillation removal organic solvent, then in 70 DEG C of stirred in water bath aquation 12min, is finally stirred at room temperature
40min, mixing obtain product.
Above-mentioned is the preferred embodiment of the present invention, is not departing from what the appended claims specification of the present invention was limited
In scope of the present invention, in form and details to any variation of the invention done, protection scope of the present invention is belonged to.
Claims (2)
1. a kind of preparation method of albendazole liposomes preparation, it is characterised in that include the following steps：
（1）The preparation of diethyl ether solution：In parts by weight, 10~90 parts of soybean lecithins are weighed and 5~40 parts of cholesterol are molten successively
Solution is placed in stirring and dissolving at 50 ~ 65 DEG C of temperature and obtains diethyl ether solution completely in 50~120 parts of anhydrous ethers, spare；
（2）The preparation of albendazole solution：It weighs 1 ~ 2 part of albendazole and is dissolved in a concentration of 100~200mmol/L phosphate-buffereds
It in solution, is placed in stirring and dissolving at 60 ~ 70 DEG C of temperature and obtains albendazole solution completely, keep the temperature, it is spare；The albendazole with
The mass ratio of 100~200mmol/L phosphate buffer solutions is 1；（L0~100）；
（3）By step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shaking are ultrasonically treated 5
~10min, vacuum distillation removal organic solvent, then in 65~70 DEG C of stirred in water bath 10~20min of aquation, most after room temperature
30~60min of lower stirring, mixing obtain product.
2. the preparation method of albendazole liposomes preparation according to claim 1, it is characterised in that：
Step（1）In, in parts by weight, weigh 75 parts of soybean lecithins and 25 parts of cholesterol are dissolved in 80 parts of anhydrous ethers successively
In, it is placed in stirring and dissolving at 50 ~ 65 DEG C of temperature and obtains diethyl ether solution completely, it is spare；
Step（2）In, it weighs 1 part of albendazole and is dissolved in a concentration of 100mmol/L phosphate buffer solutions, be placed in 65 DEG C of temperature
Lower stirring and dissolving obtains albendazole solution completely, heat preservation, spare；The albendazole and 100mmol/L phosphate-buffereds are molten
The mass ratio of liquid is 1；50；
Step（3）In, by step（2）Obtained albendazole solution and step（1）Obtained diethyl ether solution mixing, shakes, surpasses
Sonication 10min, vacuum distillation removal organic solvent, then in 65 DEG C of stirred in water bath aquation 15min, is finally stirred at room temperature
40min is mixed, mixing obtains product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115006349A (en) * | 2022-04-20 | 2022-09-06 | 南昌大学抚州医学院 | Preparation method and application of albendazole liposome |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329885A (en) * | 2001-07-16 | 2002-01-09 | 中国人民解放军第四一一医院 | Preparing process and application of clam lipoid |
| CN1422611A (en) * | 2001-11-21 | 2003-06-11 | 新疆医科大学第一附属医院 | Albendazole lipid and method for preparing said lipid by neutralization method |
| JP2015199765A (en) * | 2007-12-06 | 2015-11-12 | バーグ リミテッド ライアビリティ カンパニー | Inhalable compositions having enhanced bioavailability |
| CN105232465A (en) * | 2015-11-11 | 2016-01-13 | 郑州后羿制药有限公司 | Fenbendazole liposome preparation and preparing method thereof |
| CN105232464A (en) * | 2015-11-11 | 2016-01-13 | 郑州后羿制药有限公司 | Hydrochloric acid ciprofloxacin lipidosome preparation and preparation method thereof |
-
2016
- 2016-12-13 CN CN201611148608.4A patent/CN108210460A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329885A (en) * | 2001-07-16 | 2002-01-09 | 中国人民解放军第四一一医院 | Preparing process and application of clam lipoid |
| CN1422611A (en) * | 2001-11-21 | 2003-06-11 | 新疆医科大学第一附属医院 | Albendazole lipid and method for preparing said lipid by neutralization method |
| JP2015199765A (en) * | 2007-12-06 | 2015-11-12 | バーグ リミテッド ライアビリティ カンパニー | Inhalable compositions having enhanced bioavailability |
| CN105232465A (en) * | 2015-11-11 | 2016-01-13 | 郑州后羿制药有限公司 | Fenbendazole liposome preparation and preparing method thereof |
| CN105232464A (en) * | 2015-11-11 | 2016-01-13 | 郑州后羿制药有限公司 | Hydrochloric acid ciprofloxacin lipidosome preparation and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘蜀宝: "《药剂学》", 31 July 2007 * |
| 陈蓓，等: ""阿苯达唑的平衡溶解度和表观油水分配系数的测定"", 《中国药房》 * |
| 鲜涛等: "包虫病的脂质体药物制备研究进展", 《现代农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115006349A (en) * | 2022-04-20 | 2022-09-06 | 南昌大学抚州医学院 | Preparation method and application of albendazole liposome |
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