CN104957603B - Improving memory type nutritious supplementary and its preparation method - Google Patents
Improving memory type nutritious supplementary and its preparation method Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Improving memory type nutritious supplementary and its preparation method, belong to food-processing preparing technical field. described Improving memory type nutritious supplementary is by weight percentage, its raw material packet contains: maltodextrin 25.00%��40.00%, enzymolysis oatmeal 20.00%��35.00%, whey-protein 8.00%��20.00%, soybean phospholipid 5.00%��20.00%, whole milk powder 5.00%��12.00%, food fibre 2.00%��5.00%, soy peptide powder 1.00%��5.00%, phosphopeptide caseinate 1.00%��5.00%, phosphatidylserine 0.10%��6.00%, algae oil DHA? 0.10%��0.50%, chicken powder 0.10%��0.50%, beef powder 0.10%��0.50%, carrot meal 0.10%��0.50%, Lotus root congee 0.10%��0.50%, wolfberry fruit powder 0.10%��0.50%, vitamin complex 0.10%��0.20%, and composite mineral matter 0.50%��2.00%. not only nutritive ingredient is comprehensive for this nutritious supplementary, and the function improving brain has between main component the effect of complementary synergy, is applicable in participation to examine the children of college entrance examination, is in dysthymia disorders and the elderly of Alzheimer high-incidence season.
Description
Technical field
The present invention relates to a kind of dietary supplement and its preparation method, particularly relate to a kind of Improving memory type nutritious supplementary and its preparation method, belong to food-processing preparing technical field.
Background technology
The concept of dietary supplement general in the world refers to that those are because people's diet formula is unreasonable or cannot be absorbed by normal meals channel and the nutritive substance that can not lack of human body. And in China, this kind of nutrition agent is divided into special diet food, protective foods and the enteral nutrition agent for various disease patient respectively.
As special diet food, comprise sports beverages, homogenate diet etc., it is a class comprehensive nutrition, balanced nutritional supplement product, can be used for the diet of sportsmen, strong physical work person and various malnutritive crowd and substitute or need the nutritional supplementation improving physiological function crowd.
As enteral nutrition agent, homogenate diet has flexible, safe, the inexpensive feature of the physiological patterns that more meets people, using method. It is generally acknowledged, when patient and cannot be reluctant to ingest through mouth through mouth because of primary disease or because treating the needs with diagnosis, or the food taken in is not enough to meet physiological requirements, and when small intestine absorptive function still can tolerate, all can adopt enteral nutrition. Enteral nutrition agent is usually used in following several situation: preoperative, the Nursing treatment of malnutritive patient; Serious wound, burn contour catabolic patient; The malnutrition that tumour causes; Pipe intestinal digesting absorptive function is bad; Old malnutritive, fear food disease; The patient for the treatment of fed by the pipe such as cerebral apoplexy, stupor; Long-term or serious diarrhea patient; The patient of liquid diet is needed behind oral cavity, ent surgery. Whether special diet food, or enteral nutrition agent, its theoretical basis is all Chinese residents dietary nutrients Dietary reference intakes (China's trophology meeting that China's trophology can propose, 2000, " Chinese residents dietary nutrients Dietary reference intakes ", China Light Industry Press, 458 pages).
About special diet food and enteral nutrition agent, NUTRICIA (NUTRICIA) company that general headquarters are positioned at Holland State Food and Drug Administration have registered predigestion formula, high energy formula, diabetic subject's proiprietary formula, containing MCT formula, containing the suspensoid product of nine accurate words of traditional Chinese medicines such as food fibre formula and the whole protein prescription of standard; Hua Rui pharmacy company limited also have registered high energy formula in State Food and Drug Administration, containing MCT formula, containing six emulsion products such as monounsaturated fatty acids formula, tumour patient formulas. Relevant Chinese patent literature has: CN200910153070.X relates to the manufacture method of a kind of dry powder of homogenate meal, is formulated by 5��10% fruits raw material dry powder, 5��10% greengrocery raw material dry powder, 10��25% meat raw material dry powder, 35��50% grain class raw material dry powder, 2��5% nuts raw material dry powder and 10��25% marine and aquatic product class raw material dry powder blend; CN201280011304.7 relates to a kind of enteral nutrition agent, it is characterised in that be not easy to cause diarrhoea; CN201110136299.X relates to a kind of sugar-free type homogenate diet, mainly for diabetic subject; CN201110136080.X relates to a kind of special homogenate diet for kidney diseases, it is characterised in that the protein of low sodium, low potassium, low-phosphorous and appropriate high-quality; CN200610123806.5 relates to a kind of clinical enternal nutrition made from halobios, makes primarily of marine prods.
As can be seen here, except the said products and technology, not yet find a kind of can improve face in examine, the memory of the students of college entrance examination, the pressure alleviating numerous middle-aged people, the homogenate diet of Alzheimer of control the elderly and the relevant report of production technology thereof.
And as protective foods, protective foods be then a class human body is had specific health-care effect, can the product of production and sales after specific program is examined through State Food and Drug Administration.
About protective foods, the auxiliary improvement of memory class protective foods ratified at present has 118, mainly being divided into following type: one is take DHA as primary efficacy factor type, mainstream product has her grace milk powder of Erie's board, auxiliary improvement of memory soft capsule, soup minister, and doubly strong fish oil Taurine Soft Capsules, the chewable tablet of board many one hundred of many one hundred, precious enlightening board are recalled side oral liquid, are never forgotten board star and sprout capsule and pill; Two is take herbal medicine as main raw material class, mainstream product have recall far-reaching board ginseng dragon capsule, hundred standing grain board zinc rhizoma polygonati oral liquid, Sharpleaf Galangal Fruit board sealwort cover benefit capsule, three strange auxiliary improvement of memory particles; Three is take soybean phospholipid as main raw material class, and mainstream product has Ai Shente board concentrated phosphatide soft capsule, preserves health board concentrated phosphatide linolenic acid soft capsule.
The DHA efficacy factor adopted in above-mentioned technology has definite auxiliary improvement of memory effect really, but, whether having DHA or algae oil DHA to be all highly unsaturated fatty acids, it is the technical barrier of puzzlement industry in the production of protective foods, processing and finished stock storage always, the soybean phospholipid efficacy factor adopted also has definite auxiliary improvement of memory effect really, soybean phospholipid is a kind of mixture, the factor really with auxiliary improvement of memory effect is phosphatidylserine wherein and phosphatidylcholine, in general, almost not containing phosphatidylserine in capsule soybean phospholipid protective foods, and the content of phosphatidylcholine is only the 18��20% of its sign content, the research of present inventor finds, reach the intake of 2 grams of phosphatidylcholines every day (playing the minimum quantity of effect), just need to take the soft capsule that more than at least 15 contents are 1 gram, this is undoubtedly a bigger burden concerning human consumer, in addition, whether phosphatidylserine or phosphatidylcholine are all very unstable materials, run into oxygen (air), light and water will oxidation deactivations, it is that the protective foods made of main raw material is all using Total saponin, Crude polysaccharides, total flavones etc. as significant functional component taking herbal medicine, auxiliary improvement of memory effect can indicate like this, auxiliary lipid-lowering efficacy can also indicate like this, this is because the composition of Chinese medicine mixing prescription is too complicated on the one hand, definite functional factor (significant composition) cannot be found out, also expose its functional factor (significant composition) indefinite defect on the other hand.
Relevant statistic data display: China examines in having 1000��1,200 ten thousand people to participate in every year, and 800��1,000 ten thousand people participate in college entrance examination; The grownup suffering from mild depression has reached more than 9,000 ten thousand people, and has the trend become younger; The number suffering from alzheimer's disease (senile dementia) has reached more than 6,000,000, ranks first in the world, and the speed increase with annual 30��400,000 people.
In the face of powerful and well-equipped army crosses the situation of single-plank bridge, these participation are examined, pressure that the children of college entrance examination bear well imagine, although the heads of a family are carrying out the conditioning in diet for the child of oneself with trying one's best, but, for the major part head of a family, it is very difficult to reach the effect got twice the result with half the effort.
Shao Ruilin (Shao Ruilin, " China depressive anxiety patient reaches 9,000 ten thousand ", Beijing Morning, 2015-3-25) reports: China depressive anxiety patient reaches 9,000 ten thousand! World Health Organization's research display, the annual loading of whole world dysthymia disorders is about 11%, and from Disease Spectrum, current dysthymia disorders has become the big disease in the world the 4th, it is contemplated that may will become the second largest illness of the mankind being only second to coronary heart disease to the year two thousand twenty. And according to incompletely statistics, current China dysthymia disorders sickness rate is up to 5%��6%, according to another an epidemiology survey estimation, China depressive anxiety patient has reached 9,000 ten thousand people, in patients with depression, the patient of 75%��80% understands multiple relapse, and dysthymia disorders is extensively fallen ill in all kinds of crowd, the professionals of operating pressure high-pressure big, spiritual, the elderly, the women etc. of special physiological phase (postpartum, climacterium) are main " targets " of dysthymia disorders.
The differentiation of China resident diet formula in decades causes a lot of the elderly not focus on the nutrition of brain for a long time, thus cause the number suffering from alzheimer's disease (senile dementia) to rise year by year, the annual direct economic loss thus caused has reached 10,000,000,000 more than, meanwhile, the burden brought to family and society is inestimable.
In sum, it is provided that a kind of there is Improving memory effect dietary supplement and its preparation method be this area technical problem urgently to be resolved hurrily.
Summary of the invention
Technical problem
It is an object of the invention to provide a kind of Improving memory type nutritious supplementary. Not only nutritive ingredient is comprehensive for this nutritious supplementary, and, experiment proves, the function improving brain has between main component the effect of complementary synergy.
Another object of the present invention is to provide the preparation method of above-mentioned Improving memory type nutritious supplementary.
Technical scheme
According to an aspect of the present invention, Improving memory type nutritious supplementary provided by the invention, by weight percentage, its raw material packet contains:
According to a further aspect in the invention, the present invention provides the preparation method of above-mentioned Improving memory type nutritious supplementary, the method comprises: by phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin by the pre-mixing in premixed device of its weight percentage, wherein, before pre-mixing, in premixed device, pour nitrogen rear enclosed premixed device, after pre-mixing evenly, obtain Preblend; Then, this Preblend is mixed by its weight percentage with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex, chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder, improve memory-type nutritious supplementary dry powder, i.e. pulvis (as shown in Figure 1). As required, this dry powder can adopt conventional preparation method, makes other formulation of tablet, capsule etc.
Useful effect
The Improving memory type nutritious supplementary of the present invention adopts soybean phospholipid on the one hand, and containing the solid fat (hydrogenated vegetable oil) of the height generally used in common powder-type ready-to-eat, special diet food and enteral nutrition agent etc. containing trans fatty acid, thus avoid because taking in trans fats excessive acid and the various diseases such as cardiac trigger is sick, diabetes, cancer, Aging and sacroiliitis; On the other hand, maltodextrin is adopted phosphatidylserine, algae oil DHA and these active factores of soybean phospholipid to be wrapped up in advance by complete processing mixed in advance, simultaneously, before pre-mixing, in premixed device, pour nitrogen, thus avoid the deterioration by oxidation of these active factores in following process process; Thus, for those participation are examined, the children of college entrance examination, it is in dysthymia disorders and the elderly of Alzheimer high-incidence season provides a kind of effective nutritious supplementary; To improving, China's resident's mental health conditions has major and immediate significance for this.
Accompanying drawing explanation
Fig. 1 is the process flow sheet of the Improving memory type nutritious supplementary preparation method of the present invention.
Embodiment
Below, the present invention is carried out more specifically with detailed description.
The Improving memory type nutritious supplementary of the present invention, the whey-protein and soy peptide powder, phosphopeptide caseinate and the whole milk powder that adopt high bioavailability are major nitrogen source, it is that primary fat is originated taking soybean phospholipid, originate by main carbohydrate of maltodextrin and enzymolysis oatmeal, be aided with natural dietary fiber, Improving memory type nutritious supplementary that chicken powder, beef powder, carrot meal, Lotus root congee, wolfberry fruit powder, vitamin complex, composite mineral matter, algae oil DHA, phosphatidylserine are prepared from a kind of pulvis, tablet or capsule.
More specifically, Improving memory type nutritious supplementary provided by the invention, by weight percentage, its raw material packet contains:
In a preferred embodiment of the present invention, Improving memory type nutritious supplementary provided by the invention, by weight percentage, its raw material packet contains:
In the present invention, it is that primary fat is originated taking soybean phospholipid, do not adopt the height that generally uses in common powder-type ready-to-eat, special diet food and enteral nutrition agent etc. containing the solid fat (hydrogenated vegetable oil) of trans fatty acid, thus avoid because taking in trans fats excessive acid and the various diseases such as cardiac trigger is sick, diabetes, cancer, Aging and sacroiliitis.
Human body is made up of 200 various kinds of cell, and total cellular score amount is about 60,000,000. Different types of cell is because of the difference of its structure, function, and the content of phosphatide is also different. Brain and liver are nervous center and the metabolism maincenters of human body, are also the places that phospholipids content is maximum, reach 43.0% and 10.3% respectively, and in these phosphatide, phosphatidylcholine (PC) and kephalin (PE) are the ratio of 1:1 substantially. In lung, phosphatide is then based on phosphatidylcholine (PC), reaches 47.5%. When people's tonic phosphatide, phosphatide content in blood is also just improved, and human body 200 various kinds of cell all can be benefited. But the difference due to each organ phospholipids content, can seem more obvious to the effect of brain and liver during tonic phosphatide. In human body vitals, phospholipids content is shown in table 1 (PardunH., 1988, DiePflanzenlecithine, 8900Ausburg1:Verlagfuerchem.IndustrieH.ZiolkowskyKG.419) below.
Phospholipids content in table 1 human body vitals
Described soybean phospholipid, it is desired to acetone insoluble matter content >=95wt%, phosphatidylcholine content >=20wt%. In the Improving memory type nutritious supplementary of the present invention, based on its gross weight, the content of soybean phospholipid is 5.00%��20.00%, it is preferable to 8%��15%, it is most preferred that 10%��12%.
Phosphatidylserine (PS) is a member in phosphatide family, it is uniquely can the phosphatide (ParrisMKidd of regulating cell film key protein functional status, 1996, Phosphatidylserine, MembraneNuttrientforMemory, AClinicalandMechanisticAssessment, AlteernativeMedicineRewiew, (1): 70-84). As far back as 2010, it was new resource food (being called now new food) that Ministry of Health of the People's Republic of China just ratifies to have announced phosphatidylserine. For a long time, numerous scientific worker's research shows, phosphatidylserine (is called for short PS) and has following effect:
Improving memory power
(the Tang Yong such as Tang Yong, Zhang Qianyong, gruel is boundless, 2011, strengthening phosphatidylserine pure milk Improving memory power crowd's test-meal research, Chongqing medical science, 40 (10): 3022��3026) the phosphatidylserine raw material of 50% purity is added into pure fresh milk with the ratio of 0.08%, it is made as " PS milk " containing phosphatidylserine through superhigh temperature sterilized milk technique. 120 17��18 years old middle school student being divided into intervention group and control group at random, adopts double-blind method, the former is PS milk 250mL daily, and the latter takes the pure milk not adding PS, trial period 40d. Before and after test, experimenter being carried out memory scoring, marking mode adopts Clinical Memory Test standard method, subscale comprise point to memory, associative learning, image are freed recall, re-recognize without meaning figure, portrait feature contacts memory. Result control group takes each subscale score in front and back and the equal not statistically significant of total score difference, and each subscale score and total score are than there being significance to improve (P < 0.05) before test after the test of PS intervention group, simultaneously, test terminates each subscale score of rear PS intervention group and total score is significantly higher than control group, and difference has statistical significance (P < 0.05). Thus student memory power is significantly improved and raising effect by PS.
Improve the Alzheimer of the elderly
Alzheimer is general neurodegenerative diseases, can cause the loss of memory or confusion, and its principal causative mechanism is that amyloid beta or gamma-interferon activate mesoglia, and release neurotoxic molecule, causes inflammation and illness occur. Suppress inflammation energy patron saint's warp of microgliacyte, potential treatment Alzheimer's. PS has neuroprotective and antioxygenation, improves effect of Alzheimer's, and programmed earlier can be indicated dead. Hashioka (HashiokaSetal, 2007, Phosphatidylserineandphosphatidylcholine-containinglipos omesinhibitamyloidpandinterferon-inducedmicroglialactiva tion, FreeRadicalBiologyandMedicine, (42): 945-954) research finds, the mesoglia inflammation of amyloid beta and gamma-interferon induction, as tumour necrosis factor, oxynitrides and superoxide can be suppressed by 1��2mmolPS/PC (mol ratio is 3:7) compound capsule and pill. Engel (EngelRRetal., 1992, Double-blindcross-overstudyofphosphatidylserinevs.placeb oinpatientswithearlydementiaoftheAlzheimertype, EuropeanNeuropsychopharmacology, (2) double blind experiment that 33 are suffered from slight primary degenerative dementia Patient Participation: 149-155) has been done, take PS or the placebo of 300mg every day, medication 8 weeks. Experiment shows: improving than the clinical comprehensive impression grade of most patient taking PS with the patient taking placebo, leading the fractal intensity of EEG signals tends to normal level, and the state of an illness takes a turn for the better to some extent. Patel and Good (PatelDandGoodT, 2007, Arapidmethodtomeasurebeta-amyloidinducedneurotoxicityvit ro, JournalofNeuroscienceMethods, (161): 1-10) having found a kind of method of external quick mensuration amyloid beta Inducement of neurotoxicity, in experiment, PS is used to refer to the death of programmed earlier sexual cell.
Antidepressant
The monoamine neurotransmitter such as norepinephrine and serotonin can transmit excitement, therefore the decline of single amine or lack and will suppress excited transmission, causes dysthymia disorders. Maggioni (MaggioniM, PiccottiGB, BondiolottiGP, etal., Efectsofphosphatidylserinetherapyingeriatricpatientswith depressivedisorders, ActaPsychiatr, 1990, 81 (3): 265-270) clinical experiment is done to 10 female's patients with depression, first give the blank placebo of patient 15 days, then to the BCPS (ox pallium PS) taking 300mg/ days, continuous 30 days, before and after the blank agent of clothes and after treating with BCPS (ox pallium PS), with the melancholy grading scale of Han Mierdun, the observation assessment of nurse, in blood plasma, the changing conditions of norepinephrine and serotonin monitors the changing conditions of dysthymia disorders, find to take norepinephrine and serotonin concentration in the blood plasma of patient before and after PS to rise, depression degree reduces by 70%, dysthymia disorders is significantly improved, and take depressive symptom before and after blank placebo and do not improve. when animal can not escape in the presence of a harsh environment, behavioral despair just occurs, it can not be in the state of one, be a kind of rat depression model effectively evaluating thymoleptic. Castilho (CastilhoJCetal., 2004, Phosphatidylserine:anantidepressiveoracognitiveenhancer? ProgressinNeuro-PychopharmacologyandBiologicalPsychiatry, (28): 731-738) with 50,100, BCPS (ox pallium PS) the intramuscular injection experimental mouse of 200mg/kg, and do contrast to assess the antidepressant effect of BCPS (ox pallium PS) with 25mg/kg imipramine (a kind of thymoleptic). forced swim test finds, the effect of BCPS (ox pallium PS) is similar to imipramine, compare with blank group, along with the increase of PS injected dose, the experimental mice dead time is reduction trend, that is in the dosage range of 50��200mg/kg, antidepressant effect along with the increase of dosage in rising trend.
Described phosphatidylserine, it is desired to purity >=50wt%.
Described whey-protein is take milk as the lactalbumin powder that raw material is made, its protein content >=80wt%.
Described algae oil DHA, wherein DHA content >=10wt%.
According to a further aspect in the invention, the present invention provides the preparation method of above-mentioned Improving memory type nutritious supplementary, the method comprises: by phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin by the pre-mixing in premixed device of its weight percentage, wherein, before pre-mixing, in premixed device, pour nitrogen rear enclosed premixed device, after pre-mixing evenly, obtain Preblend; Then, this Preblend is mixed by its weight percentage with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder, improve memory-type nutritious supplementary dry powder, i.e. pulvis (as shown in Figure 1). As required, this dry powder can adopt conventional preparation method, makes other formulation of tablet, hard capsule etc.
More specifically, step 1: phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin are mixed pre-mixing in powder device by its weight percentage 25��1000 liters of three-dimensionals, wherein, in the mixed powder device of three-dimensional, nitrogen is poured 5��10 minutes before pre-mixing, nitrogen flow is 1��50 liter/min, and rear enclosed three-dimensional mixer; This three-dimensional mixer mixes 20��60 minutes in advance, after mixing, obtains Preblend. This is that the technology in this preparation method is crucial, main composition is wrapped up by one side maltodextrin, simultaneously, before pre-mixing, in premixed device, pour nitrogen, thus avoid the deterioration by oxidation of these active factores in following process process, on the other hand, improve the mobility of material, it is beneficial to following process and produces.
Step 2: then, this Preblend is mixed 30��120 minutes by its weight percentage with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex, chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder in the mixed powder device of three-dimensional, improve memory-type nutritious supplementary dry powder, i.e. pulvis.
Step 3: the pulvis mixed that step 2 is obtained be delivered in Full-automatic sack filling machine pack, tinning vanning, every packed amount can be 1��50g; Or, the pulvis mixed step 2 obtained is delivered in tabletting machine compressing tablet, bottling, every sheet 0.5��1.0g; Or, the pulvis mixed step 2 obtained is delivered to encapsulated in dress hard capsule machine, bottling, every hard capsule loading amount 0.5��1.0g.
, coming that the present invention is described further in conjunction with specific embodiments below, following each embodiment is only for illustrating the present invention, and protection scope of the present invention is not provided constraints.
Embodiment 1
Improving memory type nutritious supplementary is composed as follows:
Preparation process is as follows:
Step 1: phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin are joined in the mixed powder device of 1000 liters of three-dimensionals by its weight, with the flow velocity inflated with nitrogen 10 minutes of 50 liters/min, close three-dimensional mixer, pre-mixed 30 minutes, after mixing, obtain Preblend;
Step 2: then, this Preblend is mixed 120 minutes by its weight with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex, chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder in the mixed powder device of three-dimensional, improve memory-type nutritious supplementary dry powder, i.e. pulvis;
Step 3: the pulvis mixed that step 2 is obtained be delivered in Full-automatic sack filling machine pack, tinning vanning, this pulvis, 50g/ bag, 10 bags/tank (big bag), is suitable for for meal enteral nutrition agent, it is proposed that every day dose 300��500 grams.
Embodiment 2
Improving memory type nutritious supplementary is composed as follows:
Preparation method is identical with embodiment 1, and difference is: in step 3,25g/ bag, 20 bags/tank, is suitable for needing all kinds of crowds improving brain function, it is proposed that dose is every day one bag.
Embodiment 3
Improving memory type nutritious supplementary is composed as follows:
Preparation method is identical with embodiment 1, and difference is: in step 3, and the pulvis mixed step 2 obtained is delivered to encapsulated in dress hard capsule machine, bottling, this capsule, 1g/ grain, 60/bottle, suggestion dose is every day 6, each 3, takes after breakfast and lunch.
Embodiment 4
This Improving memory type nutritious supplementary composition is identical with embodiment 3.
Preparation method is identical with embodiment 3, and difference is: in step 3, and the pulvis mixed step 2 obtained is delivered in tabletting machine compressing tablet, bottling, this tablet, 1g/ sheet, 60 slices/bottle, suggestion dose is every day 6, each 3, takes after breakfast and lunch.
Test example (animal experiment)
In embodiment 2��4, product is as tested material, studies it to the effect of rat Improving memory.
Laboratory animal is healthy male adult rat, and 60 rats are divided into 5 groups at random, often organizes 12. One group is control group, gavage deionized water; One group is phosphatidylserine group, every day gavage 0.008g/kg (being equivalent to body weight is 120 kilograms of Coming-of-Age Days take in phosphatidylserine 1000mg) phosphatidylserine suspension; Product in its excess-three group difference every day gavage embodiment 2��4, gavage amount is respectively 0.52g/kg, 0.14g/kg, 0.14g/kg (being equivalent to body weight is 120 kilograms of Coming-of-Age Days take in phosphatidylserine 1000mg). Feed adopts complete feed, freely takes food and drinks water, and after the 30th day, five groups of rats carries out with water maze the swimming training lasting five days, and in trip, safety island required time is in table 2.
The difference of rats'swimming time respectively organized by table 2
Note: PS is the english abbreviation of phosphatidylserine; * P < 0.05 is compared with control group; * P < 0.01
Result shows, and phosphatidylserine group has significant Improving memory effect (p < 0.05) compared with control group; In embodiment 2��4 product as the test group of tested material has very significant Improving memory effect (p < 0.01). Result of study shows, effect of Improving memory type its Improving memory of nutritious supplementary after composite is more remarkable than one-component.
Claims (10)
1. an Improving memory type nutritious supplementary, by weight percentage, its raw material is:
2. Improving memory type nutritious supplementary according to claim 1, is characterized in that, described Improving memory type nutritious supplementary, and by weight percentage, its raw material is:
3. Improving memory type nutritious supplementary according to claim 1 and 2, is characterized in that, acetone insoluble matter content >=95wt% in described soybean phospholipid, phosphatidylcholine content >=20wt%.
4. Improving memory type nutritious supplementary according to claim 3, is characterized in that, in described Improving memory type nutritious supplementary, the content of soybean phospholipid is 10%��12%.
5. Improving memory type nutritious supplementary according to claim 1 and 2, is characterized in that, the purity >=50wt% of described phosphatidylserine.
6. Improving memory type nutritious supplementary according to claim 1 and 2, is characterized in that, described whey-protein is the lactalbumin powder made with milk, its protein content >=80wt%.
7. Improving memory type nutritious supplementary according to claim 1 and 2, is characterized in that, described algae oil DHA, wherein DHA content >=10wt%.
8. the preparation method of Improving memory type nutritious supplementary described in any one in a claim 1 to 7, it is characterized in that, the method comprises: by phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin by the pre-mixing in premixed device of its weight percentage, wherein, before pre-mixing, in premixed device, pour nitrogen rear enclosed premixed device, after pre-mixing evenly, obtain Preblend; Then, this Preblend is mixed by its weight percentage with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex, chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder, improve memory-type nutritious supplementary dry powder, i.e. pulvis.
9. preparation method according to claim 8, is characterized in that, the method comprises:
Step 1: phosphatidylserine, soybean phospholipid and algae oil DHA and maltodextrin are mixed pre-mixing in powder device by its weight percentage 25��1000 liters of three-dimensionals, wherein, in the mixed powder device of three-dimensional, nitrogen is poured 5��10 minutes before pre-mixing, nitrogen flow is 1��50 liter/min, and rear enclosed three-dimensional mixer; In the mixed powder device of this three-dimensional, pre-mixing 20��60 minutes, after mixing, obtains Preblend;
Step 2: described Preblend is mixed 30��120 minutes by its weight percentage with lactalbumin powder, whole milk powder, soy peptide powder, phosphopeptide caseinate, enzymolysis oatmeal, food fibre powder, composite mineral matter, vitamin complex, chicken powder, beef powder, carrot meal, Lotus root congee and wolfberry fruit powder in the mixed powder device of three-dimensional, improve memory-type nutritious supplementary dry powder, i.e. pulvis;
Step 3: the pulvis mixed that step 2 is obtained be delivered in Full-automatic sack filling machine pack, tinning vanning, every packed amount can be 1��50g; Or, the pulvis mixed step 2 obtained is delivered in tabletting machine compressing tablet, bottling, every sheet 0.5��1.0g; Or, the pulvis mixed step 2 obtained is delivered to encapsulated in dress hard capsule machine, bottling, every hard capsule loading amount 0.5��1.0g.
10. preparation method according to claim 8, it is characterised in that: this dry powder adopts conventional preparation method, makes tablet or capsule.
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