CN104955950B - 具有改善的脱靶特征谱的寡核苷酸 - Google Patents

具有改善的脱靶特征谱的寡核苷酸 Download PDF

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CN104955950B
CN104955950B CN201380057694.6A CN201380057694A CN104955950B CN 104955950 B CN104955950 B CN 104955950B CN 201380057694 A CN201380057694 A CN 201380057694A CN 104955950 B CN104955950 B CN 104955950B
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CN104955950A (zh
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T·莫勒
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Guangdong Maijinjia Biotechnology Co Ltd
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MIRRX THERAPEUTICS
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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CN201380057694.6A 2012-09-26 2013-09-26 具有改善的脱靶特征谱的寡核苷酸 Active CN104955950B (zh)

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US201261705668P 2012-09-26 2012-09-26
DKPA201200587 2012-09-26
US61/705,668 2012-09-26
DKPA201200587 2012-09-26
PCT/DK2013/050308 WO2014048441A1 (en) 2012-09-26 2013-09-26 Oligomers with improved off-target profile

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CN104955950B true CN104955950B (zh) 2019-04-26

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US (1) US9725721B2 (https=)
EP (1) EP2900822B1 (https=)
JP (1) JP6352269B2 (https=)
CN (1) CN104955950B (https=)
AU (1) AU2013324716B2 (https=)
CA (1) CA2886116C (https=)
WO (1) WO2014048441A1 (https=)

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CA2886745A1 (en) 2012-10-02 2014-04-10 Centenary Institute Of Cancer Medicine And Cell Biology Modulation of rna activity and vascular permeability
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
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CN104826133B (zh) * 2015-05-01 2020-11-24 北京博奥医学检验所有限公司 一种与肺腺癌有关的miRNA及其药物组合物
CN107058474B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过血浆microRNA-3591-3p诊断急性高山病的诊断试剂盒
CN107058475B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒
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CN107058473B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-3591诊断急性高山病的试剂盒
CN107058470B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒
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CN104955950A (zh) 2015-09-30
AU2013324716A1 (en) 2015-04-09
EP2900822B1 (en) 2021-11-24
US9725721B2 (en) 2017-08-08
AU2013324716B2 (en) 2019-06-13
CA2886116C (en) 2022-06-07
JP6352269B2 (ja) 2018-07-04
EP2900822A4 (en) 2016-05-25
US20160145620A1 (en) 2016-05-26
EP2900822A1 (en) 2015-08-05
WO2014048441A1 (en) 2014-04-03
JP2016513950A (ja) 2016-05-19
CA2886116A1 (en) 2014-04-03

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