CN104946755B - Brca1蛋白在制备逆转肿瘤细胞对mtx耐药性的药物中的应用 - Google Patents
Brca1蛋白在制备逆转肿瘤细胞对mtx耐药性的药物中的应用 Download PDFInfo
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- CN104946755B CN104946755B CN201510319265.2A CN201510319265A CN104946755B CN 104946755 B CN104946755 B CN 104946755B CN 201510319265 A CN201510319265 A CN 201510319265A CN 104946755 B CN104946755 B CN 104946755B
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6841—In situ hybridisation
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6844—Nucleic acid amplification reactions
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
- G01N2333/9065—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5)
- G01N2333/90655—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1) in general
- G01N2333/90661—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1) in general with a definite EC number (1.5.1.-)
- G01N2333/90666—Dihydrofolate reductase [DHFR] (1.5.1.3)
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Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510319265.2A CN104946755B (zh) | 2015-06-11 | 2015-06-11 | Brca1蛋白在制备逆转肿瘤细胞对mtx耐药性的药物中的应用 |
Applications Claiming Priority (1)
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CN201510319265.2A CN104946755B (zh) | 2015-06-11 | 2015-06-11 | Brca1蛋白在制备逆转肿瘤细胞对mtx耐药性的药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN104946755A CN104946755A (zh) | 2015-09-30 |
CN104946755B true CN104946755B (zh) | 2017-07-11 |
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CN201510319265.2A Active CN104946755B (zh) | 2015-06-11 | 2015-06-11 | Brca1蛋白在制备逆转肿瘤细胞对mtx耐药性的药物中的应用 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106492217B (zh) * | 2016-10-31 | 2018-12-28 | 哈尔滨医科大学 | Parp1抑制剂在制备逆转肿瘤细胞对氨甲蝶呤耐药性药物中的应用 |
CN109289051B (zh) * | 2018-09-14 | 2021-01-08 | 哈尔滨医科大学 | Msh2抑制剂在制备逆转mtx耐药肿瘤细胞耐药性的药物中的应用 |
CN109200288B (zh) * | 2018-09-14 | 2021-05-18 | 哈尔滨医科大学 | Msh3蛋白抑制剂在制备逆转mtx耐药肿瘤细胞耐药性的药物中的应用 |
CN110408696B (zh) * | 2019-04-29 | 2023-05-16 | 南昌大学第二附属医院 | Rock2在制备治疗逆转骨肉瘤细胞对trail耐药药物中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103301447A (zh) * | 2013-06-25 | 2013-09-18 | 哈尔滨医科大学 | DNA-PKcs在制备改变肿瘤细胞对MTX耐药性的药物中的应用 |
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2015
- 2015-06-11 CN CN201510319265.2A patent/CN104946755B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103301447A (zh) * | 2013-06-25 | 2013-09-18 | 哈尔滨医科大学 | DNA-PKcs在制备改变肿瘤细胞对MTX耐药性的药物中的应用 |
Non-Patent Citations (4)
Title |
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BRCA1 Up-Regulation Is Associated with Repair-mediated Resistance to cis-Diamminedichloroplatinum;Amreen Husain;《cancer research》;19980331;第58卷(第6期);第1120-1123页 * |
BRCA1/2基因与Eμ-Myc p19Arf-/-细胞药物敏感性及其表达在乳腺癌中的临床意义;刘璐;《中国博士学位论文全文数据库 医药卫生科技辑》;20140415(第04期);第35-37页、图1-10、1-11 * |
Gene amplification in human cells knocked down for RAD54;Ruiz-Herrera等;《Genome integrity》;20110318;第2卷(第1期);第1-10页 * |
Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells;Xiangning Meng;《JOURNAL OF MEDICAL GENETICS》;20141223;第52卷(第2期);第135-144页 * |
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