CN104946510B - 集核酸扩增和微阵列检测于一体的微流控装置 - Google Patents
集核酸扩增和微阵列检测于一体的微流控装置 Download PDFInfo
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510145687.2A CN104946510B (zh) | 2014-03-31 | 2015-03-30 | 集核酸扩增和微阵列检测于一体的微流控装置 |
Applications Claiming Priority (3)
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CN201410126515 | 2014-03-31 | ||
CN2014101265156 | 2014-03-31 | ||
CN201510145687.2A CN104946510B (zh) | 2014-03-31 | 2015-03-30 | 集核酸扩增和微阵列检测于一体的微流控装置 |
Publications (2)
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CN104946510A CN104946510A (zh) | 2015-09-30 |
CN104946510B true CN104946510B (zh) | 2017-06-06 |
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CN201520185304.XU Active CN204727866U (zh) | 2014-03-31 | 2015-03-30 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
CN201510145687.2A Active CN104946510B (zh) | 2014-03-31 | 2015-03-30 | 集核酸扩增和微阵列检测于一体的微流控装置 |
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CN201520185304.XU Active CN204727866U (zh) | 2014-03-31 | 2015-03-30 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
Country Status (5)
Country | Link |
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US (1) | US11396020B2 (zh) |
EP (1) | EP3126485B1 (zh) |
JP (1) | JP6542797B2 (zh) |
CN (2) | CN204727866U (zh) |
WO (1) | WO2015149569A1 (zh) |
Families Citing this family (24)
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CN204727866U (zh) | 2014-03-31 | 2015-10-28 | 博奥生物集团有限公司 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
EP3394293B1 (en) | 2015-12-22 | 2021-05-26 | Canon U.S. Life Sciences, Inc. | Sample-to-answer system for microorganism detection featuring target enrichment, amplification and detection |
US11285478B2 (en) | 2016-04-04 | 2022-03-29 | Combinati Incorporated | Microfluidic siphoning array for nucleic acid quantification |
US9845499B2 (en) * | 2016-04-04 | 2017-12-19 | Combinati Incorporated | Microfluidic siphoning array for nucleic acid quantification |
EP3984642B1 (en) | 2016-11-17 | 2023-09-06 | Combinati Incorporated | Methods and systems for nucleic acid analysis and quantification |
CN107723210B (zh) * | 2017-11-19 | 2021-05-04 | 杭州安弼晟生物科技有限公司 | 新型核酸检测微流控芯片装置 |
CN107893026A (zh) * | 2017-12-29 | 2018-04-10 | 苏州绘真医学检验所有限公司 | 检测人类病毒核酸的微流控芯片、检测方法及检测系统 |
CN110117646A (zh) * | 2018-02-05 | 2019-08-13 | 北京博奥晶典生物技术有限公司 | 一种检测23项遗传性耳聋基因突变的方法 |
CN108728327B (zh) * | 2018-05-23 | 2021-11-23 | 博奥生物集团有限公司 | 一种全自动样本制备微流控系统及其制备方法与使用方法 |
CN108642148B (zh) * | 2018-07-09 | 2024-01-30 | 南京岚煜生物科技有限公司 | 一种核酸扩增检测微流控芯片及其检测方法 |
CN109234154B (zh) * | 2018-08-20 | 2021-10-15 | 中国科学院半导体研究所 | 一种具有温度控制功能的硅基生化检测芯片 |
CN109055203A (zh) * | 2018-09-21 | 2018-12-21 | 中国人民解放军军事科学院军事医学研究院 | 一种全自动生物芯片工作站及其检测方法 |
US11097274B2 (en) | 2018-12-20 | 2021-08-24 | Cerflux, Inc. | Biomimetic array device and methods of using same |
CN109576150A (zh) * | 2018-12-29 | 2019-04-05 | 西南民族大学 | 膜芯片杂交仪 |
CN112175787B (zh) * | 2019-07-01 | 2022-05-06 | 申翌生物科技(杭州)有限公司 | 利用pcr反应系统进行pcr反应的方法 |
JP7310475B2 (ja) * | 2019-09-13 | 2023-07-19 | ウシオ電機株式会社 | 光照射装置 |
TW202142856A (zh) | 2019-11-17 | 2021-11-16 | 美商伯克利之光生命科技公司 | 用於生物樣本之分析的系統及方法 |
CN110904274A (zh) * | 2019-12-13 | 2020-03-24 | 福建工程学院 | 一种流控式的hpv基因分型芯片检测方法 |
US20230105360A1 (en) * | 2020-03-09 | 2023-04-06 | Nuclein, Llc | Apparatus and methods for molecular diagnostics |
CN111269823B (zh) * | 2020-03-10 | 2020-11-03 | 杭州博日科技股份有限公司 | 热循环装置及pcr仪 |
CN111635931B (zh) * | 2020-05-27 | 2021-10-22 | 北京理工大学 | 一种多靶标miRNA检测微流控芯片、检测方法及其快速定量检测系统 |
CN114768894B (zh) * | 2021-01-22 | 2023-08-11 | 中国科学院上海微系统与信息技术研究所 | 一种检测芯片及检测方法 |
CN113583839A (zh) * | 2021-08-04 | 2021-11-02 | 苏州含光微纳科技有限公司 | 一种多轴向微流控芯片及其加工方法 |
CN113736643A (zh) * | 2021-09-23 | 2021-12-03 | 吉特吉生物技术(苏州)有限公司 | 一种核酸扩增检测微流控芯片 |
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2015
- 2015-03-30 CN CN201520185304.XU patent/CN204727866U/zh active Active
- 2015-03-30 CN CN201510145687.2A patent/CN104946510B/zh active Active
- 2015-03-31 US US15/128,794 patent/US11396020B2/en active Active
- 2015-03-31 JP JP2016559817A patent/JP6542797B2/ja active Active
- 2015-03-31 EP EP15774049.9A patent/EP3126485B1/en active Active
- 2015-03-31 WO PCT/CN2015/000225 patent/WO2015149569A1/en active Application Filing
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CN103571740A (zh) * | 2013-10-15 | 2014-02-12 | 周国华 | 集核酸提取、扩增与检测一体化的装置 |
CN204727866U (zh) * | 2014-03-31 | 2015-10-28 | 博奥生物集团有限公司 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
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Also Published As
Publication number | Publication date |
---|---|
EP3126485A4 (en) | 2017-11-29 |
CN204727866U (zh) | 2015-10-28 |
US20170095818A1 (en) | 2017-04-06 |
JP6542797B2 (ja) | 2019-07-10 |
WO2015149569A1 (en) | 2015-10-08 |
US11396020B2 (en) | 2022-07-26 |
EP3126485B1 (en) | 2019-04-24 |
CN104946510A (zh) | 2015-09-30 |
JP2017516083A (ja) | 2017-06-15 |
EP3126485A1 (en) | 2017-02-08 |
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