CN104903302B - 大环广谱抗生素 - Google Patents

大环广谱抗生素 Download PDF

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Publication number
CN104903302B
CN104903302B CN201380069987.6A CN201380069987A CN104903302B CN 104903302 B CN104903302 B CN 104903302B CN 201380069987 A CN201380069987 A CN 201380069987A CN 104903302 B CN104903302 B CN 104903302B
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CN201380069987.6A
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Chinese (zh)
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CN104903302A (zh
Inventor
塔克·柯伦·罗伯茨
彼得·安德鲁·史密斯
罗伯特·I·希古奇
大卫·坎贝尔
普拉苏纳·帕拉塞利
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RQx Pharmaceuticals Inc
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RQx Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380069987.6A 2012-11-21 2013-11-20 大环广谱抗生素 Active CN104903302B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261729249P 2012-11-21 2012-11-21
US201261729253P 2012-11-21 2012-11-21
US61/729,253 2012-11-21
US61/729,249 2012-11-21
PCT/US2013/071093 WO2014081886A1 (en) 2012-11-21 2013-11-20 Macrocyclic broad spectrum antibiotics

Publications (2)

Publication Number Publication Date
CN104903302A CN104903302A (zh) 2015-09-09
CN104903302B true CN104903302B (zh) 2019-03-29

Family

ID=50728492

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380069987.6A Active CN104903302B (zh) 2012-11-21 2013-11-20 大环广谱抗生素

Country Status (12)

Country Link
US (1) US9309285B2 (enExample)
EP (1) EP2922829B1 (enExample)
JP (2) JP6437443B2 (enExample)
KR (1) KR20150088292A (enExample)
CN (1) CN104903302B (enExample)
AR (1) AR093581A1 (enExample)
BR (1) BR112015011697A2 (enExample)
CA (1) CA2892027A1 (enExample)
EA (1) EA201590871A1 (enExample)
MX (1) MX2015006340A (enExample)
TW (1) TWI631127B (enExample)
WO (1) WO2014081886A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
BR112015021036A2 (pt) 2013-03-15 2017-10-10 Univ Pennsylvania composições e métodos para tratar mps1
KR20170027721A (ko) 2014-05-20 2017-03-10 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
PL3289355T3 (pl) * 2015-04-30 2025-11-24 Idexx Laboratories, Inc. Sposoby wykrywania chorób nerek
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
KR20180109858A (ko) * 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
UA126027C2 (uk) * 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
IL288294B (en) * 2019-05-28 2022-09-01 Hoffmann La Roche A broad-spectrum macrocyclic antibiotic

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics
WO2001014346A1 (en) * 1999-08-20 2001-03-01 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
CN1675236A (zh) * 2002-06-17 2005-09-28 拜耳医药保健股份公司 抗菌的酰胺大环类物质
WO2011112441A1 (en) * 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
WO2012036907A2 (en) * 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
JP2007536200A (ja) 2003-07-17 2007-12-13 ミジェニックス インコーポレイテッド リポペプチド抗生物質誘導体の組成物およびその使用方法
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
WO2011120071A1 (en) 2010-04-01 2011-10-06 The University Of Queensland Oxytocin peptide analogues
WO2012166665A2 (en) 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
KR20140140580A (ko) 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics
WO2001014346A1 (en) * 1999-08-20 2001-03-01 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
CN1675236A (zh) * 2002-06-17 2005-09-28 拜耳医药保健股份公司 抗菌的酰胺大环类物质
WO2011112441A1 (en) * 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
WO2012036907A2 (en) * 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tu 6075;Holtzel A等;《J Antibiot (Tokyo)》;20020630;第55卷(第6期);第565-577页 *
Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide-based Inhibitor;Mark Paetzel等;《J. B. Chem.》;20040716;第279卷(第29期);第30781–30790页 *
多肽类抗菌剂研究进展;李艳萍等;《国外医药抗生素分册》;20091231;第30卷(第4期);第148-153页 *

Also Published As

Publication number Publication date
JP6662960B2 (ja) 2020-03-11
TW201434848A (zh) 2014-09-16
US9309285B2 (en) 2016-04-12
JP2016501864A (ja) 2016-01-21
KR20150088292A (ko) 2015-07-31
EP2922829B1 (en) 2021-08-11
TWI631127B (zh) 2018-08-01
CA2892027A1 (en) 2014-05-30
AR093581A1 (es) 2015-06-10
WO2014081886A1 (en) 2014-05-30
EP2922829A4 (en) 2016-11-02
BR112015011697A2 (pt) 2017-07-11
JP6437443B2 (ja) 2018-12-12
CN104903302A (zh) 2015-09-09
EP2922829A1 (en) 2015-09-30
JP2018184435A (ja) 2018-11-22
US20140142029A1 (en) 2014-05-22
MX2015006340A (es) 2015-09-07
EA201590871A1 (ru) 2015-11-30

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