CN104886594B - Preparation method of siraitia grosvenorii compound capsules - Google Patents
Preparation method of siraitia grosvenorii compound capsules Download PDFInfo
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- CN104886594B CN104886594B CN201510298167.5A CN201510298167A CN104886594B CN 104886594 B CN104886594 B CN 104886594B CN 201510298167 A CN201510298167 A CN 201510298167A CN 104886594 B CN104886594 B CN 104886594B
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- fructus momordicae
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- 241001409321 Siraitia grosvenorii Species 0.000 title 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of siraitia grosvenorii compound capsules. The preparation method comprises the following steps: crushing raw and auxiliary materials; screening the crushed raw and auxiliary materials; mixing the screened raw and auxiliary materials; pelleting the mixed raw and auxiliary materials; coating the pelleted raw and auxiliary materials; drying the coated raw and auxiliary materials; stuffing the capsules. Each of the siraitia grosvenorii compound capsule comprises the following raw and auxiliary materials in parts by weight: 23-27% of siraitia grosvenorii compound extracts, 5-10% of persimmon powder, 30-35% of corn starch, 25-30% of maltodextrin and 5-10% of microcrystalline cellulose. The siraitia grosvenorii compound extracts use a siraitia grosvenorii extracting solution as a solvent and dried tea leaves of dried aloe leaves, dried shrub althea flowers and dried sweet basil herb as the raw materials so as to perform the extraction, the mass ratio of the dried aloe leaves to the dried shrub althea flowers and the dried sweet basil herb is 2:(0.5-2.0):(1-1.5):(0.1-1), and the material-solvent ratio is 1:(5-10); The siraitia grosvenorii compound capsules prepared by the preparation method disclosed by the invention have the oxidation resistant effect, the bacteriostasis effect and the immunity enhancing effect.
Description
Technical field
The present invention relates to field of plant extraction, the preparation method of especially one Plant Extracts compound capsule.
Background technology
Fructus Momordicae is a kind of " medicine-food two-purpose " rare Chinese medicine, and it is cool in nature to have a sweet in the mouth, and return lung, large intestine channel have nourishing the lung to arrest cough,
Effect of promoting the production of body fluid to quench thirst.Fructus Momordicae deep processing at present is mainly extracts Fructus Momordicae glycoside, as sweeting agent.Extracting mogroside
During class, in the Fructus Momordicae extracting solution of discarding, also contain abundant nutrient substance, such as momordica grosvenori polysaccharide, Fructose, flavone,
Vitamin c.Think to reclaim further processing, due to there being the polymer substances such as pectin, dietary fiber, protein, so concentrating and spraying
Mist drying is difficult to carry out, and causes to extract the later Fructus Momordicae extracting solution discarding of Fructus Momordicae glycoside material, wastes Fructus Momordicae resource, give
Environmental protection brings pressure.Chinese invention patent application Publication No. cn101007042a, discloses a kind of decolouring, de- hardship, containing arhat
The method for preparing extractive of fruit glycoside;After extracting Fructus Momordicae glycoside, Fructus Momordicae extracting solution can also reclaim profit to this method
With.
Tea polyphenols are the antioxidative food additives extracting from Folium Camelliae sinensis, mainly by catechin, flavonol, anthocyanidin, phenol
Acid etc. forms, based on catechin.Tea polyphenols can remove harmful free radicals, blocks lipid peroxidation process, improves human enzymes
Activity, thus playing effect of antioxidation, mutation, anticancer, prevention and auxiliary to kinds cancers such as gastric cancer, intestinal cancer are controlled
Treat all helpful.
Aloe is Liliaceae evergreen herbage, containing anthraquinone analog compound, Aloe polysaccharide, aminoacid, organic acid, dimension life
Element, mineral the effects such as composition, can be used for food, medicine, cosmetics, have loosening bowel to relieve constipation, enhance immunity, moisturizing, beauty treatment,
The health-care effecies such as sterilization.Chinese patent application cn101670037, a kind of compound Aloe capsule and preparation method thereof, disclose one
Plant with Aloe, Indigo Naturaliss, Cinnabaris and succinum as raw material, after processing through Preparation process, Hydrolysis kinetics respectively, through mixing, pelletizing, fill
A kind of hard capsule Chinese medicine preparation that method manufactures such as fill out, have liver heat removing purge heat, the function of loosening bowel to relieve constipation, mind tranquilizing and the heart calming;Described reed
Luxuriant growth refers to the medicinal aloe in pharmacopeia, and Aloe salidroside content is more than 18%.
Hibiscus syriacus L., machaka.The flower of Hibiscus syriacus L., really, root, leaf and Pi Junke be used as medicine.Have and prevent and treat viral disease and reduction
The effect of cholesterol.Flos Hibisci high in nutritive value, containing protein, fat, crude fibre, and reducing sugar, vitamin c,
Aminoacid, ferrum, calcium, zinc etc., and contain flavonoids active material, there is the health-care effects such as refreshment of quenching the thirst, removing scurf and relieving itching.Flos Hibisci
Take orally and control regurgitation, dysentery, proctoptosis, haematemesis, hematochezia, mumps, leukorrhagia etc., external application can be treated furuncle and be swollen.Flos Hibisci contains soap
Careless glycoside, isovitexin, Saponin etc., it has certain inhibitory action to staphylococcus aureuses and Bacillus typhi, can treat hemorrhoidal hamorrhage and rush down
Blood.
Herba Ocimi (Herba Ocimi Pilosi) is " medicine-food two-purpose " Labiatae fragrant plant, have powerful, stimulate, fragrant abnormal smells from the patient.Herba Ocimi (Herba Ocimi Pilosi) contains volatile oil
0.02 ~ 0.04%, pure Basil Essential has very strong sterilizing rate, is mainly used as perfumery raw material.Herba Ocimi (Herba Ocimi Pilosi) all herbal medicine, has treatment head
Bitterly, sinusitis, bronchitis, Common Cold, dyspepsia, enteritis, diarrhea, staitinodermia, traumatic injury etc., decoct washing eczema
And dermatitis pimples, acne, have moisten effect to dryness hydropenia and aging coarse, wrinkle skin it can also be used to frequent overtime work and
The black eye of computer appearance, eye pouch faced by long-term.
Astringent persimmon fruit also known as Zhu fruit, are a kind of very high fruit of nutritive value, enjoy the good reputation of " fruit Zisco product ".In astringent persimmon fruit
Containing 2.0% about puckery persimmon tannin, also contain saccharide, protein, the necessary aminoacid of human body, trace element, multivitamin,
Organic acid etc., has suppression human lymphocyte leukemia, blood pressure lowering, removing interior free yl, absorption yttrium etc. many
Plant effect.Application for a patent for invention cn101328194 discloses a kind of persimmon powder and its production technology;It is by Fructus Kaki squeeze the juice with
Afterwards, juice carry out digesting, filter, enzyme denaturing, concentration, vacuum lyophilization and powder that tannin content be 1%~99% is obtained.
Content of the invention
The technical problem to be solved is to provide a kind of Fructus Momordicae compound capsule preparation method;By the method energy
Access a kind of Fructus Momordicae compound extract, and then obtain a kind of there is antioxidation, the antibacterial, Fructus Momordicae of enhancing immunity effect
Compound capsule.
In order to solve this technical problem, the present invention adopts the technical scheme that:
Part I produces Fructus Momordicae compound extract, and its step is as follows:
1st, carry at the beginning of Fructus Momordicae
With dried fructus momordicae as raw material, using pure water extraction, concentrate, column chromatography, eluting, extract Fructus Momordicae glycoside material,
Then reclaim the Fructus Momordicae effluent by column chromatography.
2nd, extracted with Fructus Momordicae effluent for solvent
Stem tea, dry aloe leaf, dry Flos Hibisci, dry Herba Ocimi (Herba Ocimi Pilosi) example in mass ratio are weighed up, as raw material;Stem tea: dry
Aloe leaf: dry Flos Hibisci: the ratio of dry Herba Ocimi (Herba Ocimi Pilosi) is 2:(0.5-2.0): (1-1.5): (0.1-1.0), with Fructus Momordicae effluent
Extracted for solvent, quality solid-liquid ratio is 1:(5-10), it is then heated to 70-100 DEG C, the time is 4-8 hour, is carried
Take.
3rd, filter, cool down
After extraction terminates, through vibrosieve, extracting solution is made to separate with medicinal residues;Then extracting solution being cooled to temperature is 50 DEG C of left sides
Right.
4th, enzymolysis, decolouring, filtration, sterilization
Example adds the pectase of 0.01-0.1%, the papain of 0.05-0.2%, the fiber of 0.05-0.2% in mass ratio
Plain enzyme, stirs, and controls temperature to be 40-55 DEG C, and the time is 20-30 minute;Add the activated carbon of 0.1%-2.5% again, insulation
30-50 minute, then filters.Enzyme preparation first can also use water dissolution, then adds.
Filtration can be plate-and-frame filtration, or kieselguhr filters, and obtains cleaner liquid;0.05- can be added during filtration
0.5% kieselguhr drainage, so that filtrate reaches clarification;Kieselguhr have thickness point, thickness kieselguhr is preferably in a proportion of 1 when adding:
1, to reach filtration clarification optimum efficiency;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (uht) sterilization, and sterilization temperature controls at 121-125 DEG C;Or bar
Family name sterilizes, and obtains extracting stock solution.
5th, membrance separation
Stock solution will be extracted and first use micro-filtrate membrane filtration, and then use NF membrane room temperature to concentrate.
Preferably membrane aperture is 0.45 μm of micro-filtration membrane, obtains the filtrate by micro-filtration membrane.
Then nanofiltration, will pass through NF membrane at normal temperatures by the filtrate of micro-filtration membrane, concentrates at normal temperatures, obtain nanofiltration dense
Contracting liquid;Concentrated solution can concentrating under reduced pressure further, obtain high power concentrated solution.
6th, it is dried
Can be spray drying, lyophilization or other drying meanss.Will be dense to the nanofiltration concentrate obtaining or high power
Contracting liquid drying, or pulverize further, obtain Fructus Momordicae compound extract.
The preparation of Part II Fructus Momordicae compound capsule, its step is as follows:
It is raw material using Fructus Momordicae compound extract and persimmon powder, add corn starch, maltodextrin, Microcrystalline Cellulose etc.
Adjuvant;Size-reduced, sieve, mix, pelletizing, coating, filling, aluminum-plastic packaged, finished product.
The proportioning of Fructus Momordicae compound capsule is, based on butt quality %,
Fructus Momordicae compound extract 23-27;
Persimmon powder 5-10;
Corn starch 30-35;
Maltodextrin 25-30;
Microcrystalline Cellulose 5-10;
Coating adopts 2.0% hydroxypropyl methyl cellulose (hpmc), and coating solution is made solvent using 60% ethanol, is made into concentration
For 6.0%-8.0% coating solution.
The quality of capsule is every 0.3g.Normal usage is daily 2-3 time, each 1-2 grain.
First each supplementary material is pulverized, cross the sieve of 200 mesh to 300 mesh, then adopt v mixer to mix;Pelletize and select
95% ethanol soft material, vibrating sieving machine is pelletized, coating, then in 40 DEG C of 35- drying under reduced pressure immediately, with remove further ethanol and
Moisture, after being dried, material moisture controls below 3.0%.Then it is filled into the hard capsule of 0.3g with 1# capsule shells.
The present invention, on the premise of keeping the basic ratio of Fructus Momordicae compound extract and persimmon powder, can also make other
Peroral dosage form, such as tablet, granule.
The present invention has following advantages and a characteristic:
1st, comprehensive utilization of resources.Recycle extracting the later Fructus Momordicae extracting solution of Fructus Momordicae glycoside material, as one kind
Solvent, for extracting Folium Camelliae sinensis, Aloe, Flos Hibisci, Herba Ocimi (Herba Ocimi Pilosi), obtains a kind of Fructus Momordicae compound extract, further and persimmon powder
Compounding prescription, is processed into compound capsule, and Fructus Momordicae resource is comprehensively utilized, and product effect is unique, reduces cost.
2nd, combination technique is novel.After reclaiming Fructus Momordicae effluent, as Extraction solvent;4 kinds of dry medical materials are according to regulation
Ratio, as raw material, is then extracted.According to the rules 4 Chinese crude drugs and solid-liquid ratio extract it is ensured that extract substantially effective
Stable components.The purpose adding enzyme preparation is depolymerized pectin, cellulose and the macromolecular substances such as protein-based, reduces extracting solution and glues
Degree, is smoothed out laying the first stone moreover it is possible to improve extract for the operation of the units such as follow-up membrance separation, concentrating under reduced pressure, spray drying
Yield and dissolubility.The activated carbon adding is it is therefore an objective to decolouring and drainage are it is ensured that the extract color obtaining is faint yellow.Filter
Clear liquid sterilization is to kill antibacterial and the enzyme adding, being easy to subsequent unit operation steady quality.Preferably membrane aperture is 0.45 μm
Micro-filtration membrane be for remove impurity, clarification, be easy to nanofiltration membrane operations, increase the service life, can also reduce multiple many as far as possible
The retention of sugared composition and loss.NF membrane is selected to be to concentrate it is ensured that quality, reduces cost at normal temperatures.These technology are special
Levy fixed Combination together, sequentially can not overturn, inseparable, support mutually, collective effect, just can obtain that dissolubility is good, become
This is low, have antioxidation, antibacterial, the Fructus Momordicae compound extract of enhancing immunity effect.Compound with persimmon powder further, make
Compound capsule;Persimmon powder extracts and is not placed in compound extract extraction process, is present to ensure that effective ingredient in persimmon powder
Content stable is it is ensured that the quality stability of compound capsule and effect.Welded joint is novel, is not known technology, is not
The superposition of simple technique combination, has prominent substantive distinguishing features and significantly improves.
Specific embodiment
Described below example is described in detail by the present invention.
Embodiment 1
The preparation of Part I Fructus Momordicae compound extract
1st, Fructus Momordicae tentatively extracts
New fresh Fructus Momordicae is first placed in the pure water of 6 times of its quality and is decocted, obtain Luohanguo's residue and Aqueous extracts a;
Luohanguo's residue is placed in the pure water of 8 times of its quality again and is decocted, obtain Aqueous extracts b;A is merged with b, filters, obtain
To Fructus Momordicae first extract;
2nd, Fructus Momordicae glycoside material separates
Fructus Momordicae first extract is carried out concentrating under reduced pressure, obtains concentrated solution;Concentrated solution is carried out plate-and-frame filtration, obtains concentrated solution
Clear liquid;By Fructus Momordicae concentrated solution clear liquid d101 styrene type copolymer macroporous resin adsorption, decolouring;Reclaim Fructus Momordicae to flow out
Liquid;
3rd, extracted with Fructus Momordicae effluent for solvent
Weigh qualified stem tea 200kg, dry aloe leaf 100kg, dry Flos Hibisci 120kg, dry Herba Ocimi (Herba Ocimi Pilosi) 50kg as former
Material;Extracted in 5 tons of extraction pot for solvent with 3000kg Fructus Momordicae effluent, be first to heat to 70 DEG C, be then turned on auxiliary
Ultrasound wave is helped to be extracted, after 4 hours, extraction terminates.
After extraction terminates, through vibrosieve, extracting solution is made to separate with medicinal residues;Then extracting solution is cooled to 50 DEG C.
4th, enzymolysis, decolouring, filtration, sterilization
Weigh pectase 0.5kg, papain 2.0 kg, cellulase 1.0kg, plus 10kg water dissolution, stirring are all
Even, it is then added in the extracting solution of 2000kg, is digested, control temperature to be 50 DEG C, the time is 30 minutes;Add again
The Powdered Activated Carbon of 2.5kg, continues insulation 30 minutes, is decoloured;Then filtered with diatomite filter;During filtration, add
The thick kieselguhr of 5kg, the thin kieselguhr of 5kg, as filter aid, are first precoated, are then filtered, obtained cleaner liquid;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (uht) sterilization, and sterilization temperature controls at 125 DEG C, obtains extracting former
Liquid 1800kg.
5th, membrance separation
1800kg is extracted stock solution first with 0.45 μm of micro-filtrate membrane filtration;Then pass through NF membrane at normal temperatures, carry out dense
Contracting, obtains nanofiltration concentrate 300kg, and detection soluble solid is 10.2%;Concentrated solution is subtracted with single effect evaporator further
Pressure concentrates, and obtains high power concentrated solution 50kg, and detection soluble solid is 51.2%.
6th, it is dried
With spray drying device, high power concentrated solution 50kg is spray-dried, the Fructus Momordicae compound recipe obtaining 22.8kg carries
Take thing.
The preparation of Part II Fructus Momordicae compound capsule
1st, Fructus Momordicae compound extract prepared by said method, the persimmon powder jet mill of purchase is pulverized respectively,
Cross 200 mesh sieves, obtain qualified Fructus Momordicae compound extract and persimmon powder, standby;Corn starch, maltodextrin, microcrystalline cellulose
Element is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, standby.
2nd, weigh the corn starch 30g crushing, Fructus Momordicae compound extract 25g, persimmon powder 10g, maltodextrin 30g,
Microcrystalline Cellulose 5g, puts in mixer successively, is sufficiently mixed, obtains mixture.
3rd, by mixture with 95% ethanol soft material, vibrosieve pelletize.
4th, coating.Weigh hydroxypropyl methyl cellulose (hpmc) 20g, be made into 8% coating solution, coating control with 60% ethanol
Coating kettle temperature processed, in 40 DEG C of 35-, controls rotating speed in 30-35 turns/min, uniformly sprays into coating solution with high-pressure spray gun, and
Constantly stir granule.Until coating solution bag is complete.Take out, decompression (not heating) is dried 2h, obtains qualified granule.
5th, qualified granule is filled into the hard capsule of 0.3g every in capsule filling machine with 1# capsule shells, polishing, then
Make aluminium-plastic panel, mounted box, make finished product.
Embodiment 2
Part I, the preparation of Fructus Momordicae compound extract
1st, extracted with Fructus Momordicae effluent for solvent.
Weigh qualified stem tea 10kg, dry aloe leaf 2.5kg, dry Flos Hibisci 5.0kg as raw material;With sieve 100kg
Chinese fruit effluent is solvent, is extracted in the extraction pot of 500l.It is first to heat to 90 DEG C, be then turned on auxiliary ultrasonic and carry out
Extract, after 6 hours, extraction terminates.After extraction terminates, through vibrosieve, extracting solution is made to separate with medicinal residues;Then extracting solution is cooled down
To 50 DEG C.
2nd, enzymolysis, decolouring, filtration, sterilization.
Weigh pectase 20g, papain 100g, cellulase 50g, be added in the extracting solution of 100kg, carry out
Enzymolysis, controls temperature to be 45 DEG C, and the time is 20 minutes;Add the Powdered Activated Carbon of 50g again, continue insulation 40 minutes, taken off
Color;Then filtered with diatomite filter, add kieselguhr as filter aid, obtained cleaner liquid;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (uht) sterilization, and sterilization temperature controls at 125 DEG C, obtains extracting former
Liquid 80kg.
5th, membrance separation.
80kg is extracted stock solution first with 0.45 μm of micro-filtrate membrane filtration;Then concentrated by NF membrane at normal temperatures,
Obtain nanofiltration concentrate 8.6kg, detection soluble solid is 13.5%.
6th, it is dried
With freeze drying equipment, concentrated solution is dried, obtains the Fructus Momordicae compound extract of 1.2kg.
Part II, the preparation of Fructus Momordicae compound capsule
1st, Fructus Momordicae compound extract prepared by said method, the persimmon powder jet mill of purchase is pulverized respectively,
Cross 200 mesh sieves, obtain qualified Fructus Momordicae compound extract and persimmon powder, standby;Corn starch, maltodextrin, microcrystalline cellulose
Element is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, standby.
2nd, the corn starch 330g crushing, Fructus Momordicae compound extract 230g, persimmon powder 80g, maltodextrin are weighed
300g, Microcrystalline Cellulose 50g, put in mixer successively, be sufficiently mixed, obtain mixture.
3rd, by mixture with 95% ethanol soft material, vibrosieve pelletize.
4th, coating.Weigh hydroxypropyl methyl cellulose (hpmc) 20g, be made into 8% coating solution with 60% ethanol, wrapped
Clothing.Take out, do not heat and carry out drying under reduced pressure 2h, obtain qualified granule.
5th, qualified granule is filled into the hard capsule of 0.3g every in capsule filling machine with 1# capsule shells, polishing, then
Make aluminium-plastic panel, mounted box, make finished product.
Embodiment 3
1st, extracted with Fructus Momordicae effluent for solvent.
Weigh qualified stem tea 2kg, dry aloe leaf 2kg, dry Flos Hibisci 1.5kg, dry Herba Ocimi (Herba Ocimi Pilosi) 1.0kg as raw material;
With 60kg Fructus Momordicae effluent as solvent, extracted in the extraction pot of 100l, be first to heat to 70 DEG C, carried out extracting 4 little
When.After extraction terminates, separate through dreg-liquid separator, extracting solution is separated with medicinal residues;Then extracting solution is cooled to 50 DEG C.
It is solvent with 60kg Fructus Momordicae effluent again, repeat to extract 2 times.Merge the extracting solution after cooling.
2nd, enzymolysis, decolouring, filtration, sterilization.
Weigh pectase 15g, protease 120g, cellulase 80g, be added in 50kg extracting solution, digested, control
Temperature is 50 DEG C, and the time is 30 minutes;Add the Powdered Activated Carbon of 50g again, continue insulation 30 minutes, decoloured;Then use
Diatomite filter filters;With kieselguhr as filter aid, first obtained cleaner liquid;
3rd, sterilize.
Cross cleaner liquid and adopt pasteurize, sterilization temperature controls at 95 DEG C, keep 30 minutes, then cool down, extracted
Stock solution.
4th, membrance separation.
Stock solution will be extracted first with 0.45 μm of micro-filtrate membrane filtration;Then at normal temperatures by multi-functional NF membrane, carry out dense
Contracting, obtains nanofiltration concentrate.
6th, it is dried
Concentrated solution 10kg is spray-dried, with obtaining the Fructus Momordicae compound extract of 1.8kg.
Part II, the preparation of Fructus Momordicae compound capsule
1st, Fructus Momordicae compound extract prepared by said method, the persimmon powder jet mill of purchase is pulverized respectively,
Cross 200 mesh sieves, obtain qualified Fructus Momordicae compound extract and persimmon powder, standby;Corn starch, maltodextrin, microcrystalline cellulose
Element is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, standby.
2nd, the corn starch 330g crushing, Fructus Momordicae compound extract 270g, persimmon powder 100g, maltodextrin are weighed
250g, Microcrystalline Cellulose 50g, put in mixer successively, be sufficiently mixed, obtain mixture.
3rd, by mixture with 95% ethanol soft material, vibrosieve pelletize.
4th, coating.Weigh hydroxypropyl methyl cellulose (hpmc) 20g, be made into 8% coating solution with 60% ethanol, wrapped
Clothing.Take out, do not heat and carry out drying under reduced pressure 2h, obtain qualified granule.
5th, qualified granule is filled into the hard capsule of 0.3g every in capsule filling machine with 1# capsule shells, polishing, then
Make aluminium-plastic panel, mounted box, make finished product.
Claims (3)
1. a kind of preparation method of Fructus Momordicae compound capsule, pulverizes including by each supplementary material, sieves, and mixing is pelletized, coating, does
Dry, capsule fill, plate-making it is characterised in that: the proportioning of described Fructus Momordicae compound capsule is, based on butt quality %,
Fructus Momordicae compound extract 23-27;
Persimmon powder 5-10;
Corn starch 30-35;
Maltodextrin 25-30;
Microcrystalline Cellulose 5-10;
Coating adopts 2.0% hydroxypropyl methyl cellulose (hpmc), and coating solution makees solvent using 60% ethanol, and being made into concentration is
6.0%-8.0% coating solution;
Described Fructus Momordicae compound extract is using following processing step:
1) carry at the beginning of Fructus Momordicae
With dried fructus momordicae as raw material, using pure water extraction, concentrate, column chromatography, eluting, extract Fructus Momordicae glycoside material, then
Reclaim the Fructus Momordicae effluent by column chromatography;
2) extracted with Fructus Momordicae effluent for solvent
Stem tea, dry aloe leaf, dry Flos Hibisci, dry Herba Ocimi (Herba Ocimi Pilosi) example in mass ratio are weighed up, as raw material;
Stem tea: dry aloe leaf: dry Flos Hibisci: the ratio of dry Herba Ocimi (Herba Ocimi Pilosi) is 2:(0.5-2.0): (1-1.5): (0.1-1);
Extracted with Fructus Momordicae effluent for solvent;Quality solid-liquid ratio is 1:(5-10);It is then heated to 70-100 DEG C, the time
For 4-8 hour, extracted;
3) filter, cool down
After extraction terminates, through vibrosieve, extracting solution is separated with medicinal residues;Extracting solution cools down;
4) enzymolysis, decolouring, filtration, sterilization
Add the pectase of 0.01-0.1%, the papain of 0.05-0.2%, the fibre of 0.05-0.2% by extracting solution mass ratio
The plain enzyme of dimension, controls temperature to be 40-55 DEG C, the time is digested for 20-30 minute;
Add the activated carbon of 0.1%-2.5% again, be incubated 30-50 minute, decoloured, then filter;
Cross cleaner liquid to be sterilized, obtain extracting stock solution;
5) membrance separation
Stock solution will be extracted and first use micro-filtrate membrane filtration, and then use NF membrane room temperature to concentrate;
Concentrated solution can concentrating under reduced pressure further, obtain high power concentrated solution;
6) it is dried
With spray drying or lyophilization or other drying meanss, by the nanofiltration concentrate obtaining or high power concentrated solution
Drying, or pulverize further, obtain Fructus Momordicae compound extract.
2. method according to claim 1 it is characterised in that: step 2) described in carried out with Fructus Momordicae effluent for solvent
Extract, repeat extraction medicinal residues 2-3 time with Fructus Momordicae effluent.
3. the Fructus Momordicae compound capsule obtaining according to the preparation method described in claim 1.
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