CN104886594A - Preparation method of siraitia grosvenorii compound capsules - Google Patents
Preparation method of siraitia grosvenorii compound capsules Download PDFInfo
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- CN104886594A CN104886594A CN201510298167.5A CN201510298167A CN104886594A CN 104886594 A CN104886594 A CN 104886594A CN 201510298167 A CN201510298167 A CN 201510298167A CN 104886594 A CN104886594 A CN 104886594A
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- momordica grosvenori
- extract
- dry
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- 241001409321 Siraitia grosvenorii Species 0.000 title 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of siraitia grosvenorii compound capsules. The preparation method comprises the following steps: crushing raw and auxiliary materials; screening the crushed raw and auxiliary materials; mixing the screened raw and auxiliary materials; pelleting the mixed raw and auxiliary materials; coating the pelleted raw and auxiliary materials; drying the coated raw and auxiliary materials; stuffing the capsules. Each of the siraitia grosvenorii compound capsule comprises the following raw and auxiliary materials in parts by weight: 23-27% of siraitia grosvenorii compound extracts, 5-10% of persimmon powder, 30-35% of corn starch, 25-30% of maltodextrin and 5-10% of microcrystalline cellulose. The siraitia grosvenorii compound extracts use a siraitia grosvenorii extracting solution as a solvent and dried tea leaves of dried aloe leaves, dried shrub althea flowers and dried sweet basil herb as the raw materials so as to perform the extraction, the mass ratio of the dried aloe leaves to the dried shrub althea flowers and the dried sweet basil herb is 2:(0.5-2.0):(1-1.5):(0.1-1), and the material-solvent ratio is 1:(5-10); The siraitia grosvenorii compound capsules prepared by the preparation method disclosed by the invention have the oxidation resistant effect, the bacteriostasis effect and the immunity enhancing effect.
Description
Technical field
The present invention relates to field of plant extraction, especially the preparation method of a Plant Extracts compound capsule.
Background technology
Momordica grosvenori is a kind of " medicine-food two-purpose " rare traditional Chinese medicine, has taste sweet cool in nature, returns lung, large intestine channel, moisten the lung and relieve the cough, the effect promoted the production of body fluid to quench thirst.Current Momordica grosvenori deep processing mainly extracts Momordica grosvenori glucoside, as sweetener.In the process extracting Momordica grosvenori glucoside, also containing abundant nutriment in the Momordica grosvenori extract abandoned, such as momordica grosvenori polysaccharide, fructose, flavones, vitamin C.Think to reclaim processing further, owing to there being the polymer substances such as pectin, dietary fiber, protein, be difficult to carry out with spraying dry so concentrated, cause the Momordica grosvenori extract extracting Momordica grosvenori glucoside material later to abandon, waste Momordica grosvenori resource, brings pressure to environmental protection.Chinese invention patent application publication number is CN101007042A, discloses a kind of decolouring, debitterize, containing the method for preparing extractive of Momordica grosvenori glucoside; This method is after extraction Momordica grosvenori glucoside, and Momordica grosvenori extract can also be recycled.
Tea Polyphenols is the antioxidative food additive extracted from tealeaves, primarily of compositions such as catechin, flavonols, anthocyanidin, phenolic acid, based on catechin.Tea Polyphenols can remove harmful free radicals, blocks lipid peroxidation process, improves the activity of human enzymes, thus plays effect of anti-oxidant, anti-sudden change, anticancer, to the prevention of the kinds cancer such as cancer of the stomach, intestinal cancer and supplemental treatment all helpful.
Aloe is Liliaceae evergreen herbage, containing functional components such as anthraquinone analog compound, aloe polysaccharide, amino acid, organic acid, vitamin, mineral matters, can be used for food, medicine, cosmetics, there is relaxing bowel, improve immunity, moisturizing, beauty treatment, the health-care efficacy such as sterilization.Chinese patent application CN101670037, a kind of compound aloe capsule and preparation method thereof, disclose one with aloe, indigo naturalis, cinnabar and amber for raw material, respectively after Preparation process, Hydrolysis kinetics process, through a kind of hard shell capsules Chinese medicine preparation of the method such as mixing, granulation, filling manufactures, have that clearing liver is purged heat, relaxed bowel, the function of antitoxic heart-soothing and sedative; Described aloe refers to the medicinal aloe in pharmacopeia, and barbaloin content is greater than 18%.
The rose of Sharon, machaka.The flower of the rose of Sharon, really, root, leaf and Pi Junke be used as medicine.There is the effect preventing and treating viral disease and reduce cholesterol.The high nutritive value of shrub althea flower, containing protein, fat, crude fibre, and reduced sugar, vitamin C, amino acid, iron, calcium, zinc etc., and containing flavonoids active material, there is the health-care effect such as restoring consciouness, anti-dandruff and itching-relieving that quenches the thirst.Shrub althea flower is for oral administration controls gastric disorder causing nausea, dysentery, prolapse of the anus, haematemesis, lower blood, mumps, leukorrhea etc., and external application can treat sore furuncle.Shrub althea flower is containing saponarin, isovitexin, saponin etc., and it has certain inhibitory action to staphylococcus aureus and typhoid bacillus, can treat intestines diarrhea due to wind-evil blood.
Sweet basil is " medicine-food two-purpose " Labiatae fragrant plant, have powerful, stimulate, fragrant smell.Sweet basil is containing volatile oil 0.02 ~ 0.04%, and pure Basil Essential has very strong sterilizing rate, main as blending raw material.Sweet basil all herbal medicine, there is treatment headache, nasosinusitis, bronchitis, cold, indigestion, enteritis, diarrhea, staitinodermia, traumatic injuries etc., decoct washing eczema and dermatitis pimples, acne, have to dryness lack of water and aging skin that is coarse, wrinkle the effect of moistening, also can be used for often overtime work and long-term livid ring around eye, the pouch occurred in the face of computer.
Astringent persimmon fruit has another name called Zhu fruit, is the fruit that a kind of nutritive value is very high, enjoys the good reputation of " fruit Zisco product ".Containing about 2.0% puckery persimmon tannin in astringent persimmon fruit, also containing amino acid, trace element, multivitamin, organic acid etc. that carbohydrate, protein, human body are necessary, have suppress human lymphocyte leukaemia, hypotensive, remove the multiple efficacies such as interior free yl, absorption yttrium.Application for a patent for invention CN101328194 discloses a kind of persimmon powder and production technology thereof; It is after being squeezed the juice by persimmon, and juice carries out enzymolysis, filters, the enzyme that goes out, concentrated, vacuum freeze drying and obtained tannin content is the powder of 1% ~ 99%.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Momordica grosvenori compound capsule preparation method; A kind of Momordica grosvenori compound extract can be obtained by the method, and then obtain a kind of there is Momordica grosvenori compound capsule that is anti-oxidant, antibacterial, develop immunitypty effect.
In order to solve this technical problem, the technical scheme that the present invention takes is:
Part I produces Momordica grosvenori compound extract, and its step is as follows:
1, carry at the beginning of Momordica grosvenori
Take dried fructus momordicae as raw material, adopt pure water to extract, concentrated, column chromatography, wash-out, extracts Momordica grosvenori glucoside material, then reclaims the Momordica grosvenori efflux by column chromatography.
2, with Momordica grosvenori efflux for solvent extracts
By stem tea, dry aloe leaf, dry shrub althea flower, dry sweet basil in mass ratio example weigh up, as raw material; Stem tea: dry aloe leaf: dry shrub althea flower: the ratio of dry sweet basil is 2:(0.5-2.0): (1-1.5): (0.1-1.0), with Momordica grosvenori efflux for solvent extracts, quality solid-liquid ratio is 1:(5-10), be then heated to 70-100 DEG C, time is 4-8 hour, extracts.
3, filter, cool
After extraction terminates, through vibratory sieve, extract is separated with the dregs of a decoction; Then temperature is cooled to by extract to be about 50 DEG C.
4, enzymolysis, decolouring, filtration, sterilization
Example adds the pectase of 0.01-0.1% in mass ratio, the papain of 0.05-0.2%, and the cellulase of 0.05-0.2%, stirs, and control temperature is 40-55 DEG C, and the time is 20-30 minute; Add the active carbon of 0.1%-2.5% again, insulation 30-50 minute, then filters.Enzyme preparation also can first use water-soluble solution, then adds.
Filtration can be plate-frame filtering, or diatomite filtration, obtains cleaner liquid; 0.05-0.5% diatomite drainage can be added, so that filtrate reaches clarification during filtration; Diatomite has dividing of thickness, and when thickness diatomite adds, preferred proportion is 1:1, filters clarification optimum efficiency to reach;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (UHT) sterilization, and sterilization temperature controls at 121-125 DEG C; Or pasteurize, obtains extracting stoste.
5, UF membrane
Extraction stoste is first used micro-filtrate membrane filtration, then concentrates with NF membrane normal temperature.
Preferred film aperture is the microfiltration membranes of 0.45 μm, obtains the filtrate by microfiltration membranes.
Then nanofiltration, by the filtrate by microfiltration membranes at normal temperatures by NF membrane, concentrates at normal temperatures, obtains nanofiltration concentrate; Concentrate can reduced pressure concentration further, obtains high power concentrate.
6, dry
Can be spraying dry, freeze drying or other drying means.By the nanofiltration concentrate that obtains or high power concentrate drying, or pulverize further, obtain Momordica grosvenori compound extract.
The preparation of Part II Momordica grosvenori compound capsule, its step is as follows:
Adopt Momordica grosvenori compound extract and persimmon powder to be raw material, add cornstarch, maltodextrin, the auxiliary materials such as microcrystalline cellulose; Through pulverizing, sieving, mix, granulate, dressing, filling, aluminum-plastic packaged, obtained finished product.
The proportioning of Momordica grosvenori compound capsule is, by butt quality %,
Momordica grosvenori compound extract 23-27;
Persimmon powder 5-10;
Cornstarch 30-35;
Maltodextrin 25-30;
Microcrystalline cellulose 5-10;
Dressing adopts 2.0% hydroxypropyl methylcellulose (HPMC), and coating solution adopts the ethanol of 60% to make solvent, and being made into concentration is 6.0%-8.0% coating solution.
The quality of capsule is every 0.3g.Positive usual amounts is every day 2-3 time, each 1-2 grain.
First each supplementary material is pulverized, cross 200 orders and sieve to 300 objects, then adopt the mixing of V mixer; The ethanol softwood of 95% is selected in granulation, and vibrating sieving machine is granulated, dressing, and then at 35-40 DEG C drying under reduced pressure immediately, to remove ethanol and moisture further, after dry, material moisture controls below 3.0%.Then the hard shell capsules of 0.3g is filled to by 1# capsule shells.
The present invention, under the prerequisite of basic ratio keeping Momordica grosvenori compound extract and persimmon powder, can also make other peroral dosage forms, such as tablet, granule.
The present invention has following advantages and characteristic:
1, comprehensive utilization of resources.The later Momordica grosvenori extract recycling of Momordica grosvenori glucoside material will be extracted, as a kind of solvent, be used for extracting tealeaves, aloe, shrub althea flower, sweet basil, obtain a kind of Momordica grosvenori compound extract, the composite prescription with persimmon powder further again, be processed into compound capsule, Momordica grosvenori resource obtains comprehensive utilization, product effect is unique, reduces cost.
2, combination technique is novel.After reclaiming Momordica grosvenori efflux, as Extraction solvent; 4 kinds of dry medicinal materials, then extract as raw material according to the ratio of regulation.4 Chinese medicines and solid-liquid ratio extract according to the rules, guarantee that the basic effective constituents of extract is stablized.Adding the object of enzyme preparation is depolymerized pectin, cellulose and the macromolecular substances such as protein-based, reduce extract viscosity, for the unit operations such as subsequent film separation, reduced pressure concentration, spraying dry lay the first stone smoothly, yield and the solubility of extract can also be improved.The active carbon added, object is decolouring and drainage, guarantees that the extract color obtained is faint yellow.Crossing cleaner liquid sterilization is in order to the enzyme killing bacterium He add, and is convenient to subsequent unit operation steady quality.Preferred film aperture is the microfiltration membranes of 0.45 μm is in order to removal of impurities, clarification, is convenient to NF membrane operation, increases the service life, can also reduce retaining and losing of multiple polysaccharide component as far as possible.Selecting NF membrane to be to concentrate at normal temperatures, ensuring the quality of products, reducing costs.These technical characteristic fixed Combination together, can not put upside down, inseparable, supports mutually, acting in conjunction by order, just can obtain that dissolubility is good, cost is low, it is anti-oxidant, antibacterial to have, the Momordica grosvenori compound extract of develop immunitypty effect.Composite with persimmon powder further, make compound capsule; Persimmon powder extracts not to be placed in compound extract leaching process and goes, and is stablizing in order to ensure active constituent content in persimmon powder, guarantees quality stability and effect of compound capsule.Welded joint is novel, is not known technology, is not the superposition of simple technique combination, has outstanding substantive distinguishing features and significant progress.
Detailed description of the invention
The following stated example understands the present invention in detail.
Embodiment 1
The preparation of Part I Momordica grosvenori compound extract
1, Momordica grosvenori tentatively extracts
The pure water that new fresh fructus momordicae is first placed in 6 times of its quality is decocted, obtains Luohanguo's residue and Aqueous extracts A; Pure water Luohanguo's residue being placed in again 8 times of its quality decocts, and obtains Aqueous extracts B; A and B is merged, filters, obtain Momordica grosvenori just extract;
2, Momordica grosvenori glucoside separating substances
First for Momordica grosvenori extract is carried out reduced pressure concentration, obtains concentrate; Concentrate is carried out plate-frame filtering, obtains concentrate clear liquid; By Momordica grosvenori concentrate clear liquid D101 styrene type EVA macroporous resin adsorption, decolouring; Reclaim Momordica grosvenori efflux;
3, with Momordica grosvenori efflux for solvent extracts
Take qualified stem tea 200kg, dry aloe leaf 100kg, dry shrub althea flower 120kg, dry sweet basil 50kg as raw material; Extract in the extractor of 5 tons for solvent with 3000kg Momordica grosvenori efflux, be first heated to 70 DEG C, then open auxiliary ultrasonic and extract, after 4 hours, extract and terminate.
After extraction terminates, through vibratory sieve, extract is separated with the dregs of a decoction; Then extract is cooled to 50 DEG C.
4, enzymolysis, decolouring, filtration, sterilization
Take pectase 0.5kg, papain 2.0 kg, cellulase 1.0kg, add the water-soluble solution of 10kg, stir, then join in the extract of 2000kg, carry out enzymolysis, control temperature is 50 DEG C, and the time is 30 minutes; Add the Powdered Activated Carbon of 2.5kg again, continue insulation 30 minutes, decolour; Then filter with diatomite filter; During filtration, add the thick diatomite of 5kg, the thin diatomite of 5kg as filter aid, first carry out precoating, then filter, obtained cleaner liquid;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (UHT) sterilization, and sterilization temperature controls at 125 DEG C, obtains extracting stoste 1800kg.
5, UF membrane
1800kg is extracted the micro-filtrate membrane filtration that stoste first uses 0.45 μm; Then at normal temperatures by NF membrane, concentrate, obtain nanofiltration concentrate 300kg, detecting soluble solid is 10.2%; Concentrate carries out reduced pressure concentration with single effect evaporator further, obtains high power concentrate 50kg, and detecting soluble solid is 51.2%.
6, dry
With spray drying device, high power concentrate 50kg is carried out spraying dry, obtain the Momordica grosvenori compound extract of 22.8kg.
The preparation of Part II Momordica grosvenori compound capsule
1, the Momordica grosvenori compound extract prepared by said method, the persimmon powder airslide disintegrating mill of purchase is pulverized respectively, crosses 200 mesh sieves, obtains qualified Momordica grosvenori compound extract and persimmon powder, for subsequent use; Cornstarch, maltodextrin, microcrystalline cellulose is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, for subsequent use.
2, take the cornstarch 30g crushed, Momordica grosvenori compound extract 25g, persimmon powder 10g, maltodextrin 30g, microcrystalline cellulose 5g, drop in mixer successively, fully mix, obtain mixture.
3, by mixture with 95% ethanol softwood, vibratory sieve granulate.
4, dressing.Take hydroxypropyl methylcellulose (HPMC) 20g, ethanol with 60% is made into the coating solution of 8%, and dressing controls dressing kettle temperature 35-40 DEG C, controls rotating speed at 30-35 turns/min, evenly spray into coating solution with high-pressure spray gun, and constantly stir particle.Until coating solution bag is complete.Take out, decompression (not heating) dry 2h, obtains qualified particle.
5, qualified particle 1# capsule shells is filled to the hard shell capsules of 0.3g every at capsule filling machine, polishing, then makes aluminium-plastic panel, and mounted box makes finished product.
Embodiment 2
Part I, the preparation of Momordica grosvenori compound extract
1, with Momordica grosvenori efflux for solvent extracts.
Take qualified stem tea 10kg, dry aloe leaf 2.5kg, dry shrub althea flower 5.0kg as raw material; With 100kg Momordica grosvenori efflux for solvent, extract in the extractor of 500L.First be heated to 90 DEG C, then open auxiliary ultrasonic and extract, after 6 hours, extract and terminate.After extraction terminates, through vibratory sieve, extract is separated with the dregs of a decoction; Then extract is cooled to 50 DEG C.
2, enzymolysis, decolouring, filtration, sterilization.
Take pectase 20g, papain 100g, cellulase 50g, join in the extract of 100kg, carry out enzymolysis, control temperature is 45 DEG C, and the time is 20 minutes; Add the Powdered Activated Carbon of 50g again, continue insulation 40 minutes, decolour; Then filter with diatomite filter, add diatomite as filter aid, obtained cleaner liquid;
Crossing cleaner liquid adopts instantaneous superhigh temperature to kill bacterium (UHT) sterilization, and sterilization temperature controls at 125 DEG C, obtains extracting stoste 80kg.
5, UF membrane.
80kg is extracted the micro-filtrate membrane filtration that stoste first uses 0.45 μm; Then concentrated by NF membrane at normal temperatures, obtain nanofiltration concentrate 8.6kg, detecting soluble solid is 13.5%.
6, dry
With freeze drying equipment, concentrate is carried out drying, obtain the Momordica grosvenori compound extract of 1.2kg.
Part II, the preparation of Momordica grosvenori compound capsule
1, the Momordica grosvenori compound extract prepared by said method, the persimmon powder airslide disintegrating mill of purchase is pulverized respectively, crosses 200 mesh sieves, obtains qualified Momordica grosvenori compound extract and persimmon powder, for subsequent use; Cornstarch, maltodextrin, microcrystalline cellulose is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, for subsequent use.
2, take the cornstarch 330g crushed, Momordica grosvenori compound extract 230g, persimmon powder 80g, maltodextrin 300g, microcrystalline cellulose 50g, drop in mixer successively, fully mix, obtain mixture.
3, by mixture with 95% ethanol softwood, vibratory sieve granulate.
4, dressing.Take hydroxypropyl methylcellulose (HPMC) 20g, the ethanol with 60% is made into the coating solution of 8%, carries out dressing.Take out, do not heat and carry out drying under reduced pressure 2h, obtain qualified particle.
5, qualified particle 1# capsule shells is filled to the hard shell capsules of 0.3g every at capsule filling machine, polishing, then makes aluminium-plastic panel, and mounted box makes finished product.
Embodiment 3
1, with Momordica grosvenori efflux for solvent extracts.
Take qualified stem tea 2kg, dry aloe leaf 2kg, dry shrub althea flower 1.5kg, dry sweet basil 1.0kg as raw material; With 60kg Momordica grosvenori efflux for solvent, extract in the extractor of 100L, be first heated to 70 DEG C, carry out extraction 4 hours.After extraction terminates, be separated through dreg-liquid separator, extract is separated with the dregs of a decoction; Then extract is cooled to 50 DEG C.
Be solvent with 60kg Momordica grosvenori efflux again, repeat extraction 2 times.Merge cooled extract.
2, enzymolysis, decolouring, filtration, sterilization.
Take pectase 15g, protease 120g, cellulase 80g, join in 50kg extract, carry out enzymolysis, control temperature is 50 DEG C, and the time is 30 minutes; Add the Powdered Activated Carbon of 50g again, continue insulation 30 minutes, decolour; Then filter with diatomite filter; With diatomite as filter aid, first obtained cleaner liquid;
3, sterilization.
Cross cleaner liquid and adopt pasteurize, sterilization temperature controls at 95 DEG C, keeps 30 minutes, then cools, and obtains extracting stoste.
4, UF membrane.
Extraction stoste is first used the micro-filtrate membrane filtration of 0.45 μm; Then at normal temperatures by multi-functional NF membrane, concentrate, obtain nanofiltration concentrate.
6, dry
Concentrate 10kg is carried out spraying dry, with the Momordica grosvenori compound extract obtaining 1.8kg.
Part II, the preparation of Momordica grosvenori compound capsule
1, the Momordica grosvenori compound extract prepared by said method, the persimmon powder airslide disintegrating mill of purchase is pulverized respectively, crosses 200 mesh sieves, obtains qualified Momordica grosvenori compound extract and persimmon powder, for subsequent use; Cornstarch, maltodextrin, microcrystalline cellulose is pulverized with Universalpulverizer respectively, crosses 200 mesh sieves, for subsequent use.
2, take the cornstarch 330g crushed, Momordica grosvenori compound extract 270g, persimmon powder 100g, maltodextrin 250g, microcrystalline cellulose 50g, drop in mixer successively, fully mix, obtain mixture.
3, by mixture with 95% ethanol softwood, vibratory sieve granulate.
4, dressing.Take hydroxypropyl methylcellulose (HPMC) 20g, the ethanol with 60% is made into the coating solution of 8%, carries out dressing.Take out, do not heat and carry out drying under reduced pressure 2h, obtain qualified particle.
5, qualified particle 1# capsule shells is filled to the hard shell capsules of 0.3g every at capsule filling machine, polishing, then makes aluminium-plastic panel, and mounted box makes finished product.
Claims (4)
1. a preparation method for Momordica grosvenori compound capsule, comprises and being pulverized by each supplementary material, sieve, mixing, granulates, and dressing is dry, capsule-filling, plate-making,
It is characterized in that: the proportioning of described Momordica grosvenori compound capsule is, by butt quality %,
Momordica grosvenori compound extract 23-27;
Persimmon powder 5-10;
Cornstarch 30-35;
Maltodextrin 25-30;
Microcrystalline cellulose 5-10;
Dressing adopts 2.0% hydroxypropyl methylcellulose (HPMC), and coating solution adopts the ethanol of 60% to make solvent, and being made into concentration is 6.0%-8.0% coating solution.
2., according to the preparation method described in claim 1, described Momordica grosvenori compound extract adopts following processing step:
1) carry at the beginning of Momordica grosvenori
Take dried fructus momordicae as raw material, adopt pure water to extract, concentrated, column chromatography, wash-out, extracts Momordica grosvenori glucoside material, then reclaims the Momordica grosvenori efflux by column chromatography;
It is characterized in that: also adopt following steps:
2) with Momordica grosvenori efflux for solvent extracts
By stem tea, dry aloe leaf, dry shrub althea flower, dry sweet basil in mass ratio example weigh up, as raw material;
Stem tea: dry aloe leaf: dry shrub althea flower: the ratio of dry sweet basil is 2:(0.5-2.0): (1-1.5): (0.1-1);
With Momordica grosvenori efflux for solvent extracts; Quality solid-liquid ratio is 1:(5-10); Then be heated to 70-100 DEG C, the time is 4-8 hour, extracts;
3) filter, cool
After extraction terminates, through vibratory sieve, extract is separated with the dregs of a decoction; Extract cools;
4) enzymolysis, decolouring, filtration, sterilization
Add the pectase of 0.01-0.1% by extract mass ratio, the papain of 0.05-0.2%, the cellulase of 0.05-0.2%, control temperature is 40-55 DEG C, and the time is carry out enzymolysis in 20-30 minute;
Add the active carbon of 0.1%-2.5% again, insulation 30-50 minute, decolours, then filters;
Cross cleaner liquid and carry out sterilization, obtain extracting stoste;
5) UF membrane
Extraction stoste is first used micro-filtrate membrane filtration, then concentrates with NF membrane normal temperature;
Concentrate can reduced pressure concentration further, obtains high power concentrate;
6) dry
With spraying dry or freeze drying or other drying means, by the nanofiltration concentrate that obtains or high power concentrate drying, or pulverize further, obtain Momordica grosvenori compound extract.
3. method according to claim 1 and 2, is characterized in that: step 2) described in extract, repeat to extract dregs of a decoction 2-3 time with Momordica grosvenori efflux.
4. according to the Momordica grosvenori compound capsule that preparation method according to claim 1 obtains.
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Application publication date: 20150909 Assignee: Guilin Xinjiatianxia Food Co.,Ltd. Assignor: GUILIN University OF ELECTRONIC TECHNOLOGY Contract record no.: X2023980046008 Denomination of invention: Preparation method of Luohanguo compound capsule Granted publication date: 20170118 License type: Common License Record date: 20231108 |