CN104884462A - 用于治疗病毒感染和癌症的嘧啶核苷及其单磷酸酯前药 - Google Patents

用于治疗病毒感染和癌症的嘧啶核苷及其单磷酸酯前药 Download PDF

Info

Publication number
CN104884462A
CN104884462A CN201380068925.3A CN201380068925A CN104884462A CN 104884462 A CN104884462 A CN 104884462A CN 201380068925 A CN201380068925 A CN 201380068925A CN 104884462 A CN104884462 A CN 104884462A
Authority
CN
China
Prior art keywords
alkyl
substituted
group
aryl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380068925.3A
Other languages
English (en)
Chinese (zh)
Inventor
弗兰克·安布拉尔
斯蒂文·J·科阿斯
雷蒙德·F·斯基那兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMORY UNIV
Eutectic Pharmacy Stock Co Ltd
Original Assignee
AMORY UNIV
Eutectic Pharmacy Stock Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMORY UNIV, Eutectic Pharmacy Stock Co Ltd filed Critical AMORY UNIV
Publication of CN104884462A publication Critical patent/CN104884462A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN201380068925.3A 2012-10-29 2013-10-29 用于治疗病毒感染和癌症的嘧啶核苷及其单磷酸酯前药 Pending CN104884462A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261719696P 2012-10-29 2012-10-29
US61/719,696 2012-10-29
US201361763534P 2013-02-12 2013-02-12
US61/763,534 2013-02-12
PCT/US2013/067309 WO2014070771A1 (en) 2012-10-29 2013-10-29 Pyrimidine nucleotides and their monophosphate prodrugs for treatment of viral infections and cancer

Publications (1)

Publication Number Publication Date
CN104884462A true CN104884462A (zh) 2015-09-02

Family

ID=50627997

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380068925.3A Pending CN104884462A (zh) 2012-10-29 2013-10-29 用于治疗病毒感染和癌症的嘧啶核苷及其单磷酸酯前药

Country Status (11)

Country Link
US (1) US9809616B2 (cg-RX-API-DMAC7.html)
EP (1) EP2912050A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015535261A (cg-RX-API-DMAC7.html)
KR (1) KR20150090894A (cg-RX-API-DMAC7.html)
CN (1) CN104884462A (cg-RX-API-DMAC7.html)
BR (1) BR112015009636A8 (cg-RX-API-DMAC7.html)
CA (1) CA2889717A1 (cg-RX-API-DMAC7.html)
HK (1) HK1214270A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015005500A (cg-RX-API-DMAC7.html)
RU (1) RU2015119999A (cg-RX-API-DMAC7.html)
WO (1) WO2014070771A1 (cg-RX-API-DMAC7.html)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427529A (zh) * 2014-12-26 2017-12-01 埃莫里大学 N4‑羟基胞苷和衍生物及与其相关的抗病毒用途
CN110075291A (zh) * 2019-02-01 2019-08-02 广州中医药大学(广州中医药研究院) 一种单磷酸类酯A缀合Tn抗肿瘤疫苗及其应用
CN113278041A (zh) * 2021-07-16 2021-08-20 南京颐媛生物医学研究院有限公司 一种核苷磷酸酯及其合成方法与抗肝炎病毒的制药应用
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途
CN113476469A (zh) * 2017-03-10 2021-10-08 莱克伍德阿美达克斯股份有限公司 抗微生物化合物、组合物及其用途
CN113735928A (zh) * 2021-10-21 2021-12-03 药康众拓(江苏)医药科技有限公司 一种n4-羟基胞苷衍生物及其制备方法和用途
CN115215914A (zh) * 2021-04-15 2022-10-21 中国科学院上海药物研究所 核苷类似物及其用途
WO2023025319A1 (zh) * 2021-08-27 2023-03-02 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115819483A (zh) * 2021-09-17 2023-03-21 南京知和医药科技有限公司 用于治疗癌症的核苷类衍生物及其用途
WO2023197791A1 (zh) * 2022-04-11 2023-10-19 广东晨康生物科技有限公司 一种环状碳酸酯核苷类化合物及其应用
US12030908B2 (en) 2017-03-10 2024-07-09 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
WO2024259930A1 (zh) * 2022-06-24 2024-12-26 润佳（苏州）医药科技有限公司 一种膦酸酯类化合物及其医药用途

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
PE20151433A1 (es) 2012-12-21 2015-10-16 Alios Biopharma Inc Nucleosidos sustituidos, nucleotidos y analogos de los mismos
JP6562908B2 (ja) 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク． 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
US9828409B2 (en) * 2014-03-19 2017-11-28 Minghong Zhong Bridged-cyclo-ProTides as prodrugs of therapeutic nucleosides and nucleotides
US10358458B2 (en) * 2014-09-26 2019-07-23 Riboscience Llc 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication
BR112017012859A2 (pt) 2014-12-15 2017-12-26 Univ Emory fosforamidatos para o tratamento do vírus da hepatite b
EP4667053A2 (en) 2015-03-06 2025-12-24 ATEA Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
MX382566B (es) 2015-05-01 2025-03-13 Univ Emory Analogos de nucleosidos para el tratamiento de la familia de virus flaviviridae y cancer
WO2017156380A1 (en) * 2016-03-10 2017-09-14 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2017165489A1 (en) 2016-03-23 2017-09-28 Emory University Antiviral agents for treating zika and dengue virus infections
EA201990059A1 (ru) * 2016-06-24 2019-07-31 Эмори Юниверсити Фосфорамидаты для лечения вируса гепатита b
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
SMT202200072T1 (it) 2016-09-07 2022-03-21 Atea Pharmaceuticals Inc Nucleotidi purinici 2'-sostituiti-n6-sostituiti per il trattamento dei virus rna
FI3577124T3 (fi) 2017-02-01 2025-02-13 Atea Pharmaceuticals Inc Nukleotidihemisulfaattisuola hepatiitti C -viruksen hoitoon
RS66222B1 (sr) * 2017-12-07 2024-12-31 Univ Emory N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim
JP2021521118A (ja) 2018-04-10 2021-08-26 アテア ファーマシューティカルズ， インコーポレイテッド 肝硬変を伴うｈｃｖ感染患者の治療
MX2020011912A (es) * 2018-05-09 2021-01-29 Cocrystal Pharma Inc Terapia de combinacion para el tratamiento del virus de la hepatitis c (vhc).
EP3947388A4 (en) 2019-04-02 2022-12-21 Aligos Therapeutics, Inc. PRMT5 TARGETING COMPOUNDS
KR20220026538A (ko) 2019-06-05 2022-03-04 에모리 유니버시티 코로나바이러스 및 피코르나바이러스 감염 치료용 펩티도모방체
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto
JP7774836B2 (ja) * 2021-01-29 2025-11-25 国立大学法人東海国立大学機構 プロドラッグ化合物
US20240239832A1 (en) * 2021-05-06 2024-07-18 Council Of Scientific And Industrial Research A process for the preparation of n4-hydroxycytidine and its derivatives
AU2022291927A1 (en) 2021-06-17 2024-01-04 Atea Pharmaceuticals, Inc. Advantageous anti-hcv combination therapy
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
EP4493573A1 (en) 2022-03-15 2025-01-22 Rome Therapeutics, Inc. Compounds and methods for treating disease
WO2024123206A1 (ru) * 2022-12-08 2024-06-13 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Способ получения 5',-о-(3-фенилпропионил)-n4-гидроксицитидина
WO2024123207A1 (ru) * 2022-12-08 2024-06-13 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации 5'-о-(3-фенилпропионил)-n4-гидроксицитидин и его применение
WO2024249234A1 (en) * 2023-05-26 2024-12-05 Altesa BioSciences, Inc. Method of treating hepatitis c virus in patients
WO2025024346A2 (en) * 2023-07-27 2025-01-30 Merck Sharp & Dohme Llc Solid dosage form of a small molecule antiviral and uses thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1084177A (zh) * 1992-06-22 1994-03-23 伊莱利利公司 具抗病毒和抗癌活性的2′-脱氧-2′，2′-二氟(4-取代嘧啶)核苷以及中间体
US5496935A (en) * 1988-08-17 1996-03-05 Max-Delbru/ ck-Centrum 2',3'-dideoxynucleoside pyrimidine compounds and carbocyclic analogs
WO2002032920A2 (en) * 2000-10-18 2002-04-25 Pharmasset Limited Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
WO2004037159A2 (en) * 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
US20050026902A1 (en) * 2003-01-31 2005-02-03 Timothy Maziasz Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
US20050043268A1 (en) * 2001-11-07 2005-02-24 David Loakes Inhibition of viruses
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
CN1626543A (zh) * 2003-12-12 2005-06-15 河南省科学院质量检验与分析测试研究中心 β－L－2'－脱氧－核苷衍生物、其合成方法及其药物用途
US20090105186A1 (en) * 2004-10-21 2009-04-23 Max-Delbrueck-Centrum Fuer Molekulare Medizin Beta-L-N4-Hydroxycytosine Deoxynucleosides and their use as Pharmaceutical Agents in the Prophylaxis or Therapy of Viral Diseases
CN102351931A (zh) * 2010-09-07 2012-02-15 河南省科学院高新技术研究中心 嘧啶核苷衍生物、合成方法及其在制备抗肿瘤、抗病毒药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1081477A (zh) 1992-07-23 1994-02-02 康那香企业股份有限公司 纸纤不织布高分子吸水层的制造方法
JPH07155184A (ja) 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
JP2005530759A (ja) * 2002-05-06 2005-10-13 ジェネラブズ テクノロジーズ インコーポレーティッド Ｃ型肝炎ウイルス感染症を治療するためのヌクレオシド誘導体
EP1572097A4 (en) * 2002-09-30 2010-02-17 Smithkline Beecham Corp NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF INFECTIONS WITH THE HEPATITIS C-VIRUS
US7799908B2 (en) * 2003-01-15 2010-09-21 Valeant Pharmaceuticals North America Synthesis and use of 2′-substituted-N6 -modified nucleosides
US8609627B2 (en) * 2009-02-06 2013-12-17 Rfs Pharma, Llc Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
CN102558263A (zh) * 2010-12-28 2012-07-11 上海瑞广生化科技开发有限公司 去氧氟尿苷类衍生物,其制备方法及其制药用途

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496935A (en) * 1988-08-17 1996-03-05 Max-Delbru/ ck-Centrum 2',3'-dideoxynucleoside pyrimidine compounds and carbocyclic analogs
CN1084177A (zh) * 1992-06-22 1994-03-23 伊莱利利公司 具抗病毒和抗癌活性的2′-脱氧-2′，2′-二氟(4-取代嘧啶)核苷以及中间体
WO2002032920A2 (en) * 2000-10-18 2002-04-25 Pharmasset Limited Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
US20050043268A1 (en) * 2001-11-07 2005-02-24 David Loakes Inhibition of viruses
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
WO2004037159A2 (en) * 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
US20050026902A1 (en) * 2003-01-31 2005-02-03 Timothy Maziasz Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
CN1626543A (zh) * 2003-12-12 2005-06-15 河南省科学院质量检验与分析测试研究中心 β－L－2'－脱氧－核苷衍生物、其合成方法及其药物用途
US20090105186A1 (en) * 2004-10-21 2009-04-23 Max-Delbrueck-Centrum Fuer Molekulare Medizin Beta-L-N4-Hydroxycytosine Deoxynucleosides and their use as Pharmaceutical Agents in the Prophylaxis or Therapy of Viral Diseases
CN102351931A (zh) * 2010-09-07 2012-02-15 河南省科学院高新技术研究中心 嘧啶核苷衍生物、合成方法及其在制备抗肿瘤、抗病毒药物中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CRISTINA GARDELLI，等: "Phosphoramidate Prodrugs of 2’-C-Methylcytidine for Therapy of Hepatitis C Virus Infection", 《J. MED. CHEM.》 *
JUNXING SHI，等: ""Synthesis and anti-viral activity of a series of D- and L-2’-deoxy-2’-fluororibonucleosides in the subgenomic HCV replicon system"", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
MICHAEL D.TOPAL，等: ""DNA precursors in chemical mutagenesis: a novel application of DNA sequencing"", 《NATURE》 *
TETSUYA SUZUKI，等: ""Template properties of mutagenic cytosine analogues in reverse transcription"", 《NUCLEIC ACIDS RESEARCH》 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427529A (zh) * 2014-12-26 2017-12-01 埃莫里大学 N4‑羟基胞苷和衍生物及与其相关的抗病毒用途
CN113476469B (zh) * 2017-03-10 2024-04-19 莱克伍德阿美达克斯股份有限公司 抗微生物化合物、组合物及其用途
CN113476469A (zh) * 2017-03-10 2021-10-08 莱克伍德阿美达克斯股份有限公司 抗微生物化合物、组合物及其用途
US12030908B2 (en) 2017-03-10 2024-07-09 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
CN110075291A (zh) * 2019-02-01 2019-08-02 广州中医药大学(广州中医药研究院) 一种单磷酸类酯A缀合Tn抗肿瘤疫苗及其应用
CN110075291B (zh) * 2019-02-01 2023-01-06 广州中医药大学(广州中医药研究院) 一种单磷酸类酯A缀合Tn抗肿瘤疫苗及其应用
CN115215914A (zh) * 2021-04-15 2022-10-21 中国科学院上海药物研究所 核苷类似物及其用途
CN115215914B (zh) * 2021-04-15 2024-05-28 中国科学院上海药物研究所 核苷类似物及其用途
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途
CN113278041A (zh) * 2021-07-16 2021-08-20 南京颐媛生物医学研究院有限公司 一种核苷磷酸酯及其合成方法与抗肝炎病毒的制药应用
WO2023025319A1 (zh) * 2021-08-27 2023-03-02 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115960148B (zh) * 2021-08-27 2023-12-12 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115960148A (zh) * 2021-08-27 2023-04-14 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115819483A (zh) * 2021-09-17 2023-03-21 南京知和医药科技有限公司 用于治疗癌症的核苷类衍生物及其用途
CN113735928A (zh) * 2021-10-21 2021-12-03 药康众拓(江苏)医药科技有限公司 一种n4-羟基胞苷衍生物及其制备方法和用途
WO2023197791A1 (zh) * 2022-04-11 2023-10-19 广东晨康生物科技有限公司 一种环状碳酸酯核苷类化合物及其应用
WO2024259930A1 (zh) * 2022-06-24 2024-12-26 润佳（苏州）医药科技有限公司 一种膦酸酯类化合物及其医药用途

Also Published As

Publication number Publication date
BR112015009636A2 (pt) 2017-12-12
BR112015009636A8 (pt) 2018-04-17
US9809616B2 (en) 2017-11-07
EP2912050A1 (en) 2015-09-02
KR20150090894A (ko) 2015-08-06
RU2015119999A (ru) 2016-12-20
JP2015535261A (ja) 2015-12-10
WO2014070771A1 (en) 2014-05-08
EP2912050A4 (en) 2016-09-28
US20140235566A1 (en) 2014-08-21
MX2015005500A (es) 2016-02-09
HK1214270A1 (zh) 2016-07-22
CA2889717A1 (en) 2014-05-08

Similar Documents

Publication Publication Date Title
US9809616B2 (en) Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer
CA2751458C (en) Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
US8895531B2 (en) 2′-fluoronucleoside phosphonates as antiviral agents
CA2984421C (en) Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
CN1972696B (zh) 用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯
US20140212382A1 (en) Purine monophosphate prodrugs for treatment of viral infections
CA2946867C (en) 2'-disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
US20090274686A1 (en) Nucleoside phosphonate derivatives
WO2016069975A1 (en) 2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
US20120142627A1 (en) Monophosphate prodrugs of dapd and analogs thereof

Legal Events

Date Code Title Description
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1214270

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150902

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1214270

Country of ref document: HK