CN104873822A - Traditional Chinese medicine preparation for treating cervicitis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating cervicitis and preparation method thereof Download PDFInfo
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- CN104873822A CN104873822A CN201510310219.6A CN201510310219A CN104873822A CN 104873822 A CN104873822 A CN 104873822A CN 201510310219 A CN201510310219 A CN 201510310219A CN 104873822 A CN104873822 A CN 104873822A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating cervicitis and a preparation method thereof. The traditional Chinese medicine preparation is prepared by the following raw medicinal materials in parts by weight: 15 to 20 parts of golden cypress, 10 to 15 parts of dandelion, 5 to 10 parts of motherwort, 0.05 to 0.1 part of white alum, 5 to 8 parts of Chinese mugwort leaf, 6 to 9 parts of lalang grass rhizome, 10 to 12 parts of white peony root, 6 to 10 parts of wolfberry fruit, 2 to 5 parts of tortoise-shell glue, 10 to 15 parts of fructus forsythiae, and 5 to 10 parts of magnolia officinalis flower. The preparation method comprises the following steps of weighing the corresponding parts of raw materials in weight, extracting by 10 times of ethanol in weight, drying the extract, adding a proper amount of white alum, adding glycerin, and preparing into gel. The traditional Chinese medicine preparation for treating the cervicitis has the advantages that during therapy, the medicine is applied to the local part, and the focus of infection is directly acted, so the therapy effect is improved; the preparation is used for two times each day, and is continuously used for seven days as a treatment course, the effect is obtained after 2 to 3 treatment courses, and the cervicitis can be cured after 3 to 4 treatment courses; after clinical verification, the effect is good and fast, any toxic and side effect is avoided, the preparation method is simple, the convenience in use is realized, the cost is low, and the traditional Chinese medicine preparation is mainly used for treating the chronic cervicitis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of cervicitis and preparation method thereof.
Background technology
Cervicitis (cervicitis) is common gynaecopathia, the multiple women being born in the childbearing age.Old people also has and falls ill with vaginitis.Cervicitis main manifestations is leucorrhoea grow in quantity, in purulence, or has abnormal bleeding as intermenstrual bleeding, postcoital bleeding etc.Often with the soreness of waist and hypogastric region discomfort.Have acute and chronic two kinds, the normal and acute endometritis of acute cervicitis or acute vaginitis exist simultaneously, but common with chronic cervicitis.Generation and the sexual life of cervicitis have relation, nature or artificial abortion, and diagnostic curettage and childbirth all can cause cervical lesions and cause inflammation.Therapeutic strategy is mainly antibiotic medication.For acquisition pathogen person, select sensitive antibiotic for pathogen.Empirical treatment should comprise the treatment for various possible pathogenic microorganism, need comprise aerobe, anaerobe, chlamydia (with or gonococcus), mycoplasma etc.
Cervicitis is the key factor causing inflammatory disease of pelvic organs, many relevant with parillomarvirus infections, disease time is lasting and be easy to repeatedly, the life quality of severe jamming women, even whole quality of life, if treat not in time, also Cervical cancer can be developed into, be the very common pertinacious diseases of the women of child-bearing age, painful large, sickness rate is high.
Although current existing Therapeutic Method is a lot, all respectively there is deficiency.Treatment Cervicitis generally comprises Drug therapy and topical therapeutic, this type of therapy can cure diseases in certain degree, but disease easily recurs after treatment, in addition, the medicine of Drug therapy is mostly Western medicine, Western medicine side effect is large, and many patients have untoward reaction to Western medicine, and the therapeutic effect for Cervicitis is not remarkable.
Object of the present invention is exactly to provide a kind of Chinese medicine preparation for the treatment of cervicitis and preparation method thereof.
The present invention is achieved by the following technical solutions:
Treating a Chinese medicine preparation for Cervicitis, is be made up of the crude drug of following weight portion: Cortex Phellodendri 15-20 part, Herba Taraxaci 10-15 part, Herba Leonuri 5-10 part, Alumen 0.05-0.1 part, Folium Artemisiae Argyi 5-8 part, Rhizoma Imperatae 6-9 part, Radix Paeoniae Alba 10-12 part, Fructus Lycii 6-10 part, Colla Plastri Testudinis 2-5 part, Fructus Forsythiae 10-15 part, Flos Magnoliae Officinalis 5-10 part.
Preferably treating a Chinese medicine preparation for cervicitis, is be made up of the crude drug of following weight portion: Cortex Phellodendri 17-19 part, Herba Taraxaci 12-14 part, Herba Leonuri 6-8 part, Alumen 0.05-0.08 part, Folium Artemisiae Argyi 6-8 part, Rhizoma Imperatae 7-9 part, Radix Paeoniae Alba 10-12 part, Fructus Lycii 8-10 part, Colla Plastri Testudinis 2-4 part, Fructus Forsythiae 11-13 part, Flos Magnoliae Officinalis 6-8 part.
Further preferably, treating a Chinese medicine preparation for cervicitis, is be made up of the crude drug of following weight portion: Cortex Phellodendri 18 parts, Herba Taraxaci 13 parts, 8 parts, 0.05 part, Alumen, Folium Artemisiae Argyi 7 parts, Rhizoma Imperatae 8 parts, the Radix Paeoniae Alba 11 parts, Fructus Lycii 9 parts, Colla Plastri Testudinis 3 parts, Fructus Forsythiae 12 parts, Flos Magnoliae Officinalis 7 parts.
The dosage form of said medicine is gel.
Being made up of the following step of above-mentioned gel medicine:
(1) Cortex Phellodendri, Herba Taraxaci, Herba Leonuri, Alumen, Folium Artemisiae Argyi, Rhizoma Imperatae, the Radix Paeoniae Alba, Fructus Lycii, Colla Plastri Testudinis, Fructus Forsythiae, Flos Magnoliae Officinalis is taken in proportion, the mass fraction adding 8-10 (preferably 10) times weight is 60-70% ethanol, extracts 3-5 time, each 1-2 hour, filter, merging filtrate, is evaporated to the thick paste that relative density is 1.20-1.25,50 DEG C of vacuum dryings, pulverize, cross 80-100 mesh sieve, obtain extract fine powder, for subsequent use;
(2) get fine powder prepared by Alumen fine powder and step (1), add water appropriate, be heated to dissolve completely, with dilute hydrochloric acid adjust ph to 4.0-5.0, obtain A liquid;
(3) take sodium carboxymethyl cellulose and be placed in beaker, glycerol adding mixes, and slowly adds A liquid after placing 20-40 (preferably 30) minute, limit edged stirs to evenly, add water to appropriate after placing 1-2 hour again, stir evenly in rearmounted bottle, capping, in 100 DEG C of flowing steam sterilization 30-40 minute, subpackage and get final product, the weight ratio of described sodium carboxymethyl cellulose and Cortex Phellodendri is, 1.5-2.5:15-20, the weight ratio of described sodium carboxymethyl cellulose and glycerol, 1.5-2.5:40-50.
Medicament gelling agent of the present invention, its preparation method does not limit to above method, when making gel, other acceptable adjuvants can also be added, such as: lactose, chitin, mannitol, agar, sodium lauryl sulphate, hydroxypropyl emthylcellulose parabens, eucalyptus oil, sodium benzoate, benzoic acid, benzalkonium bromide, acetic acid chloroethene are fixed, sorbic acid and its esters etc.
The consumption of Chinese medicine preparation of the present invention, by active component (i.e. crude drug) total weight, is 1-20 gram/day, can smears every day once or secondary.
The Chinese medicine preparation for the treatment of cervicitis of the present invention, the pharmacological property of its each crude drug is as follows:
Cortex Phellodendri: bitter in the mouth, cold in nature.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.For damp-heat dysentery, leukorrhagia pudendal pruritus, sore swollen toxin, eczema eczema.
Herba Taraxaci: bitter sweet, cold.Heat-clearing and toxic substances removing, diuresis eliminating stagnation.Furuncle carbuncle toxin can be controlled, cold, fever and bacteriological infection etc.
Herba Leonuri: bitter, pungent, is slightly cold.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Be usually used in menoxenia, dysmenorrhea amenorrhea, lochiorrhea, edema oliguria, sore swollen toxin.Coordinating the actions of various ingredients in a prescription.
Folium Artemisiae Argyi: pungent, bitter, temperature; Warming the meridian for stopping bleeding, dispersing cold for relieving pain; For spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile.
Rhizoma Imperatae: sweet, cold; Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.
The Radix Paeoniae Alba: bitter, sour, is slightly cold; Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Fructus Lycii: sweet is flat; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Colla Plastri Testudinis: salty, sweet, cool.YIN nourishing, nourishes blood, hemostasis.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, soreness of the waist and knees, blood deficiency and yellow complexion, bleeding not during menses.
Fructus Forsythiae: bitter, is slightly cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.
Flos Magnoliae Officinalis: bitter, tepor.Removing dampness by means of aromatics, regulating the flow of QI to ease the stomach.For taste retention of damp leading to blockage of QI, the vexed distension of breast gastral cavity painful abdominal mass, poor appetite.
It is monarch drug that the present invention chooses Cortex Phellodendri, heat clearing and damp drying, antitoxin except skin ulcer.Herba Taraxaci is ministerial drug, heat-clearing and toxic substances removing, control skin ulcer swell.Assistant is with Herba Leonuri, and three medicines share, and compatibility is reasonable, clear curative effect, removing toxic substances, detumescence, antiinflammatory, meets primary disease treatment.
The Traditional Chinese medicinal gel preparation for the treatment of cervicitis of the present invention, through clinical verification for many years, good effect, instant effect, has no side effect, and preparation is simple, easy to use, cheap, can be used for treatment cervicitis and precancerous lesions of uterine cervix.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
The Traditional Chinese medicinal gel preparation of preparation treatment cervicitis
Formula is: Cortex Phellodendri 1.8kg, Herba Taraxaci 1.3kg, Herba Leonuri 0.8kg, Alumen 5g, Folium Artemisiae Argyi 0.7kg, Rhizoma Imperatae 0.8kg, Radix Paeoniae Alba 1.1kg, Fructus Lycii 0.9kg, Colla Plastri Testudinis 0.3kg, Fructus Forsythiae 1.2kg, Flos Magnoliae Officinalis 0.7kg.
Preparation method is:
Take the clean Cortex Phellodendri of corresponding weight, Herba Taraxaci, Herba Leonuri, Alumen, Folium Artemisiae Argyi, Rhizoma Imperatae, the Radix Paeoniae Alba, Fructus Lycii, Colla Plastri Testudinis, Fructus Forsythiae, Flos Magnoliae Officinalis, the mass fraction adding 95L is 70% ethanol, extracts 3 times, each 1.5 hours, filter, merging filtrate, volatilization ethanol, be evaporated to the thick paste that relative density is 1.20,50 DEG C of vacuum dryings, pulverize, and cross 80 mesh sieves, obtain extract fine powder, for subsequent use;
Get fine powder in Alumen fine powder and step (1), add water 38kg, is heated to dissolve completely, with dilute hydrochloric acid adjust ph to 4.0, obtains A liquid;
Take CMC-Na (sodium carboxymethyl cellulose) 1.9kg and be placed in beaker, glycerol adding 5kg fully mixes, place and slowly add A liquid after 30 minutes, limit edged stirs to evenly, add water to 64L after placing 2 hours again, stir evenly in rearmounted infusion bottle, capping, in 100 DEG C of flowing steam sterilizations 30 minutes, subpackage and get final product.
Embodiment 2
The Traditional Chinese medicinal gel preparation of preparation treatment cervicitis
Formula is: Cortex Phellodendri 1.5kg, Herba Taraxaci 1.0kg, Herba Leonuri 0.5kg, Alumen 5g, Folium Artemisiae Argyi 0.5kg, Rhizoma Imperatae 0.6kg, Radix Paeoniae Alba 1.0kg, Fructus Lycii 0.6kg, Colla Plastri Testudinis 0.2kg, Fructus Forsythiae 1.0kg, Flos Magnoliae Officinalis 0.5kg.
Preparation method is:
Take the clean Cortex Phellodendri of corresponding weight, Herba Taraxaci, Herba Leonuri, Alumen, Folium Artemisiae Argyi, Rhizoma Imperatae, the Radix Paeoniae Alba, Fructus Lycii, Colla Plastri Testudinis, Fructus Forsythiae, Flos Magnoliae Officinalis, add 60% ethanol of 42L, extract 3 times, each 1 hour, filter, merging filtrate, volatilization ethanol, be evaporated to the thick paste that relative density is 1.25,50 DEG C of vacuum dryings, pulverize, and cross 80 mesh sieves, obtain extract fine powder, for subsequent use;
Get the extract fine powder of Alumen fine powder and above-mentioned steps, add water 56kg, is heated to dissolve completely, with dilute hydrochloric acid adjust ph to 5.0, obtains A liquid;
Take CMC-Na (sodium carboxymethyl cellulose) 2.8kg and be placed in beaker, glycerol adding 7kg fully mixes, place and slowly add A liquid after 20 minutes, limit edged stirs to evenly, add water to 100L after placing 2 hours again, stir evenly in rearmounted infusion bottle, capping, in 100 DEG C of flowing steam sterilizations 30 minutes, subpackage and get final product.
Embodiment 3
The Traditional Chinese medicinal gel preparation of preparation treatment cervicitis
Formula is: Cortex Phellodendri 2.0kg, Herba Taraxaci 1.5kg, Herba Leonuri 1.0kg, Alumen 0.01kg, Folium Artemisiae Argyi 0.8kg, Rhizoma Imperatae 0.9kg, Radix Paeoniae Alba 1.2kg, Fructus Lycii 1.0kg, Colla Plastri Testudinis 0.5kg, Fructus Forsythiae 1.5kg, Flos Magnoliae Officinalis 1.0kg.
Preparation method is:
Take the clean Cortex Phellodendri of corresponding weight, Herba Taraxaci, Herba Leonuri, Alumen, Folium Artemisiae Argyi, Rhizoma Imperatae, the Radix Paeoniae Alba, Fructus Lycii, Colla Plastri Testudinis, Fructus Forsythiae, Flos Magnoliae Officinalis, add 65% ethanol of 50L, extract 3 times, each 1.5 hours, filter, merging filtrate, volatilization ethanol, be evaporated to the thick paste that relative density is 1.20,50 DEG C of vacuum dryings, pulverize, and cross 80 mesh sieves, obtain extract fine powder, for subsequent use;
Get the extract fine powder of Alumen fine powder and above-mentioned steps, add water 60kg, is heated to dissolve completely, with dilute hydrochloric acid adjust ph to 4.0, obtains A liquid;
Take CMC-Na (sodium carboxymethyl cellulose) 5.0kg and be placed in beaker, glycerol adding 12.5kg fully mixes, place and slowly add A liquid after 40 minutes, limit edged stirs to evenly, add water to 150L after placing 2 hours again, stir evenly in rearmounted infusion bottle, capping, in 100 DEG C of flowing steam sterilizations 30 minutes, subpackage and get final product.
Clinical verification
(1) physical data
The medicine that Application Example 1 is made carries out clinical treatment to 90 routine patients, and the age of patient, in 25-47 year, mostly is the multiparity women of child-bearing age, is chronic cervicitis.
(2) Therapeutic Method
Patient is divided into treatment group and matched group at random, the Chinese medicine preparation that treatment group adopts embodiment 1 to prepare, smear affected part every day 2 times, being used in conjunction 7 is a course for the treatment of.Healing person, does not re-use.Unhealed, proceeds the next course for the treatment of.Matched group adopts the clean gel of side Lovell, takes to specifications or follows the doctor's advice.
(3) the standard of curative effect evaluation:
Cure: clinical symptom disappearance, detect normal.
Take a turn for the better: clinical symptoms partial disappearance or be clearly better.
Invalid: Clinical symptom and sign is without improvement.
(4) therapeutic effect
Treatment group most of patients uses to take effect 2-3 the course for the treatment of, healing 3-4 course for the treatment of, the course of disease is longer, the state of an illness than more severe case, need 5-6 the course for the treatment of be used, take the therapeutic outcome after 5 courses for the treatment of in table 1.
Table 1 therapeutic outcome
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate (%) |
| Treat 1 group | 40 | 35 | 5 | 0 | 100 |
| Matched group | 40 | 30 | 6 | 4 | 90 |
Model case
1, side so-and-so, female, 30 years old, patient found cervicitis before 3 years, leucorrhoea grow in quantity, sometimes in secretions with the blood streak, lower abdomen is pain sometimes.Use medicine of the present invention (embodiment 1) to treat, after treating for 4 courses for the treatment of, transference cure, continues use 1 the lasting effects course for the treatment of; Pay a return visit after half a year, have no recurrence.
2, rise so-and-so, female, 40 years old, for many years, vaginal secretions increases Chronic cervicitis, in yellow, is sometimes with purulence, time have contact bleeding, gynecologial examination finds that cervix uteri be that rotten to the corn sample changes, and has yellow secretions covering cervical orifice.Use medicine of the present invention (embodiment 1) to treat, after treating for 4 courses for the treatment of, symptom obviously alleviates, and continues 2 courses for the treatment of of use, cures.Recurrence of following up a case by regular visits to that so far there are no.
The specific embodiment of the present invention is described although above-mentioned in conjunction with the embodiments; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme of the present invention, those skilled in the art do not need to pay various amendment or distortion that creative work can make still within protection scope of the present invention.
Claims (10)
1. treating a Chinese medicine preparation for Cervicitis, it is characterized in that, is be made up of the crude drug of following weight portion:
Cortex Phellodendri 15-20 part, Herba Taraxaci 10-15 part, Herba Leonuri 5-10 part, Alumen 0.05-0.1 part, Folium Artemisiae Argyi 5-8 part, Rhizoma Imperatae 6-9 part, Radix Paeoniae Alba 10-12 part, Fructus Lycii 6-10 part, Colla Plastri Testudinis 2-5 part, Fructus Forsythiae 10-15 part, Flos Magnoliae Officinalis 5-10 part.
2. the Chinese medicine preparation for the treatment of cervicitis as claimed in claim 1, it is characterized in that, be made up of the raw material of following weight portion:
Cortex Phellodendri 17-19 part, Herba Taraxaci 12-14 part, Herba Leonuri 6-8 part, Alumen 0.05-0.08 part, Folium Artemisiae Argyi 6-8 part, Rhizoma Imperatae 7-9 part, Radix Paeoniae Alba 10-12 part, Fructus Lycii 8-10 part, Colla Plastri Testudinis 2-4 part, Fructus Forsythiae 11-13 part, Flos Magnoliae Officinalis 6-8 part.
3. the Chinese medicine preparation for the treatment of cervicitis as claimed in claim 1, it is characterized in that, be made up of the raw material of following weight portion:
Cortex Phellodendri 18 parts, Herba Taraxaci 13 parts, 8 parts, 0.05 part, Alumen, Folium Artemisiae Argyi 7 parts, Rhizoma Imperatae 8 parts, the Radix Paeoniae Alba 11 parts, Fructus Lycii 9 parts, Colla Plastri Testudinis 3 parts, Fructus Forsythiae 12 parts, Flos Magnoliae Officinalis 7 parts.
4. the Chinese medicine preparation as described in as arbitrary in claim 1-3, it is characterized in that, dosage form is gel.
5. the preparation method of Chinese medicine preparation as claimed in claim 4, is characterized in that, be made up of the following step:
(1) Cortex Phellodendri, Herba Taraxaci, Herba Leonuri, Alumen, Folium Artemisiae Argyi, Rhizoma Imperatae, the Radix Paeoniae Alba, Fructus Lycii, Colla Plastri Testudinis, Fructus Forsythiae, Flos Magnoliae Officinalis is taken in proportion, the mass fraction adding 8-10 times of weight is 60-70% ethanol, extracts 2-5 time, each 1-2 hour, filter, merging filtrate, is evaporated to the thick paste that relative density is 1.20-1.25, vacuum drying, pulverize, cross 80-100 mesh sieve, obtain extract fine powder, for subsequent use;
(2) get the extract fine powder of Alumen fine powder and above-mentioned steps, add water appropriate, be heated to dissolve completely, with dilute hydrochloric acid adjust ph to 4.0-5.0, obtain A liquid;
(3) take sodium carboxymethyl cellulose and be placed in beaker, glycerol adding mixes, and places and slowly adds A liquid after 20-40 minute, limit edged stirs to evenly, add water to appropriate after placing 1-2 hour again, stir evenly in rearmounted bottle, capping, in 100 DEG C of flowing steam sterilization 30-40 minute, subpackage and get final product, the weight ratio of described sodium carboxymethyl cellulose and Cortex Phellodendri is, 1.5-2.5:15-20, the weight ratio of described sodium carboxymethyl cellulose and glycerol, 1.5-2.5:40-50.
6. Chinese medicine preparation as claimed in claim 4, it is characterized in that, in described gel, also comprise that lactose, chitin, mannitol, agar, sodium lauryl sulphate, hydroxypropyl emthylcellulose parabens, eucalyptus oil, sodium benzoate, benzoic acid, benzalkonium bromide, acetic acid chloroethene are fixed, in sorbic acid and its esters any one or multiple.
7. preparation method as claimed in claim 5, it is characterized in that, in described step (1), the mass fraction adding 10 times of weight is 65% ethanol, extracts 3 times, each 1.5 hours.
8. preparation method as claimed in claim 5, is characterized in that, in described step (2), with dilute hydrochloric acid adjust ph.
9. preparation method as claimed in claim 5, is characterized in that, in described step (3), place and slowly add A liquid after 30 minutes.
10. preparation method as claimed in claim 5, is characterized in that, in described step (1), and 50 DEG C of vacuum dryings.
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| CN201510310219.6A CN104873822A (en) | 2015-06-08 | 2015-06-08 | Traditional Chinese medicine preparation for treating cervicitis and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050214393A1 (en) * | 2004-03-26 | 2005-09-29 | Osama Kandil | Lipid fraction of Nigella sativa L. seeds |
| CN1698766A (en) * | 2005-06-06 | 2005-11-23 | 孙鲜玲 | Soft capsule for treating gynecological inflammation and its preparation method |
-
2015
- 2015-06-08 CN CN201510310219.6A patent/CN104873822A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050214393A1 (en) * | 2004-03-26 | 2005-09-29 | Osama Kandil | Lipid fraction of Nigella sativa L. seeds |
| CN1698766A (en) * | 2005-06-06 | 2005-11-23 | 孙鲜玲 | Soft capsule for treating gynecological inflammation and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 王华: "王国书老中医明方三首介绍", 《贵阳中医学院学报》 * |
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Application publication date: 20150902 |